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The map label for this gene is metA

Identifier: 110635412

GI number: 110635412

Start: 3354615

End: 3355553

Strand: Reverse

Name: metA

Synonym: Meso_3083

Alternate gene names: 110635412

Gene position: 3355553-3354615 (Counterclockwise)

Preceding gene: 110635415

Following gene: 110635409

Centisome position: 76.05

GC content: 59.11

Gene sequence:

>939_bases
ATGCCGATCAAGATTCCCGATCAGCTGCCTGCCCGCGAGGTGCTTGTGCGCGAGGGCGTCTCCGTCATGGATGAAAAGAC
GGCGCTGCGTCAGGACATTCGTCCGCTGCAGATCGGGCTCTTGAATCTCATGCCGAACAAGATCCGCACCGAGACGCAGT
TCGCCCGCCTGATCGGGGCCAGCCCGCTCCAGGTGGAACTGACGCTGGTGCGCATCGGCAACCACAAAGCCAAGAACACG
CCGGAAGATCACCTCATCACCTTCTACGAAACCTGGGAAGAGGTGGCGCCGCGCAAGTTCGACGGCTTTATCGTGACGGG
TGCTCCCATCGAGCTTTTGCCTTACGAGGACGTCACCTATTGGAACGAAATGACGCGCATTCTCGATTGGACCACTTCCC
ACGTCCACTCCTCGTTTTTCATCTGCTGGGGCGCGATGGCCGCGGCCTGGCATTTCCACGGCATTCCGAAGCATACGTTG
GATAAAAAGGCGTTTGGGGTGTTCCGGCACCGCAACAATGCTCCCGCCTCTCCCTATCTCGCCGGGTTCTCGGACGATTT
GGCGCTTCCAGTCTCGCGCTGGACGGAGGTGCGCACTGCCGATATTCCCGCTAATTCCGGCTTGGAAATGCTCATGGATT
CGGACGAAACCGGCCCATGCCTGCTCGCGGAAGCCGCCGGGAACCGGCTCTATATGTTCAATCACATCGAGTATGATTCC
ACATCGCTCAAGGAGGAGTATGACCGGGACGTGGCCGCCGGTGTGCCGATCGAGGTGCCACATGAATATTACCCGGGCAA
TGATCCGACGCGGCCGCCGCTCAATCGCTGGCGCTCACACGCACATCTGCTCTTCGGCAACTGGATCAACCAGGTGTATC
AGACCACGCCTTACGATCTGGACAAGATCGGCAGGAACTTGGAGCATGCCCTTTCCTGA

Upstream 100 bases:

>100_bases
TTGCAGCCACGTAAAAGAAGTCGCTAAAAGGCCGTGGATACCAAGTCCGTTGGGACCGGCCGCGATTTCGCCGCCGGTCT
TTTTTGTTTGGAGTTTCACG

Downstream 100 bases:

>100_bases
CGGGCAACCAGGATAGCCTCATCACCCTAGAAGCGCCGCTGCATCTTTTGCGAGCTTCAGCGTGAGTTCGCCTGCGGGCA
TTGCCCTTGCAAGTGGCGCG

Product: homoserine O-succinyltransferase

Products: NA

Alternate protein names: Homoserine O-transsuccinylase; HTS

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MPIKIPDQLPAREVLVREGVSVMDEKTALRQDIRPLQIGLLNLMPNKIRTETQFARLIGASPLQVELTLVRIGNHKAKNT
PEDHLITFYETWEEVAPRKFDGFIVTGAPIELLPYEDVTYWNEMTRILDWTTSHVHSSFFICWGAMAAAWHFHGIPKHTL
DKKAFGVFRHRNNAPASPYLAGFSDDLALPVSRWTEVRTADIPANSGLEMLMDSDETGPCLLAEAAGNRLYMFNHIEYDS
TSLKEEYDRDVAAGVPIEVPHEYYPGNDPTRPPLNRWRSHAHLLFGNWINQVYQTTPYDLDKIGRNLEHALS

Sequences:

>Translated_312_residues
MPIKIPDQLPAREVLVREGVSVMDEKTALRQDIRPLQIGLLNLMPNKIRTETQFARLIGASPLQVELTLVRIGNHKAKNT
PEDHLITFYETWEEVAPRKFDGFIVTGAPIELLPYEDVTYWNEMTRILDWTTSHVHSSFFICWGAMAAAWHFHGIPKHTL
DKKAFGVFRHRNNAPASPYLAGFSDDLALPVSRWTEVRTADIPANSGLEMLMDSDETGPCLLAEAAGNRLYMFNHIEYDS
TSLKEEYDRDVAAGVPIEVPHEYYPGNDPTRPPLNRWRSHAHLLFGNWINQVYQTTPYDLDKIGRNLEHALS
>Mature_311_residues
PIKIPDQLPAREVLVREGVSVMDEKTALRQDIRPLQIGLLNLMPNKIRTETQFARLIGASPLQVELTLVRIGNHKAKNTP
EDHLITFYETWEEVAPRKFDGFIVTGAPIELLPYEDVTYWNEMTRILDWTTSHVHSSFFICWGAMAAAWHFHGIPKHTLD
KKAFGVFRHRNNAPASPYLAGFSDDLALPVSRWTEVRTADIPANSGLEMLMDSDETGPCLLAEAAGNRLYMFNHIEYDST
SLKEEYDRDVAAGVPIEVPHEYYPGNDPTRPPLNRWRSHAHLLFGNWINQVYQTTPYDLDKIGRNLEHALS

Specific function: Methionine biosynthesis; HTS variant; first step. [C]

COG id: COG1897

COG function: function code E; Homoserine trans-succinylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HTS family

Homologues:

Organism=Escherichia coli, GI1790443, Length=309, Percent_Identity=43.3656957928803, Blast_Score=268, Evalue=3e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): META_MESSB (Q11DS0)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_675620.1
- ProteinModelPortal:   Q11DS0
- SMR:   Q11DS0
- STRING:   Q11DS0
- GeneID:   4183270
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_3083
- NMPDR:   fig|266779.1.peg.201
- eggNOG:   COG1897
- HOGENOM:   HBG362506
- OMA:   QAGLYYH
- PhylomeDB:   Q11DS0
- ProtClustDB:   PRK05368
- BioCyc:   MSP266779:MESO_3083-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00295
- InterPro:   IPR005697
- PANTHER:   PTHR20919
- PIRSF:   PIRSF000450
- ProDom:   PD037892
- TIGRFAMs:   TIGR01001

Pfam domain/function: PF04204 HTS

EC number: =2.3.1.46

Molecular weight: Translated: 35573; Mature: 35442

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: NA

Important sites: ACT_SITE 142-142

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIKIPDQLPAREVLVREGVSVMDEKTALRQDIRPLQIGLLNLMPNKIRTETQFARLIGA
CCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHCC
SPLQVELTLVRIGNHKAKNTPEDHLITFYETWEEVAPRKFDGFIVTGAPIELLPYEDVTY
CCCEEEEEEEEECCCCCCCCCHHHEEEHHHHHHHHCCCCCCCEEEECCCEEEECCCCHHH
WNEMTRILDWTTSHVHSSFFICWGAMAAAWHFHGIPKHTLDKKAFGVFRHRNNAPASPYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCEE
AGFSDDLALPVSRWTEVRTADIPANSGLEMLMDSDETGPCLLAEAAGNRLYMFNHIEYDS
CCCCCCCCCCHHHHCCEEEECCCCCCCHHEEECCCCCCCEEEEECCCCEEEEEEECCCCC
TSLKEEYDRDVAAGVPIEVPHEYYPGNDPTRPPLNRWRSHAHLLFGNWINQVYQTTPYDL
HHHHHHHCCHHHCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCH
DKIGRNLEHALS
HHHCCHHHHHCC
>Mature Secondary Structure 
PIKIPDQLPAREVLVREGVSVMDEKTALRQDIRPLQIGLLNLMPNKIRTETQFARLIGA
CCCCCCCCCHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHCC
SPLQVELTLVRIGNHKAKNTPEDHLITFYETWEEVAPRKFDGFIVTGAPIELLPYEDVTY
CCCEEEEEEEEECCCCCCCCCHHHEEEHHHHHHHHCCCCCCCEEEECCCEEEECCCCHHH
WNEMTRILDWTTSHVHSSFFICWGAMAAAWHFHGIPKHTLDKKAFGVFRHRNNAPASPYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCEE
AGFSDDLALPVSRWTEVRTADIPANSGLEMLMDSDETGPCLLAEAAGNRLYMFNHIEYDS
CCCCCCCCCCHHHHCCEEEECCCCCCCHHEEECCCCCCCEEEEECCCCEEEEEEECCCCC
TSLKEEYDRDVAAGVPIEVPHEYYPGNDPTRPPLNRWRSHAHLLFGNWINQVYQTTPYDL
HHHHHHHCCHHHCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCH
DKIGRNLEHALS
HHHCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA