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The map label for this gene is hslU

Identifier: 110635818

GI number: 110635818

Start: 3764221

End: 3765531

Strand: Reverse

Name: hslU

Synonym: Meso_3490

Alternate gene names: 110635818

Gene position: 3765531-3764221 (Counterclockwise)

Preceding gene: 110635819

Following gene: 110635817

Centisome position: 85.34

GC content: 59.73

Gene sequence:

>1311_bases
ATGAGCAATTTTTCACCCCGTGAGATCGTTTCCGAGCTCGACCGCTACATTATCGGCCAGAAGGAGGCGAAGCGAGCGGT
CGCGATTGCACTGCGGAACCGCTGGAGACGCCAGCAGCTCGAGCCTGGCCTGCGCGAAGAGGTGATGCCGAAGAACATCC
TGATGATCGGGCCGACAGGCGTCGGCAAGACCGAAATCTCGAGGCGCCTGGCCAAACTCGCCGGGGCACCTTTCGTGAAG
GTGGAGGCAACCAAATTCACTGAAGTCGGCTATGTGGGCCGCGATGTTGAGCAGATCGTGCGCGACCTGGTCGAGGTGGC
GATCGCGCTTACGCGCGAGAAGATGCGCGAGGGCGTGGAGGCACGTGCGCATCTGAACGCCGAGGAACGCGTGCTGGAGG
CGCTGGTGGGCCGCACCGCAAGCCCCGCCACACGCGACAGCTTTCGCCAAAAGCTCAGGAGCGGCGAGCTGGACGACAAA
GAGATCGAGATCCAAGTGGCTGATGCGGGCGGCGGTATGGGCAGTTTCGAAATTCCCGGCATGCCCGGAGCCAATATCGG
TGTTCTGAATATCAACGACATGCTGCAGAAGGCCATGGGCGGCGGGCGAACCAAGACCGTCAAGACCACCGTCAAGGATT
CGTATAAATTCCTCATCAATGATGAGTCGGACAAGCTGCTCGACCAGGACGAGGTCGTGCGGCGGGCGCTCTCTTCCGCC
GAGAATGACGGCATCGTTTTCATTGACGAGATCGACAAAATTGCCTCGCGCGAAGGCGGCATGGGCGCCGGTGTGTCCCG
CGAAGGCGTGCAGCGAGACCTCCTGCCGCTTGTCGAAGGCACGACGGTCGCGACCAAATACGGACCGGTCAAGACTGACC
ATGTCCTATTCATCGCCTCCGGCGCATTCCATGTGGCAAAGCCCTCGGACCTGCTTCCCGAACTGCAGGGCCGCCTGCCT
ATAAGAGTCGAGTTGCGGGCCTTGGAGAAGGAGGATTTTCGCAGGATCCTCACCGAAACTGAAGCGAGCCTCATAAAGCA
GTACATCGCCTTGATGGAGACGGAGGGCGTCGAACTCGAATTCACCGAAGATGCCATCGTCAGATTGGCGGAAGTCGCTG
TCGACCTCAATGCAAGCGTCGAGAATATCGGCGCTCGGCGGCTGCAGACCGTGATGGAACGGGTGCTTGACGAGATTTCC
TACAACGCGCCGGATCGTTCAGGCAGCAAGATGGTGATCGATGCTGCCTATGTAGACCAGCATGTGGGCGATCTTGCCAA
GAACACGGACCTCTCGCGCTTTATTCTGTGA

Upstream 100 bases:

>100_bases
CCTATCGGAAAGCAGGTTTTAGGCCTGTTCCTTGGCTCGAAGGGCGCTCCGGCAACGCCCTGATCATGCAATACGATCCC
AATACAGACGAGACAACGAT

Downstream 100 bases:

>100_bases
CCTGTATGACACGGCCAAGGCGGGCGCTTTCGGGCGAATTTTAATTCGCTCGACTCAAGCCCCCGCTTTCCGTAGGTTCC
CGCAAAAACTCATTACAACC

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MSNFSPREIVSELDRYIIGQKEAKRAVAIALRNRWRRQQLEPGLREEVMPKNILMIGPTGVGKTEISRRLAKLAGAPFVK
VEATKFTEVGYVGRDVEQIVRDLVEVAIALTREKMREGVEARAHLNAEERVLEALVGRTASPATRDSFRQKLRSGELDDK
EIEIQVADAGGGMGSFEIPGMPGANIGVLNINDMLQKAMGGGRTKTVKTTVKDSYKFLINDESDKLLDQDEVVRRALSSA
ENDGIVFIDEIDKIASREGGMGAGVSREGVQRDLLPLVEGTTVATKYGPVKTDHVLFIASGAFHVAKPSDLLPELQGRLP
IRVELRALEKEDFRRILTETEASLIKQYIALMETEGVELEFTEDAIVRLAEVAVDLNASVENIGARRLQTVMERVLDEIS
YNAPDRSGSKMVIDAAYVDQHVGDLAKNTDLSRFIL

Sequences:

>Translated_436_residues
MSNFSPREIVSELDRYIIGQKEAKRAVAIALRNRWRRQQLEPGLREEVMPKNILMIGPTGVGKTEISRRLAKLAGAPFVK
VEATKFTEVGYVGRDVEQIVRDLVEVAIALTREKMREGVEARAHLNAEERVLEALVGRTASPATRDSFRQKLRSGELDDK
EIEIQVADAGGGMGSFEIPGMPGANIGVLNINDMLQKAMGGGRTKTVKTTVKDSYKFLINDESDKLLDQDEVVRRALSSA
ENDGIVFIDEIDKIASREGGMGAGVSREGVQRDLLPLVEGTTVATKYGPVKTDHVLFIASGAFHVAKPSDLLPELQGRLP
IRVELRALEKEDFRRILTETEASLIKQYIALMETEGVELEFTEDAIVRLAEVAVDLNASVENIGARRLQTVMERVLDEIS
YNAPDRSGSKMVIDAAYVDQHVGDLAKNTDLSRFIL
>Mature_435_residues
SNFSPREIVSELDRYIIGQKEAKRAVAIALRNRWRRQQLEPGLREEVMPKNILMIGPTGVGKTEISRRLAKLAGAPFVKV
EATKFTEVGYVGRDVEQIVRDLVEVAIALTREKMREGVEARAHLNAEERVLEALVGRTASPATRDSFRQKLRSGELDDKE
IEIQVADAGGGMGSFEIPGMPGANIGVLNINDMLQKAMGGGRTKTVKTTVKDSYKFLINDESDKLLDQDEVVRRALSSAE
NDGIVFIDEIDKIASREGGMGAGVSREGVQRDLLPLVEGTTVATKYGPVKTDHVLFIASGAFHVAKPSDLLPELQGRLPI
RVELRALEKEDFRRILTETEASLIKQYIALMETEGVELEFTEDAIVRLAEVAVDLNASVENIGARRLQTVMERVLDEISY
NAPDRSGSKMVIDAAYVDQHVGDLAKNTDLSRFIL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily

Homologues:

Organism=Escherichia coli, GI1790366, Length=447, Percent_Identity=59.0604026845638, Blast_Score=498, Evalue=1e-142,
Organism=Escherichia coli, GI1786642, Length=108, Percent_Identity=43.5185185185185, Blast_Score=92, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6319704, Length=123, Percent_Identity=34.9593495934959, Blast_Score=73, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HSLU_MESSB (Q11CL4)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_676026.1
- ProteinModelPortal:   Q11CL4
- SMR:   Q11CL4
- STRING:   Q11CL4
- GeneID:   4182150
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_3490
- NMPDR:   fig|266779.1.peg.1044
- eggNOG:   COG1220
- HOGENOM:   HBG745965
- OMA:   EASKFTE
- PhylomeDB:   Q11CL4
- ProtClustDB:   PRK05201
- BioCyc:   MSP266779:MESO_3490-MONOMER
- HAMAP:   MF_00249
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491
- PANTHER:   PTHR11262:SF3
- SMART:   SM00382
- TIGRFAMs:   TIGR00390

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small

EC number: NA

Molecular weight: Translated: 48140; Mature: 48009

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: BINDING 18-18 BINDING 249-249 BINDING 314-314 BINDING 386-386

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNFSPREIVSELDRYIIGQKEAKRAVAIALRNRWRRQQLEPGLREEVMPKNILMIGPTG
CCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCEEEECCCC
VGKTEISRRLAKLAGAPFVKVEATKFTEVGYVGRDVEQIVRDLVEVAIALTREKMREGVE
CCHHHHHHHHHHHHCCCEEEEECCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHH
ARAHLNAEERVLEALVGRTASPATRDSFRQKLRSGELDDKEIEIQVADAGGGMGSFEIPG
HHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCCC
MPGANIGVLNINDMLQKAMGGGRTKTVKTTVKDSYKFLINDESDKLLDQDEVVRRALSSA
CCCCCEEEEEHHHHHHHHHCCCCCEEEEEECCCCEEEEEECCCHHHCCHHHHHHHHHHCC
ENDGIVFIDEIDKIASREGGMGAGVSREGVQRDLLPLVEGTTVATKYGPVKTDHVLFIAS
CCCCEEEEECHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEEC
GAFHVAKPSDLLPELQGRLPIRVELRALEKEDFRRILTETEASLIKQYIALMETEGVELE
CCEECCCCHHHHHHHHCCCCEEEEHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
FTEDAIVRLAEVAVDLNASVENIGARRLQTVMERVLDEISYNAPDRSGSKMVIDAAYVDQ
ECHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHH
HVGDLAKNTDLSRFIL
HHHHHHHCCCHHHHCC
>Mature Secondary Structure 
SNFSPREIVSELDRYIIGQKEAKRAVAIALRNRWRRQQLEPGLREEVMPKNILMIGPTG
CCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCEEEECCCC
VGKTEISRRLAKLAGAPFVKVEATKFTEVGYVGRDVEQIVRDLVEVAIALTREKMREGVE
CCHHHHHHHHHHHHCCCEEEEECCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHH
ARAHLNAEERVLEALVGRTASPATRDSFRQKLRSGELDDKEIEIQVADAGGGMGSFEIPG
HHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCCC
MPGANIGVLNINDMLQKAMGGGRTKTVKTTVKDSYKFLINDESDKLLDQDEVVRRALSSA
CCCCCEEEEEHHHHHHHHHCCCCCEEEEEECCCCEEEEEECCCHHHCCHHHHHHHHHHCC
ENDGIVFIDEIDKIASREGGMGAGVSREGVQRDLLPLVEGTTVATKYGPVKTDHVLFIAS
CCCCEEEEECHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEEC
GAFHVAKPSDLLPELQGRLPIRVELRALEKEDFRRILTETEASLIKQYIALMETEGVELE
CCEECCCCHHHHHHHHCCCCEEEEHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
FTEDAIVRLAEVAVDLNASVENIGARRLQTVMERVLDEISYNAPDRSGSKMVIDAAYVDQ
ECHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHH
HVGDLAKNTDLSRFIL
HHHHHHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA