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The map label for this gene is alkB [H]

Identifier: 110635828

GI number: 110635828

Start: 3771385

End: 3771999

Strand: Reverse

Name: alkB [H]

Synonym: Meso_3500

Alternate gene names: 110635828

Gene position: 3771999-3771385 (Counterclockwise)

Preceding gene: 110635829

Following gene: 110635820

Centisome position: 85.49

GC content: 60.33

Gene sequence:

>615_bases
ATGCTCTCCCTCCCTCCCGGAATAAGGCATATGCCAGGCCTCCTGTCACCCACCGAACAGGCGGCTTTGCTCACCGAAAT
CCGCGCGGTGGTGATTGCGGCACCGCTTTATGTGCCGACCATGCCACGCACGGGAAAGCCCATGAGCGTGCGCATGACGA
ATTGCGGCGTGCTCGGCTGGGTGACCGACAAGGAGAGGGGATACCGTTATCAGGAAACGCATCCCGCCACGGGAAAGCGA
TGGCCGCTGATCCCGCAGCGTCTGCTAGAACTTTGGGATGAAGTGTCCGGTTATCCTCATTCGCCGGAGGCATGCCTCAT
CAATTTCTATTCGCAAGACGCCAAGATGGGGCTACACCAGGATCGCGACGAGAAAAACTTCGCAGCACCCGTAGTCTCCG
TCTCATTGGGCGACGATTGCCTGTTTCGCGTCGGCGGCAATGATCGCGAAAGCGGCACCGCCTCGTTTCGGCTGTCGAGT
GGGGACGTGGTGGTGCTCGGCGGGGAAGGGCGGCTTGCCTTCCATGGGGTGGACCGGATCTATCCCCACACGTCCGATCT
TCTGAAAAATGGCGGGCGCATCAACCTCACGCTGCGCCGGGTGAATCTGCCTTAA

Upstream 100 bases:

>100_bases
GTTCCACCGTAAAGAAGATGCGCGGGAGAGTCTCTTTCGACTGAAGAAGGCTGTGCCGTTGATTGCAGTTCGACTTAGGG
CAAGGTTCACCCGATAGCAC

Downstream 100 bases:

>100_bases
AGTTTCCTGAGCGCCACTTCCTGGACCAGATGATTTGTGCCTTTTCTCAAAATGAGGTCTGCGCGCGGACGGGTCGGCAG
AATGTTCTCACGCAGGTTCT

Product: 2OG-Fe(II) oxygenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 204; Mature: 204

Protein sequence:

>204_residues
MLSLPPGIRHMPGLLSPTEQAALLTEIRAVVIAAPLYVPTMPRTGKPMSVRMTNCGVLGWVTDKERGYRYQETHPATGKR
WPLIPQRLLELWDEVSGYPHSPEACLINFYSQDAKMGLHQDRDEKNFAAPVVSVSLGDDCLFRVGGNDRESGTASFRLSS
GDVVVLGGEGRLAFHGVDRIYPHTSDLLKNGGRINLTLRRVNLP

Sequences:

>Translated_204_residues
MLSLPPGIRHMPGLLSPTEQAALLTEIRAVVIAAPLYVPTMPRTGKPMSVRMTNCGVLGWVTDKERGYRYQETHPATGKR
WPLIPQRLLELWDEVSGYPHSPEACLINFYSQDAKMGLHQDRDEKNFAAPVVSVSLGDDCLFRVGGNDRESGTASFRLSS
GDVVVLGGEGRLAFHGVDRIYPHTSDLLKNGGRINLTLRRVNLP
>Mature_204_residues
MLSLPPGIRHMPGLLSPTEQAALLTEIRAVVIAAPLYVPTMPRTGKPMSVRMTNCGVLGWVTDKERGYRYQETHPATGKR
WPLIPQRLLELWDEVSGYPHSPEACLINFYSQDAKMGLHQDRDEKNFAAPVVSVSLGDDCLFRVGGNDRESGTASFRLSS
GDVVVLGGEGRLAFHGVDRIYPHTSDLLKNGGRINLTLRRVNLP

Specific function: Dioxygenase that repairs alkylated DNA and RNA containing 3-methylcytosine or 1-methyladenine by oxidative demethylation. Has highest activity towards 3-methylcytosine. Has lower activity towards alkylated DNA containing ethenoadenine, and no detectable a

COG id: COG3145

COG function: function code L; Alkylated DNA repair protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Fe2OG dioxygenase domain [H]

Homologues:

Organism=Homo sapiens, GI87298840, Length=131, Percent_Identity=29.7709923664122, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1788541, Length=187, Percent_Identity=42.7807486631016, Blast_Score=129, Evalue=1e-31,
Organism=Drosophila melanogaster, GI45555401, Length=94, Percent_Identity=37.2340425531915, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 22518; Mature: 22518

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSLPPGIRHMPGLLSPTEQAALLTEIRAVVIAAPLYVPTMPRTGKPMSVRMTNCGVLGW
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEECCCCCCCCCEEEEEECCEEEEE
VTDKERGYRYQETHPATGKRWPLIPQRLLELWDEVSGYPHSPEACLINFYSQDAKMGLHQ
ECCCCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCC
DRDEKNFAAPVVSVSLGDDCLFRVGGNDRESGTASFRLSSGDVVVLGGEGRLAFHGVDRI
CCCCCCCCCCEEEEEECCCEEEEECCCCCCCCEEEEEECCCCEEEECCCCEEEEECCHHC
YPHTSDLLKNGGRINLTLRRVNLP
CCCHHHHHHCCCEEEEEEEEECCC
>Mature Secondary Structure
MLSLPPGIRHMPGLLSPTEQAALLTEIRAVVIAAPLYVPTMPRTGKPMSVRMTNCGVLGW
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEECCCCCCCCCEEEEEECCEEEEE
VTDKERGYRYQETHPATGKRWPLIPQRLLELWDEVSGYPHSPEACLINFYSQDAKMGLHQ
ECCCCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCC
DRDEKNFAAPVVSVSLGDDCLFRVGGNDRESGTASFRLSSGDVVVLGGEGRLAFHGVDRI
CCCCCCCCCCEEEEEECCCEEEEECCCCCCCCEEEEEECCCCEEEECCCCEEEEECCHHC
YPHTSDLLKNGGRINLTLRRVNLP
CCCHHHHHHCCCEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9150207 [H]