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The map label for this gene is gloB

Identifier: 110635409

GI number: 110635409

Start: 3351897

End: 3352664

Strand: Reverse

Name: gloB

Synonym: Meso_3080

Alternate gene names: 110635409

Gene position: 3352664-3351897 (Counterclockwise)

Preceding gene: 110635412

Following gene: 110635403

Centisome position: 75.98

GC content: 58.85

Gene sequence:

>768_bases
ATGACGCTCGAAATCGAACAGTTCATGTGCCGCAGCGATAATTTCGGGATTCTCGCCCGCGATTCCGAAACCGGTATCAC
GGCCCTGGTGGATGCACCGGAGGAGCAGGCTATTCTGGAGGCGATCAAGCGTACCGGGTGGACGCCCTCGCTGCTTCTCA
TCACGCATCATCATGCCGATCACGTGGAAGCCAATCTGGCGCTCAAGGAGCGTTTCGGCCTTACCATTATTGGCCCCGCA
AAGGAGGCGAGCAAGATTCCCGGCATTGACCGGCAGGTTAACGAGGGCGACGTGGTGCGCGTCGGCAACCAGGAAGCGCG
GGTGATCGAAACGCCCGGGCATACGGCAGGTCATATCACCTTTTATTTTGCCAAGGCCGGCATTGCGTTCACCGCAGACA
CGCTGTTTGCGCTGGGGTGCGGCCGGCTCTTCGAATGCAAGCCACCGGTCATGTACGAGTCGCTCAAGAAACTGGTCGAA
CTGCCGCTCGAGACCGTCATCTATTGCGGCCACGAATATACGGAGTCCAACGCCCGTTTCGCGCTTTCGGTCGACCCGAC
CAATTCCGCACTCAAGGAGAGGGCGAAGAAGATCGAGGCACTGAGGCGCGAAGGCAGACCCACGCTGCCCACCACGCTCG
GCGAAGAAATGGCCACGAATCCCTTCCTGCGTTGCCATGACCCGGTTCTTCGGAACAATCTCGGCATGAAGAACGCTGCG
GATGTCGAGGTCTTTGCCGAAATCCGCAAAAGGAAGGACGTGTTCTAG

Upstream 100 bases:

>100_bases
AAGAGGGTAAGCATCCCCGGCGATTGCTTCAAGAAAGTCTTTCGGCGGGTGACAAAGGTTGGCCTAAACTTTATGTCTCA
CGGGAACAAAGGAGGCGACG

Downstream 100 bases:

>100_bases
CCTCAGGCCGCGTTGCCCGCGGTCGCCTGCTTGCGGCGGAGGATCATATTCTTCGCGGCAAGCGCTGCGCCGCCCGTGAT
GAGAAGACATGCGGCAAGAG

Product: beta-lactamase-like

Products: NA

Alternate protein names: Glyoxalase II; Glx II

Number of amino acids: Translated: 255; Mature: 254

Protein sequence:

>255_residues
MTLEIEQFMCRSDNFGILARDSETGITALVDAPEEQAILEAIKRTGWTPSLLLITHHHADHVEANLALKERFGLTIIGPA
KEASKIPGIDRQVNEGDVVRVGNQEARVIETPGHTAGHITFYFAKAGIAFTADTLFALGCGRLFECKPPVMYESLKKLVE
LPLETVIYCGHEYTESNARFALSVDPTNSALKERAKKIEALRREGRPTLPTTLGEEMATNPFLRCHDPVLRNNLGMKNAA
DVEVFAEIRKRKDVF

Sequences:

>Translated_255_residues
MTLEIEQFMCRSDNFGILARDSETGITALVDAPEEQAILEAIKRTGWTPSLLLITHHHADHVEANLALKERFGLTIIGPA
KEASKIPGIDRQVNEGDVVRVGNQEARVIETPGHTAGHITFYFAKAGIAFTADTLFALGCGRLFECKPPVMYESLKKLVE
LPLETVIYCGHEYTESNARFALSVDPTNSALKERAKKIEALRREGRPTLPTTLGEEMATNPFLRCHDPVLRNNLGMKNAA
DVEVFAEIRKRKDVF
>Mature_254_residues
TLEIEQFMCRSDNFGILARDSETGITALVDAPEEQAILEAIKRTGWTPSLLLITHHHADHVEANLALKERFGLTIIGPAK
EASKIPGIDRQVNEGDVVRVGNQEARVIETPGHTAGHITFYFAKAGIAFTADTLFALGCGRLFECKPPVMYESLKKLVEL
PLETVIYCGHEYTESNARFALSVDPTNSALKERAKKIEALRREGRPTLPTTLGEEMATNPFLRCHDPVLRNNLGMKNAAD
VEVFAEIRKRKDVF

Specific function: Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family

Homologues:

Organism=Homo sapiens, GI94538322, Length=261, Percent_Identity=33.3333333333333, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI94538320, Length=260, Percent_Identity=33.0769230769231, Blast_Score=152, Evalue=2e-37,
Organism=Homo sapiens, GI21703352, Length=256, Percent_Identity=33.203125, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI116642887, Length=256, Percent_Identity=33.203125, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI14150041, Length=246, Percent_Identity=34.9593495934959, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI46361987, Length=202, Percent_Identity=35.1485148514851, Blast_Score=113, Evalue=1e-25,
Organism=Homo sapiens, GI41327741, Length=169, Percent_Identity=31.3609467455621, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1786406, Length=247, Percent_Identity=40.080971659919, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1787158, Length=139, Percent_Identity=33.0935251798561, Blast_Score=81, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17536925, Length=265, Percent_Identity=35.0943396226415, Blast_Score=147, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17538952, Length=125, Percent_Identity=35.2, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320478, Length=252, Percent_Identity=30.5555555555556, Blast_Score=88, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324614, Length=226, Percent_Identity=31.858407079646, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21356335, Length=263, Percent_Identity=36.1216730038023, Blast_Score=162, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24667711, Length=263, Percent_Identity=36.1216730038023, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24667703, Length=263, Percent_Identity=36.1216730038023, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI221330176, Length=171, Percent_Identity=33.3333333333333, Blast_Score=86, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLO2_MESSB (Q11DS3)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_675617.1
- ProteinModelPortal:   Q11DS3
- SMR:   Q11DS3
- STRING:   Q11DS3
- GeneID:   4183267
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_3080
- NMPDR:   fig|266779.1.peg.204
- eggNOG:   COG0491
- HOGENOM:   HBG753931
- OMA:   FGHEYTL
- PhylomeDB:   Q11DS3
- ProtClustDB:   CLSK863794
- BioCyc:   MSP266779:MESO_3080-MONOMER
- HAMAP:   MF_01374
- InterPro:   IPR001279
- InterPro:   IPR017782
- SMART:   SM00849
- TIGRFAMs:   TIGR03413

Pfam domain/function: PF00753 Lactamase_B

EC number: =3.1.2.6

Molecular weight: Translated: 28314; Mature: 28183

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLEIEQFMCRSDNFGILARDSETGITALVDAPEEQAILEAIKRTGWTPSLLLITHHHAD
CEEEHHHHHHCCCCCEEEEECCCCCEEEEEECCHHHHHHHHHHHCCCCCEEEEEEECCCC
HVEANLALKERFGLTIIGPAKEASKIPGIDRQVNEGDVVRVGNQEARVIETPGHTAGHIT
CHHHHEEEHHHCCEEEECCCHHHHHCCCCCCCCCCCCEEEECCCCCEEEECCCCCCCEEE
FYFAKAGIAFTADTLFALGCGRLFECKPPVMYESLKKLVELPLETVIYCGHEYTESNARF
EEEEECCCEEHHHHHHHHCCCCEECCCCCHHHHHHHHHHHCCHHHEEECCCCCCCCCCEE
ALSVDPTNSALKERAKKIEALRREGRPTLPTTLGEEMATNPFLRCHDPVLRNNLGMKNAA
EEEECCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCEEECCHHHHCCCCCCCCC
DVEVFAEIRKRKDVF
HHHHHHHHHHHCCCC
>Mature Secondary Structure 
TLEIEQFMCRSDNFGILARDSETGITALVDAPEEQAILEAIKRTGWTPSLLLITHHHAD
EEEHHHHHHCCCCCEEEEECCCCCEEEEEECCHHHHHHHHHHHCCCCCEEEEEEECCCC
HVEANLALKERFGLTIIGPAKEASKIPGIDRQVNEGDVVRVGNQEARVIETPGHTAGHIT
CHHHHEEEHHHCCEEEECCCHHHHHCCCCCCCCCCCCEEEECCCCCEEEECCCCCCCEEE
FYFAKAGIAFTADTLFALGCGRLFECKPPVMYESLKKLVELPLETVIYCGHEYTESNARF
EEEEECCCEEHHHHHHHHCCCCEECCCCCHHHHHHHHHHHCCHHHEEECCCCCCCCCCEE
ALSVDPTNSALKERAKKIEALRREGRPTLPTTLGEEMATNPFLRCHDPVLRNNLGMKNAA
EEEECCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCEEECCHHHHCCCCCCCCC
DVEVFAEIRKRKDVF
HHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA