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The map label for this gene is rnhA

Identifier: 110834085

GI number: 110834085

Start: 1394457

End: 1394912

Strand: Direct

Name: rnhA

Synonym: ABO_1224

Alternate gene names: 110834085

Gene position: 1394457-1394912 (Clockwise)

Preceding gene: 110834084

Following gene: 110834086

Centisome position: 44.69

GC content: 53.95

Gene sequence:

>456_bases
TTGAAAAATGTGATTATCTACACTGACGGCGCTTGCCGTGGTAATCCCGGTCCGGGTGGTTGGGGCGCTATTCTTCTCTA
TGGTGATAAGGAGAAAGAGTTATTCGGCGGTGAGCCGGAAACCACCAACAATCGTATGGAACTGATGGCGGCGATTGTCG
CGCTTGAAACGCTCAACACGCCCTGTCAGGTGGTCTTGACCACGGATTCAAAGTACGTGATGGATGGCATTACACAGTGG
ATGGCGAACTGGAAAAAGCGAGGCTGGAAAACGGCATCCAAGCAGCCTGTAAAGAACGTTGACTTATGGCAGCGCCTAGA
TGCGGCAGTGCAACGCCACGACATCGACTGGCAGTGGGTCAAGGGACACAGTGGCCACCCAGGTAACGAGCGCGCTGACG
CGCTGGCTAACCGGGGGATTGATGAAATGAAACACAAGCAGGGGCAAGCTAGCTAA

Upstream 100 bases:

>100_bases
GTTCGTCCGTTGGCCAGCCGACAACGCAGAGTGCCGCGCAATGCTGTGGTGCCAGTACCAGTGGCCCGCTGGGGCCAACA
GAACAGGGAGCCTTGAGTCT

Downstream 100 bases:

>100_bases
TGCGTCAGGTTGTATTGGATACGGAAACCACAGGTCTTGAGCCGAATGACGGGCACCGGGTGATCGAAATTGGTTGTGTG
GAGATGGAAAATCGCCGCCT

Product: ribonuclease H

Products: NA

Alternate protein names: RNase H

Number of amino acids: Translated: 151; Mature: 151

Protein sequence:

>151_residues
MKNVIIYTDGACRGNPGPGGWGAILLYGDKEKELFGGEPETTNNRMELMAAIVALETLNTPCQVVLTTDSKYVMDGITQW
MANWKKRGWKTASKQPVKNVDLWQRLDAAVQRHDIDWQWVKGHSGHPGNERADALANRGIDEMKHKQGQAS

Sequences:

>Translated_151_residues
MKNVIIYTDGACRGNPGPGGWGAILLYGDKEKELFGGEPETTNNRMELMAAIVALETLNTPCQVVLTTDSKYVMDGITQW
MANWKKRGWKTASKQPVKNVDLWQRLDAAVQRHDIDWQWVKGHSGHPGNERADALANRGIDEMKHKQGQAS
>Mature_151_residues
MKNVIIYTDGACRGNPGPGGWGAILLYGDKEKELFGGEPETTNNRMELMAAIVALETLNTPCQVVLTTDSKYVMDGITQW
MANWKKRGWKTASKQPVKNVDLWQRLDAAVQRHDIDWQWVKGHSGHPGNERADALANRGIDEMKHKQGQAS

Specific function: Endonuclease that specifically degrades the RNA of RNA- DNA hybrids

COG id: COG0328

COG function: function code L; Ribonuclease HI

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase H domain

Homologues:

Organism=Homo sapiens, GI21359816, Length=141, Percent_Identity=39.7163120567376, Blast_Score=87, Evalue=7e-18,
Organism=Escherichia coli, GI1786408, Length=136, Percent_Identity=69.1176470588235, Blast_Score=202, Evalue=8e-54,
Organism=Caenorhabditis elegans, GI115532542, Length=143, Percent_Identity=37.7622377622378, Blast_Score=87, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17505482, Length=130, Percent_Identity=38.4615384615385, Blast_Score=73, Evalue=5e-14,
Organism=Drosophila melanogaster, GI17137476, Length=152, Percent_Identity=41.4473684210526, Blast_Score=106, Evalue=7e-24,
Organism=Drosophila melanogaster, GI45552509, Length=152, Percent_Identity=41.4473684210526, Blast_Score=106, Evalue=7e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNH_ALCBS (Q0VQ76)

Other databases:

- EMBL:   AM286690
- RefSeq:   YP_692944.1
- ProteinModelPortal:   Q0VQ76
- SMR:   Q0VQ76
- STRING:   Q0VQ76
- GeneID:   4212166
- GenomeReviews:   AM286690_GR
- KEGG:   abo:ABO_1224
- eggNOG:   COG0328
- HOGENOM:   HBG742437
- OMA:   NGWRTAD
- PhylomeDB:   Q0VQ76
- BioCyc:   ABOR393595:ABO_1224-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00042
- InterPro:   IPR022892
- InterPro:   IPR012337
- InterPro:   IPR002156

Pfam domain/function: PF00075 RnaseH; SSF53098 RNaseH_fold

EC number: =3.1.26.4

Molecular weight: Translated: 16861; Mature: 16861

Theoretical pI: Translated: 8.23; Mature: 8.23

Prosite motif: PS50879 RNASE_H

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNVIIYTDGACRGNPGPGGWGAILLYGDKEKELFGGEPETTNNRMELMAAIVALETLNT
CCCEEEEECCCCCCCCCCCCEEEEEEECCCCCHHCCCCCCCCCHHHHHHHHHHHHHHCCC
PCQVVLTTDSKYVMDGITQWMANWKKRGWKTASKQPVKNVDLWQRLDAAVQRHDIDWQWV
CEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEE
KGHSGHPGNERADALANRGIDEMKHKQGQAS
CCCCCCCCCHHHHHHHHCCHHHHHHHCCCCC
>Mature Secondary Structure
MKNVIIYTDGACRGNPGPGGWGAILLYGDKEKELFGGEPETTNNRMELMAAIVALETLNT
CCCEEEEECCCCCCCCCCCCEEEEEEECCCCCHHCCCCCCCCCHHHHHHHHHHHHHHCCC
PCQVVLTTDSKYVMDGITQWMANWKKRGWKTASKQPVKNVDLWQRLDAAVQRHDIDWQWV
CEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEE
KGHSGHPGNERADALANRGIDEMKHKQGQAS
CCCCCCCCCHHHHHHHHCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA