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The map label for this gene is sdhA [H]

Identifier: 110635573

GI number: 110635573

Start: 3511047

End: 3512882

Strand: Reverse

Name: sdhA [H]

Synonym: Meso_3244

Alternate gene names: 110635573

Gene position: 3512882-3511047 (Counterclockwise)

Preceding gene: 110635574

Following gene: 110635572

Centisome position: 79.61

GC content: 64.43

Gene sequence:

>1836_bases
ATGGCTGCTGCAGTTCAGAACAAGGCCGGCCCGGCCTATACTTACGTCGATCATGTCTTTGATGTGGTGGTGGTCGGGGC
CGGTGGCGCGGGCCTTCGCGCTACGCTCGGCATGGCCGAACAAGGGCTGAAGACGGCCTGCATCACGAAAGTGTTCCCTA
CCCGTTCACATACCGTGGCGGCCCAGGGCGGCATTGCCGCCTCCCTGCGCAATATGGGGCCGGACGATTGGCAGTGGCAC
CTTTACGATACGGTGAAGGGCTCCGATTGGCTGGGCGATGTGGACGCCATGGAGTATCTGGCGCGCGAGGCGCCGGCCGC
CATCTACGAGCTGGAGCATTACGGGGTGCCCTTTTCCCGCACCGACGACGGCCGGATCTACCAGCGCCCCTTCGGCGGCC
ATATGCAGAACTTCGGCGACGGCCCACCCGTGCAGCGCACCTGCGCGGCCGCCGACCGCACGGGCCACGCGATCCTGCAC
ACGCTCTACGGCCAGTCCGTCAAGCATCATGCGCAGTTCTTCGTGGAATATTTCGCGCTCGACCTCATCATGTCGCCGGA
CGGCGTCTGCACCGGCGTGGTGGCGTGGAACCTGGAGGACGGCACCATCCACCGCTTCGCGGCCAAGATGGTGGTGCTTG
CCACGGGTGGCTATGGCCGCGCTTATTTCTCCTGCACTTCCGCCCATACCTGCACCGGCGACGGGAACGGTATGGTTGCC
CGCGCGGGGCTGCCGCTGCAGGACATGGAATTCGTTCAATTCCACCCGACCGGCGTCTACGGCGCGGGCGTGCTTATCAC
CGAGGGCGCGCGGGGTGAGGGCGGCTATCTCGTCAATGCCGAGGGCGAGCGCTTCATGGAGCGCTATGCGCCCTCCGCCA
AGGATCTTGCCTCGCGCGATGTGGTTTCACGCTGCATGACGTTGGAGATCCGCGAGGGCCGCGGGGTCGGACCGAAGAAG
GACCATATCTTCCTTCATCTCGATCATCTCGACCCGGCAGTGCTGCATGAAAGGCTGCCCGGCATTACCGAAAGCGCCCG
CATTTTCGCCGGCGTCGACCTGACGCGCGAGCCGATCCCAGTTCTGCCGACGGTGCACTACAATATGGGCGGCATCCCGA
CCAATTATCACGGCGAGGTGCTCAATCCCACGCTGGACAATCCGGACGCGATCGTTCCCGGCCTGATGGCGGCGGGCGAG
GCTGCCTGTGCCTCCGTCCATGGCGCGAACCGTCTCGGCTCAAACTCGCTAACGGACCTGGTGGTGTTCGGCCGCGCTGC
CGCCATTCGCGCCGGCATGGTGGTGGACCGCGAGTCCAAGGTGCCGCCGATCGACCTAGCCGCCTGCGAGAAGATCATGG
ACCGCTTCGACCGCATCCGCCATGCAAGCGGCTCCACGCCGACGGCGGCCCTACGCGAAAAAATGCAGCGGGCCATGCAG
GAGGATGCAGCGGTTTTCCGAACCCAGGAATCGCTCGAGCAGGGTTGCAGGCGCGTTTCGCAAGCATGGGGTGAGCTCTC
CGACATCAAGGTTCAGGATCGCTCGATGATCTGGAACTCCGATCTCATGGAAACGCTGGAGCTCGAAAACCTGATGGCGA
ATGCCATCGCCACCGTCTTTTCGGCGGAGGCGCGCAAGGAAAGCCGAGGCGCACATGCGCGGGAGGACTTCACCGAGCGC
GATGACGCGAATTGGCGCAAGCACACGCTTTCCTGGGTGGATCCGGACGGCACCGTCCGCCTCGACTATCGCCCGGTGCA
TACTGAGCCGATGCTGAAGCCCGAGAATGGCGGCATCGATCCGGCAAGGATCGCGCCGAAGAAGCGCGTATACTGA

Upstream 100 bases:

>100_bases
AAGATCGCACTCATCCTCCTCAATACTTTCTTTCCCGTCATCGTCGGCGCGATCGCGCTCTATTCCCTCCTCAGAATTGC
CTTCGGAGGCTGAAGTCTAA

Downstream 100 bases:

>100_bases
GGCAGAGGACATCATGGTCCAACTTACTCTTCCCAAGAACTCGAAGGTCAAGCAAGGCAAGGTCTGGCCGAAGCCGGAAG
GCGCCACAAACCTGCGCGAA

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 611; Mature: 610

Protein sequence:

>611_residues
MAAAVQNKAGPAYTYVDHVFDVVVVGAGGAGLRATLGMAEQGLKTACITKVFPTRSHTVAAQGGIAASLRNMGPDDWQWH
LYDTVKGSDWLGDVDAMEYLAREAPAAIYELEHYGVPFSRTDDGRIYQRPFGGHMQNFGDGPPVQRTCAAADRTGHAILH
TLYGQSVKHHAQFFVEYFALDLIMSPDGVCTGVVAWNLEDGTIHRFAAKMVVLATGGYGRAYFSCTSAHTCTGDGNGMVA
RAGLPLQDMEFVQFHPTGVYGAGVLITEGARGEGGYLVNAEGERFMERYAPSAKDLASRDVVSRCMTLEIREGRGVGPKK
DHIFLHLDHLDPAVLHERLPGITESARIFAGVDLTREPIPVLPTVHYNMGGIPTNYHGEVLNPTLDNPDAIVPGLMAAGE
AACASVHGANRLGSNSLTDLVVFGRAAAIRAGMVVDRESKVPPIDLAACEKIMDRFDRIRHASGSTPTAALREKMQRAMQ
EDAAVFRTQESLEQGCRRVSQAWGELSDIKVQDRSMIWNSDLMETLELENLMANAIATVFSAEARKESRGAHAREDFTER
DDANWRKHTLSWVDPDGTVRLDYRPVHTEPMLKPENGGIDPARIAPKKRVY

Sequences:

>Translated_611_residues
MAAAVQNKAGPAYTYVDHVFDVVVVGAGGAGLRATLGMAEQGLKTACITKVFPTRSHTVAAQGGIAASLRNMGPDDWQWH
LYDTVKGSDWLGDVDAMEYLAREAPAAIYELEHYGVPFSRTDDGRIYQRPFGGHMQNFGDGPPVQRTCAAADRTGHAILH
TLYGQSVKHHAQFFVEYFALDLIMSPDGVCTGVVAWNLEDGTIHRFAAKMVVLATGGYGRAYFSCTSAHTCTGDGNGMVA
RAGLPLQDMEFVQFHPTGVYGAGVLITEGARGEGGYLVNAEGERFMERYAPSAKDLASRDVVSRCMTLEIREGRGVGPKK
DHIFLHLDHLDPAVLHERLPGITESARIFAGVDLTREPIPVLPTVHYNMGGIPTNYHGEVLNPTLDNPDAIVPGLMAAGE
AACASVHGANRLGSNSLTDLVVFGRAAAIRAGMVVDRESKVPPIDLAACEKIMDRFDRIRHASGSTPTAALREKMQRAMQ
EDAAVFRTQESLEQGCRRVSQAWGELSDIKVQDRSMIWNSDLMETLELENLMANAIATVFSAEARKESRGAHAREDFTER
DDANWRKHTLSWVDPDGTVRLDYRPVHTEPMLKPENGGIDPARIAPKKRVY
>Mature_610_residues
AAAVQNKAGPAYTYVDHVFDVVVVGAGGAGLRATLGMAEQGLKTACITKVFPTRSHTVAAQGGIAASLRNMGPDDWQWHL
YDTVKGSDWLGDVDAMEYLAREAPAAIYELEHYGVPFSRTDDGRIYQRPFGGHMQNFGDGPPVQRTCAAADRTGHAILHT
LYGQSVKHHAQFFVEYFALDLIMSPDGVCTGVVAWNLEDGTIHRFAAKMVVLATGGYGRAYFSCTSAHTCTGDGNGMVAR
AGLPLQDMEFVQFHPTGVYGAGVLITEGARGEGGYLVNAEGERFMERYAPSAKDLASRDVVSRCMTLEIREGRGVGPKKD
HIFLHLDHLDPAVLHERLPGITESARIFAGVDLTREPIPVLPTVHYNMGGIPTNYHGEVLNPTLDNPDAIVPGLMAAGEA
ACASVHGANRLGSNSLTDLVVFGRAAAIRAGMVVDRESKVPPIDLAACEKIMDRFDRIRHASGSTPTAALREKMQRAMQE
DAAVFRTQESLEQGCRRVSQAWGELSDIKVQDRSMIWNSDLMETLELENLMANAIATVFSAEARKESRGAHAREDFTERD
DANWRKHTLSWVDPDGTVRLDYRPVHTEPMLKPENGGIDPARIAPKKRVY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=619, Percent_Identity=61.389337641357, Blast_Score=746, Evalue=0.0,
Organism=Escherichia coli, GI1786942, Length=593, Percent_Identity=52.7824620573356, Blast_Score=567, Evalue=1e-163,
Organism=Escherichia coli, GI1790597, Length=587, Percent_Identity=41.0562180579216, Blast_Score=402, Evalue=1e-113,
Organism=Escherichia coli, GI1788928, Length=563, Percent_Identity=32.1492007104796, Blast_Score=214, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17550100, Length=607, Percent_Identity=61.1202635914333, Blast_Score=728, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505833, Length=619, Percent_Identity=59.1276252019386, Blast_Score=709, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322416, Length=601, Percent_Identity=62.7287853577371, Blast_Score=764, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322701, Length=593, Percent_Identity=62.9005059021922, Blast_Score=758, Evalue=0.0,
Organism=Drosophila melanogaster, GI17137288, Length=619, Percent_Identity=62.843295638126, Blast_Score=764, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655642, Length=619, Percent_Identity=62.843295638126, Blast_Score=764, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655647, Length=619, Percent_Identity=62.843295638126, Blast_Score=764, Evalue=0.0,
Organism=Drosophila melanogaster, GI24663005, Length=594, Percent_Identity=56.5656565656566, Blast_Score=687, Evalue=0.0,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 66641; Mature: 66510

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAAVQNKAGPAYTYVDHVFDVVVVGAGGAGLRATLGMAEQGLKTACITKVFPTRSHTVA
CCCCCCCCCCCHHHHHHHHHEEEEECCCCCCHHHHHHHHHHCCHHHHHHHHCCCCCCEEE
AQGGIAASLRNMGPDDWQWHLYDTVKGSDWLGDVDAMEYLAREAPAAIYELEHYGVPFSR
ECCCHHHHHHCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCHHEEEHHHCCCCCCC
TDDGRIYQRPFGGHMQNFGDGPPVQRTCAAADRTGHAILHTLYGQSVKHHAQFFVEYFAL
CCCCEEEECCCCCCHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
DLIMSPDGVCTGVVAWNLEDGTIHRFAAKMVVLATGGYGRAYFSCTSAHTCTGDGNGMVA
HHHCCCCCCEEEEEEEECCCCHHHHHHEEEEEEEECCCCCEEEEECCCCEECCCCCCEEE
RAGLPLQDMEFVQFHPTGVYGAGVLITEGARGEGGYLVNAEGERFMERYAPSAKDLASRD
ECCCCCCCCCEEEECCCCEEECCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHHHHHHH
VVSRCMTLEIREGRGVGPKKDHIFLHLDHLDPAVLHERLPGITESARIFAGVDLTREPIP
HHHHHHEEEEECCCCCCCCCCEEEEEECCCCHHHHHHHCCCCCCCCEEEEECCCCCCCCC
VLPTVHYNMGGIPTNYHGEVLNPTLDNPDAIVPGLMAAGEAACASVHGANRLGSNSLTDL
CCCEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHCCCCCCCCCCHHHH
VVFGRAAAIRAGMVVDRESKVPPIDLAACEKIMDRFDRIRHASGSTPTAALREKMQRAMQ
HHHCCHHHHHHCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
EDAAVFRTQESLEQGCRRVSQAWGELSDIKVQDRSMIWNSDLMETLELENLMANAIATVF
HHHHHHHHHHHHHHHHHHHHHHHCCHHCCEEECCHHEECHHHHHHHHHHHHHHHHHHHHH
SAEARKESRGAHAREDFTERDDANWRKHTLSWVDPDGTVRLDYRPVHTEPMLKPENGGID
HHHHHHHHCCCCCHHHCCCCCCCCHHHHCCEEECCCCEEEEEEEECCCCCCCCCCCCCCC
PARIAPKKRVY
HHHCCCCCCCC
>Mature Secondary Structure 
AAAVQNKAGPAYTYVDHVFDVVVVGAGGAGLRATLGMAEQGLKTACITKVFPTRSHTVA
CCCCCCCCCCHHHHHHHHHEEEEECCCCCCHHHHHHHHHHCCHHHHHHHHCCCCCCEEE
AQGGIAASLRNMGPDDWQWHLYDTVKGSDWLGDVDAMEYLAREAPAAIYELEHYGVPFSR
ECCCHHHHHHCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCHHEEEHHHCCCCCCC
TDDGRIYQRPFGGHMQNFGDGPPVQRTCAAADRTGHAILHTLYGQSVKHHAQFFVEYFAL
CCCCEEEECCCCCCHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
DLIMSPDGVCTGVVAWNLEDGTIHRFAAKMVVLATGGYGRAYFSCTSAHTCTGDGNGMVA
HHHCCCCCCEEEEEEEECCCCHHHHHHEEEEEEEECCCCCEEEEECCCCEECCCCCCEEE
RAGLPLQDMEFVQFHPTGVYGAGVLITEGARGEGGYLVNAEGERFMERYAPSAKDLASRD
ECCCCCCCCCEEEECCCCEEECCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHHHHHHH
VVSRCMTLEIREGRGVGPKKDHIFLHLDHLDPAVLHERLPGITESARIFAGVDLTREPIP
HHHHHHEEEEECCCCCCCCCCEEEEEECCCCHHHHHHHCCCCCCCCEEEEECCCCCCCCC
VLPTVHYNMGGIPTNYHGEVLNPTLDNPDAIVPGLMAAGEAACASVHGANRLGSNSLTDL
CCCEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHCCCCCCCCCCHHHH
VVFGRAAAIRAGMVVDRESKVPPIDLAACEKIMDRFDRIRHASGSTPTAALREKMQRAMQ
HHHCCHHHHHHCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
EDAAVFRTQESLEQGCRRVSQAWGELSDIKVQDRSMIWNSDLMETLELENLMANAIATVF
HHHHHHHHHHHHHHHHHHHHHHHCCHHCCEEECCHHEECHHHHHHHHHHHHHHHHHHHHH
SAEARKESRGAHAREDFTERDDANWRKHTLSWVDPDGTVRLDYRPVHTEPMLKPENGGID
HHHHHHHHCCCCCHHHCCCCCCCCHHHHCCEEECCCCEEEEEEEECCCCCCCCCCCCCCC
PARIAPKKRVY
HHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA