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The map label for this gene is hemE

Identifier: 110635804

GI number: 110635804

Start: 3753928

End: 3754956

Strand: Reverse

Name: hemE

Synonym: Meso_3476

Alternate gene names: 110635804

Gene position: 3754956-3753928 (Counterclockwise)

Preceding gene: 110635811

Following gene: 110635803

Centisome position: 85.1

GC content: 57.53

Gene sequence:

>1029_bases
GTGGCAGAACGGAAACTCCTGGAAGCGCTGAACGGACGCACGGTATTTCCTCCTCCCATCTGGTTGATGCGTCAGGCTGG
GCGATACCTTCCGGAATATCGGGAAACACGGAAGAAGGCCGGAAGTTTCCTCGATCTTTGCTATAATCCGGAGCTTGCGG
TGGAGGTTACGCTGCAGCCCATTCGGCGGTTCGGCTTCGACGCGGCTATTTTGTTTTCCGACATTTTGGTCATTCCACAT
GCGCTTGGCCGCGACCTACGCTTTGAAGAAGGCGCAGGTCCCTTGATGTCTCCTATCCAAGCAAATGAAATACCGGGGCT
TGATCCGAACCTCATTCACAACCGTCTGCAGCCCGTCTATGAAACGGTCCGGCGGTTACGGAGCGAATTATCTGAAGAGA
CCGCTTTGATCGGCTTTTGCGGTGCGCCCTGGACTGTCGCCACTTATATGATTGCCGGCCGTGGAACGCCTGACCAGGCG
CCGGCGAGGTTGTTCGGGTACAGGCATCCAAAGGAATTCTCTGAACTTCTGGACACCATCTCGGCCGCGTCCGCCGATTA
TCTCATTCGCCAGATTGATGAAGGCGCGGACGCGGTGCAGATATTCGATTCCTGGGCCGGAATCCTTGACGAGACGAGTT
TCGATCAATGGTGTCTCCGGCCGGTTGCCGAGATCGTGCGAAGAGTGCGGGAAAGGCACCCGAATGTGCCGATCATTGGC
TTCCCGAAGGGTGCAGGATGGCTTTACAGCCGCTACCGGCAGCAAACGGGGGTGACGGCGCTTGGTCTTGATTGGACAGT
TCCGCTCAGCGAAGCAAGCCGGCTGCAGGCCGAAGGCCCAGTTCAGGGCAACCTGGACCCGATGCGATTGGTGGCGGGTG
GACAGGCGCTTTCGAAGGGTGTTGAGGATATCCTAAGCGCGTTGGGCGGCGCGCCTTTCATCTTCAATCTTGGTCATGGA
ATTACGCCCGAGACGCCTATCGGGCATGTTGAGGCGATGATACAGCAAGTGCGGGAGGGCAGACTGTGA

Upstream 100 bases:

>100_bases
ACAGGAGCCAGTGGACAGGATTTAATCCACACTCCAAACAGAGTCGTAGAATCAGAATCTCTTTAGAGTTCTTTAATTAT
TTGATTTGGAGACCTGGAAC

Downstream 100 bases:

>100_bases
CGGTGGCTAGCGGGACTAATGGAAAGGCTGTCGCGCGGCGTGCCACACTCTCACTGGTGATCGTTGCAGCGCTGACGGTG
CTTCTTTTTGCGGCCGCGCC

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 342; Mature: 341

Protein sequence:

>342_residues
MAERKLLEALNGRTVFPPPIWLMRQAGRYLPEYRETRKKAGSFLDLCYNPELAVEVTLQPIRRFGFDAAILFSDILVIPH
ALGRDLRFEEGAGPLMSPIQANEIPGLDPNLIHNRLQPVYETVRRLRSELSEETALIGFCGAPWTVATYMIAGRGTPDQA
PARLFGYRHPKEFSELLDTISAASADYLIRQIDEGADAVQIFDSWAGILDETSFDQWCLRPVAEIVRRVRERHPNVPIIG
FPKGAGWLYSRYRQQTGVTALGLDWTVPLSEASRLQAEGPVQGNLDPMRLVAGGQALSKGVEDILSALGGAPFIFNLGHG
ITPETPIGHVEAMIQQVREGRL

Sequences:

>Translated_342_residues
MAERKLLEALNGRTVFPPPIWLMRQAGRYLPEYRETRKKAGSFLDLCYNPELAVEVTLQPIRRFGFDAAILFSDILVIPH
ALGRDLRFEEGAGPLMSPIQANEIPGLDPNLIHNRLQPVYETVRRLRSELSEETALIGFCGAPWTVATYMIAGRGTPDQA
PARLFGYRHPKEFSELLDTISAASADYLIRQIDEGADAVQIFDSWAGILDETSFDQWCLRPVAEIVRRVRERHPNVPIIG
FPKGAGWLYSRYRQQTGVTALGLDWTVPLSEASRLQAEGPVQGNLDPMRLVAGGQALSKGVEDILSALGGAPFIFNLGHG
ITPETPIGHVEAMIQQVREGRL
>Mature_341_residues
AERKLLEALNGRTVFPPPIWLMRQAGRYLPEYRETRKKAGSFLDLCYNPELAVEVTLQPIRRFGFDAAILFSDILVIPHA
LGRDLRFEEGAGPLMSPIQANEIPGLDPNLIHNRLQPVYETVRRLRSELSEETALIGFCGAPWTVATYMIAGRGTPDQAP
ARLFGYRHPKEFSELLDTISAASADYLIRQIDEGADAVQIFDSWAGILDETSFDQWCLRPVAEIVRRVRERHPNVPIIGF
PKGAGWLYSRYRQQTGVTALGLDWTVPLSEASRLQAEGPVQGNLDPMRLVAGGQALSKGVEDILSALGGAPFIFNLGHGI
TPETPIGHVEAMIQQVREGRL

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=330, Percent_Identity=38.7878787878788, Blast_Score=214, Evalue=1e-55,
Organism=Escherichia coli, GI2367337, Length=348, Percent_Identity=41.6666666666667, Blast_Score=243, Evalue=1e-65,
Organism=Saccharomyces cerevisiae, GI6320252, Length=334, Percent_Identity=35.0299401197605, Blast_Score=192, Evalue=5e-50,
Organism=Drosophila melanogaster, GI221330099, Length=348, Percent_Identity=39.6551724137931, Blast_Score=237, Evalue=8e-63,
Organism=Drosophila melanogaster, GI19921920, Length=350, Percent_Identity=40.2857142857143, Blast_Score=237, Evalue=8e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_MESSB (Q11CM8)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_676012.1
- ProteinModelPortal:   Q11CM8
- SMR:   Q11CM8
- STRING:   Q11CM8
- GeneID:   4179884
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_3476
- NMPDR:   fig|266779.1.peg.1057
- eggNOG:   COG0407
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- PhylomeDB:   Q11CM8
- ProtClustDB:   PRK00115
- BioCyc:   MSP266779:MESO_3476-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 37964; Mature: 37833

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 74-74 BINDING 149-149 BINDING 204-204 BINDING 319-319

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAERKLLEALNGRTVFPPPIWLMRQAGRYLPEYRETRKKAGSFLDLCYNPELAVEVTLQP
CCHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCHHHHCCCCEEEEEEHHH
IRRFGFDAAILFSDILVIPHALGRDLRFEEGAGPLMSPIQANEIPGLDPNLIHNRLQPVY
HHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
ETVRRLRSELSEETALIGFCGAPWTVATYMIAGRGTPDQAPARLFGYRHPKEFSELLDTI
HHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHCCCCCCCCHHHHHCCCCHHHHHHHHHHH
SAASADYLIRQIDEGADAVQIFDSWAGILDETSFDQWCLRPVAEIVRRVRERHPNVPIIG
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEE
FPKGAGWLYSRYRQQTGVTALGLDWTVPLSEASRLQAEGPVQGNLDPMRLVAGGQALSKG
CCCCCHHHHHHHHHHCCCEEECCCEECCHHHHHHCCCCCCCCCCCCHHHHHHCCHHHHHH
VEDILSALGGAPFIFNLGHGITPETPIGHVEAMIQQVREGRL
HHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AERKLLEALNGRTVFPPPIWLMRQAGRYLPEYRETRKKAGSFLDLCYNPELAVEVTLQP
CHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCHHHHCCCCEEEEEEHHH
IRRFGFDAAILFSDILVIPHALGRDLRFEEGAGPLMSPIQANEIPGLDPNLIHNRLQPVY
HHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
ETVRRLRSELSEETALIGFCGAPWTVATYMIAGRGTPDQAPARLFGYRHPKEFSELLDTI
HHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHCCCCCCCCHHHHHCCCCHHHHHHHHHHH
SAASADYLIRQIDEGADAVQIFDSWAGILDETSFDQWCLRPVAEIVRRVRERHPNVPIIG
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEE
FPKGAGWLYSRYRQQTGVTALGLDWTVPLSEASRLQAEGPVQGNLDPMRLVAGGQALSKG
CCCCCHHHHHHHHHHCCCEEECCCEECCHHHHHHCCCCCCCCCCCCHHHHHHCCHHHHHH
VEDILSALGGAPFIFNLGHGITPETPIGHVEAMIQQVREGRL
HHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA