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The map label for this gene is tesB [H]

Identifier: 110635567

GI number: 110635567

Start: 3505556

End: 3506422

Strand: Reverse

Name: tesB [H]

Synonym: Meso_3238

Alternate gene names: 110635567

Gene position: 3506422-3505556 (Counterclockwise)

Preceding gene: 110635571

Following gene: 110635566

Centisome position: 79.47

GC content: 61.48

Gene sequence:

>867_bases
ATGCCGTCCGCAATGCAGGATCTTCTAGACATACTTAACCTCGAAAAGCTTGAACACAACCTCTATCGCGGCCACAGCCC
GCAGGTGGGGTGGCAGCGTGTTTTTGGTGGTCAGGTCATCGGGCAGGCGCTGGTCGCGGCGCAGAGGACGGTCGTGGTCG
ACCGGCATGTGCACTCCCTGCATTGCTACTTCATGCGTCCGGGGGACCCAGCCGTTCCCATCATCTACGAAGTTGACCGC
ATACGCGACGGCGGCAGTTTCACAACAAGGCGCGTGGTCGCTATCCAGCACGGTCACGCGATTTTTTCGCTTTCCGCTTC
CTTTCAGGTCGATGAGGTTGGCCTGCAGCACCAGCTTTCGATGCCGGAAGGCATTCCCGCGCCGGAGACGCTTAGGTCGC
AGCGGGAGTTGCTGGCTGCCCTGGGGGACGATGTGCCGGAAAATATTCGCCGGTATTGGCAGCGCGAGCGCCCGGTCGAG
ATCCGGCCGGTGACTTCCGAGCATTACACGACAAACGAAAAGCTGCCGCCGTTTCAGCATGTCTGGATGCGGGCGACCGA
CCCCGTGCCGAACGATCGCGCGCTGCAGTCGGCAGCGCTTGCCTATTTTTCCGACATGACGCTGATCGACACCGCCACCT
ATCCCCACGGCCGCTCCGTATTCGATTCGCAACTTCAGATGGCGAGCCTCGACCATGCGATATGGTTCCACAGGCCCGAC
GCGCTGAACGACTGGCTTCTCTATACCCAGGACAGCCCGTCTTCGGGCGGCGCGCGTGGGTTCGCCCGCGGCAGCATCTA
TTCCCGTGACGGCGCGCTGATCGCTTCCGTTGCGCAGGAAGGTCTTCTGCGACTGCGCACAAAATAG

Upstream 100 bases:

>100_bases
GTCTTCTCGCCCATACTCGACTTCTCCTTTTCCTGCAGCCTTGACTTGATGCGCGGCCTCCGGTTTCTCGAACAAACCGA
ACGCTGCCGGAGGAAATCGA

Downstream 100 bases:

>100_bases
GCAGAATAAAATTACTGCACATTTTTTGTTCACTTGCTGTTCGCCCAGATTGAGGGCGGGCGCGGAGGCGCATCATTTTA
GCTAAGTAAATCAGCGCCTT

Product: acyl-CoA thioesterase II

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII [H]

Number of amino acids: Translated: 288; Mature: 287

Protein sequence:

>288_residues
MPSAMQDLLDILNLEKLEHNLYRGHSPQVGWQRVFGGQVIGQALVAAQRTVVVDRHVHSLHCYFMRPGDPAVPIIYEVDR
IRDGGSFTTRRVVAIQHGHAIFSLSASFQVDEVGLQHQLSMPEGIPAPETLRSQRELLAALGDDVPENIRRYWQRERPVE
IRPVTSEHYTTNEKLPPFQHVWMRATDPVPNDRALQSAALAYFSDMTLIDTATYPHGRSVFDSQLQMASLDHAIWFHRPD
ALNDWLLYTQDSPSSGGARGFARGSIYSRDGALIASVAQEGLLRLRTK

Sequences:

>Translated_288_residues
MPSAMQDLLDILNLEKLEHNLYRGHSPQVGWQRVFGGQVIGQALVAAQRTVVVDRHVHSLHCYFMRPGDPAVPIIYEVDR
IRDGGSFTTRRVVAIQHGHAIFSLSASFQVDEVGLQHQLSMPEGIPAPETLRSQRELLAALGDDVPENIRRYWQRERPVE
IRPVTSEHYTTNEKLPPFQHVWMRATDPVPNDRALQSAALAYFSDMTLIDTATYPHGRSVFDSQLQMASLDHAIWFHRPD
ALNDWLLYTQDSPSSGGARGFARGSIYSRDGALIASVAQEGLLRLRTK
>Mature_287_residues
PSAMQDLLDILNLEKLEHNLYRGHSPQVGWQRVFGGQVIGQALVAAQRTVVVDRHVHSLHCYFMRPGDPAVPIIYEVDRI
RDGGSFTTRRVVAIQHGHAIFSLSASFQVDEVGLQHQLSMPEGIPAPETLRSQRELLAALGDDVPENIRRYWQRERPVEI
RPVTSEHYTTNEKLPPFQHVWMRATDPVPNDRALQSAALAYFSDMTLIDTATYPHGRSVFDSQLQMASLDHAIWFHRPDA
LNDWLLYTQDSPSSGGARGFARGSIYSRDGALIASVAQEGLLRLRTK

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known [H]

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI34577075, Length=291, Percent_Identity=40.893470790378, Blast_Score=219, Evalue=2e-57,
Organism=Escherichia coli, GI1786657, Length=270, Percent_Identity=45.9259259259259, Blast_Score=259, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI71988741, Length=294, Percent_Identity=39.4557823129252, Blast_Score=191, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI17558508, Length=306, Percent_Identity=38.562091503268, Blast_Score=176, Evalue=9e-45,
Organism=Caenorhabditis elegans, GI115532456, Length=272, Percent_Identity=36.0294117647059, Blast_Score=154, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI17531889, Length=272, Percent_Identity=36.0294117647059, Blast_Score=153, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI17531885, Length=272, Percent_Identity=36.0294117647059, Blast_Score=153, Evalue=9e-38,
Organism=Caenorhabditis elegans, GI212645202, Length=266, Percent_Identity=35.7142857142857, Blast_Score=144, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI71982224, Length=295, Percent_Identity=31.864406779661, Blast_Score=122, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6322480, Length=333, Percent_Identity=27.6276276276276, Blast_Score=96, Evalue=7e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003703 [H]

Pfam domain/function: PF02551 Acyl_CoA_thio [H]

EC number: 3.1.2.- [C]

Molecular weight: Translated: 32426; Mature: 32295

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSAMQDLLDILNLEKLEHNLYRGHSPQVGWQRVFGGQVIGQALVAAQRTVVVDRHVHSL
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEECCEEEE
HCYFMRPGDPAVPIIYEVDRIRDGGSFTTRRVVAIQHGHAIFSLSASFQVDEVGLQHQLS
EEEEECCCCCCCEEEEEEECCCCCCCCCEEEEEEEECCCEEEEEECCCEEHHHCHHHHCC
MPEGIPAPETLRSQRELLAALGDDVPENIRRYWQRERPVEIRPVTSEHYTTNEKLPPFQH
CCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHH
VWMRATDPVPNDRALQSAALAYFSDMTLIDTATYPHGRSVFDSQLQMASLDHAIWFHRPD
HHEECCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHCHHEEEECCC
ALNDWLLYTQDSPSSGGARGFARGSIYSRDGALIASVAQEGLLRLRTK
CCCCCEEEECCCCCCCCCCCEECCCEECCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PSAMQDLLDILNLEKLEHNLYRGHSPQVGWQRVFGGQVIGQALVAAQRTVVVDRHVHSL
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEECCEEEE
HCYFMRPGDPAVPIIYEVDRIRDGGSFTTRRVVAIQHGHAIFSLSASFQVDEVGLQHQLS
EEEEECCCCCCCEEEEEEECCCCCCCCCEEEEEEEECCCEEEEEECCCEEHHHCHHHHCC
MPEGIPAPETLRSQRELLAALGDDVPENIRRYWQRERPVEIRPVTSEHYTTNEKLPPFQH
CCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHH
VWMRATDPVPNDRALQSAALAYFSDMTLIDTATYPHGRSVFDSQLQMASLDHAIWFHRPD
HHEECCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHCHHEEEECCC
ALNDWLLYTQDSPSSGGARGFARGSIYSRDGALIASVAQEGLLRLRTK
CCCCCEEEECCCCCCCCCCCEECCCEECCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]