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The map label for this gene is upp [H]

Identifier: 110635983

GI number: 110635983

Start: 3949884

End: 3950330

Strand: Reverse

Name: upp [H]

Synonym: Meso_3658

Alternate gene names: 110635983

Gene position: 3950330-3949884 (Counterclockwise)

Preceding gene: 110635984

Following gene: 110635976

Centisome position: 89.53

GC content: 65.1

Gene sequence:

>447_bases
ATGGAAGCGCCGACGCTGGAGGGCAAGAAGCTGGTCTTCGCCTCGGTGCTGCGCGCCGGCAACGGCCTCCTCGACGGCAT
GCTGGACCTGGTGCCGGCCGCCCGCGTGGCCCATATTGGCCTCTACCGTGACCAGGAGACCCTGGAGGCGGTGGAATATT
TCTTCAAGTCGCCGAGCGATCTGGAAAACCGGCTGGTGATCGTGGTCGACCCCATGCTGGCCACCGCCAATTCGGCTGTT
GCGGCGGTCGACAAGCTCAAATCGCGCGGCGCCACCAACATCCGCTTCCTCTGCCTGCTTGCCGCCCCCGAGGGGATCCA
GCATTTCCGGGAAATGCACCCGGACGTGCCGGTCTTCACCGCCTCGATCGATGAGCGGCTCAACGAGCATGGCTATATCC
TGCCGGGGCTGGGGGATGCCGGCGACCGGATGTACGGCACGAAATGA

Upstream 100 bases:

>100_bases
CTTCCGCAGGCTGCTGCGCGAGATCTCGCTGCTGCTTTGCTATGAGGTCACGCGCGACCTGGAGCTGACCACGCGCATCA
TCGAAACCCCGCTCACCACC

Downstream 100 bases:

>100_bases
GTGCAGCCGCGGGGAGTTGCGCAGCTCTGCGGGCGCGTGGGCGCGAAGGATGAAGCGAAGACGCTAACAACCCACACGTC
GGAAGAGAGGGGGTGCTTAG

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 148; Mature: 148

Protein sequence:

>148_residues
MEAPTLEGKKLVFASVLRAGNGLLDGMLDLVPAARVAHIGLYRDQETLEAVEYFFKSPSDLENRLVIVVDPMLATANSAV
AAVDKLKSRGATNIRFLCLLAAPEGIQHFREMHPDVPVFTASIDERLNEHGYILPGLGDAGDRMYGTK

Sequences:

>Translated_148_residues
MEAPTLEGKKLVFASVLRAGNGLLDGMLDLVPAARVAHIGLYRDQETLEAVEYFFKSPSDLENRLVIVVDPMLATANSAV
AAVDKLKSRGATNIRFLCLLAAPEGIQHFREMHPDVPVFTASIDERLNEHGYILPGLGDAGDRMYGTK
>Mature_148_residues
MEAPTLEGKKLVFASVLRAGNGLLDGMLDLVPAARVAHIGLYRDQETLEAVEYFFKSPSDLENRLVIVVDPMLATANSAV
AAVDKLKSRGATNIRFLCLLAAPEGIQHFREMHPDVPVFTASIDERLNEHGYILPGLGDAGDRMYGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=142, Percent_Identity=30.2816901408451, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI57863312, Length=142, Percent_Identity=30.2816901408451, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI87082118, Length=148, Percent_Identity=52.7027027027027, Blast_Score=175, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6321920, Length=138, Percent_Identity=38.4057971014493, Blast_Score=103, Evalue=8e-24,
Organism=Drosophila melanogaster, GI28573516, Length=149, Percent_Identity=29.5302013422819, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28573514, Length=149, Percent_Identity=29.5302013422819, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28573512, Length=149, Percent_Identity=29.5302013422819, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI45550449, Length=149, Percent_Identity=29.5302013422819, Blast_Score=79, Evalue=1e-15,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 16123; Mature: 16123

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEAPTLEGKKLVFASVLRAGNGLLDGMLDLVPAARVAHIGLYRDQETLEAVEYFFKSPSD
CCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCC
LENRLVIVVDPMLATANSAVAAVDKLKSRGATNIRFLCLLAAPEGIQHFREMHPDVPVFT
CCCCEEEEECCHHHHCCHHHHHHHHHHHCCCCCEEEEEEEECCHHHHHHHHHCCCCCEEE
ASIDERLNEHGYILPGLGDAGDRMYGTK
CCHHHHHCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MEAPTLEGKKLVFASVLRAGNGLLDGMLDLVPAARVAHIGLYRDQETLEAVEYFFKSPSD
CCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCC
LENRLVIVVDPMLATANSAVAAVDKLKSRGATNIRFLCLLAAPEGIQHFREMHPDVPVFT
CCCCEEEEECCHHHHCCHHHHHHHHHHHCCCCCEEEEEEEECCHHHHHHHHHCCCCCEEE
ASIDERLNEHGYILPGLGDAGDRMYGTK
CCHHHHHCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]