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The map label for this gene is prfC

Identifier: 110833504

GI number: 110833504

Start: 711394

End: 712983

Strand: Direct

Name: prfC

Synonym: ABO_0643

Alternate gene names: 110833504

Gene position: 711394-712983 (Clockwise)

Preceding gene: 110833503

Following gene: 110833505

Centisome position: 22.8

GC content: 56.54

Gene sequence:

>1590_bases
TTGAGCCCCATGAGCCTGCAAGACCAGGTGGCCACGCGCCGCACCTTCGCGATCATCTCGCACCCGGACGCCGGTAAAAC
CACCATTACCGAAAAATTGCTGTTGTACGGAAACCTGATCCAAAGTGCAGGCACCGTGAAAGGCAAGAAGTCTGGTAAGC
ACGCCACCTCCGACTGGATGGAGATGGAGAAGGAGCGGGGCATTTCCGTGACTACCTCGGTGATGCAGTTCCCTTACAAG
GGTGCCACCGTCAATTTGCTGGATACCCCAGGCCACGCGGATTTCTCTGAAGATACCTATCGCACCCTCACTGCCGTGGA
TTCGGCATTAATGGTTATTGACGCTGCTAAGGGTGTGGAGCAGCGAACCGTAAAACTGATGGAAGTGTGTCGCCTGCGCG
ATACCCCGATTCTCACCTTTATTAACAAGTTGGATCGGGATGTGCGCGATGGCATCGACGTGCTGGACGAAATCGAGGAC
GTACTCAATATTGAGTGCGCCCCGATTACCTGGCCCATCGGCATGGGCAAGAGCTTCAAGGGTGTTTACAACCTGCTCAC
CGACACTACCGTGCTCTACAAGACTGGTCAGGGCCATACTGTGCAGGATGTGCGCGAGGTTAAGGGCCTCAACAATCCGG
AGTTGGATGAGGCGGTGGGCACCGACTACGCTGAAGAACTGCGCGACACCCTGGAGCTGGTGCAGGGCGCCAGCCATGAA
TTCGACCTAGAGCGTTTTCTGGCCGGTAAGTTGACCCCGGTTTTCTTCGGTACGGCTCTGGGTAATTTCGGCGTGGATCA
TATGCTCGATGGCCTGGTGCAGTGGGCGCCGCCGCCGCAGCCCCGTGATGCTACCGCTCGCACGGTAGAGGCCGATGAGC
CCAAAATGACCGGTTTCGTGTTCAAGATCCAGGCCAATATGGACCCTCGTCACCGAGACCGCATTGCCTTCATGCGTATT
TGCTCGGGCACCTATCGAAAAGGTATCAAGCTCAAGCAGGTGCGTACCGGTAAAGATGTGCGTATTGCCGATGCCCTGAC
TTTTCTGGCCGGTGAGCGCGATAATGTGGAAGAAGCCTTTTCCGGTGACATTATCGGTTTGCACAACCATGGCACCATCC
AAATCGGTGACACGTTCACCGAAGGCGAAGAGCTTGCCTTCACCGGCATTCCGCACTTCGCGCCGGAATTGTTCCAGCGG
GTGGTGCTCAATGATCCGCTCAAGAGCAAGCAGCTACACAAGGGCCTGACTCAGCTGGCTGAAGAAGGCGCGACCCAGGT
ATTTTTCCCGCTGCGTAATAACGATGTGATTCTTGGTGCTGTGGGCTCGTTGCAGTTCGATGTGGTCGCCGCGCGCTTGA
AAGGGGAATATGGCGTCGATTGCCGTTATGAACCGGTCAGTGTAGCGACAGCCCGGTGGGTTGAGGCCGATAGCGATAAA
GAGTTGGCTGCCTTTGAACGCAAGGCCCATGACAATCTGTCCCGGGATGGCGCCGGGCATCTGACATACCTGGCGCCGAC
GCGGGTTAATCTGCAACTGGCACAGGAACGTCATCCGGATATCCGCTTCCGCGAAACCCGGGAAATCTGA

Upstream 100 bases:

>100_bases
CTGATGCGCCAGCGCCAACTGAAAGGGTCTGGGTTGGTCTGACGGGAAATCAGGCCGCGAAGGCTGTTATACTCGCGCCC
TCGAAATATCCAGTCAGAGA

Downstream 100 bases:

>100_bases
GGGCAATTGTTGCCGTAACCTTATTGACGGCGCGTCTGGATAAAATCGGGTGATCGACATGGATGTTGATGTGGTACGAG
ATTATCTCTTGGGTAAGCCT

Product: peptide chain release factor 3

Products: NA

Alternate protein names: RF-3

Number of amino acids: Translated: 529; Mature: 528

Protein sequence:

>529_residues
MSPMSLQDQVATRRTFAIISHPDAGKTTITEKLLLYGNLIQSAGTVKGKKSGKHATSDWMEMEKERGISVTTSVMQFPYK
GATVNLLDTPGHADFSEDTYRTLTAVDSALMVIDAAKGVEQRTVKLMEVCRLRDTPILTFINKLDRDVRDGIDVLDEIED
VLNIECAPITWPIGMGKSFKGVYNLLTDTTVLYKTGQGHTVQDVREVKGLNNPELDEAVGTDYAEELRDTLELVQGASHE
FDLERFLAGKLTPVFFGTALGNFGVDHMLDGLVQWAPPPQPRDATARTVEADEPKMTGFVFKIQANMDPRHRDRIAFMRI
CSGTYRKGIKLKQVRTGKDVRIADALTFLAGERDNVEEAFSGDIIGLHNHGTIQIGDTFTEGEELAFTGIPHFAPELFQR
VVLNDPLKSKQLHKGLTQLAEEGATQVFFPLRNNDVILGAVGSLQFDVVAARLKGEYGVDCRYEPVSVATARWVEADSDK
ELAAFERKAHDNLSRDGAGHLTYLAPTRVNLQLAQERHPDIRFRETREI

Sequences:

>Translated_529_residues
MSPMSLQDQVATRRTFAIISHPDAGKTTITEKLLLYGNLIQSAGTVKGKKSGKHATSDWMEMEKERGISVTTSVMQFPYK
GATVNLLDTPGHADFSEDTYRTLTAVDSALMVIDAAKGVEQRTVKLMEVCRLRDTPILTFINKLDRDVRDGIDVLDEIED
VLNIECAPITWPIGMGKSFKGVYNLLTDTTVLYKTGQGHTVQDVREVKGLNNPELDEAVGTDYAEELRDTLELVQGASHE
FDLERFLAGKLTPVFFGTALGNFGVDHMLDGLVQWAPPPQPRDATARTVEADEPKMTGFVFKIQANMDPRHRDRIAFMRI
CSGTYRKGIKLKQVRTGKDVRIADALTFLAGERDNVEEAFSGDIIGLHNHGTIQIGDTFTEGEELAFTGIPHFAPELFQR
VVLNDPLKSKQLHKGLTQLAEEGATQVFFPLRNNDVILGAVGSLQFDVVAARLKGEYGVDCRYEPVSVATARWVEADSDK
ELAAFERKAHDNLSRDGAGHLTYLAPTRVNLQLAQERHPDIRFRETREI
>Mature_528_residues
SPMSLQDQVATRRTFAIISHPDAGKTTITEKLLLYGNLIQSAGTVKGKKSGKHATSDWMEMEKERGISVTTSVMQFPYKG
ATVNLLDTPGHADFSEDTYRTLTAVDSALMVIDAAKGVEQRTVKLMEVCRLRDTPILTFINKLDRDVRDGIDVLDEIEDV
LNIECAPITWPIGMGKSFKGVYNLLTDTTVLYKTGQGHTVQDVREVKGLNNPELDEAVGTDYAEELRDTLELVQGASHEF
DLERFLAGKLTPVFFGTALGNFGVDHMLDGLVQWAPPPQPRDATARTVEADEPKMTGFVFKIQANMDPRHRDRIAFMRIC
SGTYRKGIKLKQVRTGKDVRIADALTFLAGERDNVEEAFSGDIIGLHNHGTIQIGDTFTEGEELAFTGIPHFAPELFQRV
VLNDPLKSKQLHKGLTQLAEEGATQVFFPLRNNDVILGAVGSLQFDVVAARLKGEYGVDCRYEPVSVATARWVEADSDKE
LAAFERKAHDNLSRDGAGHLTYLAPTRVNLQLAQERHPDIRFRETREI

Specific function: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-

COG id: COG4108

COG function: function code J; Peptide chain release factor RF-3

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. PrfC subfamily

Homologues:

Organism=Homo sapiens, GI18390331, Length=480, Percent_Identity=28.5416666666667, Blast_Score=192, Evalue=6e-49,
Organism=Homo sapiens, GI19923640, Length=511, Percent_Identity=26.8101761252446, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI25306283, Length=393, Percent_Identity=28.2442748091603, Blast_Score=150, Evalue=4e-36,
Organism=Homo sapiens, GI25306287, Length=483, Percent_Identity=25.6728778467909, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI157426893, Length=168, Percent_Identity=33.9285714285714, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI94966754, Length=147, Percent_Identity=31.2925170068027, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI4503483, Length=159, Percent_Identity=30.188679245283, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI310132016, Length=120, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI310110807, Length=120, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI310123363, Length=120, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1790835, Length=520, Percent_Identity=71.9230769230769, Blast_Score=787, Evalue=0.0,
Organism=Escherichia coli, GI1789738, Length=499, Percent_Identity=27.0541082164329, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1788922, Length=157, Percent_Identity=33.7579617834395, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI48994988, Length=195, Percent_Identity=30.7692307692308, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17533571, Length=490, Percent_Identity=28.1632653061224, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17556745, Length=175, Percent_Identity=33.1428571428571, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17557151, Length=165, Percent_Identity=30.3030303030303, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17506493, Length=171, Percent_Identity=30.4093567251462, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71988819, Length=133, Percent_Identity=29.3233082706767, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71988811, Length=133, Percent_Identity=29.3233082706767, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323098, Length=477, Percent_Identity=27.6729559748428, Blast_Score=188, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6322359, Length=536, Percent_Identity=25, Blast_Score=124, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6324707, Length=159, Percent_Identity=31.4465408805031, Blast_Score=78, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6320593, Length=159, Percent_Identity=31.4465408805031, Blast_Score=78, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6323320, Length=151, Percent_Identity=29.1390728476821, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24582462, Length=480, Percent_Identity=28.75, Blast_Score=189, Evalue=6e-48,
Organism=Drosophila melanogaster, GI221458488, Length=517, Percent_Identity=25.531914893617, Blast_Score=149, Evalue=7e-36,
Organism=Drosophila melanogaster, GI78706572, Length=136, Percent_Identity=36.0294117647059, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24585709, Length=162, Percent_Identity=31.4814814814815, Blast_Score=79, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24585711, Length=160, Percent_Identity=31.25, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24585713, Length=160, Percent_Identity=31.25, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RF3_ALCBS (Q0VRV7)

Other databases:

- EMBL:   AM286690
- RefSeq:   YP_692363.1
- ProteinModelPortal:   Q0VRV7
- SMR:   Q0VRV7
- STRING:   Q0VRV7
- GeneID:   4212278
- GenomeReviews:   AM286690_GR
- KEGG:   abo:ABO_0643
- NMPDR:   fig|393595.12.peg.643
- eggNOG:   COG4108
- HOGENOM:   HBG285678
- OMA:   HERTVEP
- PhylomeDB:   Q0VRV7
- ProtClustDB:   CLSK2779248
- BioCyc:   ABOR393595:ABO_0643-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00072
- InterPro:   IPR009022
- InterPro:   IPR004548
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR004161
- InterPro:   IPR009000
- PRINTS:   PR00315
- TIGRFAMs:   TIGR00503
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2; SSF54980 EFG_III_V; SSF50447 Translat_factor

EC number: NA

Molecular weight: Translated: 58774; Mature: 58643

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPMSLQDQVATRRTFAIISHPDAGKTTITEKLLLYGNLIQSAGTVKGKKSGKHATSDWM
CCCCCCHHHHHHCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
EMEKERGISVTTSVMQFPYKGATVNLLDTPGHADFSEDTYRTLTAVDSALMVIDAAKGVE
HHHHHCCCEEEHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHEEEHHCCHH
QRTVKLMEVCRLRDTPILTFINKLDRDVRDGIDVLDEIEDVLNIECAPITWPIGMGKSFK
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCEEEECCCCCCHH
GVYNLLTDTTVLYKTGQGHTVQDVREVKGLNNPELDEAVGTDYAEELRDTLELVQGASHE
HHHHHHHCCEEEEECCCCCCHHHHHHHCCCCCCCHHHHHCCHHHHHHHHHHHHHHCCCCC
FDLERFLAGKLTPVFFGTALGNFGVDHMLDGLVQWAPPPQPRDATARTVEADEPKMTGFV
CCHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCEEEEE
FKIQANMDPRHRDRIAFMRICSGTYRKGIKLKQVRTGKDVRIADALTFLAGERDNVEEAF
EEEECCCCCCHHHHHHHHHHHCHHHHCCCEEEEECCCCCEEHHHHHHHHCCCCCCHHHHH
SGDIIGLHNHGTIQIGDTFTEGEELAFTGIPHFAPELFQRVVLNDPLKSKQLHKGLTQLA
CCCEEEECCCCEEEECCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
EEGATQVFFPLRNNDVILGAVGSLQFDVVAARLKGEYGVDCRYEPVSVATARWVEADSDK
HCCCCEEEEEECCCCEEEEECCCCEEHHHHHHHCCCCCCCCEECCCCHHHHHEECCCCCC
ELAAFERKAHDNLSRDGAGHLTYLAPTRVNLQLAQERHPDIRFRETREI
HHHHHHHHHHCCCCCCCCCCEEEECCCEEEEEEHHCCCCCCCCHHCCCC
>Mature Secondary Structure 
SPMSLQDQVATRRTFAIISHPDAGKTTITEKLLLYGNLIQSAGTVKGKKSGKHATSDWM
CCCCCHHHHHHCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
EMEKERGISVTTSVMQFPYKGATVNLLDTPGHADFSEDTYRTLTAVDSALMVIDAAKGVE
HHHHHCCCEEEHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHEEEHHCCHH
QRTVKLMEVCRLRDTPILTFINKLDRDVRDGIDVLDEIEDVLNIECAPITWPIGMGKSFK
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCEEEECCCCCCHH
GVYNLLTDTTVLYKTGQGHTVQDVREVKGLNNPELDEAVGTDYAEELRDTLELVQGASHE
HHHHHHHCCEEEEECCCCCCHHHHHHHCCCCCCCHHHHHCCHHHHHHHHHHHHHHCCCCC
FDLERFLAGKLTPVFFGTALGNFGVDHMLDGLVQWAPPPQPRDATARTVEADEPKMTGFV
CCHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCEEEEE
FKIQANMDPRHRDRIAFMRICSGTYRKGIKLKQVRTGKDVRIADALTFLAGERDNVEEAF
EEEECCCCCCHHHHHHHHHHHCHHHHCCCEEEEECCCCCEEHHHHHHHHCCCCCCHHHHH
SGDIIGLHNHGTIQIGDTFTEGEELAFTGIPHFAPELFQRVVLNDPLKSKQLHKGLTQLA
CCCEEEECCCCEEEECCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
EEGATQVFFPLRNNDVILGAVGSLQFDVVAARLKGEYGVDCRYEPVSVATARWVEADSDK
HCCCCEEEEEECCCCEEEEECCCCEEHHHHHHHCCCCCCCCEECCCCHHHHHEECCCCCC
ELAAFERKAHDNLSRDGAGHLTYLAPTRVNLQLAQERHPDIRFRETREI
HHHHHHHHHHCCCCCCCCCCEEEECCCEEEEEEHHCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA