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The map label for this gene is fabG [C]

Identifier: 110833887

GI number: 110833887

Start: 1163625

End: 1164533

Strand: Direct

Name: fabG [C]

Synonym: ABO_1026

Alternate gene names: 110833887

Gene position: 1163625-1164533 (Clockwise)

Preceding gene: 110833885

Following gene: 110833890

Centisome position: 37.29

GC content: 53.03

Gene sequence:

>909_bases
ATGACCCGGTCCCGCTGGCGCCCGGCGCACATTCCCGATCTGTTTGGTAAAACGATTGTTGTCACCGGGGCTAATAGCGG
CATTGGCCTAGAAGCGGTGAAGCTGTTTGTTGCTAATGGCGCAGAAGTGATTATGGCATGTCGCAACACAGCGAAAGCTG
AAGCGGCTGCTGAGCAGGTTAAGATATTGACGCCGCAAGCTAGCTTAACAGTGTTGCCGCTAGATTTGGCTGATCTTGAG
TCGGTTAAAACGTTTGTTGCTACGCTCAAACAGCGTATTAATAAACTGGATGTGTTGCTCAATAATGCGGGAGTGATGGC
GCCACCTTTGCAGCGCACCAAGGAGGGGTTCGAGATGCAATTCGGCACTAACCATCTTGGCCATTTTGCATTGACTGGGC
CGTTATTGAGTCTGCTTGAAGCGGCGCCGGCTCCACGCATCGTTCAGATCTCCAGCTTGGCTCACCGCGGTGGAAAAATA
TTGTGGGGAAATCTGAACGCAGAGAAGCGGTATTCACGCTGGTCTTTTTATTGTCAAAGCAAGTTGGCTAACCTGATCTT
CGCTAAAGACTTGCATCGGCGTTTACAAAAATGCGGATCTTCCATTCAGGTGATGGCGGCGCACCCAGGCTACTCTGCAA
CCCATCTTCAGGACACGGTGCCCGGTGGTGGCGTGTTTAACTGGTTGTTGGCTCAGCCCGCCGAGATGGGATGCTTGCCT
GGGGTGATGGCAGCCACCAGTGATAATGTGACGTCTGGGGGATATTACGGCCCGGATGGAAAAGTTTTCGAGTTGCGAGG
TTATCCTGCTCCGGCTTTCGCGCGTAAAATCACCGATAACGTAGGGCTGGCAGAAAAGCTATGGGATGAGTCCGAGCGCC
TCACAGGGGTCCGCTACCTTAGCGCTTAG

Upstream 100 bases:

>100_bases
TTTTGGATAAAGGGGGGAGTGACAATTGGCTCAACATGAGCGTGCTTTAGAGCTGCGTGGGGAAAACAATGGTAGTCACA
ATTGACATTAAGGAGCGACC

Downstream 100 bases:

>100_bases
GTGAGAGCAGTATTAGCTTAAACGGCGAGTGTGCCATTGGTGAGCGTTGCTGATCAGGCTTGGGTAATTCGGATCAACAT
GCCGAACAAACCGTGATCGA

Product: oxidoreductase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MTRSRWRPAHIPDLFGKTIVVTGANSGIGLEAVKLFVANGAEVIMACRNTAKAEAAAEQVKILTPQASLTVLPLDLADLE
SVKTFVATLKQRINKLDVLLNNAGVMAPPLQRTKEGFEMQFGTNHLGHFALTGPLLSLLEAAPAPRIVQISSLAHRGGKI
LWGNLNAEKRYSRWSFYCQSKLANLIFAKDLHRRLQKCGSSIQVMAAHPGYSATHLQDTVPGGGVFNWLLAQPAEMGCLP
GVMAATSDNVTSGGYYGPDGKVFELRGYPAPAFARKITDNVGLAEKLWDESERLTGVRYLSA

Sequences:

>Translated_302_residues
MTRSRWRPAHIPDLFGKTIVVTGANSGIGLEAVKLFVANGAEVIMACRNTAKAEAAAEQVKILTPQASLTVLPLDLADLE
SVKTFVATLKQRINKLDVLLNNAGVMAPPLQRTKEGFEMQFGTNHLGHFALTGPLLSLLEAAPAPRIVQISSLAHRGGKI
LWGNLNAEKRYSRWSFYCQSKLANLIFAKDLHRRLQKCGSSIQVMAAHPGYSATHLQDTVPGGGVFNWLLAQPAEMGCLP
GVMAATSDNVTSGGYYGPDGKVFELRGYPAPAFARKITDNVGLAEKLWDESERLTGVRYLSA
>Mature_301_residues
TRSRWRPAHIPDLFGKTIVVTGANSGIGLEAVKLFVANGAEVIMACRNTAKAEAAAEQVKILTPQASLTVLPLDLADLES
VKTFVATLKQRINKLDVLLNNAGVMAPPLQRTKEGFEMQFGTNHLGHFALTGPLLSLLEAAPAPRIVQISSLAHRGGKIL
WGNLNAEKRYSRWSFYCQSKLANLIFAKDLHRRLQKCGSSIQVMAAHPGYSATHLQDTVPGGGVFNWLLAQPAEMGCLPG
VMAATSDNVTSGGYYGPDGKVFELRGYPAPAFARKITDNVGLAEKLWDESERLTGVRYLSA

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI225579078, Length=294, Percent_Identity=40.8163265306122, Blast_Score=186, Evalue=2e-47,
Organism=Homo sapiens, GI186928839, Length=289, Percent_Identity=37.7162629757785, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI10190746, Length=316, Percent_Identity=38.2911392405063, Blast_Score=171, Evalue=7e-43,
Organism=Homo sapiens, GI166795268, Length=290, Percent_Identity=36.8965517241379, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI19923931, Length=258, Percent_Identity=40.3100775193798, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI7706523, Length=215, Percent_Identity=40.4651162790698, Blast_Score=138, Evalue=7e-33,
Organism=Homo sapiens, GI193804850, Length=296, Percent_Identity=32.4324324324324, Blast_Score=128, Evalue=8e-30,
Organism=Homo sapiens, GI146231950, Length=295, Percent_Identity=32.8813559322034, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI7705421, Length=252, Percent_Identity=29.3650793650794, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI13375997, Length=161, Percent_Identity=30.4347826086957, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI72534732, Length=161, Percent_Identity=29.8136645962733, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17532805, Length=303, Percent_Identity=31.3531353135314, Blast_Score=127, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI193207620, Length=299, Percent_Identity=32.1070234113712, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17558006, Length=257, Percent_Identity=33.0739299610895, Blast_Score=119, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI72001364, Length=229, Percent_Identity=36.2445414847162, Blast_Score=117, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI17532791, Length=210, Percent_Identity=32.3809523809524, Blast_Score=101, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17505416, Length=266, Percent_Identity=28.5714285714286, Blast_Score=97, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI71992402, Length=210, Percent_Identity=30.952380952381, Blast_Score=94, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI32565532, Length=209, Percent_Identity=32.0574162679426, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17535059, Length=294, Percent_Identity=27.891156462585, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI115533174, Length=295, Percent_Identity=28.4745762711864, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI115533172, Length=295, Percent_Identity=28.4745762711864, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6324820, Length=304, Percent_Identity=29.6052631578947, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6323882, Length=211, Percent_Identity=29.3838862559242, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6322227, Length=214, Percent_Identity=26.6355140186916, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322067, Length=218, Percent_Identity=28.8990825688073, Blast_Score=63, Evalue=6e-11,
Organism=Drosophila melanogaster, GI28573296, Length=292, Percent_Identity=38.013698630137, Blast_Score=174, Evalue=4e-44,
Organism=Drosophila melanogaster, GI19921754, Length=204, Percent_Identity=45.5882352941176, Blast_Score=165, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24586328, Length=216, Percent_Identity=43.9814814814815, Blast_Score=164, Evalue=6e-41,
Organism=Drosophila melanogaster, GI22024069, Length=303, Percent_Identity=37.6237623762376, Blast_Score=161, Evalue=5e-40,
Organism=Drosophila melanogaster, GI45554248, Length=292, Percent_Identity=38.013698630137, Blast_Score=151, Evalue=5e-37,
Organism=Drosophila melanogaster, GI24640117, Length=292, Percent_Identity=38.013698630137, Blast_Score=151, Evalue=5e-37,
Organism=Drosophila melanogaster, GI161076371, Length=204, Percent_Identity=40.6862745098039, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI20129347, Length=299, Percent_Identity=32.7759197324415, Blast_Score=138, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24656154, Length=252, Percent_Identity=37.6984126984127, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI19922628, Length=252, Percent_Identity=37.6984126984127, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI24647946, Length=291, Percent_Identity=32.6460481099656, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI45553409, Length=291, Percent_Identity=32.6460481099656, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24647948, Length=291, Percent_Identity=32.6460481099656, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24647931, Length=216, Percent_Identity=35.1851851851852, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI21358495, Length=214, Percent_Identity=31.3084112149533, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 32669; Mature: 32538

Theoretical pI: Translated: 9.72; Mature: 9.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRSRWRPAHIPDLFGKTIVVTGANSGIGLEAVKLFVANGAEVIMACRNTAKAEAAAEQV
CCCCCCCCCCCHHHCCCEEEEECCCCCCCHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHE
KILTPQASLTVLPLDLADLESVKTFVATLKQRINKLDVLLNNAGVMAPPLQRTKEGFEMQ
EEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCEEE
FGTNHLGHFALTGPLLSLLEAAPAPRIVQISSLAHRGGKILWGNLNAEKRYSRWSFYCQS
CCCCCCCHHHHHHHHHHHHHHCCCCCEEEEHHHHHCCCEEEEECCCCHHHHHHHHHHHHH
KLANLIFAKDLHRRLQKCGSSIQVMAAHPGYSATHLQDTVPGGGVFNWLLAQPAEMGCLP
HHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHCCCCCCCHHHHHHHCCCHHHCCCC
GVMAATSDNVTSGGYYGPDGKVFELRGYPAPAFARKITDNVGLAEKLWDESERLTGVRYL
CHHHCCCCCCCCCCEECCCCCEEEEECCCCHHHHHHHHCCCCHHHHHHCCHHHHCCEEEE
SA
CC
>Mature Secondary Structure 
TRSRWRPAHIPDLFGKTIVVTGANSGIGLEAVKLFVANGAEVIMACRNTAKAEAAAEQV
CCCCCCCCCCHHHCCCEEEEECCCCCCCHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHE
KILTPQASLTVLPLDLADLESVKTFVATLKQRINKLDVLLNNAGVMAPPLQRTKEGFEMQ
EEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCEEE
FGTNHLGHFALTGPLLSLLEAAPAPRIVQISSLAHRGGKILWGNLNAEKRYSRWSFYCQS
CCCCCCCHHHHHHHHHHHHHHCCCCCEEEEHHHHHCCCEEEEECCCCHHHHHHHHHHHHH
KLANLIFAKDLHRRLQKCGSSIQVMAAHPGYSATHLQDTVPGGGVFNWLLAQPAEMGCLP
HHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHCCCCCCCHHHHHHHCCCHHHCCCC
GVMAATSDNVTSGGYYGPDGKVFELRGYPAPAFARKITDNVGLAEKLWDESERLTGVRYL
CHHHCCCCCCCCCCEECCCCCEEEEECCCCHHHHHHHHCCCCHHHHHHCCHHHHCCEEEE
SA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8383668 [H]