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The map label for this gene is ltrA [H]

Identifier: 110833496

GI number: 110833496

Start: 702432

End: 704090

Strand: Direct

Name: ltrA [H]

Synonym: ABO_0635

Alternate gene names: 110833496

Gene position: 702432-704090 (Clockwise)

Preceding gene: 110833495

Following gene: 110833497

Centisome position: 22.51

GC content: 56.66

Gene sequence:

>1659_bases
ATGAACGCATCGCTATTGATGCCTGCATTCTCCCACCCTGCCACCAGTTGGCACATGATTGATTGGGAAACCAGTCATCG
TCGGGTGAGGAGGTTACAGGCTCGTATCGCGAAAGCAGCACGGGAACAGCAGTGGAGGAGGGTGAAAGCCCTGCAACGCT
TGCTAGTCCGCTCGTTCGCCGCCAAAGCCTTGGCGGTAAAACGGGTCACTGAAAACCGGGGTCGCAAGACTCCGGGTGTC
GATGGCGAATGCTGGGACAATCCAGCATCAAAATGGGAAGCGATCCACCGTCTGAAACGGCACGGCTACAAGCCGCGTCC
GCTCCGGCGGGTTTGGATTCCGAAGGCCAACGGCAAACGCCGTCCCTTGGGAATACCGACGATGCACGACCGGGCCATGC
AGGCGTTATACCTGCTGGCTCTGGAACCGGTGTCCGAGACCACGGCGGATCGTAACTCATATGGCTTCCGGCCCATGCGC
GCTACGGCGGACGCAATCGAGCAATGTTTTGTTGTGCTTGGTCGCAAAAGCTCGGCGCAGTGGGTGCTGGAGGCTGATAT
ACAGGGTTGTTTCGACAACATAAGCCATGACTGGCTGCTGTCCCATGTCCCTATGGACAAGGCAGTGCTCGGGAAATGGC
TGAAAGCCGGGTTCATGGAATCCGGTAGGACACACCCGACCCACGCGGGAACGCCTCAGGGCGGTATTATCTCGCCGGTT
TTGGCCAACATGGCTCTGGATGGTTTGGAAGAAGTGCTAGAAGCTGCTTTCGGGCAGCGTAACACCAAAGCCAGCTACCG
GACCAAGGTCAACTACGTGCGCTACGCCGACGACTTCGTTGTCTCCGGTATCTCGAGAGAGCTGCTGGAGAGGGAGGTCA
GGCCCATCGTCGAAGCCTTTATGGCGGAGCGGGGGCTTGCATTGTCCGCGGAGAAGACGGTGGTGACGCATGTGGAGGAA
GGGTTCGACTTTCTGGGTCAGAACATTCGCAAGTATGGAGGGAAGTGCTTGATTAAGCCTGCCCAACAGAACGTGAAGCG
GTTTCTGGCCGAGGTGAAGTCGGTGTTGGACACGCACAAGACCATGCCTGCGTGGTGGATCGTCAAGACTCTGAATCCCA
AGATTCGAGGCTGGGCGAACTACCATCGGCACGTGGTTTCGAAAGCGACGTTCAACTATGTGGACTATCGGATCTGGAAG
ATGCTGTGGCAATGGTGCCGCCGACGTCATCTCAATCGACGGAAGCGGTGGGTGAAGAACAAGTATTTTCGCCCCCTCGG
CCAGCGCAGCTGGACATTCCAGGGCATGGACCCAACAGGCAAGCGGTATGCGTTGTGCTACGCCAGTGATGTGCCCATCA
AAAGGCATATCAAGATCAAGGCCGAAGCGACACGGTATGACCCCACCTTTGCTGGTTATTTCGAGGAACGCCTGGCGTAT
CTCTGGAAGAACAGCGAGAAAGGGAAGTCCAAGTTGCTACAGCTTTGGCTCCGGCAGGAGAAGCGCTGTCCTTGTTGTCG
CGAACTGATCACACGGGAAACCGGGTGGAACATCCACCACGTGATCGAACAGCATAAGGGCGGTACCGATAAGCTGGATA
ATCTGGTGTTGCTGCATCCGAACTGCCATCGGCAACTGCACTCGAAATCAATATGTTGA

Upstream 100 bases:

>100_bases
TTGTTGCCCGGTTAAACAATGTGCCCTGAGGGTGTGGACTGCGCCCTCAGGGGAAATGCGTCTGCGCCTTCTCGGGTTCC
AATCTGAGGAGGATAGCAAG

Downstream 100 bases:

>100_bases
TGATAGATGGGTGTTGAAATACAATATGTGGTGTCCTTGATCCCCAAGGGCGTTCGAATGGAGGGTCATACTTTGACCAA
ACTTTTGAATGTCCCCAAAC

Product: reverse transcriptase/maturase-like protein

Products: NA

Alternate protein names: Reverse-transcriptase; RNA maturase; DNA endonuclease [H]

Number of amino acids: Translated: 552; Mature: 552

Protein sequence:

>552_residues
MNASLLMPAFSHPATSWHMIDWETSHRRVRRLQARIAKAAREQQWRRVKALQRLLVRSFAAKALAVKRVTENRGRKTPGV
DGECWDNPASKWEAIHRLKRHGYKPRPLRRVWIPKANGKRRPLGIPTMHDRAMQALYLLALEPVSETTADRNSYGFRPMR
ATADAIEQCFVVLGRKSSAQWVLEADIQGCFDNISHDWLLSHVPMDKAVLGKWLKAGFMESGRTHPTHAGTPQGGIISPV
LANMALDGLEEVLEAAFGQRNTKASYRTKVNYVRYADDFVVSGISRELLEREVRPIVEAFMAERGLALSAEKTVVTHVEE
GFDFLGQNIRKYGGKCLIKPAQQNVKRFLAEVKSVLDTHKTMPAWWIVKTLNPKIRGWANYHRHVVSKATFNYVDYRIWK
MLWQWCRRRHLNRRKRWVKNKYFRPLGQRSWTFQGMDPTGKRYALCYASDVPIKRHIKIKAEATRYDPTFAGYFEERLAY
LWKNSEKGKSKLLQLWLRQEKRCPCCRELITRETGWNIHHVIEQHKGGTDKLDNLVLLHPNCHRQLHSKSIC

Sequences:

>Translated_552_residues
MNASLLMPAFSHPATSWHMIDWETSHRRVRRLQARIAKAAREQQWRRVKALQRLLVRSFAAKALAVKRVTENRGRKTPGV
DGECWDNPASKWEAIHRLKRHGYKPRPLRRVWIPKANGKRRPLGIPTMHDRAMQALYLLALEPVSETTADRNSYGFRPMR
ATADAIEQCFVVLGRKSSAQWVLEADIQGCFDNISHDWLLSHVPMDKAVLGKWLKAGFMESGRTHPTHAGTPQGGIISPV
LANMALDGLEEVLEAAFGQRNTKASYRTKVNYVRYADDFVVSGISRELLEREVRPIVEAFMAERGLALSAEKTVVTHVEE
GFDFLGQNIRKYGGKCLIKPAQQNVKRFLAEVKSVLDTHKTMPAWWIVKTLNPKIRGWANYHRHVVSKATFNYVDYRIWK
MLWQWCRRRHLNRRKRWVKNKYFRPLGQRSWTFQGMDPTGKRYALCYASDVPIKRHIKIKAEATRYDPTFAGYFEERLAY
LWKNSEKGKSKLLQLWLRQEKRCPCCRELITRETGWNIHHVIEQHKGGTDKLDNLVLLHPNCHRQLHSKSIC
>Mature_552_residues
MNASLLMPAFSHPATSWHMIDWETSHRRVRRLQARIAKAAREQQWRRVKALQRLLVRSFAAKALAVKRVTENRGRKTPGV
DGECWDNPASKWEAIHRLKRHGYKPRPLRRVWIPKANGKRRPLGIPTMHDRAMQALYLLALEPVSETTADRNSYGFRPMR
ATADAIEQCFVVLGRKSSAQWVLEADIQGCFDNISHDWLLSHVPMDKAVLGKWLKAGFMESGRTHPTHAGTPQGGIISPV
LANMALDGLEEVLEAAFGQRNTKASYRTKVNYVRYADDFVVSGISRELLEREVRPIVEAFMAERGLALSAEKTVVTHVEE
GFDFLGQNIRKYGGKCLIKPAQQNVKRFLAEVKSVLDTHKTMPAWWIVKTLNPKIRGWANYHRHVVSKATFNYVDYRIWK
MLWQWCRRRHLNRRKRWVKNKYFRPLGQRSWTFQGMDPTGKRYALCYASDVPIKRHIKIKAEATRYDPTFAGYFEERLAY
LWKNSEKGKSKLLQLWLRQEKRCPCCRELITRETGWNIHHVIEQHKGGTDKLDNLVLLHPNCHRQLHSKSIC

Specific function: Multifunctional protein that promotes group II intron splicing and mobility by acting both on RNA and DNA. It has three activities:reverse transcriptase (RT) for intron duplication, maturase to promote splicing, and DNA endonuclease for site- specific cle

COG id: COG3344

COG function: function code L; Retron-type reverse transcriptase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 reverse transcriptase domain [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6226521, Length=362, Percent_Identity=25.414364640884, Blast_Score=119, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6226520, Length=326, Percent_Identity=26.6871165644172, Blast_Score=110, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003615
- InterPro:   IPR002866
- InterPro:   IPR000477 [H]

Pfam domain/function: PF01348 Intron_maturas2; PF00078 RVT_1 [H]

EC number: =2.7.7.49 [H]

Molecular weight: Translated: 64110; Mature: 64110

Theoretical pI: Translated: 10.76; Mature: 10.76

Prosite motif: PS00028 ZINC_FINGER_C2H2_1 ; PS50878 RT_POL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNASLLMPAFSHPATSWHMIDWETSHRRVRRLQARIAKAAREQQWRRVKALQRLLVRSFA
CCCCEECCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKALAVKRVTENRGRKTPGVDGECWDNPASKWEAIHRLKRHGYKPRPLRRVWIPKANGKR
HHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCC
RPLGIPTMHDRAMQALYLLALEPVSETTADRNSYGFRPMRATADAIEQCFVVLGRKSSAQ
CCCCCCCHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
WVLEADIQGCFDNISHDWLLSHVPMDKAVLGKWLKAGFMESGRTHPTHAGTPQGGIISPV
EEEEHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
LANMALDGLEEVLEAAFGQRNTKASYRTKVNYVRYADDFVVSGISRELLEREVRPIVEAF
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCEEEEHHHHHHHHHHHHHHHHHHHHHHHHH
MAERGLALSAEKTVVTHVEEGFDFLGQNIRKYGGKCLIKPAQQNVKRFLAEVKSVLDTHK
HHHCCCEECCCHHHHHHHHHHHHHHHHHHHHHCCEEEECHHHHHHHHHHHHHHHHHHHHC
TMPAWWIVKTLNPKIRGWANYHRHVVSKATFNYVDYRIWKMLWQWCRRRHLNRRKRWVKN
CCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KYFRPLGQRSWTFQGMDPTGKRYALCYASDVPIKRHIKIKAEATRYDPTFAGYFEERLAY
HHCCCCCCCCCEECCCCCCCCEEEEEEECCCCCEEEEEEEEECCCCCCHHHHHHHHHHHH
LWKNSEKGKSKLLQLWLRQEKRCPCCRELITRETGWNIHHVIEQHKGGTDKLDNLVLLHP
HHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCEEEECC
NCHRQLHSKSIC
CHHHHHHHCCCC
>Mature Secondary Structure
MNASLLMPAFSHPATSWHMIDWETSHRRVRRLQARIAKAAREQQWRRVKALQRLLVRSFA
CCCCEECCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKALAVKRVTENRGRKTPGVDGECWDNPASKWEAIHRLKRHGYKPRPLRRVWIPKANGKR
HHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCC
RPLGIPTMHDRAMQALYLLALEPVSETTADRNSYGFRPMRATADAIEQCFVVLGRKSSAQ
CCCCCCCHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
WVLEADIQGCFDNISHDWLLSHVPMDKAVLGKWLKAGFMESGRTHPTHAGTPQGGIISPV
EEEEHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
LANMALDGLEEVLEAAFGQRNTKASYRTKVNYVRYADDFVVSGISRELLEREVRPIVEAF
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCEEEEHHHHHHHHHHHHHHHHHHHHHHHHH
MAERGLALSAEKTVVTHVEEGFDFLGQNIRKYGGKCLIKPAQQNVKRFLAEVKSVLDTHK
HHHCCCEECCCHHHHHHHHHHHHHHHHHHHHHCCEEEECHHHHHHHHHHHHHHHHHHHHC
TMPAWWIVKTLNPKIRGWANYHRHVVSKATFNYVDYRIWKMLWQWCRRRHLNRRKRWVKN
CCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KYFRPLGQRSWTFQGMDPTGKRYALCYASDVPIKRHIKIKAEATRYDPTFAGYFEERLAY
HHCCCCCCCCCEECCCCCCCCEEEEEEECCCCCEEEEEEEEECCCCCCHHHHHHHHHHHH
LWKNSEKGKSKLLQLWLRQEKRCPCCRELITRETGWNIHHVIEQHKGGTDKLDNLVLLHP
HHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCEEEECC
NCHRQLHSKSIC
CHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8655550; 11157264; 10488339; 9353259; 10413481; 11731786 [H]