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The map label for this gene is add

Identifier: 110635984

GI number: 110635984

Start: 3950612

End: 3951589

Strand: Reverse

Name: add

Synonym: Meso_3659

Alternate gene names: 110635984

Gene position: 3951589-3950612 (Counterclockwise)

Preceding gene: 110635985

Following gene: 110635983

Centisome position: 89.56

GC content: 62.68

Gene sequence:

>978_bases
ATGCTGCTCAAAGCCGAATTGCATTGCCATATAGAAGGCGCGGCTTCGCCCGCATTGGTGAAAGCCCAGGCACGCAAATA
CGGCGCCGACATCTCCTCCTTCATCCGGGGCGGTGCATATTATTGGCAAGACTTCACCACCTTTCTTCTCGCCTATGATC
AGGCAGCGAGCCTCTTCCGTACGCAGGAGGACTATGCGCTTCTGGCCGAGACTTATCTGAAGGAGCTTGCCGCCGGGGGC
GCGATCTATTCGGAGTTTTTCACATCGCCGGACCACGCGGAGCGAGCGGGGCTCTCTCCTCAGGCCTATACGGATGGGCT
GGCCGAGGGCATGGTCCAGGCAAAGGCTGCAACCGGCATCGAATCCCGCATGATCGTCACCGGCGTGCGCCATTTCGGGC
CGGAAGCCGTGGAGAAAGCTGCGCGCTTCGCCGCCTCGTGCGAGCACCCTCTGGTGACGGGCTTCGGCATGGCGGGCGAC
GAACGCGCCGGCCATCCCCGTGACTTCGCCTACGCCTTCGATATCGCCCGCGAAGCGGGGCTCGGCATCAGCATCCATGC
CGGTGAGTTCGGCGGGGCGGAAAGCGTGGAAGCCGCGCTGGACCATATCCGCCCCTCGCGCATCGGCCATGGCGTGCGGG
CAATCGAAAATCCCGATCTCGTGCGCCGGATTGCCGATGAAGGCGTGGTGCTGGAAGTCTGCCCTGTCTCCAATGTGGTG
CTTAAGGTCTTTCCCGAGTTCGCGCGTCATCCCTTTCCTCAGCTTGTGGCCGCGGGCTGCCGGGTGACGCTTAACTCCGA
CGATCCGCCGCATTTCCATACCAGCCTCGCGCGGGAATATGCGGTGGCGGCCGAATATTTCGGGCTCGATGAAACCACTC
TCAACGCGATCACGAGCACGGCTATCGAGGCCGCATTCGTGGATGAGAAGACCCGCGCGGCGCTATTTGCCCGCTTGAAG
CCGGTGGTGGAGTCGTGA

Upstream 100 bases:

>100_bases
CGCTGGAACAGGCGGGAGAGCGCTTTCTAGAGGCGCTGCGCAAGGCGGCTGCCTGGAGCGACGTTTGTGATATGGTCTGA
TCCCAGAACGGGACAGGACC

Downstream 100 bases:

>100_bases
CCTGAGCACAAATCTGTGGCAGGGGCGCGCCGCCGTCTGGCGGCGGGCGGCATAAGCGCTATTGTTGCCGGTCGAAAAGA
GTTTTGCGGAGAGTAGCAAT

Product: adenosine deaminase

Products: NA

Alternate protein names: Adenosine aminohydrolase

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MLLKAELHCHIEGAASPALVKAQARKYGADISSFIRGGAYYWQDFTTFLLAYDQAASLFRTQEDYALLAETYLKELAAGG
AIYSEFFTSPDHAERAGLSPQAYTDGLAEGMVQAKAATGIESRMIVTGVRHFGPEAVEKAARFAASCEHPLVTGFGMAGD
ERAGHPRDFAYAFDIAREAGLGISIHAGEFGGAESVEAALDHIRPSRIGHGVRAIENPDLVRRIADEGVVLEVCPVSNVV
LKVFPEFARHPFPQLVAAGCRVTLNSDDPPHFHTSLAREYAVAAEYFGLDETTLNAITSTAIEAAFVDEKTRAALFARLK
PVVES

Sequences:

>Translated_325_residues
MLLKAELHCHIEGAASPALVKAQARKYGADISSFIRGGAYYWQDFTTFLLAYDQAASLFRTQEDYALLAETYLKELAAGG
AIYSEFFTSPDHAERAGLSPQAYTDGLAEGMVQAKAATGIESRMIVTGVRHFGPEAVEKAARFAASCEHPLVTGFGMAGD
ERAGHPRDFAYAFDIAREAGLGISIHAGEFGGAESVEAALDHIRPSRIGHGVRAIENPDLVRRIADEGVVLEVCPVSNVV
LKVFPEFARHPFPQLVAAGCRVTLNSDDPPHFHTSLAREYAVAAEYFGLDETTLNAITSTAIEAAFVDEKTRAALFARLK
PVVES
>Mature_325_residues
MLLKAELHCHIEGAASPALVKAQARKYGADISSFIRGGAYYWQDFTTFLLAYDQAASLFRTQEDYALLAETYLKELAAGG
AIYSEFFTSPDHAERAGLSPQAYTDGLAEGMVQAKAATGIESRMIVTGVRHFGPEAVEKAARFAASCEHPLVTGFGMAGD
ERAGHPRDFAYAFDIAREAGLGISIHAGEFGGAESVEAALDHIRPSRIGHGVRAIENPDLVRRIADEGVVLEVCPVSNVV
LKVFPEFARHPFPQLVAAGCRVTLNSDDPPHFHTSLAREYAVAAEYFGLDETTLNAITSTAIEAAFVDEKTRAALFARLK
PVVES

Specific function: Unknown

COG id: COG1816

COG function: function code F; Adenosine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosine and AMP deaminases family

Homologues:

Organism=Homo sapiens, GI47078295, Length=353, Percent_Identity=23.7960339943343, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI226693318, Length=339, Percent_Identity=25.3687315634218, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI61175224, Length=221, Percent_Identity=27.6018099547511, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI1787910, Length=323, Percent_Identity=27.8637770897833, Blast_Score=115, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI32565969, Length=344, Percent_Identity=23.546511627907, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17538512, Length=344, Percent_Identity=23.546511627907, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6324188, Length=336, Percent_Identity=27.3809523809524, Blast_Score=132, Evalue=9e-32,
Organism=Drosophila melanogaster, GI24645260, Length=328, Percent_Identity=25, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24666073, Length=207, Percent_Identity=30.4347826086957, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI45553183, Length=282, Percent_Identity=27.3049645390071, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI17737615, Length=282, Percent_Identity=27.3049645390071, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI19922262, Length=160, Percent_Identity=31.875, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ADD_MESSB (Q11C48)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_676192.1
- ProteinModelPortal:   Q11C48
- SMR:   Q11C48
- STRING:   Q11C48
- GeneID:   4179536
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_3659
- NMPDR:   fig|266779.1.peg.878
- eggNOG:   COG1816
- HOGENOM:   HBG630382
- OMA:   CHIEGAA
- PhylomeDB:   Q11C48
- ProtClustDB:   PRK09358
- BioCyc:   MSP266779:MESO_3659-MONOMER
- HAMAP:   MF_00540
- InterPro:   IPR001365
- InterPro:   IPR006330
- PANTHER:   PTHR11409
- TIGRFAMs:   TIGR01430

Pfam domain/function: PF00962 A_deaminase

EC number: =3.5.4.4

Molecular weight: Translated: 35034; Mature: 35034

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS00485 A_DEAMINASE

Important sites: ACT_SITE 189-189 BINDING 10-10 BINDING 12-12 BINDING 159-159 BINDING 268-268

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLKAELHCHIEGAASPALVKAQARKYGADISSFIRGGAYYWQDFTTFLLAYDQAASLFR
CEEEEEEEEEECCCCCCHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
TQEDYALLAETYLKELAAGGAIYSEFFTSPDHAERAGLSPQAYTDGLAEGMVQAKAATGI
HHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHCCC
ESRMIVTGVRHFGPEAVEKAARFAASCEHPLVTGFGMAGDERAGHPRDFAYAFDIAREAG
CHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHCC
LGISIHAGEFGGAESVEAALDHIRPSRIGHGVRAIENPDLVRRIADEGVVLEVCPVSNVV
CCEEEECCCCCCHHHHHHHHHHCCHHHHCCCHHHCCCHHHHHHHHCCCCEEEECCCHHHH
LKVFPEFARHPFPQLVAAGCRVTLNSDDPPHFHTSLAREYAVAAEYFGLDETTLNAITST
HHHHHHHHHCCCHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
AIEAAFVDEKTRAALFARLKPVVES
HHHHHHHCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLLKAELHCHIEGAASPALVKAQARKYGADISSFIRGGAYYWQDFTTFLLAYDQAASLFR
CEEEEEEEEEECCCCCCHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
TQEDYALLAETYLKELAAGGAIYSEFFTSPDHAERAGLSPQAYTDGLAEGMVQAKAATGI
HHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHCCC
ESRMIVTGVRHFGPEAVEKAARFAASCEHPLVTGFGMAGDERAGHPRDFAYAFDIAREAG
CHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHCC
LGISIHAGEFGGAESVEAALDHIRPSRIGHGVRAIENPDLVRRIADEGVVLEVCPVSNVV
CCEEEECCCCCCHHHHHHHHHHCCHHHHCCCHHHCCCHHHHHHHHCCCCEEEECCCHHHH
LKVFPEFARHPFPQLVAAGCRVTLNSDDPPHFHTSLAREYAVAAEYFGLDETTLNAITST
HHHHHHHHHCCCHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
AIEAAFVDEKTRAALFARLKPVVES
HHHHHHHCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA