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The map label for this gene is caiC [H]

Identifier: 110635965

GI number: 110635965

Start: 3930803

End: 3932341

Strand: Reverse

Name: caiC [H]

Synonym: Meso_3639

Alternate gene names: 110635965

Gene position: 3932341-3930803 (Counterclockwise)

Preceding gene: 110635966

Following gene: 110635964

Centisome position: 89.12

GC content: 63.29

Gene sequence:

>1539_bases
ATGACCTCTCCGTTTCTCCGAATCTTCGACCTTGCGCAGATGGACCCAGAGCGCCTCTATGCACGCTTCGGAGAACGCGA
CATCACCATAGGGGACGTTGCGAGAAATTCCGAAGCCGTCGCACGGATCCTGCTTGCTTCTGGACTCACGCCCGGTGCCC
GCGTCGCGGTGATGATGGAGAACCGCCCCCTTACAATCTCACTGATCTTCGGCATCGCGCGGGCCGGCATGGTCTGGGTG
CCGATCAACACGCGCCAGCAAGGCGATTCCCTTGCTTATCAACTGGGCCATTGCAGACCCGCATTGCTAATCGTTGACGA
GGCGCTACTGGCGAAAGTGCGCGATTGCGGGGCGGACGACGGCCACCTGGCGATCCATTCCCTGGCCGACGATGCAGACA
CGCTCGACCTCCCGAATAATGGCCGCGCCGATGCCTTGCCTGCCCCTGTGGAAGCCGGCGAGACCTTCGCGATTATGTAT
ACGTCCGGCACCACCGGAGCGCCGAAAGGCGTACAGGTTACGCACCGCATGTTCGACTACGCCGCCAGGGCAGTCTCGAT
CGCCGGCGGGATCGAGGACGGCGACGTCATGTTCGTGTGGGAGCCGCTCTACCACATCGGCGGCAGTCAGCTTCTCCTTC
TACCGCTGATGCACCGCGTGCACCTTCATCTCGTGCGGCGATTCAGCGCTTCCGGCTTCTGGGGCGACGTGCATGCCAGC
GGCGCCACCCACATTCATTTCCTCGGTGGGATTCTGCAGATCCTGCTGCGCAATCCTCCCTCACCGAACGACAGGGGACA
CCGCGTGCGTGTCGCCTGGGGCGGCGGCTGCGCGAGGGACGATTGGCAGGCGTTCGAACACCGCTTCGGTGTCGACATCC
GCGAAGCCTATGGGATGACCGAGGCTTCGAGCATAACGACAATCAATGTCGGCGGCCCGGTCGGATCGGTCGGCAAGCCG
GTGCCTTGGTTCAAGGTCGAACTGCTCGACGAGGCAGGACAGCCGGTGCCGCCTGGCGAGCGCGGCGAGATTGTCGTGAG
CGAACTCGAAGAAGGCGCGCTCTTCAAAGGCTATCTCGACGCGCCCGAGGCAAACGCGCGCGTGCTGCGCGGCGGCCGGC
TCTTCACGGGCGATGTCGGCATTTTCTCCGAGGATGGCTGGCTGACATTCCAGGGGCGGCTGAACGACTCGATCCGCCGC
CGCGGAGAGAACATCTCCGCATGGGAGATCGAAAGCGCCGCCCTCAAACATCCAGCCATAGCAGAGGTGGCGATGATCGG
CGTGAAAGCCGACATCGGCGAGCAGGAGATAAAGCTGTTCGTCCGACCGGCCGACGGACACTCCATCGATGCTCCGCAGC
TGCACGGCTGGCTGACGGAACAGCTCGGCCGCTATCGCGCTCCACGCTACATCGCCTTCGTGGATAGTTTTCCGAAAACA
CCCAGCGAGCGCATCCGAAAGGGATTGCTCCCCCAAACCACGGACGATTGCTGGGATGCCGAATCGCACGCCCGCACCCT
CCTGACGAGGACCGCATGA

Upstream 100 bases:

>100_bases
TGCAGCGCCAGAGCTACGGCAGCGGCGAGCCTGCCGTGATGATGGAGAACTTTCTCAAGCGAAACAACAAGGCATCGGCG
TGAGCGCGGAGCAGCCCTGC

Downstream 100 bases:

>100_bases
TGAACCGATCGCAGGCACAGAAACAGCTACAGGGCAAGAGCGTCGAGGCGGGAGGCACACTGCATCGCCTGTGTGTTCGA
CAGTCGGTGCCGGTCACGAT

Product: AMP-dependent synthetase and ligase

Products: AMP; diphosphate; acyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 512; Mature: 511

Protein sequence:

>512_residues
MTSPFLRIFDLAQMDPERLYARFGERDITIGDVARNSEAVARILLASGLTPGARVAVMMENRPLTISLIFGIARAGMVWV
PINTRQQGDSLAYQLGHCRPALLIVDEALLAKVRDCGADDGHLAIHSLADDADTLDLPNNGRADALPAPVEAGETFAIMY
TSGTTGAPKGVQVTHRMFDYAARAVSIAGGIEDGDVMFVWEPLYHIGGSQLLLLPLMHRVHLHLVRRFSASGFWGDVHAS
GATHIHFLGGILQILLRNPPSPNDRGHRVRVAWGGGCARDDWQAFEHRFGVDIREAYGMTEASSITTINVGGPVGSVGKP
VPWFKVELLDEAGQPVPPGERGEIVVSELEEGALFKGYLDAPEANARVLRGGRLFTGDVGIFSEDGWLTFQGRLNDSIRR
RGENISAWEIESAALKHPAIAEVAMIGVKADIGEQEIKLFVRPADGHSIDAPQLHGWLTEQLGRYRAPRYIAFVDSFPKT
PSERIRKGLLPQTTDDCWDAESHARTLLTRTA

Sequences:

>Translated_512_residues
MTSPFLRIFDLAQMDPERLYARFGERDITIGDVARNSEAVARILLASGLTPGARVAVMMENRPLTISLIFGIARAGMVWV
PINTRQQGDSLAYQLGHCRPALLIVDEALLAKVRDCGADDGHLAIHSLADDADTLDLPNNGRADALPAPVEAGETFAIMY
TSGTTGAPKGVQVTHRMFDYAARAVSIAGGIEDGDVMFVWEPLYHIGGSQLLLLPLMHRVHLHLVRRFSASGFWGDVHAS
GATHIHFLGGILQILLRNPPSPNDRGHRVRVAWGGGCARDDWQAFEHRFGVDIREAYGMTEASSITTINVGGPVGSVGKP
VPWFKVELLDEAGQPVPPGERGEIVVSELEEGALFKGYLDAPEANARVLRGGRLFTGDVGIFSEDGWLTFQGRLNDSIRR
RGENISAWEIESAALKHPAIAEVAMIGVKADIGEQEIKLFVRPADGHSIDAPQLHGWLTEQLGRYRAPRYIAFVDSFPKT
PSERIRKGLLPQTTDDCWDAESHARTLLTRTA
>Mature_511_residues
TSPFLRIFDLAQMDPERLYARFGERDITIGDVARNSEAVARILLASGLTPGARVAVMMENRPLTISLIFGIARAGMVWVP
INTRQQGDSLAYQLGHCRPALLIVDEALLAKVRDCGADDGHLAIHSLADDADTLDLPNNGRADALPAPVEAGETFAIMYT
SGTTGAPKGVQVTHRMFDYAARAVSIAGGIEDGDVMFVWEPLYHIGGSQLLLLPLMHRVHLHLVRRFSASGFWGDVHASG
ATHIHFLGGILQILLRNPPSPNDRGHRVRVAWGGGCARDDWQAFEHRFGVDIREAYGMTEASSITTINVGGPVGSVGKPV
PWFKVELLDEAGQPVPPGERGEIVVSELEEGALFKGYLDAPEANARVLRGGRLFTGDVGIFSEDGWLTFQGRLNDSIRRR
GENISAWEIESAALKHPAIAEVAMIGVKADIGEQEIKLFVRPADGHSIDAPQLHGWLTEQLGRYRAPRYIAFVDSFPKTP
SERIRKGLLPQTTDDCWDAESHARTLLTRTA

Specific function: Could catalyze the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle [H]

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI227499619, Length=532, Percent_Identity=28.3834586466165, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI38524616, Length=551, Percent_Identity=29.7640653357532, Blast_Score=165, Evalue=8e-41,
Organism=Homo sapiens, GI13236579, Length=498, Percent_Identity=29.718875502008, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI40807357, Length=497, Percent_Identity=27.5653923541247, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI157311624, Length=499, Percent_Identity=27.6553106212425, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI157311622, Length=499, Percent_Identity=27.6553106212425, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI58082049, Length=497, Percent_Identity=26.5593561368209, Blast_Score=152, Evalue=1e-36,
Organism=Homo sapiens, GI13325057, Length=372, Percent_Identity=31.7204301075269, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI227499621, Length=528, Percent_Identity=26.1363636363636, Blast_Score=143, Evalue=4e-34,
Organism=Homo sapiens, GI62865631, Length=521, Percent_Identity=25.9117082533589, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI13325055, Length=521, Percent_Identity=25.9117082533589, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI38505220, Length=485, Percent_Identity=26.5979381443299, Blast_Score=139, Evalue=9e-33,
Organism=Homo sapiens, GI42544132, Length=478, Percent_Identity=26.3598326359833, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI115511026, Length=502, Percent_Identity=25.2988047808765, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI122937307, Length=210, Percent_Identity=32.3809523809524, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI156151445, Length=530, Percent_Identity=25.4716981132075, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI187761345, Length=382, Percent_Identity=27.4869109947644, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI187761343, Length=382, Percent_Identity=27.4869109947644, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI13375727, Length=516, Percent_Identity=23.6434108527132, Blast_Score=76, Evalue=9e-14,
Organism=Escherichia coli, GI221142682, Length=470, Percent_Identity=30, Blast_Score=211, Evalue=7e-56,
Organism=Escherichia coli, GI1788107, Length=523, Percent_Identity=26.9598470363289, Blast_Score=143, Evalue=3e-35,
Organism=Escherichia coli, GI145693145, Length=505, Percent_Identity=24.3564356435644, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1786810, Length=514, Percent_Identity=23.1517509727626, Blast_Score=96, Evalue=8e-21,
Organism=Escherichia coli, GI1786801, Length=468, Percent_Identity=25, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1790505, Length=365, Percent_Identity=24.3835616438356, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI1786529, Length=524, Percent_Identity=25.5725190839695, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI1789201, Length=281, Percent_Identity=27.0462633451957, Blast_Score=69, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17551278, Length=518, Percent_Identity=27.4131274131274, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI115534440, Length=518, Percent_Identity=26.6409266409266, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI32563687, Length=507, Percent_Identity=24.4575936883629, Blast_Score=121, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71994694, Length=524, Percent_Identity=23.6641221374046, Blast_Score=118, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI71994690, Length=524, Percent_Identity=23.6641221374046, Blast_Score=118, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI71994703, Length=524, Percent_Identity=23.6641221374046, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17558820, Length=483, Percent_Identity=25.6728778467909, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17538037, Length=507, Percent_Identity=24.65483234714, Blast_Score=108, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17557194, Length=496, Percent_Identity=23.7903225806452, Blast_Score=108, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17559526, Length=373, Percent_Identity=26.5415549597855, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17531443, Length=459, Percent_Identity=23.5294117647059, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17560308, Length=523, Percent_Identity=22.1797323135755, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17560140, Length=507, Percent_Identity=20.7100591715976, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71985884, Length=355, Percent_Identity=22.5352112676056, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319515, Length=481, Percent_Identity=25.987525987526, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6319699, Length=362, Percent_Identity=29.0055248618785, Blast_Score=133, Evalue=8e-32,
Organism=Saccharomyces cerevisiae, GI6319264, Length=529, Percent_Identity=24.1965973534972, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI45552801, Length=537, Percent_Identity=25.3258845437616, Blast_Score=162, Evalue=6e-40,
Organism=Drosophila melanogaster, GI45550496, Length=534, Percent_Identity=25.0936329588015, Blast_Score=162, Evalue=7e-40,
Organism=Drosophila melanogaster, GI20130353, Length=536, Percent_Identity=25.9328358208955, Blast_Score=148, Evalue=8e-36,
Organism=Drosophila melanogaster, GI28573631, Length=536, Percent_Identity=25.9328358208955, Blast_Score=148, Evalue=9e-36,
Organism=Drosophila melanogaster, GI281364798, Length=517, Percent_Identity=24.1779497098646, Blast_Score=148, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24583465, Length=517, Percent_Identity=24.1779497098646, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24583463, Length=517, Percent_Identity=24.1779497098646, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI19922652, Length=505, Percent_Identity=24.7524752475248, Blast_Score=112, Evalue=8e-25,
Organism=Drosophila melanogaster, GI24581924, Length=500, Percent_Identity=25.4, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI18859661, Length=506, Percent_Identity=22.7272727272727, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24656500, Length=356, Percent_Identity=27.8089887640449, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24648257, Length=443, Percent_Identity=26.1851015801354, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24648260, Length=416, Percent_Identity=25, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI21356441, Length=481, Percent_Identity=23.2848232848233, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI62472339, Length=527, Percent_Identity=23.1499051233397, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24667955, Length=527, Percent_Identity=23.1499051233397, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI20130357, Length=487, Percent_Identity=20.7392197125257, Blast_Score=80, Evalue=5e-15,
Organism=Drosophila melanogaster, GI161076582, Length=486, Percent_Identity=23.4567901234568, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24653035, Length=441, Percent_Identity=23.5827664399093, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24667959, Length=421, Percent_Identity=23.5154394299287, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: 6.2.1.3

Molecular weight: Translated: 55890; Mature: 55759

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSPFLRIFDLAQMDPERLYARFGERDITIGDVARNSEAVARILLASGLTPGARVAVMME
CCCCHHHHHHHHCCCHHHHHHHHCCCCEEEHHCCCCHHHHHHHHHHCCCCCCCEEEEEEC
NRPLTISLIFGIARAGMVWVPINTRQQGDSLAYQLGHCRPALLIVDEALLAKVRDCGADD
CCCEEEEEEEHHHHCCEEEEEECCCCCCCHHHHHHCCCCEEEEEHHHHHHHHHHHCCCCC
GHLAIHSLADDADTLDLPNNGRADALPAPVEAGETFAIMYTSGTTGAPKGVQVTHRMFDY
CCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHH
AARAVSIAGGIEDGDVMFVWEPLYHIGGSQLLLLPLMHRVHLHLVRRFSASGFWGDVHAS
HHHHHHEECCCCCCCEEEEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEECC
GATHIHFLGGILQILLRNPPSPNDRGHRVRVAWGGGCARDDWQAFEHRFGVDIREAYGMT
CCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCHHHHCCCC
EASSITTINVGGPVGSVGKPVPWFKVELLDEAGQPVPPGERGEIVVSELEEGALFKGYLD
CCCCEEEEEECCCCCCCCCCCCCEEEEEHHHCCCCCCCCCCCCEEEEECCCCCEEEEECC
APEANARVLRGGRLFTGDVGIFSEDGWLTFQGRLNDSIRRRGENISAWEIESAALKHPAI
CCCCCCEEEECCEEEECCCEEEECCCEEEEECCCCHHHHHCCCCCCEEEECHHHHCCCCH
AEVAMIGVKADIGEQEIKLFVRPADGHSIDAPQLHGWLTEQLGRYRAPRYIAFVDSFPKT
HHHEEEEEECCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCC
PSERIRKGLLPQTTDDCWDAESHARTLLTRTA
HHHHHHHCCCCCCCCHHCCCHHHHHHHHHCCC
>Mature Secondary Structure 
TSPFLRIFDLAQMDPERLYARFGERDITIGDVARNSEAVARILLASGLTPGARVAVMME
CCCHHHHHHHHCCCHHHHHHHHCCCCEEEHHCCCCHHHHHHHHHHCCCCCCCEEEEEEC
NRPLTISLIFGIARAGMVWVPINTRQQGDSLAYQLGHCRPALLIVDEALLAKVRDCGADD
CCCEEEEEEEHHHHCCEEEEEECCCCCCCHHHHHHCCCCEEEEEHHHHHHHHHHHCCCCC
GHLAIHSLADDADTLDLPNNGRADALPAPVEAGETFAIMYTSGTTGAPKGVQVTHRMFDY
CCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHH
AARAVSIAGGIEDGDVMFVWEPLYHIGGSQLLLLPLMHRVHLHLVRRFSASGFWGDVHAS
HHHHHHEECCCCCCCEEEEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEECC
GATHIHFLGGILQILLRNPPSPNDRGHRVRVAWGGGCARDDWQAFEHRFGVDIREAYGMT
CCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCHHHHCCCC
EASSITTINVGGPVGSVGKPVPWFKVELLDEAGQPVPPGERGEIVVSELEEGALFKGYLD
CCCCEEEEEECCCCCCCCCCCCCEEEEEHHHCCCCCCCCCCCCEEEEECCCCCEEEEECC
APEANARVLRGGRLFTGDVGIFSEDGWLTFQGRLNDSIRRRGENISAWEIESAALKHPAI
CCCCCCEEEECCEEEECCCEEEECCCEEEEECCCCHHHHHCCCCCCEEEECHHHHCCCCH
AEVAMIGVKADIGEQEIKLFVRPADGHSIDAPQLHGWLTEQLGRYRAPRYIAFVDSFPKT
HHHEEEEEECCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCC
PSERIRKGLLPQTTDDCWDAESHARTLLTRTA
HHHHHHHCCCCCCCCHHCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; long-chain carboxylic acid; CoA

Specific reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA