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The map label for this gene is hemK [H]

Identifier: 110833385

GI number: 110833385

Start: 576148

End: 576990

Strand: Direct

Name: hemK [H]

Synonym: ABO_0524

Alternate gene names: 110833385

Gene position: 576148-576990 (Clockwise)

Preceding gene: 110833384

Following gene: 110833386

Centisome position: 18.47

GC content: 59.67

Gene sequence:

>843_bases
GTGCGCATTGATGACGCCCTGCGCCAGGCTCGCCATCGGTTGGCGTCATCCCCTTGCGCAGCGCTGGATGCCCAAGTGTT
GCTTTGCCATGTGCTGGAGCAATCTCGTACATGGCTGTTTACTTGGCCGGAGCGGGAACTGACCAGGGCTCAGCAGGCGG
AGTTTGAAGCCCTGCTGGCTCGCCGTGAGCAGGGTGAGCCCGTGGCCCACCTGATTGGAGAGCGGGAGTTTTTTGGCCGC
CGGTTTAGTGTAACCGCCGATACTCTGATTCCACGCCCCGATACTGAAACCTTGGTGGAACAGGTGCTTGCGCTGGCATT
GCCTGCTAACGCACGGGTCGTGGACTTGGGAACCGGTACCGGTGCTATCGGTATTACCCTCGCTTTGGAGCAGCCGGCTT
GGCAGGTGACGCTGGTGGACAATAGCGCGGCGGCGCTGCAAGTGGCAGCGGCAAATGCCCGCCAGTTGGGGGCTACAGTG
CGTTGCCTGCAAGGCAGCTGGCTGACCCCCTGTGATGGTTTTTTTGACCTTGTCGTTAGCAACCCTCCTTACATTGAAGA
TGGCGACGTCCATTTGGCACAAGGCGATGTGCGTTTCGAGCCTCGCTCGGCCCTAGTGGCCGGCGATCAGGGGTTGGCGG
ATCTGATCACCATTGCGCAGCAAGCAGCAGGTAAGCTGGTTGCTGGCGGTTGGTTGTTGCTGGAGCATGGCTTTGAGCAG
GGTGACGCGGTACGGGCGTTGTTGGCCGACATTGGCTTTGAAGACGTGCGTACAGAGCAGGATCTGGGCGGAAATGATCG
GGTAACCTTAGGCAAGCAATGTGCTGCTGGATCCAAGAGTTGA

Upstream 100 bases:

>100_bases
GGTTAAATGAAATCGTTGAAGGAGATTTGGATGAGATTTTGGGTGCGTTGCTGGCAGAGTATCAGGCGGATCAGCTAGCG
GCCTTAGGCGAGCATTAACC

Downstream 100 bases:

>100_bases
ACATTTGCACAGCAAAGCCAGGAACGGATCTGTTGGGTGCACGAAGTGCAGCAAGCTGTACCATAGAATCCCACGCCTTT
GAGTGCCAGGGAGACGATTA

Product: methyltransferase

Products: NA

Alternate protein names: M.VchAHemK2P [H]

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MRIDDALRQARHRLASSPCAALDAQVLLCHVLEQSRTWLFTWPERELTRAQQAEFEALLARREQGEPVAHLIGEREFFGR
RFSVTADTLIPRPDTETLVEQVLALALPANARVVDLGTGTGAIGITLALEQPAWQVTLVDNSAAALQVAAANARQLGATV
RCLQGSWLTPCDGFFDLVVSNPPYIEDGDVHLAQGDVRFEPRSALVAGDQGLADLITIAQQAAGKLVAGGWLLLEHGFEQ
GDAVRALLADIGFEDVRTEQDLGGNDRVTLGKQCAAGSKS

Sequences:

>Translated_280_residues
MRIDDALRQARHRLASSPCAALDAQVLLCHVLEQSRTWLFTWPERELTRAQQAEFEALLARREQGEPVAHLIGEREFFGR
RFSVTADTLIPRPDTETLVEQVLALALPANARVVDLGTGTGAIGITLALEQPAWQVTLVDNSAAALQVAAANARQLGATV
RCLQGSWLTPCDGFFDLVVSNPPYIEDGDVHLAQGDVRFEPRSALVAGDQGLADLITIAQQAAGKLVAGGWLLLEHGFEQ
GDAVRALLADIGFEDVRTEQDLGGNDRVTLGKQCAAGSKS
>Mature_280_residues
MRIDDALRQARHRLASSPCAALDAQVLLCHVLEQSRTWLFTWPERELTRAQQAEFEALLARREQGEPVAHLIGEREFFGR
RFSVTADTLIPRPDTETLVEQVLALALPANARVVDLGTGTGAIGITLALEQPAWQVTLVDNSAAALQVAAANARQLGATV
RCLQGSWLTPCDGFFDLVVSNPPYIEDGDVHLAQGDVRFEPRSALVAGDQGLADLITIAQQAAGKLVAGGWLLLEHGFEQ
GDAVRALLADIGFEDVRTEQDLGGNDRVTLGKQCAAGSKS

Specific function: Probable protein methyltransferase. May methylate a Gln residue in target proteins [H]

COG id: COG2890

COG function: function code J; Methylase of polypeptide chain release factors

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hemK family [H]

Homologues:

Organism=Homo sapiens, GI7705409, Length=276, Percent_Identity=28.6231884057971, Blast_Score=83, Evalue=2e-16,
Organism=Escherichia coli, GI1787463, Length=274, Percent_Identity=47.4452554744526, Blast_Score=237, Evalue=6e-64,
Organism=Escherichia coli, GI87082085, Length=190, Percent_Identity=31.0526315789474, Blast_Score=74, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24582226, Length=241, Percent_Identity=29.045643153527, Blast_Score=91, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002052
- InterPro:   IPR004556
- InterPro:   IPR019874
- InterPro:   IPR007848 [H]

Pfam domain/function: PF05175 MTS [H]

EC number: 2.1.1.-

Molecular weight: Translated: 30153; Mature: 30153

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS00092 N6_MTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIDDALRQARHRLASSPCAALDAQVLLCHVLEQSRTWLFTWPERELTRAQQAEFEALLA
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHH
RREQGEPVAHLIGEREFFGRRFSVTADTLIPRPDTETLVEQVLALALPANARVVDLGTGT
HHCCCCHHHHHHCCHHHHCCEEEEEHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCC
GAIGITLALEQPAWQVTLVDNSAAALQVAAANARQLGATVRCLQGSWLTPCDGFFDLVVS
CEEEEEEEECCCCEEEEEECCCCCEEEEEHHCHHHHHHHHEEECCCCCCCCCCHHHHEEC
NPPYIEDGDVHLAQGDVRFEPRSALVAGDQGLADLITIAQQAAGKLVAGGWLLLEHGFEQ
CCCCCCCCCEEEECCCEEECCCCEEEECCCCHHHHHHHHHHHCCCEEECCEEEEECCCCC
GDAVRALLADIGFEDVRTEQDLGGNDRVTLGKQCAAGSKS
CHHHHHHHHHCCHHHHCCHHCCCCCCCEEECCCCCCCCCC
>Mature Secondary Structure
MRIDDALRQARHRLASSPCAALDAQVLLCHVLEQSRTWLFTWPERELTRAQQAEFEALLA
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHH
RREQGEPVAHLIGEREFFGRRFSVTADTLIPRPDTETLVEQVLALALPANARVVDLGTGT
HHCCCCHHHHHHCCHHHHCCEEEEEHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCC
GAIGITLALEQPAWQVTLVDNSAAALQVAAANARQLGATVRCLQGSWLTPCDGFFDLVVS
CEEEEEEEECCCCEEEEEECCCCCEEEEEHHCHHHHHHHHEEECCCCCCCCCCHHHHEEC
NPPYIEDGDVHLAQGDVRFEPRSALVAGDQGLADLITIAQQAAGKLVAGGWLLLEHGFEQ
CCCCCCCCCEEEECCCEEECCCCEEEECCCCHHHHHHHHHHHCCCEEECCEEEEECCCCC
GDAVRALLADIGFEDVRTEQDLGGNDRVTLGKQCAAGSKS
CHHHHHHHHHCCHHHHCCHHCCCCCCCEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]