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The map label for this gene is msrA2 [H]

Identifier: 110635571

GI number: 110635571

Start: 3509480

End: 3510121

Strand: Reverse

Name: msrA2 [H]

Synonym: Meso_3242

Alternate gene names: 110635571

Gene position: 3510121-3509480 (Counterclockwise)

Preceding gene: 110635572

Following gene: 110635567

Centisome position: 79.55

GC content: 60.9

Gene sequence:

>642_bases
ATGTTCCGCCAGATCGCCGCCGCCGTTTCGTCCCTCGTCTTAATCTTCATCGGCACCTTACAGTCCGCAGCTGAGACCGG
CACAGCGATCTTCGCCGGCGGCTGCTTCTGGTGCGTGGAGTCCGATTTCGATCAGGTGCCGGGCGTCACTTCCACGATAT
CGGGCTATTCGGGCGGGAACACCCCGAATCCGACCTATGACGATTATATGGAGGGCGGGCACCGGGAAGTGGTGAAAATC
GAGTATGACGATACCCGCGTCAGCTACGATCAGCTTCTCGACGTGTTCTTTCATTCGGTCGATCCCACCGATGGCGGCGG
GCAGTTCTGCGATCGCGGCCATGCCTATTCAACGGCGATCTACGTGCTGAACGACGCTCAGCGGCAGGCGGCGGAGAACG
CGAAGAAGGCGGCGGAAGCCGAGTTAGGCCGCTCAGTGGTTACTCCGATCGAGAGCGCAGCCACCTTCTGGCCGGCCGAG
GACTATCATCAAAATTATTATCAGAGCCAGGATCGCATTCTCTCCCGGTTCGGATATGTGACGAAGGCGGACGCGTATAA
GGGGTACCGCGAGGGCTGCGGGCGGGATGCCCGGCTGAGGCAGGTCTGGGGCGAAAACGCCTTGCGCGGCCTCGCGCATT
GA

Upstream 100 bases:

>100_bases
GCGCTGTGATCCCTTCCCGCCACTCACGCAACCGTGTAGGGGCGAGAGTTTGCAGCGGGAACTCTTCGGCGGTACGAATT
GCCCCAAAAGGGAGGTAACC

Downstream 100 bases:

>100_bases
ATTCGGCTATCGGCGGATGCGCTCCATGGCCATTTCGGCCGCGATGTCGTTTGTCGGCCGCTTTTGCTGTTCGGCGCGCT
GAAATATTTCCGTAAGCGTG

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase 2; Peptide-methionine (S)-S-oxide reductase 2; Peptide Met(O) reductase 2 [H]

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MFRQIAAAVSSLVLIFIGTLQSAAETGTAIFAGGCFWCVESDFDQVPGVTSTISGYSGGNTPNPTYDDYMEGGHREVVKI
EYDDTRVSYDQLLDVFFHSVDPTDGGGQFCDRGHAYSTAIYVLNDAQRQAAENAKKAAEAELGRSVVTPIESAATFWPAE
DYHQNYYQSQDRILSRFGYVTKADAYKGYREGCGRDARLRQVWGENALRGLAH

Sequences:

>Translated_213_residues
MFRQIAAAVSSLVLIFIGTLQSAAETGTAIFAGGCFWCVESDFDQVPGVTSTISGYSGGNTPNPTYDDYMEGGHREVVKI
EYDDTRVSYDQLLDVFFHSVDPTDGGGQFCDRGHAYSTAIYVLNDAQRQAAENAKKAAEAELGRSVVTPIESAATFWPAE
DYHQNYYQSQDRILSRFGYVTKADAYKGYREGCGRDARLRQVWGENALRGLAH
>Mature_213_residues
MFRQIAAAVSSLVLIFIGTLQSAAETGTAIFAGGCFWCVESDFDQVPGVTSTISGYSGGNTPNPTYDDYMEGGHREVVKI
EYDDTRVSYDQLLDVFFHSVDPTDGGGQFCDRGHAYSTAIYVLNDAQRQAAENAKKAAEAELGRSVVTPIESAATFWPAE
DYHQNYYQSQDRILSRFGYVTKADAYKGYREGCGRDARLRQVWGENALRGLAH

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=147, Percent_Identity=40.1360544217687, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI208609995, Length=147, Percent_Identity=40.1360544217687, Blast_Score=101, Evalue=4e-22,
Organism=Homo sapiens, GI208609993, Length=98, Percent_Identity=38.7755102040816, Blast_Score=68, Evalue=5e-12,
Organism=Escherichia coli, GI1790665, Length=145, Percent_Identity=46.8965517241379, Blast_Score=117, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI17533973, Length=146, Percent_Identity=36.3013698630137, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320881, Length=153, Percent_Identity=26.797385620915, Blast_Score=62, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24664627, Length=141, Percent_Identity=36.1702127659575, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24664631, Length=141, Percent_Identity=35.4609929078014, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI45553131, Length=134, Percent_Identity=35.8208955223881, Blast_Score=80, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 23457; Mature: 23457

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRQIAAAVSSLVLIFIGTLQSAAETGTAIFAGGCFWCVESDFDQVPGVTSTISGYSGGN
CHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCEEEEECCCHHHCCCCHHHCCCCCCCC
TPNPTYDDYMEGGHREVVKIEYDDTRVSYDQLLDVFFHSVDPTDGGGQFCDRGHAYSTAI
CCCCCHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCHHHCCCCCEEEEE
YVLNDAQRQAAENAKKAAEAELGRSVVTPIESAATFWPAEDYHQNYYQSQDRILSRFGYV
EEECHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCH
TKADAYKGYREGCGRDARLRQVWGENALRGLAH
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFRQIAAAVSSLVLIFIGTLQSAAETGTAIFAGGCFWCVESDFDQVPGVTSTISGYSGGN
CHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCEEEEECCCHHHCCCCHHHCCCCCCCC
TPNPTYDDYMEGGHREVVKIEYDDTRVSYDQLLDVFFHSVDPTDGGGQFCDRGHAYSTAI
CCCCCHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCHHHCCCCCEEEEE
YVLNDAQRQAAENAKKAAEAELGRSVVTPIESAATFWPAEDYHQNYYQSQDRILSRFGYV
EEECHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCH
TKADAYKGYREGCGRDARLRQVWGENALRGLAH
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]