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The map label for this gene is rmlD [H]

Identifier: 110833772

GI number: 110833772

Start: 1019100

End: 1020014

Strand: Direct

Name: rmlD [H]

Synonym: ABO_0911

Alternate gene names: 110833772

Gene position: 1019100-1020014 (Clockwise)

Preceding gene: 110833771

Following gene: 110833773

Centisome position: 32.66

GC content: 59.13

Gene sequence:

>915_bases
ATGGCAAGGACGCAGGCAAAAAAGACAATCTTGCTGCTAGGCAAAAACGGACAGGTCGGCTGGGAGTTGCAGCGTGCCCT
GGCGCCGTTCGGTCAACTCATCGCCTTGGATCGCGCCGGCCAAAATGGATGGTGTGGTGATATTGGCAACCTGGATGGCC
TGCGCGAAACCATCGAGCACATCAAGCCGGACGTGCTGGTCAACGCCGCGGGCTACACTGCAGTAGATCAGGCCCAGAGC
GAACCGGAGCTGGCTGAGCGACTCAATCATCAGGCTCCGGCCTTGATGGCAGAGTTGATGAAAGCACATGGCGGCTGGCT
GGTACATTACTCTACGGATTACGTCTTCGATGGCAGCGGCAACCAGCCCTGGAAAGAAACAGACAGCGCCGGCCCCCTCA
ACGTCTACGGCGCCACGAAGCTGGCCGGCGAGCAGGCCATTCAGGCCAGCGGCTGCCAGCATCTGATATTCCGCACCAGC
TGGGTGTATGCCAGCCGGGGCAACAACTTCGCCAAAACCATGCTGCGCCTTGCCAAAGAGCGCGACACGCTGAATGTGAT
CGACGATCAGATCGGCGCGCCCACCGGTGCCGAACTGATTGCAGATGTAACGGCCCACGCGCTGCGCCAGTGGCAACAAC
AGCCTGACGTCTCAGGCCTTTACCACCTGGCCGCCAGCGGCGAGACGTCGTGGTACGACTATGCCTGCTACGTGTTCGGC
TGGGCGCAAAATGAAGGACTGCCGCTGGCGATTCAGTCAGTCAACCCGATCCTCAGCGAAGACTACCCAGTACCCGCCAT
CCGGCCTAAAAACTCCCGCCTGGATGGCCAAAAGCTGGAAACCACCTTCAACCTCCAATTACCAGAGTGGAAGCAGGGCG
TGGAACACATGATGTCTGAGGTGTTTGATGTTTAA

Upstream 100 bases:

>100_bases
ATCTCGATAACAGCGAATGGTGCCAACGAGTGCAGGATGGCAGCTACCGGCGCGAACGGCTTGGCACCGGTTCAGGCACT
GAGGGAAAGGAATAAAGGCC

Downstream 100 bases:

>100_bases
CAGCTTGCAGATTGGTAGAGCGGTAGCTGCATTATTAGTTGTCTTGCACCATGCGACGTTGGGAAGCCGCAAGTTTTATG
GTGAGGCATTTGGTGGATTT

Product: dTDP-4-dehydrorhamnose reductase

Products: NA

Alternate protein names: dTDP-4-keto-L-rhamnose reductase; dTDP-6-deoxy-L-lyxo-4-hexulose reductase; dTDP-6-deoxy-L-mannose dehydrogenase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MARTQAKKTILLLGKNGQVGWELQRALAPFGQLIALDRAGQNGWCGDIGNLDGLRETIEHIKPDVLVNAAGYTAVDQAQS
EPELAERLNHQAPALMAELMKAHGGWLVHYSTDYVFDGSGNQPWKETDSAGPLNVYGATKLAGEQAIQASGCQHLIFRTS
WVYASRGNNFAKTMLRLAKERDTLNVIDDQIGAPTGAELIADVTAHALRQWQQQPDVSGLYHLAASGETSWYDYACYVFG
WAQNEGLPLAIQSVNPILSEDYPVPAIRPKNSRLDGQKLETTFNLQLPEWKQGVEHMMSEVFDV

Sequences:

>Translated_304_residues
MARTQAKKTILLLGKNGQVGWELQRALAPFGQLIALDRAGQNGWCGDIGNLDGLRETIEHIKPDVLVNAAGYTAVDQAQS
EPELAERLNHQAPALMAELMKAHGGWLVHYSTDYVFDGSGNQPWKETDSAGPLNVYGATKLAGEQAIQASGCQHLIFRTS
WVYASRGNNFAKTMLRLAKERDTLNVIDDQIGAPTGAELIADVTAHALRQWQQQPDVSGLYHLAASGETSWYDYACYVFG
WAQNEGLPLAIQSVNPILSEDYPVPAIRPKNSRLDGQKLETTFNLQLPEWKQGVEHMMSEVFDV
>Mature_303_residues
ARTQAKKTILLLGKNGQVGWELQRALAPFGQLIALDRAGQNGWCGDIGNLDGLRETIEHIKPDVLVNAAGYTAVDQAQSE
PELAERLNHQAPALMAELMKAHGGWLVHYSTDYVFDGSGNQPWKETDSAGPLNVYGATKLAGEQAIQASGCQHLIFRTSW
VYASRGNNFAKTMLRLAKERDTLNVIDDQIGAPTGAELIADVTAHALRQWQQQPDVSGLYHLAASGETSWYDYACYVFGW
AQNEGLPLAIQSVNPILSEDYPVPAIRPKNSRLDGQKLETTFNLQLPEWKQGVEHMMSEVFDV

Specific function: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose. RmlD uses NADH and NADPH nearly equally well [H]

COG id: COG1091

COG function: function code M; dTDP-4-dehydrorhamnose reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose reductase family [H]

Homologues:

Organism=Homo sapiens, GI11034825, Length=268, Percent_Identity=28.7313432835821, Blast_Score=101, Evalue=7e-22,
Organism=Homo sapiens, GI33519455, Length=268, Percent_Identity=28.7313432835821, Blast_Score=101, Evalue=9e-22,
Organism=Escherichia coli, GI1788352, Length=293, Percent_Identity=58.7030716723549, Blast_Score=368, Evalue=1e-103,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005913
- InterPro:   IPR016040 [H]

Pfam domain/function: PF04321 RmlD_sub_bind [H]

EC number: =1.1.1.133 [H]

Molecular weight: Translated: 33489; Mature: 33358

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARTQAKKTILLLGKNGQVGWELQRALAPFGQLIALDRAGQNGWCGDIGNLDGLRETIEH
CCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCHHHHHHHHHH
IKPDVLVNAAGYTAVDQAQSEPELAERLNHQAPALMAELMKAHGGWLVHYSTDYVFDGSG
CCCCEEEECCCCCHHHHCCCCHHHHHHHCCCCHHHHHHHHHHCCCEEEEEECCEEEECCC
NQPWKETDSAGPLNVYGATKLAGEQAIQASGCQHLIFRTSWVYASRGNNFAKTMLRLAKE
CCCCCCCCCCCCEEECCCHHHHHHHHHHHCCCCEEEEEEEEEEECCCCHHHHHHHHHHHH
RDTLNVIDDQIGAPTGAELIADVTAHALRQWQQQPDVSGLYHLAASGETSWYDYACYVFG
CCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEEEEE
WAQNEGLPLAIQSVNPILSEDYPVPAIRPKNSRLDGQKLETTFNLQLPEWKQGVEHMMSE
EECCCCCCEEEECCCCHHCCCCCCCCCCCCCCCCCCCEECEEEEEECCHHHHHHHHHHHH
VFDV
HHCC
>Mature Secondary Structure 
ARTQAKKTILLLGKNGQVGWELQRALAPFGQLIALDRAGQNGWCGDIGNLDGLRETIEH
CCCCCCCEEEEEECCCCCHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCHHHHHHHHHH
IKPDVLVNAAGYTAVDQAQSEPELAERLNHQAPALMAELMKAHGGWLVHYSTDYVFDGSG
CCCCEEEECCCCCHHHHCCCCHHHHHHHCCCCHHHHHHHHHHCCCEEEEEECCEEEECCC
NQPWKETDSAGPLNVYGATKLAGEQAIQASGCQHLIFRTSWVYASRGNNFAKTMLRLAKE
CCCCCCCCCCCCEEECCCHHHHHHHHHHHCCCCEEEEEEEEEEECCCCHHHHHHHHHHHH
RDTLNVIDDQIGAPTGAELIADVTAHALRQWQQQPDVSGLYHLAASGETSWYDYACYVFG
CCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEEEEE
WAQNEGLPLAIQSVNPILSEDYPVPAIRPKNSRLDGQKLETTFNLQLPEWKQGVEHMMSE
EECCCCCCEEEECCCCHHCCCCCCCCCCCCCCCCCCCEECEEEEEECCHHHHHHHHHHHH
VFDV
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1710759; 11677609 [H]