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The map label for this gene is rmlB [H]

Identifier: 110833771

GI number: 110833771

Start: 1018012

End: 1019094

Strand: Direct

Name: rmlB [H]

Synonym: ABO_0910

Alternate gene names: 110833771

Gene position: 1018012-1019094 (Clockwise)

Preceding gene: 110833770

Following gene: 110833772

Centisome position: 32.63

GC content: 56.14

Gene sequence:

>1083_bases
ATGAAAATTCTGGTCACCGGCGGTGCAGGCTTTATCGGTTCCGCCGTTATTCGTCACATCATCAGCAACACGGACGACAG
TGTCGTCAATGTGGACAAGCTCACCTATGCCGGCAACCTGGAAAGCCTGCTCAGTGTCAGCGACAGTCCCCGCTATACCT
TTGAAAAAGTGGATATTTGTGACCGGCATACCTTGGATGGGGTATTACAACGGCACCAGCCCGATGTGATCATGCACCTC
GCCGCAGAAAGCCACGTGGACCGTTCCATTGATGGCCCGGCGGCCTTCATGGAAACCAACATCATAGGGACCTACACCTT
GCTGGAAGCGGCACGCCAATACTGGAACAGCCTAGACGACACTGCCCAGCAGGCTTTCCGCTTCCATCACATCTCCACCG
ATGAAGTGTACGGCGATCTGGATGGCCCGGAAGACTTGTTTACCGAAACCACTCCCTATGCACCCAGCTCCCCGTATTCC
GCCAGCAAGGCCAGCTCCGACCATCTGGTGCGCGCCTGGTTGCGGACCTATGGCTTTCCCACACTGATCACCAACTGCTC
CAACAATTACGGGCCTTTCCACTTCCCGGAAAAGCTCATCCCGCTGATGATCCTCAATGCCCTGGAAGGAAAACCTTTAC
CGGTGTACGGCCAGGGTACCCAGGTACGTGACTGGCTCTACGTGGAAGACCATGCCCGCGCCCTCTACAAAGTGGCAACT
GAAGGCAAAGTGGGGGAGACCTACAATATCGGCGGCCACAACGAAAAACAGAACATCGACGTGGTACACACCCTCTGTGA
TCTGCTCGAAGAGCTGGTACCGAGTAAACCAGAAGGTATCAGCCAGTACCGGGATCTGATCACACATGTCCGGGACCGCC
CAGGCCATGATCTGCGCTACGCCATCGACGCCAGTAAGATCGAGCGAGAGCTGGGCTGGACCCCGCAAGAAACTTTTGAA
ACCGGCATCCGCAAGACCGTGCTGTGGTATCTCGATAACAGCGAATGGTGCCAACGAGTGCAGGATGGCAGCTACCGGCG
CGAACGGCTTGGCACCGGTTCAGGCACTGAGGGAAAGGAATAA

Upstream 100 bases:

>100_bases
CACAAGAGTTGCTGGGCTATGAACCCGCCTACCGCATTTACGATGGCATCGGTAAGGCCATGCCCTGGTACGAAAGCACA
CTGAATACTGGAAGCGACGC

Downstream 100 bases:

>100_bases
AGGCCATGGCAAGGACGCAGGCAAAAAAGACAATCTTGCTGCTAGGCAAAAACGGACAGGTCGGCTGGGAGTTGCAGCGT
GCCCTGGCGCCGTTCGGTCA

Product: dTDP-glucose 4,6-dehydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MKILVTGGAGFIGSAVIRHIISNTDDSVVNVDKLTYAGNLESLLSVSDSPRYTFEKVDICDRHTLDGVLQRHQPDVIMHL
AAESHVDRSIDGPAAFMETNIIGTYTLLEAARQYWNSLDDTAQQAFRFHHISTDEVYGDLDGPEDLFTETTPYAPSSPYS
ASKASSDHLVRAWLRTYGFPTLITNCSNNYGPFHFPEKLIPLMILNALEGKPLPVYGQGTQVRDWLYVEDHARALYKVAT
EGKVGETYNIGGHNEKQNIDVVHTLCDLLEELVPSKPEGISQYRDLITHVRDRPGHDLRYAIDASKIERELGWTPQETFE
TGIRKTVLWYLDNSEWCQRVQDGSYRRERLGTGSGTEGKE

Sequences:

>Translated_360_residues
MKILVTGGAGFIGSAVIRHIISNTDDSVVNVDKLTYAGNLESLLSVSDSPRYTFEKVDICDRHTLDGVLQRHQPDVIMHL
AAESHVDRSIDGPAAFMETNIIGTYTLLEAARQYWNSLDDTAQQAFRFHHISTDEVYGDLDGPEDLFTETTPYAPSSPYS
ASKASSDHLVRAWLRTYGFPTLITNCSNNYGPFHFPEKLIPLMILNALEGKPLPVYGQGTQVRDWLYVEDHARALYKVAT
EGKVGETYNIGGHNEKQNIDVVHTLCDLLEELVPSKPEGISQYRDLITHVRDRPGHDLRYAIDASKIERELGWTPQETFE
TGIRKTVLWYLDNSEWCQRVQDGSYRRERLGTGSGTEGKE
>Mature_360_residues
MKILVTGGAGFIGSAVIRHIISNTDDSVVNVDKLTYAGNLESLLSVSDSPRYTFEKVDICDRHTLDGVLQRHQPDVIMHL
AAESHVDRSIDGPAAFMETNIIGTYTLLEAARQYWNSLDDTAQQAFRFHHISTDEVYGDLDGPEDLFTETTPYAPSSPYS
ASKASSDHLVRAWLRTYGFPTLITNCSNNYGPFHFPEKLIPLMILNALEGKPLPVYGQGTQVRDWLYVEDHARALYKVAT
EGKVGETYNIGGHNEKQNIDVVHTLCDLLEELVPSKPEGISQYRDLITHVRDRPGHDLRYAIDASKIERELGWTPQETFE
TGIRKTVLWYLDNSEWCQRVQDGSYRRERLGTGSGTEGKE

Specific function: Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction [H]

COG id: COG1088

COG function: function code M; dTDP-D-glucose 4,6-dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. dTDP-glucose dehydratase subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=333, Percent_Identity=35.4354354354354, Blast_Score=221, Evalue=8e-58,
Organism=Homo sapiens, GI42516563, Length=340, Percent_Identity=25.2941176470588, Blast_Score=96, Evalue=5e-20,
Organism=Escherichia coli, GI48994969, Length=350, Percent_Identity=78, Blast_Score=582, Evalue=1e-167,
Organism=Escherichia coli, GI1788353, Length=354, Percent_Identity=72.8813559322034, Blast_Score=544, Evalue=1e-156,
Organism=Escherichia coli, GI1786974, Length=358, Percent_Identity=28.2122905027933, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1788366, Length=189, Percent_Identity=28.5714285714286, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17568069, Length=348, Percent_Identity=35.9195402298851, Blast_Score=208, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI115532424, Length=329, Percent_Identity=32.2188449848024, Blast_Score=170, Evalue=8e-43,
Organism=Caenorhabditis elegans, GI71982035, Length=361, Percent_Identity=27.4238227146814, Blast_Score=87, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI71982038, Length=363, Percent_Identity=27.2727272727273, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17539532, Length=338, Percent_Identity=25.4437869822485, Blast_Score=87, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319493, Length=364, Percent_Identity=27.4725274725275, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI19923002, Length=363, Percent_Identity=27.8236914600551, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI21356223, Length=353, Percent_Identity=25.2124645892351, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24158427, Length=289, Percent_Identity=25.9515570934256, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005888
- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.46 [H]

Molecular weight: Translated: 40493; Mature: 40493

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILVTGGAGFIGSAVIRHIISNTDDSVVNVDKLTYAGNLESLLSVSDSPRYTFEKVDIC
CEEEEECCCHHHHHHHHHHHHCCCCCCEEEHHHEEECCCHHHHHHCCCCCCEEEHHCCHH
DRHTLDGVLQRHQPDVIMHLAAESHVDRSIDGPAAFMETNIIGTYTLLEAARQYWNSLDD
HHHHHHHHHHHCCCCCEEEEHHHHHCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHH
TAQQAFRFHHISTDEVYGDLDGPEDLFTETTPYAPSSPYSASKASSDHLVRAWLRTYGFP
HHHHHHHHHCCCHHHHCCCCCCHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCH
TLITNCSNNYGPFHFPEKLIPLMILNALEGKPLPVYGQGTQVRDWLYVEDHARALYKVAT
HHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEECCCCCCEEEEEEHHHHHHHHHHHC
EGKVGETYNIGGHNEKQNIDVVHTLCDLLEELVPSKPEGISQYRDLITHVRDRPGHDLRY
CCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCEEE
AIDASKIERELGWTPQETFETGIRKTVLWYLDNSEWCQRVQDGSYRRERLGTGSGTEGKE
EECHHHHHHHHCCCHHHHHHHHHHEEEEEEECCHHHHHHHHCCCHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MKILVTGGAGFIGSAVIRHIISNTDDSVVNVDKLTYAGNLESLLSVSDSPRYTFEKVDIC
CEEEEECCCHHHHHHHHHHHHCCCCCCEEEHHHEEECCCHHHHHHCCCCCCEEEHHCCHH
DRHTLDGVLQRHQPDVIMHLAAESHVDRSIDGPAAFMETNIIGTYTLLEAARQYWNSLDD
HHHHHHHHHHHCCCCCEEEEHHHHHCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHH
TAQQAFRFHHISTDEVYGDLDGPEDLFTETTPYAPSSPYSASKASSDHLVRAWLRTYGFP
HHHHHHHHHCCCHHHHCCCCCCHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCH
TLITNCSNNYGPFHFPEKLIPLMILNALEGKPLPVYGQGTQVRDWLYVEDHARALYKVAT
HHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEECCCCCCEEEEEEHHHHHHHHHHHC
EGKVGETYNIGGHNEKQNIDVVHTLCDLLEELVPSKPEGISQYRDLITHVRDRPGHDLRY
CCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCEEE
AIDASKIERELGWTPQETFETGIRKTVLWYLDNSEWCQRVQDGSYRRERLGTGSGTEGKE
EECHHHHHHHHCCCHHHHHHHHHHEEEEEEECCHHHHHHHHCCCHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1379743; 9278503; 7559340 [H]