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The map label for this gene is deoD [H]

Identifier: 110833882

GI number: 110833882

Start: 1158635

End: 1159375

Strand: Direct

Name: deoD [H]

Synonym: ABO_1021

Alternate gene names: 110833882

Gene position: 1158635-1159375 (Clockwise)

Preceding gene: 110833881

Following gene: 110833883

Centisome position: 37.13

GC content: 57.76

Gene sequence:

>741_bases
ATGTTGGCGTTTATTGGTGGTACAGGCCTGACGCGTATGGACAACCTGCGCATCATCGACTCGCACACACCTGAGACCCG
CTTTGGGGCTGCTTCTGCGCCGGTGGTAGAAGGGGCACTGAATGGGCAGAGAGTCTTGTTTTTAGCCCGTCATGGCGACC
CCCATCTGCTGTTACCCCACCAGGTGAATTACCGGGCGAATCTGGCGGCGTTGAAAGCGGCGGGGGCTACCGCCATTGTT
GCGACCAATGCGGTGGGGGGCATTACTGCCCAAGCGCCCACTGGCGCGCTGGTGTTACCCGATCAGATTATCGATTACAC
CTACGGTCGGGAGATGACCCTGTTCGACAATCTTAGCGAACCGTTGGTGCATGTGGATTTCAGTTGGCCGTTTGATGTTA
CTTTACGCAATGCTCTGAAAGCGCGACTTGGCGCGGCTGATCTGCACTGGAACGATGGGGGATGTTACGGTGCGACCCAA
GGCCCACGGCTGGAAACGGCGGCGGAAATTGACCGCTTGGAGCGTGATGGTTGCGATATCGTCGGCATGACCGGTATGCC
GGAAGCGGTTCTGGCTCGGGAGCTAGAGCTGCCTTACGCCATGCTGTCTCTGGTAGTGAATCCGGCGGCCGGCAAGTCCA
GCCATGAAATTACCATGGCGGAAATTGACGCGGTGATACACGATGGCATGGCCAATGTACGACAGGTGCTAGCGGACTTC
GCGGCGCATTACATACCCTAA

Upstream 100 bases:

>100_bases
TCGAAGCGGATGACTATTACCTCTTTGGTATGGGTATGGATTACAAGGGCTTCTGGCGCAATGCTCCGGGTATTTATGCG
GTCAAAGAGAGTGATCTCTA

Downstream 100 bases:

>100_bases
TAACCCTGATGTGCGCGGCTCAGTTGAACCGCGTACTGGCATAAGGAGCATGCATCGGTGACGTTACTGATTATCTTCGC
CACCATCTCCATTGGCTTTT

Product: nucleoside phosphorylase

Products: NA

Alternate protein names: 5'-methylthioadenosine phosphorylase; MTA phosphorylase [H]

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MLAFIGGTGLTRMDNLRIIDSHTPETRFGAASAPVVEGALNGQRVLFLARHGDPHLLLPHQVNYRANLAALKAAGATAIV
ATNAVGGITAQAPTGALVLPDQIIDYTYGREMTLFDNLSEPLVHVDFSWPFDVTLRNALKARLGAADLHWNDGGCYGATQ
GPRLETAAEIDRLERDGCDIVGMTGMPEAVLARELELPYAMLSLVVNPAAGKSSHEITMAEIDAVIHDGMANVRQVLADF
AAHYIP

Sequences:

>Translated_246_residues
MLAFIGGTGLTRMDNLRIIDSHTPETRFGAASAPVVEGALNGQRVLFLARHGDPHLLLPHQVNYRANLAALKAAGATAIV
ATNAVGGITAQAPTGALVLPDQIIDYTYGREMTLFDNLSEPLVHVDFSWPFDVTLRNALKARLGAADLHWNDGGCYGATQ
GPRLETAAEIDRLERDGCDIVGMTGMPEAVLARELELPYAMLSLVVNPAAGKSSHEITMAEIDAVIHDGMANVRQVLADF
AAHYIP
>Mature_246_residues
MLAFIGGTGLTRMDNLRIIDSHTPETRFGAASAPVVEGALNGQRVLFLARHGDPHLLLPHQVNYRANLAALKAAGATAIV
ATNAVGGITAQAPTGALVLPDQIIDYTYGREMTLFDNLSEPLVHVDFSWPFDVTLRNALKARLGAADLHWNDGGCYGATQ
GPRLETAAEIDRLERDGCDIVGMTGMPEAVLARELELPYAMLSLVVNPAAGKSSHEITMAEIDAVIHDGMANVRQVLADF
AAHYIP

Specific function: Catalyzes the formation of methylthio-D-ribose 1- phosphate (MTR-1-P) from methylthioadenosine (MTA) [H]

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=221, Percent_Identity=31.2217194570136, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI71980569, Length=242, Percent_Identity=33.4710743801653, Blast_Score=127, Evalue=8e-30,
Organism=Saccharomyces cerevisiae, GI6323045, Length=236, Percent_Identity=34.3220338983051, Blast_Score=106, Evalue=3e-24,
Organism=Drosophila melanogaster, GI20130079, Length=242, Percent_Identity=28.5123966942149, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI221459247, Length=216, Percent_Identity=32.8703703703704, Blast_Score=113, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: =2.4.2.28 [H]

Molecular weight: Translated: 26289; Mature: 26289

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS01240 PNP_MTAP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAFIGGTGLTRMDNLRIIDSHTPETRFGAASAPVVEGALNGQRVLFLARHGDPHLLLPH
CEEEECCCCCCEECCEEEEECCCCCCCCCCCCCCHHHHCCCCCEEEEEEECCCCCEECCC
QVNYRANLAALKAAGATAIVATNAVGGITAQAPTGALVLPDQIIDYTYGREMTLFDNLSE
CCCCCCCHHHHHHCCCEEEEEECCCCCEEECCCCCEEEECHHHHHHCCCCEEEECCCCCC
PLVHVDFSWPFDVTLRNALKARLGAADLHWNDGGCYGATQGPRLETAAEIDRLERDGCDI
CEEEEECCCCCCHHHHHHHHHHCCCCEEEECCCCEECCCCCCCCHHHHHHHHHHHCCCCE
VGMTGMPEAVLARELELPYAMLSLVVNPAAGKSSHEITMAEIDAVIHDGMANVRQVLADF
EECCCCCHHHHHHHHCCCHHHHHHHCCCCCCCCCCEEEHHHHHHHHHCCHHHHHHHHHHH
AAHYIP
HHHCCC
>Mature Secondary Structure
MLAFIGGTGLTRMDNLRIIDSHTPETRFGAASAPVVEGALNGQRVLFLARHGDPHLLLPH
CEEEECCCCCCEECCEEEEECCCCCCCCCCCCCCHHHHCCCCCEEEEEEECCCCCEECCC
QVNYRANLAALKAAGATAIVATNAVGGITAQAPTGALVLPDQIIDYTYGREMTLFDNLSE
CCCCCCCHHHHHHCCCEEEEEECCCCCEEECCCCCEEEECHHHHHHCCCCEEEECCCCCC
PLVHVDFSWPFDVTLRNALKARLGAADLHWNDGGCYGATQGPRLETAAEIDRLERDGCDI
CEEEEECCCCCCHHHHHHHHHHCCCCEEEECCCCEECCCCCCCCHHHHHHHHHHHCCCCE
VGMTGMPEAVLARELELPYAMLSLVVNPAAGKSSHEITMAEIDAVIHDGMANVRQVLADF
EECCCCCHHHHHHHHCCCHHHHHHHCCCCCCCCCCEEEHHHHHHHHHCCHHHHHHHHHHH
AAHYIP
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]