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The map label for this gene is hutI

Identifier: 110635315

GI number: 110635315

Start: 3246306

End: 3247559

Strand: Reverse

Name: hutI

Synonym: Meso_2986

Alternate gene names: 110635315

Gene position: 3247559-3246306 (Counterclockwise)

Preceding gene: 110635321

Following gene: 110635314

Centisome position: 73.6

GC content: 62.68

Gene sequence:

>1254_bases
ATGACTCGGAACAATTTTTCCGGAGCGGCCGCACACTCCGCTCGTTCGATTTGGCGCAATGGGCGTCTGGCGACGCTGCG
GGAGGATTTGCAGGGGCTCGGTATTGTCGAGAACGGCGCTGTCGTCTGCGAAGGCGGGCGCATCCTCTTTGCCGGACCGG
AAGGCGAACTGCCCGCTGAGCTGATCGAGAATACCGAGATCACCGATCTTGAGGGACGCTGGGTCACACCCGGCCTCGTC
GATTGCCACACGCATATCGTCTATGGCGGCAACCGGGCGCGCGAATTCGAGATGCGCCTCCAAGGCGCGACCTATGAAGA
AATTGCGCGTGCCGGCGGCGGCATCGTCTCCTCCGTGAAGGCGACCAACGCGCTCTCCGTCGAAGGATTGGTCGAAGCCG
CGCTGCCGCGGCTCGACACACTGATCTCGGAAGGTGTCACCACCGTCGAGATCAAGTCCGGCTATGGCCTCAATATCGAG
GCGGAGCTGAAAATGCTGTGCGCTGCCCGAGCTCTTGAGCAGATTCGCCCGGTGCGGGTCGTCACCTCCTATCTCGGCGC
CCATGCAACGCCCGTCGAATACAAGGGACGAAACGGGGATTACATTTCCGAGGTGGTCCTGCCCGGACTTGAACGGGCGC
ATGCCGAGGGCCTCGTCGATGCAGTAGACGGCTTCTGCGAAGGCATCGCCTTCTCGGTGGACGAGATAAGGCGGGTCTTC
GACAAGGCCCGTTCGCTCGGTATTCCCGTCAAGCTTCATGCAGAGCAGCTCTCTAATCTCGGCGGCGCCAAACTCGCCGC
CTCCTATGGCGCGCTTTCGGCCGATCATCTGGAATATTTGGATGAGGATGGCGCGCGCGCAATGGCGGCTGCCGGCACGG
TCGCAGTCCTGCTTCCGGGCGCCTTCTACGCTATCAACGAAAAGCAAAAGCCGCCCGTTGAGGCGCTGCGGCAAGCCGGC
GTGCATATCGCGATCGCAACGGACAGCAATCCGGGCACCTCGCCGCTGACCTCTCTGCTGCTCACCATGAACATGTCGGC
CACGCTGTTCAGGCTGACCGTGGAAGAATGCATTGCCGGCGCCACCCGCGAGGGCGCCCGTGCGCTCGGCCTGCTGGCTG
AGACCGGCACGATCGAAGCCGGCAAGTCCGCCGATCTGGCGATCTGGAATATCGAGAGCCCCGCCGAGCTCGTCTACCGC
ATCGGCTTCAACCCGCTTCACGCACATATTTTCAAGGGCCGGAGGATCGACTGA

Upstream 100 bases:

>100_bases
GTGCTTGCTTCGGCTCGAAATCTGAGGCGGCGAGATTCCGCTTGCGGCCTACATCATTATGTATATACATGTATGATGAG
TTTTGAAGGGCGAAAAGCTG

Downstream 100 bases:

>100_bases
TGACTATCATCCTACACCCTGGTTCGGTCTTGCTTCGGGATCTCGCGACAATTTACTGGACCGGCGTCCCGGCCAGGCTT
GATCCGTCTTTCGACGCAGG

Product: imidazolonepropionase

Products: NA

Alternate protein names: Imidazolone-5-propionate hydrolase

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MTRNNFSGAAAHSARSIWRNGRLATLREDLQGLGIVENGAVVCEGGRILFAGPEGELPAELIENTEITDLEGRWVTPGLV
DCHTHIVYGGNRAREFEMRLQGATYEEIARAGGGIVSSVKATNALSVEGLVEAALPRLDTLISEGVTTVEIKSGYGLNIE
AELKMLCAARALEQIRPVRVVTSYLGAHATPVEYKGRNGDYISEVVLPGLERAHAEGLVDAVDGFCEGIAFSVDEIRRVF
DKARSLGIPVKLHAEQLSNLGGAKLAASYGALSADHLEYLDEDGARAMAAAGTVAVLLPGAFYAINEKQKPPVEALRQAG
VHIAIATDSNPGTSPLTSLLLTMNMSATLFRLTVEECIAGATREGARALGLLAETGTIEAGKSADLAIWNIESPAELVYR
IGFNPLHAHIFKGRRID

Sequences:

>Translated_417_residues
MTRNNFSGAAAHSARSIWRNGRLATLREDLQGLGIVENGAVVCEGGRILFAGPEGELPAELIENTEITDLEGRWVTPGLV
DCHTHIVYGGNRAREFEMRLQGATYEEIARAGGGIVSSVKATNALSVEGLVEAALPRLDTLISEGVTTVEIKSGYGLNIE
AELKMLCAARALEQIRPVRVVTSYLGAHATPVEYKGRNGDYISEVVLPGLERAHAEGLVDAVDGFCEGIAFSVDEIRRVF
DKARSLGIPVKLHAEQLSNLGGAKLAASYGALSADHLEYLDEDGARAMAAAGTVAVLLPGAFYAINEKQKPPVEALRQAG
VHIAIATDSNPGTSPLTSLLLTMNMSATLFRLTVEECIAGATREGARALGLLAETGTIEAGKSADLAIWNIESPAELVYR
IGFNPLHAHIFKGRRID
>Mature_416_residues
TRNNFSGAAAHSARSIWRNGRLATLREDLQGLGIVENGAVVCEGGRILFAGPEGELPAELIENTEITDLEGRWVTPGLVD
CHTHIVYGGNRAREFEMRLQGATYEEIARAGGGIVSSVKATNALSVEGLVEAALPRLDTLISEGVTTVEIKSGYGLNIEA
ELKMLCAARALEQIRPVRVVTSYLGAHATPVEYKGRNGDYISEVVLPGLERAHAEGLVDAVDGFCEGIAFSVDEIRRVFD
KARSLGIPVKLHAEQLSNLGGAKLAASYGALSADHLEYLDEDGARAMAAAGTVAVLLPGAFYAINEKQKPPVEALRQAGV
HIAIATDSNPGTSPLTSLLLTMNMSATLFRLTVEECIAGATREGARALGLLAETGTIEAGKSADLAIWNIESPAELVYRI
GFNPLHAHIFKGRRID

Specific function: Unknown

COG id: COG1228

COG function: function code Q; Imidazolonepropionase and related amidohydrolases

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hutI family

Homologues:

Organism=Homo sapiens, GI223972677, Length=388, Percent_Identity=36.340206185567, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17555004, Length=371, Percent_Identity=33.4231805929919, Blast_Score=194, Evalue=6e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTI_MESSB (Q11E17)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_675523.1
- ProteinModelPortal:   Q11E17
- SMR:   Q11E17
- STRING:   Q11E17
- GeneID:   4181422
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_2986
- NMPDR:   fig|266779.1.peg.1514
- eggNOG:   COG1228
- HOGENOM:   HBG686142
- OMA:   MNMACTL
- ProtClustDB:   PRK09356
- BioCyc:   MSP266779:MESO_2986-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00372
- InterPro:   IPR006680
- InterPro:   IPR005920
- InterPro:   IPR011059
- TIGRFAMs:   TIGR01224

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.2.7

Molecular weight: Translated: 44375; Mature: 44244

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: BINDING 92-92 BINDING 105-105 BINDING 155-155 BINDING 188-188 BINDING 256-256

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRNNFSGAAAHSARSIWRNGRLATLREDLQGLGIVENGAVVCEGGRILFAGPEGELPAE
CCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCEEECCEEEEECCEEEEECCCCCCCHH
LIENTEITDLEGRWVTPGLVDCHTHIVYGGNRAREFEMRLQGATYEEIARAGGGIVSSVK
HHCCCCEEECCCCCCCCCCEECEEEEEECCCCCEEEEEEECCCCHHHHHHCCCCCEEHHH
ATNALSVEGLVEAALPRLDTLISEGVTTVEIKSGYGLNIEAELKMLCAARALEQIRPVRV
HCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCHHHH
VTSYLGAHATPVEYKGRNGDYISEVVLPGLERAHAEGLVDAVDGFCEGIAFSVDEIRRVF
HHHHHCCCCCCCEECCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
DKARSLGIPVKLHAEQLSNLGGAKLAASYGALSADHLEYLDEDGARAMAAAGTVAVLLPG
HHHHHCCCCEEEEHHHHCCCCCHHHHHHHCCCCHHHHHHHCCCCCHHHHHCCEEEEEECC
AFYAINEKQKPPVEALRQAGVHIAIATDSNPGTSPLTSLLLTMNMSATLFRLTVEECIAG
EEEEECCCCCCHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHCCCHHHHHEEHHHHHCC
ATREGARALGLLAETGTIEAGKSADLAIWNIESPAELVYRIGFNPLHAHIFKGRRID
CCCCCHHHHHEEEECCCCCCCCCCCEEEEECCCHHHHHHHCCCCHHHHHHCCCCCCC
>Mature Secondary Structure 
TRNNFSGAAAHSARSIWRNGRLATLREDLQGLGIVENGAVVCEGGRILFAGPEGELPAE
CCCCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCEEECCEEEEECCEEEEECCCCCCCHH
LIENTEITDLEGRWVTPGLVDCHTHIVYGGNRAREFEMRLQGATYEEIARAGGGIVSSVK
HHCCCCEEECCCCCCCCCCEECEEEEEECCCCCEEEEEEECCCCHHHHHHCCCCCEEHHH
ATNALSVEGLVEAALPRLDTLISEGVTTVEIKSGYGLNIEAELKMLCAARALEQIRPVRV
HCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCHHHH
VTSYLGAHATPVEYKGRNGDYISEVVLPGLERAHAEGLVDAVDGFCEGIAFSVDEIRRVF
HHHHHCCCCCCCEECCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
DKARSLGIPVKLHAEQLSNLGGAKLAASYGALSADHLEYLDEDGARAMAAAGTVAVLLPG
HHHHHCCCCEEEEHHHHCCCCCHHHHHHHCCCCHHHHHHHCCCCCHHHHHCCEEEEEECC
AFYAINEKQKPPVEALRQAGVHIAIATDSNPGTSPLTSLLLTMNMSATLFRLTVEECIAG
EEEEECCCCCCHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHCCCHHHHHEEHHHHHCC
ATREGARALGLLAETGTIEAGKSADLAIWNIESPAELVYRIGFNPLHAHIFKGRRID
CCCCCHHHHHEEEECCCCCCCCCCCEEEEECCCHHHHHHHCCCCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA