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The map label for this gene is lpxD

Identifier: 110834014

GI number: 110834014

Start: 1310976

End: 1311986

Strand: Direct

Name: lpxD

Synonym: ABO_1153

Alternate gene names: 110834014

Gene position: 1310976-1311986 (Clockwise)

Preceding gene: 110834013

Following gene: 110834015

Centisome position: 42.02

GC content: 52.92

Gene sequence:

>1011_bases
ATGTTGACTCTCGGTGAGTTAGCAAAAAAACTGGATGCGGAGTTGATCGGTGAGGCCAGCCATGTTGTGGACGGTTTGGG
AACAATCCAGTCCGCAGGGCCAAGCCAACTGACTTTTCTTGCCAACCCCCGTTATCGGTCATTCTTGGAACAGACTAATG
CGGGTGCGGTGCTAATTCCTGAGTCCCAGCGGGAATTTTGTCCGGTGCCGGCATTGATTGTTAAAGACCCATACTTGTCT
TTTGCCAAAGCCAGTGCGTTTTTTGAAGTGGCACCGCAAGTGCAGCCGGGTGTGCATCCTGCTGCGGTTGTGGATGCGAC
GGCACAGATTCACACCTCTGCGTCCATTGGCCCGAATGCGGTGGTGGAAGCGGGTGTGATAGTGGGAGAGGGCGCCGTAA
TCATGGCCAACAGCGTGGTTGGTGCCGGCTGTCATATCGGTGATCAGTGTCGAATTTGGCCAAATGTTACAATTTACCAT
GGTGTGACACTGGGTCCACGCACTACTATACACGCCAATTGCGTAATCGGTGGTGATGGTTTTGGCTTCGCCTTCAATGG
CGCCGGTTGGACCAAACTTCATCAAGTCGGTGGCGTTACCATCGGTGCAGATGTGGAAATCGGTGCTGGCACGACAGTTG
ATCGTGGTGCCATTGAAGATACCATCATTGGTGACGGTGTGATTCTGGATAATCAGATCCAGGTGGCCCATAACGTTGTC
ATCGGTGATCACACGGCTATCGCTGGGAAAGCGGGTATTGCGGGTTCAGCCAAAATAGGTTCTTTCTGCCTGATAGGTGG
GGCCGCTGGTATAGCTGGCCACATCGAAGTATGTGACAAGGTGCAAATTCTGGCCATGTCCTTGGTCTCCAGCTCTATCA
AAGAACCGGGTACATACGGTTCTGCTCTGCCTGTGGATAGCCAATCTCGCTATCGCAGGAATGTGGCGCGTTTCCGAAAT
CTGGATGATTTGGCCCGCCGTGTACGCAAGCTCGAGCGTTTAAGCGACTAA

Upstream 100 bases:

>100_bases
AAAAGCTGGATGTAGTGCTCAATGCCCAAGCTGTGATGTACACCAAGCCGGATCTAGATATTACTGAAGCGGTGGGCAAG
CAACTGAACAGTATGAAATA

Downstream 100 bases:

>100_bases
TTTCCGCATGTTGCGGTACTTGCCTGTTTGGAACACATGATGATGGACATTAAAGAGGTCAGGGAATATCTGCCCCATCG
TTACCCCTTTCTGTTAATTG

Product: UDP-3-O-[3-hydroxymyristoyl] glucosaminen-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MLTLGELAKKLDAELIGEASHVVDGLGTIQSAGPSQLTFLANPRYRSFLEQTNAGAVLIPESQREFCPVPALIVKDPYLS
FAKASAFFEVAPQVQPGVHPAAVVDATAQIHTSASIGPNAVVEAGVIVGEGAVIMANSVVGAGCHIGDQCRIWPNVTIYH
GVTLGPRTTIHANCVIGGDGFGFAFNGAGWTKLHQVGGVTIGADVEIGAGTTVDRGAIEDTIIGDGVILDNQIQVAHNVV
IGDHTAIAGKAGIAGSAKIGSFCLIGGAAGIAGHIEVCDKVQILAMSLVSSSIKEPGTYGSALPVDSQSRYRRNVARFRN
LDDLARRVRKLERLSD

Sequences:

>Translated_336_residues
MLTLGELAKKLDAELIGEASHVVDGLGTIQSAGPSQLTFLANPRYRSFLEQTNAGAVLIPESQREFCPVPALIVKDPYLS
FAKASAFFEVAPQVQPGVHPAAVVDATAQIHTSASIGPNAVVEAGVIVGEGAVIMANSVVGAGCHIGDQCRIWPNVTIYH
GVTLGPRTTIHANCVIGGDGFGFAFNGAGWTKLHQVGGVTIGADVEIGAGTTVDRGAIEDTIIGDGVILDNQIQVAHNVV
IGDHTAIAGKAGIAGSAKIGSFCLIGGAAGIAGHIEVCDKVQILAMSLVSSSIKEPGTYGSALPVDSQSRYRRNVARFRN
LDDLARRVRKLERLSD
>Mature_336_residues
MLTLGELAKKLDAELIGEASHVVDGLGTIQSAGPSQLTFLANPRYRSFLEQTNAGAVLIPESQREFCPVPALIVKDPYLS
FAKASAFFEVAPQVQPGVHPAAVVDATAQIHTSASIGPNAVVEAGVIVGEGAVIMANSVVGAGCHIGDQCRIWPNVTIYH
GVTLGPRTTIHANCVIGGDGFGFAFNGAGWTKLHQVGGVTIGADVEIGAGTTVDRGAIEDTIIGDGVILDNQIQVAHNVV
IGDHTAIAGKAGIAGSAKIGSFCLIGGAAGIAGHIEVCDKVQILAMSLVSSSIKEPGTYGSALPVDSQSRYRRNVARFRN
LDDLARRVRKLERLSD

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily

Homologues:

Organism=Escherichia coli, GI1786376, Length=332, Percent_Identity=46.3855421686747, Blast_Score=322, Evalue=2e-89,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXD_ALCBS (Q0VQE7)

Other databases:

- EMBL:   AM286690
- RefSeq:   YP_692873.1
- ProteinModelPortal:   Q0VQE7
- STRING:   Q0VQE7
- GeneID:   4211463
- GenomeReviews:   AM286690_GR
- KEGG:   abo:ABO_1153
- NMPDR:   fig|393595.12.peg.1164
- eggNOG:   COG1044
- HOGENOM:   HBG469615
- OMA:   CFVGKNT
- PhylomeDB:   Q0VQE7
- BioCyc:   ABOR393595:ABO_1153-MONOMER
- HAMAP:   MF_00523
- InterPro:   IPR001451
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573
- TIGRFAMs:   TIGR01853

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD; SSF51161 Trimer_LpxA_like

EC number: 2.3.1.-

Molecular weight: Translated: 34847; Mature: 34847

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTLGELAKKLDAELIGEASHVVDGLGTIQSAGPSQLTFLANPRYRSFLEQTNAGAVLIP
CCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHCCCCEEEEE
ESQREFCPVPALIVKDPYLSFAKASAFFEVAPQVQPGVHPAAVVDATAQIHTSASIGPNA
CCCCCCCCCCEEEECCCCHHHHHHHHHEEECCCCCCCCCCHHHHCCHHHEEECCCCCCCH
VVEAGVIVGEGAVIMANSVVGAGCHIGDQCRIWPNVTIYHGVTLGPRTTIHANCVIGGDG
HEECCEEEECCCEEEECCEEECCCCCCCCEEECCCEEEEECEEECCCCEEEEEEEEECCC
FGFAFNGAGWTKLHQVGGVTIGADVEIGAGTTVDRGAIEDTIIGDGVILDNQIQVAHNVV
CEEEECCCCHHHHHHHCCEEECCEEEECCCCCCCCCCCCCEEECCCEEECCEEEEEEEEE
IGDHTAIAGKAGIAGSAKIGSFCLIGGAAGIAGHIEVCDKVQILAMSLVSSSIKEPGTYG
ECCCCEECCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
SALPVDSQSRYRRNVARFRNLDDLARRVRKLERLSD
CCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLTLGELAKKLDAELIGEASHVVDGLGTIQSAGPSQLTFLANPRYRSFLEQTNAGAVLIP
CCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHCCCCEEEEE
ESQREFCPVPALIVKDPYLSFAKASAFFEVAPQVQPGVHPAAVVDATAQIHTSASIGPNA
CCCCCCCCCCEEEECCCCHHHHHHHHHEEECCCCCCCCCCHHHHCCHHHEEECCCCCCCH
VVEAGVIVGEGAVIMANSVVGAGCHIGDQCRIWPNVTIYHGVTLGPRTTIHANCVIGGDG
HEECCEEEECCCEEEECCEEECCCCCCCCEEECCCEEEEECEEECCCCEEEEEEEEECCC
FGFAFNGAGWTKLHQVGGVTIGADVEIGAGTTVDRGAIEDTIIGDGVILDNQIQVAHNVV
CEEEECCCCHHHHHHHCCEEECCEEEECCCCCCCCCCCCCEEECCCEEECCEEEEEEEEE
IGDHTAIAGKAGIAGSAKIGSFCLIGGAAGIAGHIEVCDKVQILAMSLVSSSIKEPGTYG
ECCCCEECCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
SALPVDSQSRYRRNVARFRNLDDLARRVRKLERLSD
CCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA