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The map label for this gene is pyrD [H]

Identifier: 110833864

GI number: 110833864

Start: 1141100

End: 1142206

Strand: Direct

Name: pyrD [H]

Synonym: ABO_1003

Alternate gene names: 110833864

Gene position: 1141100-1142206 (Clockwise)

Preceding gene: 110833863

Following gene: 110833866

Centisome position: 36.57

GC content: 54.74

Gene sequence:

>1107_bases
TTGGTTCACTGTTCTTCCTACTGTTCGACACAAAACATCGAAGTCCCCGATGCCCTTGGCTATAATGCCGGCGATTACTA
CCGATCGGGCTCTTTCATGCTGTACTCCTTGGCACGACCTTTATTGTTCTCTCTATCAGAAGAGCATTCCCATGAGTTGA
CTCTGGCGCTGCTGCGCAAGCGTGCAGGCAAGCTATGGCCCGGTACGGTACCGGCGGTGCCTAAGACAGTAATGGGGATC
GAATTCCCTAATCCAGTGGGCTTAGCGGCTGGCCTGGACAAAAATGGTGACTGCATCGATGGCTTGGCGGATCTGGGGTT
TGGCTTTATTGAAGTCGGTACTGTAACGCCGCGGCCGCAATCGGGTAACCCACAGCCTCGTTTGTTCCGGCTGCCGGAGG
CCCAAGCGCTGATTAACCGCATGGGGTTCAACAATCTGGGTGTAGATTACCTAGTGGCTGCAGTCAAACGCAGCCGCTAC
AAGGGCGTATTAGGCATCAATATCGGCAAGAACAAGGACACCCCGGTTGAAGATGCCGTGCAGGACTACCTGATTTGCCA
GCAGAAAGTGCATGCCTATGCCAGCTATCTGGTGGTGAATGTCTCCTCTCCGAACACGCCCGGACTGCGAACCTTGCAAC
ATGGCGCGGCACTGGATGAGTTGTTGGACACGCTGCGAGAAGCCCAGACACGCTTGGATCAAGAGCAGCGTCGTCGAGTG
CCTCTGGTCATCAAAATTGCCCCGGACAACAGTGAAGAAGAGCTGCAGAGCATGGCTGAAGCCTTCTTACAGCATGGAAT
CGATGGGGTTTGTGTTGGTAACACCACACTTTCCCGTGATGGTGTGCAGAACCTGAAAAATGGTGGGGAGCAAGGTGGCC
TCAGTGGTACACCGCTAACCCCCATCGCCAACCGGGCGCTGGCAGTTATGCGCAATACGCTCAATGGCCGCATTCCGATT
ATCGGTGTAGGCGGCATTAATAGCGCGGGCGATGCGTTGGAAAAGCAGCGCCAAGGTGCTGACTTGGTACAAATTTACAG
CGGTCTGATTTATCAGGGGCCCGGTTTAATCGGCGATATTGCTCGCGCCTGGCCGAAGAGCATCTGA

Upstream 100 bases:

>100_bases
GCTCTGCCGGGTTTTTTTATGCCGTTTTGCGGCTGCTAGAGCGCCCGTAGCATGTCACCTGTTCAACAATTGAGACTGTG
GACGTAGGCTGGGTGCTCAA

Downstream 100 bases:

>100_bases
GTTTGAGTTGATATTAAAAAGGGCCCGGGTGGGGCCCTGCGGGCCGGCGCTGAATGCGCCGGTGTTGTGAAAATGGAAGG
AACTAACCGATATTTTTTAG

Product: dihydroorotate dehydrogenase

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MVHCSSYCSTQNIEVPDALGYNAGDYYRSGSFMLYSLARPLLFSLSEEHSHELTLALLRKRAGKLWPGTVPAVPKTVMGI
EFPNPVGLAAGLDKNGDCIDGLADLGFGFIEVGTVTPRPQSGNPQPRLFRLPEAQALINRMGFNNLGVDYLVAAVKRSRY
KGVLGINIGKNKDTPVEDAVQDYLICQQKVHAYASYLVVNVSSPNTPGLRTLQHGAALDELLDTLREAQTRLDQEQRRRV
PLVIKIAPDNSEEELQSMAEAFLQHGIDGVCVGNTTLSRDGVQNLKNGGEQGGLSGTPLTPIANRALAVMRNTLNGRIPI
IGVGGINSAGDALEKQRQGADLVQIYSGLIYQGPGLIGDIARAWPKSI

Sequences:

>Translated_368_residues
MVHCSSYCSTQNIEVPDALGYNAGDYYRSGSFMLYSLARPLLFSLSEEHSHELTLALLRKRAGKLWPGTVPAVPKTVMGI
EFPNPVGLAAGLDKNGDCIDGLADLGFGFIEVGTVTPRPQSGNPQPRLFRLPEAQALINRMGFNNLGVDYLVAAVKRSRY
KGVLGINIGKNKDTPVEDAVQDYLICQQKVHAYASYLVVNVSSPNTPGLRTLQHGAALDELLDTLREAQTRLDQEQRRRV
PLVIKIAPDNSEEELQSMAEAFLQHGIDGVCVGNTTLSRDGVQNLKNGGEQGGLSGTPLTPIANRALAVMRNTLNGRIPI
IGVGGINSAGDALEKQRQGADLVQIYSGLIYQGPGLIGDIARAWPKSI
>Mature_368_residues
MVHCSSYCSTQNIEVPDALGYNAGDYYRSGSFMLYSLARPLLFSLSEEHSHELTLALLRKRAGKLWPGTVPAVPKTVMGI
EFPNPVGLAAGLDKNGDCIDGLADLGFGFIEVGTVTPRPQSGNPQPRLFRLPEAQALINRMGFNNLGVDYLVAAVKRSRY
KGVLGINIGKNKDTPVEDAVQDYLICQQKVHAYASYLVVNVSSPNTPGLRTLQHGAALDELLDTLREAQTRLDQEQRRRV
PLVIKIAPDNSEEELQSMAEAFLQHGIDGVCVGNTTLSRDGVQNLKNGGEQGGLSGTPLTPIANRALAVMRNTLNGRIPI
IGVGGINSAGDALEKQRQGADLVQIYSGLIYQGPGLIGDIARAWPKSI

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=295, Percent_Identity=46.7796610169492, Blast_Score=244, Evalue=1e-64,
Organism=Escherichia coli, GI1787177, Length=333, Percent_Identity=56.1561561561562, Blast_Score=368, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17509475, Length=302, Percent_Identity=45.0331125827815, Blast_Score=231, Evalue=5e-61,
Organism=Drosophila melanogaster, GI281361352, Length=346, Percent_Identity=40.7514450867052, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI17137316, Length=346, Percent_Identity=40.7514450867052, Blast_Score=249, Evalue=3e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 39670; Mature: 39670

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVHCSSYCSTQNIEVPDALGYNAGDYYRSGSFMLYSLARPLLFSLSEEHSHELTLALLRK
CCCCCCCCCCCCCCCCHHCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAGKLWPGTVPAVPKTVMGIEFPNPVGLAAGLDKNGDCIDGLADLGFGFIEVGTVTPRPQ
HCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEECCCCCCCC
SGNPQPRLFRLPEAQALINRMGFNNLGVDYLVAAVKRSRYKGVLGINIGKNKDTPVEDAV
CCCCCCCEEECCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHH
QDYLICQQKVHAYASYLVVNVSSPNTPGLRTLQHGAALDELLDTLREAQTRLDQEQRRRV
HHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCC
PLVIKIAPDNSEEELQSMAEAFLQHGIDGVCVGNTTLSRDGVQNLKNGGEQGGLSGTPLT
CEEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCC
PIANRALAVMRNTLNGRIPIIGVGGINSAGDALEKQRQGADLVQIYSGLIYQGPGLIGDI
HHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHH
ARAWPKSI
HHHCCCCC
>Mature Secondary Structure
MVHCSSYCSTQNIEVPDALGYNAGDYYRSGSFMLYSLARPLLFSLSEEHSHELTLALLRK
CCCCCCCCCCCCCCCCHHCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAGKLWPGTVPAVPKTVMGIEFPNPVGLAAGLDKNGDCIDGLADLGFGFIEVGTVTPRPQ
HCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEECCCCCCCC
SGNPQPRLFRLPEAQALINRMGFNNLGVDYLVAAVKRSRYKGVLGINIGKNKDTPVEDAV
CCCCCCCEEECCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHH
QDYLICQQKVHAYASYLVVNVSSPNTPGLRTLQHGAALDELLDTLREAQTRLDQEQRRRV
HHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCC
PLVIKIAPDNSEEELQSMAEAFLQHGIDGVCVGNTTLSRDGVQNLKNGGEQGGLSGTPLT
CEEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCC
PIANRALAVMRNTLNGRIPIIGVGGINSAGDALEKQRQGADLVQIYSGLIYQGPGLIGDI
HHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHH
ARAWPKSI
HHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA