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The map label for this gene is ruvC

Identifier: 110635508

GI number: 110635508

Start: 3450468

End: 3450983

Strand: Reverse

Name: ruvC

Synonym: Meso_3179

Alternate gene names: 110635508

Gene position: 3450983-3450468 (Counterclockwise)

Preceding gene: 110635509

Following gene: 110635507

Centisome position: 78.21

GC content: 63.57

Gene sequence:

>516_bases
ATGACAGGTACGATTCGCATCATTGGCATCGATCCGGGGCTCCGGCGCACCGGTTGGGCCGTCATCGAAACGGTCGGCAA
TTCGCTCCGCTTCATCGGTGCGGGTACGGTGCGCTCAAACGATAAGGCGGATCTCGCCTCCCGCCTCTGCCAGCTTCATG
ACGGGCTGGCCGAAATTCTTCACCTTCACATGCCGCAGGAAGCGGCGGTCGAAGCTACATTCGTCAACAAGGACGCCGTG
GCGACGCTCAAGCTCGGCCAGGCGCGCGGCATCGCCATGCTCGTGCCGGCGCGCGCGGGGCTGCGCGTTGCAGAATATGC
GCCCAACGCAGTGAAAAAGGCGGTGATCGGCGTCGGCCATGGCGAGAAGCGGCAGATCCACATGATGGTGAAGGTGCTCA
TGCCCAAGGCTCTCTTCGATGGCGACGATGCGGCAGATGCCATCGCGGTCGCGATCTGCCATGCGCATCACCGGCAGTCG
CCCGCTTGGCGACTTGCTCTGGAGGCTCAGCCATGA

Upstream 100 bases:

>100_bases
CGAGAGGCTAAAGATCTTTTTCGCGCGTAGCGGCAGCGAATAGAAGCGCTGACCCTATTCGATACTCGCTATTCCCTATG
CGCTTTTCTATCCTGCCGGC

Downstream 100 bases:

>100_bases
TCGGAAAGCTGAAGGGTGTTCTCGATGAGATCGGAGAGGATCATTGCGTGGTCGATGTCGGTGGCGTCGGTTACGTCGCC
CACTGCTCGGCACGCAGCCT

Product: Holliday junction resolvase

Products: NA

Alternate protein names: Holliday junction nuclease ruvC; Holliday junction resolvase ruvC

Number of amino acids: Translated: 171; Mature: 170

Protein sequence:

>171_residues
MTGTIRIIGIDPGLRRTGWAVIETVGNSLRFIGAGTVRSNDKADLASRLCQLHDGLAEILHLHMPQEAAVEATFVNKDAV
ATLKLGQARGIAMLVPARAGLRVAEYAPNAVKKAVIGVGHGEKRQIHMMVKVLMPKALFDGDDAADAIAVAICHAHHRQS
PAWRLALEAQP

Sequences:

>Translated_171_residues
MTGTIRIIGIDPGLRRTGWAVIETVGNSLRFIGAGTVRSNDKADLASRLCQLHDGLAEILHLHMPQEAAVEATFVNKDAV
ATLKLGQARGIAMLVPARAGLRVAEYAPNAVKKAVIGVGHGEKRQIHMMVKVLMPKALFDGDDAADAIAVAICHAHHRQS
PAWRLALEAQP
>Mature_170_residues
TGTIRIIGIDPGLRRTGWAVIETVGNSLRFIGAGTVRSNDKADLASRLCQLHDGLAEILHLHMPQEAAVEATFVNKDAVA
TLKLGQARGIAMLVPARAGLRVAEYAPNAVKKAVIGVGHGEKRQIHMMVKVLMPKALFDGDDAADAIAVAICHAHHRQSP
AWRLALEAQP

Specific function: Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leav

COG id: COG0817

COG function: function code L; Holliday junction resolvasome, endonuclease subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ruvC family

Homologues:

Organism=Escherichia coli, GI1788170, Length=128, Percent_Identity=43.75, Blast_Score=108, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RUVC_MESSB (Q11DH4)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_675716.1
- ProteinModelPortal:   Q11DH4
- SMR:   Q11DH4
- STRING:   Q11DH4
- GeneID:   4182269
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_3179
- NMPDR:   fig|266779.1.peg.106
- eggNOG:   COG0817
- HOGENOM:   HBG437552
- OMA:   RTGWGVI
- PhylomeDB:   Q11DH4
- ProtClustDB:   PRK00039
- BioCyc:   MSP266779:MESO_3179-MONOMER
- HAMAP:   MF_00034
- InterPro:   IPR012337
- InterPro:   IPR020563
- InterPro:   IPR002176
- PRINTS:   PR00696
- TIGRFAMs:   TIGR00228

Pfam domain/function: PF02075 RuvC; SSF53098 RNaseH_fold

EC number: =3.1.22.4

Molecular weight: Translated: 18289; Mature: 18157

Theoretical pI: Translated: 9.83; Mature: 9.83

Prosite motif: PS01321 RUVC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGTIRIIGIDPGLRRTGWAVIETVGNSLRFIGAGTVRSNDKADLASRLCQLHDGLAEIL
CCCEEEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
HLHMPQEAAVEATFVNKDAVATLKLGQARGIAMLVPARAGLRVAEYAPNAVKKAVIGVGH
HHCCCHHHHEEEEEECCCCEEEEEECCCCCEEEEECCCCCCCHHHCCCHHHHHHHEECCC
GEKRQIHMMVKVLMPKALFDGDDAADAIAVAICHAHHRQSPAWRLALEAQP
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCC
>Mature Secondary Structure 
TGTIRIIGIDPGLRRTGWAVIETVGNSLRFIGAGTVRSNDKADLASRLCQLHDGLAEIL
CCEEEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
HLHMPQEAAVEATFVNKDAVATLKLGQARGIAMLVPARAGLRVAEYAPNAVKKAVIGVGH
HHCCCHHHHEEEEEECCCCEEEEEECCCCCEEEEECCCCCCCHHHCCCHHHHHHHEECCC
GEKRQIHMMVKVLMPKALFDGDDAADAIAVAICHAHHRQSPAWRLALEAQP
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA