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The map label for this gene is groEL

Identifier: 110833495

GI number: 110833495

Start: 699691

End: 701337

Strand: Direct

Name: groEL

Synonym: ABO_0634

Alternate gene names: 110833495

Gene position: 699691-701337 (Clockwise)

Preceding gene: 110833494

Following gene: 110833496

Centisome position: 22.42

GC content: 55.8

Gene sequence:

>1647_bases
ATGGCTAAAGAAATTTTGTTCCGTGACGAAGCTCGTCAACGTATGGCTAAAGGCGTCAACATTCTGGCAGACGCCGTCAA
AGTAACTTTGGGCCCGAAAGGCCGTAACGTGGTGCTGGAAAAATCCTTCGGCGCCCCGTCCATCACTAAAGATGGCGTTT
CCGTTGCCCGCGAAATCGAACTGGAAGATAAGTTCGAGAACATGGGTGCGCAGATGGTCAAGGAAGTGGCTTCCAAGGCC
AACGACGAAGCGGGTGACGGCACCACCACCGCCACCGTGCTGGCTCAGGCGTTCGTGAACGAAGGCCTGAAGTCCGTAAC
CGCGGGCATGAACCCCATGGACCTGAAGCGCGGCATCGATCAGGCCGTTGCGGCCGTAGTGGAAGAGCTGAAAAAGCTAT
CTACTCCGTGCGACAACACCAAGAGCATTGAGCAGGTAGGTACTATCTCTGCCAACGCCGACAAATCTGTTGGTGAGATC
ATCGCCCAGGCCATGGAAAAAGTGGGCCAGGAAGGGGTTATCACTGTTGAAGAAGGCCAGTCTCTGCAGAACGAGCTGGA
CGTGGTTGAAGGTATGCAGTTTGACCGCGGTTACCTGAGCCCTTACTTCATCAACAACCAGGAAAAGATGCAGGTCGAAC
TGGAAGACCCGTACATCCTGTTGGTGGACAAGAAGATTTCCAACATCCGTGAGCTGTTGCCAGCCCTGGAAAATGTGGCT
AAAGCAGGCAAGCCGCTGCTGATTATCGCTGAAGACATTGAAGGCGAAGCGCTGGCTACCCTGGTAGTGAACAACATGCG
CGGCATCATCAAGTGTGCCGCTGTGAAGGCGCCGGGCTTCGGTGATCGTCGCAAGGCCATGCTGCAAGATATCGCCATCC
TCACCGGCGGCACCGTCATCAGCGAAGAAGTGGGCCTGAGCTTGGAAAATGCGTCCCTGGAAGATCTGGGTACCGCCAAG
AAAGTGAACATCGACAAGGAAAACACCACCATTGTTGATGGCGCTGGCCAGCAGGCAGATATCGATGGCCGTGTGGAGCA
AATCCGCAAGGAAATCGAAAACTCTTCCTCTGACTACGACAAAGAAAAACTGCAAGAGCGCGTGGCCAAGTTGGCCGGCG
GTGTTGCGGTAATCAAGATCGGTGCTGCCACCGAAATTGAAATGAAAGAGAAGAAAGCTCGCGTTGACGATGCTCTGCAC
GCTACCCGTGCTGCGGTAGAAGAAGGTGTGGTACCGGGCGGTGGTGTTGCTCTGGTTCGCGCTCTAGCCAATGTTGGCAC
CATCAAAGGTGACAACGACGAGCAGAACGCCGGTATTGCCCTGACTTTCCGTGCGCTGGAAATGCCGCTTCGCCAGATCG
CCTATAACGCCGGCGCGGAAGCATCCGTGATTGTGCAGGAAGTGCGTAATGGCAAAGGTAACTACGGCTACAACGCAGCC
TCCGGTGAATACGGTGACATGTTGGAAATGGGTATTCTCGATCCCGCCAAAGTGACCCGTTCTGCTCTGCAGGCCGCGGC
CTCCATTGCTGGCCTGATGATCACCACCGAAGCCATGGTGGCGGACAAGCCGGAAGAAAACGCCGGTGCCGGCGCCCCAG
ACATGGGCGGCATGGGTGGAATGGGCGGAATGGGCGGCATGATGTAG

Upstream 100 bases:

>100_bases
CGAATAGCCAGGGTAACCCAGTTCCGCTCCAGACAGACATCGAACGCCCGCAAGGGCATTCAGCCCATTACTGGGTACAG
AATTGCAGAGGTATAGAAAC

Downstream 100 bases:

>100_bases
TGCGACGTGAAGTCGCGAGGTCGCTAGCCTTTGCGGGCTACTTCGGGGGCTCCGCTCCCAATTAACCGCAGAAAATAGCG
TATTCCTTACCCGGTGATCG

Product: chaperonin, 60 kDa

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60

Number of amino acids: Translated: 548; Mature: 547

Protein sequence:

>548_residues
MAKEILFRDEARQRMAKGVNILADAVKVTLGPKGRNVVLEKSFGAPSITKDGVSVAREIELEDKFENMGAQMVKEVASKA
NDEAGDGTTTATVLAQAFVNEGLKSVTAGMNPMDLKRGIDQAVAAVVEELKKLSTPCDNTKSIEQVGTISANADKSVGEI
IAQAMEKVGQEGVITVEEGQSLQNELDVVEGMQFDRGYLSPYFINNQEKMQVELEDPYILLVDKKISNIRELLPALENVA
KAGKPLLIIAEDIEGEALATLVVNNMRGIIKCAAVKAPGFGDRRKAMLQDIAILTGGTVISEEVGLSLENASLEDLGTAK
KVNIDKENTTIVDGAGQQADIDGRVEQIRKEIENSSSDYDKEKLQERVAKLAGGVAVIKIGAATEIEMKEKKARVDDALH
ATRAAVEEGVVPGGGVALVRALANVGTIKGDNDEQNAGIALTFRALEMPLRQIAYNAGAEASVIVQEVRNGKGNYGYNAA
SGEYGDMLEMGILDPAKVTRSALQAAASIAGLMITTEAMVADKPEENAGAGAPDMGGMGGMGGMGGMM

Sequences:

>Translated_548_residues
MAKEILFRDEARQRMAKGVNILADAVKVTLGPKGRNVVLEKSFGAPSITKDGVSVAREIELEDKFENMGAQMVKEVASKA
NDEAGDGTTTATVLAQAFVNEGLKSVTAGMNPMDLKRGIDQAVAAVVEELKKLSTPCDNTKSIEQVGTISANADKSVGEI
IAQAMEKVGQEGVITVEEGQSLQNELDVVEGMQFDRGYLSPYFINNQEKMQVELEDPYILLVDKKISNIRELLPALENVA
KAGKPLLIIAEDIEGEALATLVVNNMRGIIKCAAVKAPGFGDRRKAMLQDIAILTGGTVISEEVGLSLENASLEDLGTAK
KVNIDKENTTIVDGAGQQADIDGRVEQIRKEIENSSSDYDKEKLQERVAKLAGGVAVIKIGAATEIEMKEKKARVDDALH
ATRAAVEEGVVPGGGVALVRALANVGTIKGDNDEQNAGIALTFRALEMPLRQIAYNAGAEASVIVQEVRNGKGNYGYNAA
SGEYGDMLEMGILDPAKVTRSALQAAASIAGLMITTEAMVADKPEENAGAGAPDMGGMGGMGGMGGMM
>Mature_547_residues
AKEILFRDEARQRMAKGVNILADAVKVTLGPKGRNVVLEKSFGAPSITKDGVSVAREIELEDKFENMGAQMVKEVASKAN
DEAGDGTTTATVLAQAFVNEGLKSVTAGMNPMDLKRGIDQAVAAVVEELKKLSTPCDNTKSIEQVGTISANADKSVGEII
AQAMEKVGQEGVITVEEGQSLQNELDVVEGMQFDRGYLSPYFINNQEKMQVELEDPYILLVDKKISNIRELLPALENVAK
AGKPLLIIAEDIEGEALATLVVNNMRGIIKCAAVKAPGFGDRRKAMLQDIAILTGGTVISEEVGLSLENASLEDLGTAKK
VNIDKENTTIVDGAGQQADIDGRVEQIRKEIENSSSDYDKEKLQERVAKLAGGVAVIKIGAATEIEMKEKKARVDDALHA
TRAAVEEGVVPGGGVALVRALANVGTIKGDNDEQNAGIALTFRALEMPLRQIAYNAGAEASVIVQEVRNGKGNYGYNAAS
GEYGDMLEMGILDPAKVTRSALQAAASIAGLMITTEAMVADKPEENAGAGAPDMGGMGGMGGMGGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=526, Percent_Identity=49.6197718631179, Blast_Score=530, Evalue=1e-150,
Organism=Homo sapiens, GI31542947, Length=526, Percent_Identity=49.6197718631179, Blast_Score=530, Evalue=1e-150,
Organism=Escherichia coli, GI1790586, Length=527, Percent_Identity=75.1423149905123, Blast_Score=805, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=51.7958412098299, Blast_Score=542, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI193210679, Length=211, Percent_Identity=52.132701421801, Blast_Score=213, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6323288, Length=524, Percent_Identity=52.6717557251908, Blast_Score=541, Evalue=1e-154,
Organism=Saccharomyces cerevisiae, GI6322524, Length=155, Percent_Identity=27.741935483871, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=51.0436432637571, Blast_Score=556, Evalue=1e-158,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=51.0436432637571, Blast_Score=556, Evalue=1e-158,
Organism=Drosophila melanogaster, GI45550936, Length=526, Percent_Identity=50.5703422053232, Blast_Score=546, Evalue=1e-155,
Organism=Drosophila melanogaster, GI45550132, Length=526, Percent_Identity=50.5703422053232, Blast_Score=546, Evalue=1e-155,
Organism=Drosophila melanogaster, GI45550935, Length=526, Percent_Identity=50.5703422053232, Blast_Score=546, Evalue=1e-155,
Organism=Drosophila melanogaster, GI17864606, Length=551, Percent_Identity=41.5607985480944, Blast_Score=449, Evalue=1e-126,
Organism=Drosophila melanogaster, GI24584129, Length=527, Percent_Identity=37.5711574952562, Blast_Score=347, Evalue=1e-95,
Organism=Drosophila melanogaster, GI19921262, Length=527, Percent_Identity=37.5711574952562, Blast_Score=347, Evalue=1e-95,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH60_ALCBS (Q0VRW6)

Other databases:

- EMBL:   AM286690
- RefSeq:   YP_692354.1
- ProteinModelPortal:   Q0VRW6
- SMR:   Q0VRW6
- STRING:   Q0VRW6
- GeneID:   4212357
- GenomeReviews:   AM286690_GR
- KEGG:   abo:ABO_0634
- NMPDR:   fig|393595.12.peg.634
- eggNOG:   COG0459
- HOGENOM:   HBG625289
- OMA:   DKPAAGM
- PhylomeDB:   Q0VRW6
- BioCyc:   ABOR393595:ABO_0634-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 57881; Mature: 57750

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKEILFRDEARQRMAKGVNILADAVKVTLGPKGRNVVLEKSFGAPSITKDGVSVAREIE
CCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHH
LEDKFENMGAQMVKEVASKANDEAGDGTTTATVLAQAFVNEGLKSVTAGMNPMDLKRGID
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
QAVAAVVEELKKLSTPCDNTKSIEQVGTISANADKSVGEIIAQAMEKVGQEGVITVEEGQ
HHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCC
SLQNELDVVEGMQFDRGYLSPYFINNQEKMQVELEDPYILLVDKKISNIRELLPALENVA
CHHHHHHHHHCCCCCCCCCCCEEECCCCEEEEEECCCEEEEECCHHHHHHHHHHHHHHHH
KAGKPLLIIAEDIEGEALATLVVNNMRGIIKCAAVKAPGFGDRRKAMLQDIAILTGGTVI
HCCCCEEEEEECCCCHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHCCCEEE
SEEVGLSLENASLEDLGTAKKVNIDKENTTIVDGAGQQADIDGRVEQIRKEIENSSSDYD
HHHHCCEECCCCHHHCCCCCEEECCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCCCC
KEKLQERVAKLAGGVAVIKIGAATEIEMKEKKARVDDALHATRAAVEEGVVPGGGVALVR
HHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
ALANVGTIKGDNDEQNAGIALTFRALEMPLRQIAYNAGAEASVIVQEVRNGKGNYGYNAA
HHHHHCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCC
SGEYGDMLEMGILDPAKVTRSALQAAASIAGLMITTEAMVADKPEENAGAGAPDMGGMGG
CCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
MGGMGGMM
CCCCCCCC
>Mature Secondary Structure 
AKEILFRDEARQRMAKGVNILADAVKVTLGPKGRNVVLEKSFGAPSITKDGVSVAREIE
CCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHH
LEDKFENMGAQMVKEVASKANDEAGDGTTTATVLAQAFVNEGLKSVTAGMNPMDLKRGID
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
QAVAAVVEELKKLSTPCDNTKSIEQVGTISANADKSVGEIIAQAMEKVGQEGVITVEEGQ
HHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCC
SLQNELDVVEGMQFDRGYLSPYFINNQEKMQVELEDPYILLVDKKISNIRELLPALENVA
CHHHHHHHHHCCCCCCCCCCCEEECCCCEEEEEECCCEEEEECCHHHHHHHHHHHHHHHH
KAGKPLLIIAEDIEGEALATLVVNNMRGIIKCAAVKAPGFGDRRKAMLQDIAILTGGTVI
HCCCCEEEEEECCCCHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHCCCEEE
SEEVGLSLENASLEDLGTAKKVNIDKENTTIVDGAGQQADIDGRVEQIRKEIENSSSDYD
HHHHCCEECCCCHHHCCCCCEEECCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCCCC
KEKLQERVAKLAGGVAVIKIGAATEIEMKEKKARVDDALHATRAAVEEGVVPGGGVALVR
HHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
ALANVGTIKGDNDEQNAGIALTFRALEMPLRQIAYNAGAEASVIVQEVRNGKGNYGYNAA
HHHHHCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCC
SGEYGDMLEMGILDPAKVTRSALQAAASIAGLMITTEAMVADKPEENAGAGAPDMGGMGG
CCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
MGGMGGMM
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA