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The map label for this gene is aacA4 [H]

Identifier: 110635819

GI number: 110635819

Start: 3765528

End: 3766067

Strand: Reverse

Name: aacA4 [H]

Synonym: Meso_3491

Alternate gene names: 110635819

Gene position: 3766067-3765528 (Counterclockwise)

Preceding gene: 110635820

Following gene: 110635818

Centisome position: 85.35

GC content: 58.7

Gene sequence:

>540_bases
ATGCCGGCTGAGCCCACCATCCGCTTCGAGCCGGTCACGGCGGAGCATCTGCCGATGCTTCGCCACTGGTTGAAGCAGCC
GCATATGCGGGAATGGTGGGGCGAACCTGAGGAAGAACTGGGCTTTATCCGCGACATGATCGAAGGGCGAGATTCGACAC
GGCCCTTCATCATTGTCCTCGGCGATGAGCCGGTAGGCTACATTCAATACTGGTTCCTAGGCCACCACCAGAATGCGGAA
TGGATCGACGATCACCCGTGGCTTGCGGAGCTTCCCGCCGGGGCAGTGGGCGTCGATCTATCCATAGGGCATCCGGATAA
GCTGTCGAAGGGCATCGGCTCGAAGGCGCTGGCAGCATTCGTCCGCAAGCTGCGCGATGATGGGTTTGAGACAATCCTGA
TCGATCCGGACCCGGATAATCTTCGCGCGGTTGGTGCCTATCGGAAAGCAGGTTTTAGGCCTGTTCCTTGGCTCGAAGGG
CGCTCCGGCAACGCCCTGATCATGCAATACGATCCCAATACAGACGAGACAACGATATGA

Upstream 100 bases:

>100_bases
GACACGGACAAGAGCGCGGAGGAGATTGCCCGCAAGGCGATGGAGATTGCCGCAAGCATCTGCGTCTACACAAACAGCAA
TATCATCGTGGAAACGCTGG

Downstream 100 bases:

>100_bases
GCAATTTTTCACCCCGTGAGATCGTTTCCGAGCTCGACCGCTACATTATCGGCCAGAAGGAGGCGAAGCGAGCGGTCGCG
ATTGCACTGCGGAACCGCTG

Product: GCN5-related N-acetyltransferase

Products: NA

Alternate protein names: AAC(6'); Amikacin resistance protein [H]

Number of amino acids: Translated: 179; Mature: 178

Protein sequence:

>179_residues
MPAEPTIRFEPVTAEHLPMLRHWLKQPHMREWWGEPEEELGFIRDMIEGRDSTRPFIIVLGDEPVGYIQYWFLGHHQNAE
WIDDHPWLAELPAGAVGVDLSIGHPDKLSKGIGSKALAAFVRKLRDDGFETILIDPDPDNLRAVGAYRKAGFRPVPWLEG
RSGNALIMQYDPNTDETTI

Sequences:

>Translated_179_residues
MPAEPTIRFEPVTAEHLPMLRHWLKQPHMREWWGEPEEELGFIRDMIEGRDSTRPFIIVLGDEPVGYIQYWFLGHHQNAE
WIDDHPWLAELPAGAVGVDLSIGHPDKLSKGIGSKALAAFVRKLRDDGFETILIDPDPDNLRAVGAYRKAGFRPVPWLEG
RSGNALIMQYDPNTDETTI
>Mature_178_residues
PAEPTIRFEPVTAEHLPMLRHWLKQPHMREWWGEPEEELGFIRDMIEGRDSTRPFIIVLGDEPVGYIQYWFLGHHQNAEW
IDDHPWLAELPAGAVGVDLSIGHPDKLSKGIGSKALAAFVRKLRDDGFETILIDPDPDNLRAVGAYRKAGFRPVPWLEGR
SGNALIMQYDPNTDETTI

Specific function: Resistance to antibiotics containing the purpurosamine ring including gentamicin, kanamycin, tobramycin, and neomycin [H]

COG id: COG1670

COG function: function code J; Acetyltransferases, including N-acetylases of ribosomal proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 N-acetyltransferase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000182
- InterPro:   IPR016181
- InterPro:   IPR019432 [H]

Pfam domain/function: PF00583 Acetyltransf_1; PF10331 AlcB [H]

EC number: =2.3.1.82 [H]

Molecular weight: Translated: 20389; Mature: 20258

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAEPTIRFEPVTAEHLPMLRHWLKQPHMREWWGEPEEELGFIRDMIEGRDSTRPFIIVL
CCCCCCEEECCCCHHHHHHHHHHHCCCCCHHHCCCCHHHHHHHHHHHCCCCCCCCEEEEE
GDEPVGYIQYWFLGHHQNAEWIDDHPWLAELPAGAVGVDLSIGHPDKLSKGIGSKALAAF
CCCCCCEEEEEEEECCCCCCCCCCCCCHHHCCCCCEEEEEECCCCHHHHHCCCHHHHHHH
VRKLRDDGFETILIDPDPDNLRAVGAYRKAGFRPVPWLEGRSGNALIMQYDPNTDETTI
HHHHHCCCCEEEEECCCCCCCEEEHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCC
>Mature Secondary Structure 
PAEPTIRFEPVTAEHLPMLRHWLKQPHMREWWGEPEEELGFIRDMIEGRDSTRPFIIVL
CCCCCEEECCCCHHHHHHHHHHHCCCCCHHHCCCCHHHHHHHHHHHCCCCCCCCEEEEE
GDEPVGYIQYWFLGHHQNAEWIDDHPWLAELPAGAVGVDLSIGHPDKLSKGIGSKALAAF
CCCCCCEEEEEEEECCCCCCCCCCCCCHHHCCCCCEEEEEECCCCHHHHHCCCHHHHHHH
VRKLRDDGFETILIDPDPDNLRAVGAYRKAGFRPVPWLEGRSGNALIMQYDPNTDETTI
HHHHHCCCCEEEEECCCCCCCEEEHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2841303; 1963948 [H]