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The map label for this gene is gapA [H]

Identifier: 110833892

GI number: 110833892

Start: 1171183

End: 1172622

Strand: Direct

Name: gapA [H]

Synonym: ABO_1031

Alternate gene names: 110833892

Gene position: 1171183-1172622 (Clockwise)

Preceding gene: 110833891

Following gene: 110833893

Centisome position: 37.54

GC content: 52.64

Gene sequence:

>1440_bases
GTGAGCAAACTGGAAGACCATTTCGGACGCTGGAAGAACCGCGAAGAAATTGCAGAAGCCATGATTCCTATGATCGGGCG
CCTGCATCGTGAAAAGAACGTTACCACGACCGTGTACAGCCGTTCCCTGGTCAACAAGTCTGTTATCCAGATTCTGAAGA
GCCATCGTTTCGTTAAGCAGGTTGAAGATTCTGAACTGTCTGTGGTCGATACTTTCCCGATCCTTCAGGAAGTGGCTAAG
TCGGATCTCGGCCCTTGCCGGATCGATATCGGTAAATTGGCGGTGGAGTACAAAAAAGACAATCGTGGCCTCTCTATCGA
AGATTATGTGCGAGAAGAGCTGTCTGAAGCGGTGAGCAGCAAAGTCGACATGCCCGAGCGCACCGATGTGGTGCTGTACG
GGTTCGGCCGTATCGGTCGTATTCTGGCACGTCTGTTGATCGAGAAAGCCGGCTCCGGCGATGGCCTGCGCCTGAAAGCC
ATTGTGGTGCGTGAATCAGGTAAGGGTGATTTGCAAAAGCGCGCTAGCCTGATGCGTCGTGATTCTGTGCACGGCCCGTT
TGCGGGCACTATTGCTGTGGACGAGGAAGAAAATGCCATCATCGCCAACGGTAACTTCATTAAGGTGATTTACTCCAGCG
ACCCGGCGTCTATCGATTACACCGATTACGGCATTAATAATGCTGTGGTGATTGATAACACCGGTAAATGGCGTGACGAG
GAAGGTCTGTCTCAGCATTTGCAATGCAAGGGTGTGTCCCGCGTGATGTTGACTGCGCCAGGCAAGGGCAACATGAAGAA
CATCGTTCACGGAGTGAACAATGATTTGATTGAAGACAGCGACAAGATTATTTCCGCAGCAAGCTGCACCACCAATGCCA
TCGTTCCGCCGCTGAAGGCGCTGGAAGATAAGTTCGGCATCGAGTTCGGCCATGTGGAAACGGTACACTCCTACACCAAT
GACCAGAACCTGTTGGATAACTTCCACAAGGGGCCTCGTCGTGGGCGTTCGGCGCCACTGAACATGGTGTTGACTGAGAC
CGGTGCGGCGACGGCTGCCACCAAAGTATTGCCGAGCCTTAATGGCAAGCTGACCGGAAACTCCATCCGCGTTCCCACCC
CGAACGTGTCTATGGCGATCCTGAACTTGACTCTGGGCAAAGAAACTACCTTGGAAGAGCTCAACGATTACTTGCGTTGG
GTGAGCTTGCATTCTCCTCTGCAGCGCCAGGTGGATTTCGTAAGCAGCCCGGATGCAGTGTCTACGGATTTCGTTGGCTC
ACGTCACGCCTCCGTGATTGACGCAGAAGCGACTATTGTTAATGGTCGTCACTGTGTGCTGTATGTGTGGTATGACAATG
AGTTCGGTTATAGCTGTCAGGTGTTGCGTATCCTGCAGCAGATTTCTGGGGTGGAATTCCCGGTGTATCCGAAGGACTGA

Upstream 100 bases:

>100_bases
TATTATGCGCGCCCCGTACTCCACCACCGCAGGTAGGACGGCAAGCATGGCAATGATGCCGCTTTTCGTCGCCTGAACCC
AAACTGAGAGGGCCATCTCC

Downstream 100 bases:

>100_bases
ACCCGGAACAGAGAAGCCCGCCCCGCGGGCTTTTTTCGGTGCATTTTCCGTTTTCTTGTTGCCCTATAAAAGGGGCTATA
CGACAAAAGGCGGAGGCGGC

Product: glyceraldehyde-3-phosphate dehydrogenase

Products: NA

Alternate protein names: GAPDH [H]

Number of amino acids: Translated: 479; Mature: 478

Protein sequence:

>479_residues
MSKLEDHFGRWKNREEIAEAMIPMIGRLHREKNVTTTVYSRSLVNKSVIQILKSHRFVKQVEDSELSVVDTFPILQEVAK
SDLGPCRIDIGKLAVEYKKDNRGLSIEDYVREELSEAVSSKVDMPERTDVVLYGFGRIGRILARLLIEKAGSGDGLRLKA
IVVRESGKGDLQKRASLMRRDSVHGPFAGTIAVDEEENAIIANGNFIKVIYSSDPASIDYTDYGINNAVVIDNTGKWRDE
EGLSQHLQCKGVSRVMLTAPGKGNMKNIVHGVNNDLIEDSDKIISAASCTTNAIVPPLKALEDKFGIEFGHVETVHSYTN
DQNLLDNFHKGPRRGRSAPLNMVLTETGAATAATKVLPSLNGKLTGNSIRVPTPNVSMAILNLTLGKETTLEELNDYLRW
VSLHSPLQRQVDFVSSPDAVSTDFVGSRHASVIDAEATIVNGRHCVLYVWYDNEFGYSCQVLRILQQISGVEFPVYPKD

Sequences:

>Translated_479_residues
MSKLEDHFGRWKNREEIAEAMIPMIGRLHREKNVTTTVYSRSLVNKSVIQILKSHRFVKQVEDSELSVVDTFPILQEVAK
SDLGPCRIDIGKLAVEYKKDNRGLSIEDYVREELSEAVSSKVDMPERTDVVLYGFGRIGRILARLLIEKAGSGDGLRLKA
IVVRESGKGDLQKRASLMRRDSVHGPFAGTIAVDEEENAIIANGNFIKVIYSSDPASIDYTDYGINNAVVIDNTGKWRDE
EGLSQHLQCKGVSRVMLTAPGKGNMKNIVHGVNNDLIEDSDKIISAASCTTNAIVPPLKALEDKFGIEFGHVETVHSYTN
DQNLLDNFHKGPRRGRSAPLNMVLTETGAATAATKVLPSLNGKLTGNSIRVPTPNVSMAILNLTLGKETTLEELNDYLRW
VSLHSPLQRQVDFVSSPDAVSTDFVGSRHASVIDAEATIVNGRHCVLYVWYDNEFGYSCQVLRILQQISGVEFPVYPKD
>Mature_478_residues
SKLEDHFGRWKNREEIAEAMIPMIGRLHREKNVTTTVYSRSLVNKSVIQILKSHRFVKQVEDSELSVVDTFPILQEVAKS
DLGPCRIDIGKLAVEYKKDNRGLSIEDYVREELSEAVSSKVDMPERTDVVLYGFGRIGRILARLLIEKAGSGDGLRLKAI
VVRESGKGDLQKRASLMRRDSVHGPFAGTIAVDEEENAIIANGNFIKVIYSSDPASIDYTDYGINNAVVIDNTGKWRDEE
GLSQHLQCKGVSRVMLTAPGKGNMKNIVHGVNNDLIEDSDKIISAASCTTNAIVPPLKALEDKFGIEFGHVETVHSYTND
QNLLDNFHKGPRRGRSAPLNMVLTETGAATAATKVLPSLNGKLTGNSIRVPTPNVSMAILNLTLGKETTLEELNDYLRWV
SLHSPLQRQVDFVSSPDAVSTDFVGSRHASVIDAEATIVNGRHCVLYVWYDNEFGYSCQVLRILQQISGVEFPVYPKD

Specific function: Second phase of glycolysis; first step. [C]

COG id: COG0057

COG function: function code G; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7669492, Length=352, Percent_Identity=37.5, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI7657116, Length=338, Percent_Identity=34.9112426035503, Blast_Score=177, Evalue=2e-44,
Organism=Escherichia coli, GI1788079, Length=342, Percent_Identity=38.0116959064327, Blast_Score=195, Evalue=5e-51,
Organism=Escherichia coli, GI1789295, Length=346, Percent_Identity=32.6589595375723, Blast_Score=180, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17534677, Length=354, Percent_Identity=35.5932203389831, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17534679, Length=354, Percent_Identity=35.5932203389831, Blast_Score=181, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI17568413, Length=356, Percent_Identity=36.5168539325843, Blast_Score=178, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI32566163, Length=353, Percent_Identity=36.2606232294618, Blast_Score=177, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6322409, Length=342, Percent_Identity=35.0877192982456, Blast_Score=191, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6322468, Length=342, Percent_Identity=34.7953216374269, Blast_Score=190, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6321631, Length=342, Percent_Identity=34.7953216374269, Blast_Score=189, Evalue=9e-49,
Organism=Drosophila melanogaster, GI85725000, Length=341, Percent_Identity=38.1231671554252, Blast_Score=196, Evalue=4e-50,
Organism=Drosophila melanogaster, GI22023983, Length=341, Percent_Identity=38.1231671554252, Blast_Score=196, Evalue=4e-50,
Organism=Drosophila melanogaster, GI17933600, Length=341, Percent_Identity=36.950146627566, Blast_Score=193, Evalue=3e-49,
Organism=Drosophila melanogaster, GI18110149, Length=341, Percent_Identity=36.950146627566, Blast_Score=193, Evalue=3e-49,
Organism=Drosophila melanogaster, GI19922412, Length=339, Percent_Identity=37.1681415929204, Blast_Score=187, Evalue=2e-47,

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1840 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 740 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1660 Molecules/Cell In: Growth Phase, Min

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020831
- InterPro:   IPR020830
- InterPro:   IPR020829
- InterPro:   IPR020828
- InterPro:   IPR006424
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02800 Gp_dh_C; PF00044 Gp_dh_N [H]

EC number: =1.2.1.12 [H]

Molecular weight: Translated: 53023; Mature: 52892

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00071 GAPDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKLEDHFGRWKNREEIAEAMIPMIGRLHREKNVTTTVYSRSLVNKSVIQILKSHRFVKQ
CCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VEDSELSVVDTFPILQEVAKSDLGPCRIDIGKLAVEYKKDNRGLSIEDYVREELSEAVSS
HCCCCCEEEHHHHHHHHHHHCCCCCCEEEHHHEEEEEECCCCCCCHHHHHHHHHHHHHHH
KVDMPERTDVVLYGFGRIGRILARLLIEKAGSGDGLRLKAIVVRESGKGDLQKRASLMRR
CCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCHHHHHHHHHHH
DSVHGPFAGTIAVDEEENAIIANGNFIKVIYSSDPASIDYTDYGINNAVVIDNTGKWRDE
CCCCCCEEEEEEEECCCCEEEECCCEEEEEECCCCCEEEEEECCCCCEEEECCCCCCCCH
EGLSQHLQCKGVSRVMLTAPGKGNMKNIVHGVNNDLIEDSDKIISAASCTTNAIVPPLKA
HHHHHHHHHCCCCEEEEECCCCCCHHHHHHCCCCCHHCCCHHHEEHHCCCCCCCCCCHHH
LEDKFGIEFGHVETVHSYTNDQNLLDNFHKGPRRGRSAPLNMVLTETGAATAATKVLPSL
HHHHHCCEECCCHHHHHHCCCHHHHHHHHCCCCCCCCCCCEEEEECCCCHHHHHHHHHCC
NGKLTGNSIRVPTPNVSMAILNLTLGKETTLEELNDYLRWVSLHSPLQRQVDFVSSPDAV
CCEECCCEEECCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHCHHHHHHHCCCCCCCC
STDFVGSRHASVIDAEATIVNGRHCVLYVWYDNEFGYSCQVLRILQQISGVEFPVYPKD
CCCCCCCCCCEEEECCEEEECCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SKLEDHFGRWKNREEIAEAMIPMIGRLHREKNVTTTVYSRSLVNKSVIQILKSHRFVKQ
CCHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VEDSELSVVDTFPILQEVAKSDLGPCRIDIGKLAVEYKKDNRGLSIEDYVREELSEAVSS
HCCCCCEEEHHHHHHHHHHHCCCCCCEEEHHHEEEEEECCCCCCCHHHHHHHHHHHHHHH
KVDMPERTDVVLYGFGRIGRILARLLIEKAGSGDGLRLKAIVVRESGKGDLQKRASLMRR
CCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCHHHHHHHHHHH
DSVHGPFAGTIAVDEEENAIIANGNFIKVIYSSDPASIDYTDYGINNAVVIDNTGKWRDE
CCCCCCEEEEEEEECCCCEEEECCCEEEEEECCCCCEEEEEECCCCCEEEECCCCCCCCH
EGLSQHLQCKGVSRVMLTAPGKGNMKNIVHGVNNDLIEDSDKIISAASCTTNAIVPPLKA
HHHHHHHHHCCCCEEEEECCCCCCHHHHHHCCCCCHHCCCHHHEEHHCCCCCCCCCCHHH
LEDKFGIEFGHVETVHSYTNDQNLLDNFHKGPRRGRSAPLNMVLTETGAATAATKVLPSL
HHHHHCCEECCCHHHHHHCCCHHHHHHHHCCCCCCCCCCCEEEEECCCCHHHHHHHHHCC
NGKLTGNSIRVPTPNVSMAILNLTLGKETTLEELNDYLRWVSLHSPLQRQVDFVSSPDAV
CCEECCCEEECCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHCHHHHHHHCCCCCCCC
STDFVGSRHASVIDAEATIVNGRHCVLYVWYDNEFGYSCQVLRILQQISGVEFPVYPKD
CCCCCCCCCCEEEECCEEEECCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8508805; 10360571; 2401296; 7877172 [H]