Click here to switch to the map view.

The map label for this gene is hpt [H]

Identifier: 110833881

GI number: 110833881

Start: 1158063

End: 1158635

Strand: Direct

Name: hpt [H]

Synonym: ABO_1020

Alternate gene names: 110833881

Gene position: 1158063-1158635 (Clockwise)

Preceding gene: 110833880

Following gene: 110833882

Centisome position: 37.12

GC content: 51.48

Gene sequence:

>573_bases
ATGTCCAGCGCTGAAGAACTGCAAAAGGAATTAATGACAGTTCGGCGTAACGCCATCGAACTGCATTCCTCTGATCAGGT
ACAGGAAGCCATCGGTAAACTGGCCTTTGAAGTCACCGAAGCCTGCTCCGGCAAGGTGCCAGTATTCGTGACCATTATGA
ACGGTGGGATGATCTTCGCGGCGGAACTGGTCAAGCGATTGGATTTTCCGCTGGAAATGGATTATCTCCACGCCAGCCGT
TATTTGGGCGCCACCACTGGTGGTGAAGTGGAGTGGATTGTGACGCCCAGCGCCACTCTGCAAGGCCGCCATGTGGTGAT
TGTGGACGACATCCTCGATGTTGGCTCCACCTTGTTGTCGATTATCGAAGCGTGTAAGTCCCAAGGCGCAGCCTCTGTGA
AGACCTGTGTATTGGTAGACAAGAAACACGATCGAAAAGCACGACCTGGTTTGAAAGCTGATTTCACCGCTCTCGAAGCG
GATGACTATTACCTCTTTGGTATGGGTATGGATTACAAGGGCTTCTGGCGCAATGCTCCGGGTATTTATGCGGTCAAAGA
GAGTGATCTCTAA

Upstream 100 bases:

>100_bases
GCCGAATTTGCGTTCCCCACACGCACGTTGCACCTGGTTGGCCAGAACGATGATGCCCCGGCAACGGGTTTGGAAGACAG
CAACGCGGAGGAGCTCCAGC

Downstream 100 bases:

>100_bases
TGTTGGCGTTTATTGGTGGTACAGGCCTGACGCGTATGGACAACCTGCGCATCATCGACTCGCACACACCTGAGACCCGC
TTTGGGGCTGCTTCTGCGCC

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 190; Mature: 189

Protein sequence:

>190_residues
MSSAEELQKELMTVRRNAIELHSSDQVQEAIGKLAFEVTEACSGKVPVFVTIMNGGMIFAAELVKRLDFPLEMDYLHASR
YLGATTGGEVEWIVTPSATLQGRHVVIVDDILDVGSTLLSIIEACKSQGAASVKTCVLVDKKHDRKARPGLKADFTALEA
DDYYLFGMGMDYKGFWRNAPGIYAVKESDL

Sequences:

>Translated_190_residues
MSSAEELQKELMTVRRNAIELHSSDQVQEAIGKLAFEVTEACSGKVPVFVTIMNGGMIFAAELVKRLDFPLEMDYLHASR
YLGATTGGEVEWIVTPSATLQGRHVVIVDDILDVGSTLLSIIEACKSQGAASVKTCVLVDKKHDRKARPGLKADFTALEA
DDYYLFGMGMDYKGFWRNAPGIYAVKESDL
>Mature_189_residues
SSAEELQKELMTVRRNAIELHSSDQVQEAIGKLAFEVTEACSGKVPVFVTIMNGGMIFAAELVKRLDFPLEMDYLHASRY
LGATTGGEVEWIVTPSATLQGRHVVIVDDILDVGSTLLSIIEACKSQGAASVKTCVLVDKKHDRKARPGLKADFTALEAD
DYYLFGMGMDYKGFWRNAPGIYAVKESDL

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=166, Percent_Identity=26.5060240963855, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI87081689, Length=160, Percent_Identity=28.75, Blast_Score=74, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 20852; Mature: 20721

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSAEELQKELMTVRRNAIELHSSDQVQEAIGKLAFEVTEACSGKVPVFVTIMNGGMIFA
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEHH
AELVKRLDFPLEMDYLHASRYLGATTGGEVEWIVTPSATLQGRHVVIVDDILDVGSTLLS
HHHHHHCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCEEEEEHHHHHHHHHHHH
IIEACKSQGAASVKTCVLVDKKHDRKARPGLKADFTALEADDYYLFGMGMDYKGFWRNAP
HHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCCCCEEEECCCEEEEEECCCCCCCCCCCC
GIYAVKESDL
CEEEEECCCC
>Mature Secondary Structure 
SSAEELQKELMTVRRNAIELHSSDQVQEAIGKLAFEVTEACSGKVPVFVTIMNGGMIFA
CCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEHH
AELVKRLDFPLEMDYLHASRYLGATTGGEVEWIVTPSATLQGRHVVIVDDILDVGSTLLS
HHHHHHCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCEEEEEHHHHHHHHHHHH
IIEACKSQGAASVKTCVLVDKKHDRKARPGLKADFTALEADDYYLFGMGMDYKGFWRNAP
HHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCCCCEEEECCCEEEEEECCCCCCCCCCCC
GIYAVKESDL
CEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]