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The map label for this gene is moeB [H]

Identifier: 110833386

GI number: 110833386

Start: 577090

End: 577833

Strand: Direct

Name: moeB [H]

Synonym: ABO_0525

Alternate gene names: 110833386

Gene position: 577090-577833 (Clockwise)

Preceding gene: 110833385

Following gene: 110833391

Centisome position: 18.5

GC content: 58.6

Gene sequence:

>744_bases
ATGCTCAACGATGACCAGCTGCTTCGCTACAGTCGCCAGTTGATGGTGGAAGAATTCGATTTGCCTGGGCAAGAAGCTTT
GAGCAAGGCGCGGATATTGGTGGTGGGTTGTGGTGGCCTAGCCAATCCTGCTGCGCTGTATTTGGCGGGTGCTGGGGTGG
GGCAGCTGGTGCTAGCGGATGACGACCGGGTGGAGTTGAGCAACCTGCATCGACAGGTGGCGTTTCGGGGTGACCAGCTG
AATCAGGCCAAGGCGGAAGCCTTGCGCGATCAGTTGCAACTGTTGAATGCGGATGTGGATATTCGTTCCGCTGTGGTGCG
GGTGGATGATGCGTGGCTGAATGAGGCTGTTGCTGACGCCACCCTAGTACTGGACTGCACTGACAATTTTTCCACTCGCC
AGGCCATCAATCGTGCCTGTGTGGCGCACCGTACACCGCTGGTCAGTGGCGCCGCTATTCGCATGGATGGTCAGTTGGCG
GTGTTCGATTTACGCACGGAAGACAGCCCCTGTTATGCCTGCGTGTACGGCGAGGGTTCAGAGGGGGATCTGGCCTGTAG
CGAGGCGGGGATTCTCGGGCCTGTAGTGGGTATGGTGGGCACCTTGCAGGCATTGGCGGCCATACGAACCCTCACCGGTA
CCTCTGTGGCATCGGTTCTGCATTTGTTTGACGGTCGGACATTGAGTTGGCGCCAAGTGGCGATTCCCCGTGACCCCGAA
TGCCCGGTTTGCGCGATGAATTAG

Upstream 100 bases:

>100_bases
AACATTTGCACAGCAAAGCCAGGAACGGATCTGTTGGGTGCACGAAGTGCAGCAAGCTGTACCATAGAATCCCACGCCTT
TGAGTGCCAGGGAGACGATT

Downstream 100 bases:

>100_bases
TTGTCGGGCTGATTGTCCGTGGCCGTGGGTATATCTTCCATGCCTTCGGCCATGATCGGCGGTTCTTCCGCCATTAAGCC
AATCAGAACCAGAATGATGA

Product: molybdopterin biosynthesis MoeB protein

Products: NA

Alternate protein names: MoaD protein adenylase; Molybdopterin-converting factor subunit 1 adenylase [H]

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MLNDDQLLRYSRQLMVEEFDLPGQEALSKARILVVGCGGLANPAALYLAGAGVGQLVLADDDRVELSNLHRQVAFRGDQL
NQAKAEALRDQLQLLNADVDIRSAVVRVDDAWLNEAVADATLVLDCTDNFSTRQAINRACVAHRTPLVSGAAIRMDGQLA
VFDLRTEDSPCYACVYGEGSEGDLACSEAGILGPVVGMVGTLQALAAIRTLTGTSVASVLHLFDGRTLSWRQVAIPRDPE
CPVCAMN

Sequences:

>Translated_247_residues
MLNDDQLLRYSRQLMVEEFDLPGQEALSKARILVVGCGGLANPAALYLAGAGVGQLVLADDDRVELSNLHRQVAFRGDQL
NQAKAEALRDQLQLLNADVDIRSAVVRVDDAWLNEAVADATLVLDCTDNFSTRQAINRACVAHRTPLVSGAAIRMDGQLA
VFDLRTEDSPCYACVYGEGSEGDLACSEAGILGPVVGMVGTLQALAAIRTLTGTSVASVLHLFDGRTLSWRQVAIPRDPE
CPVCAMN
>Mature_247_residues
MLNDDQLLRYSRQLMVEEFDLPGQEALSKARILVVGCGGLANPAALYLAGAGVGQLVLADDDRVELSNLHRQVAFRGDQL
NQAKAEALRDQLQLLNADVDIRSAVVRVDDAWLNEAVADATLVLDCTDNFSTRQAINRACVAHRTPLVSGAAIRMDGQLA
VFDLRTEDSPCYACVYGEGSEGDLACSEAGILGPVVGMVGTLQALAAIRTLTGTSVASVLHLFDGRTLSWRQVAIPRDPE
CPVCAMN

Specific function: Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein moaD [H]

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesA/moeB/thiF family [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=229, Percent_Identity=41.4847161572052, Blast_Score=132, Evalue=3e-31,
Organism=Escherichia coli, GI1787048, Length=245, Percent_Identity=43.6734693877551, Blast_Score=207, Evalue=7e-55,
Organism=Escherichia coli, GI87082356, Length=245, Percent_Identity=46.9387755102041, Blast_Score=201, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI17540406, Length=260, Percent_Identity=40.7692307692308, Blast_Score=202, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI86565433, Length=162, Percent_Identity=30.2469135802469, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI86565431, Length=162, Percent_Identity=30.2469135802469, Blast_Score=68, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6321903, Length=256, Percent_Identity=33.203125, Blast_Score=141, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6322639, Length=172, Percent_Identity=27.906976744186, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24582879, Length=249, Percent_Identity=39.7590361445783, Blast_Score=172, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24660640, Length=166, Percent_Identity=27.710843373494, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR012730
- InterPro:   IPR016040
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 26437; Mature: 26437

Theoretical pI: Translated: 4.39; Mature: 4.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNDDQLLRYSRQLMVEEFDLPGQEALSKARILVVGCGGLANPAALYLAGAGVGQLVLAD
CCCHHHHHHHHHHHHHHHCCCCCHHHHCCCEEEEEECCCCCCCCEEEEECCCCCEEEEEC
DDRVELSNLHRQVAFRGDQLNQAKAEALRDQLQLLNADVDIRSAVVRVDDAWLNEAVADA
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHEEEECHHHHHHHHCCE
TLVLDCTDNFSTRQAINRACVAHRTPLVSGAAIRMDGQLAVFDLRTEDSPCYACVYGEGS
EEEEECCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCEEEEEEEECCCCCEEEEEECCCC
EGDLACSEAGILGPVVGMVGTLQALAAIRTLTGTSVASVLHLFDGRTLSWRQVAIPRDPE
CCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEECCCCCC
CPVCAMN
CCEECCC
>Mature Secondary Structure
MLNDDQLLRYSRQLMVEEFDLPGQEALSKARILVVGCGGLANPAALYLAGAGVGQLVLAD
CCCHHHHHHHHHHHHHHHCCCCCHHHHCCCEEEEEECCCCCCCCEEEEECCCCCEEEEEC
DDRVELSNLHRQVAFRGDQLNQAKAEALRDQLQLLNADVDIRSAVVRVDDAWLNEAVADA
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHEEEECHHHHHHHHCCE
TLVLDCTDNFSTRQAINRACVAHRTPLVSGAAIRMDGQLAVFDLRTEDSPCYACVYGEGS
EEEEECCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCEEEEEEEECCCCCEEEEEECCCC
EGDLACSEAGILGPVVGMVGTLQALAAIRTLTGTSVASVLHLFDGRTLSWRQVAIPRDPE
CCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEECCCCCC
CPVCAMN
CCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503 [H]