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The map label for this gene is hutH

Identifier: 110635314

GI number: 110635314

Start: 3244771

End: 3246306

Strand: Reverse

Name: hutH

Synonym: Meso_2985

Alternate gene names: 110635314

Gene position: 3246306-3244771 (Counterclockwise)

Preceding gene: 110635315

Following gene: 110635313

Centisome position: 73.57

GC content: 63.15

Gene sequence:

>1536_bases
ATGACTATCATCCTACACCCTGGTTCGGTCTTGCTTCGGGATCTCGCGACAATTTACTGGACCGGCGTCCCGGCCAGGCT
TGATCCGTCTTTCGACGCAGGCATCGTCAAGGCGGCTGACCGCATCGCGGAGATTGCCGCCGGCAACGCGCCGGTCTACG
GCATCAATACCGGCTTTGGTAAGCTTGCCTCGATCAAGATCGACAGCGCCGATGTAGCGGCGCTCCAGCGCAACCTCGTT
CTCTCCCATTGTTGTGGTGTCGGCGAGGCCCTGCCGGAAAATGTAGTGCGCCTCATGATGGCCCTGAAGCTTGTTTCGCT
CGGCCGTGGCGCCTCCGGCGTGCGGCTCGAACTGGTGCGGCTGATCGAGGCGATGTTGGCGCGCGGCGTCATCCCGGTCA
TTCCGGAAAAGGGCTCGGTCGGCGCTTCCGGCGACCTCGCCCCGCTCGCTCATATGGCGGCTGTCATGATGGGCCATGGC
GAGGCGTTCTTCGGCGGCGAAAGGCTGAACGGCGCGACGGCACTTCTGAAGGCCGGATTGCAGCCTGTCGAGCTCGCAGC
CAAGGAGGGACTGGCGCTTATCAACGGTACGCAGACCTCGACGGCGCTGGCGCTTGCCGGCCTGTTTCGCGCCCACCGAG
CGGCGCAATCGGCTCTGATTACCGGCGCTATGTCGACGGATGCGGCGATGGGCTCATCGGCGCCGTTCCATCCCGAGATC
CACACGCTACGCGGCCATCGCGGCCAGATCGATACGGCAGAGGCCCTGCGCGCCCTGCTTGAAAACTCTCCGATCCGCCA
GAGCCATATCGAAGGCGACGAGCGTGTTCAGGACCCTTATTGCATTCGGTGCCAGCCGCAGGTTGACGGCGCTTGTCTCG
ATCTGCTGCGCTCCGTTGCCCGCACGCTCGAGATCGAAGCCAATGCGGTGACCGACAATCCGCTGGTGCTCTCAGACAAT
TCCGTCGTCGCCGGCGGCAACTTCCACGCGGAACCCGTTGCCTTCGCAGCCGACCAGATCGTGCTTGCGATTTGCGAGAT
CGGCGCGATCGCGCAGCGCCGCATCGCCCTGCTCGTCGACCCGGCTCTCTCCTACGGCCTGCCGGCCTTCCTTGCCAAGA
AGCCGGGGCTCAATTCCGGTCTTATGATCGCCGAAGTCACATCGGCTGCGCTGATGAGCGAAAACAAGCAGATGTCGCAC
CCGGCCTCCGTCGACTCTACGCCGACATCGGCCAATCAGGAAGACCATGTCTCCATGGCCTGCCATGGCGCACGACGACT
CCTGCCGATGACTGAAAACCTCTTCGCAATTATCGGCATCGAGGCATTGTGCGCCGCACAGGGGGTGGAGCTGCGCGCAC
CGCTTGCGACCAGCCCCGAGCTTACGAAGGCGATCGCAGCCATCCGAAACGTCGTACCGTCGCTCGAGGAAGACCGTTAC
ATGGCAAACGACCTGAAAGCGGCCACGGTTCTGATTGCCAGCGGCAGTCTCAATGAATCCGTTTCAAGCGGCATCCTGCC
CGCTTTGGAGGTCTGA

Upstream 100 bases:

>100_bases
ATCTGGCGATCTGGAATATCGAGAGCCCCGCCGAGCTCGTCTACCGCATCGGCTTCAACCCGCTTCACGCACATATTTTC
AAGGGCCGGAGGATCGACTG

Downstream 100 bases:

>100_bases
CATGTCTGTTTTCGAAGTCAAACAAGGCACCTCCCCCGTTATCCTCGGCTTTCCCCATACCGGCACCGAGGTTCCGCCCG
ATATATGGGAGCGCCTGAAC

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase

Number of amino acids: Translated: 511; Mature: 510

Protein sequence:

>511_residues
MTIILHPGSVLLRDLATIYWTGVPARLDPSFDAGIVKAADRIAEIAAGNAPVYGINTGFGKLASIKIDSADVAALQRNLV
LSHCCGVGEALPENVVRLMMALKLVSLGRGASGVRLELVRLIEAMLARGVIPVIPEKGSVGASGDLAPLAHMAAVMMGHG
EAFFGGERLNGATALLKAGLQPVELAAKEGLALINGTQTSTALALAGLFRAHRAAQSALITGAMSTDAAMGSSAPFHPEI
HTLRGHRGQIDTAEALRALLENSPIRQSHIEGDERVQDPYCIRCQPQVDGACLDLLRSVARTLEIEANAVTDNPLVLSDN
SVVAGGNFHAEPVAFAADQIVLAICEIGAIAQRRIALLVDPALSYGLPAFLAKKPGLNSGLMIAEVTSAALMSENKQMSH
PASVDSTPTSANQEDHVSMACHGARRLLPMTENLFAIIGIEALCAAQGVELRAPLATSPELTKAIAAIRNVVPSLEEDRY
MANDLKAATVLIASGSLNESVSSGILPALEV

Sequences:

>Translated_511_residues
MTIILHPGSVLLRDLATIYWTGVPARLDPSFDAGIVKAADRIAEIAAGNAPVYGINTGFGKLASIKIDSADVAALQRNLV
LSHCCGVGEALPENVVRLMMALKLVSLGRGASGVRLELVRLIEAMLARGVIPVIPEKGSVGASGDLAPLAHMAAVMMGHG
EAFFGGERLNGATALLKAGLQPVELAAKEGLALINGTQTSTALALAGLFRAHRAAQSALITGAMSTDAAMGSSAPFHPEI
HTLRGHRGQIDTAEALRALLENSPIRQSHIEGDERVQDPYCIRCQPQVDGACLDLLRSVARTLEIEANAVTDNPLVLSDN
SVVAGGNFHAEPVAFAADQIVLAICEIGAIAQRRIALLVDPALSYGLPAFLAKKPGLNSGLMIAEVTSAALMSENKQMSH
PASVDSTPTSANQEDHVSMACHGARRLLPMTENLFAIIGIEALCAAQGVELRAPLATSPELTKAIAAIRNVVPSLEEDRY
MANDLKAATVLIASGSLNESVSSGILPALEV
>Mature_510_residues
TIILHPGSVLLRDLATIYWTGVPARLDPSFDAGIVKAADRIAEIAAGNAPVYGINTGFGKLASIKIDSADVAALQRNLVL
SHCCGVGEALPENVVRLMMALKLVSLGRGASGVRLELVRLIEAMLARGVIPVIPEKGSVGASGDLAPLAHMAAVMMGHGE
AFFGGERLNGATALLKAGLQPVELAAKEGLALINGTQTSTALALAGLFRAHRAAQSALITGAMSTDAAMGSSAPFHPEIH
TLRGHRGQIDTAEALRALLENSPIRQSHIEGDERVQDPYCIRCQPQVDGACLDLLRSVARTLEIEANAVTDNPLVLSDNS
VVAGGNFHAEPVAFAADQIVLAICEIGAIAQRRIALLVDPALSYGLPAFLAKKPGLNSGLMIAEVTSAALMSENKQMSHP
ASVDSTPTSANQEDHVSMACHGARRLLPMTENLFAIIGIEALCAAQGVELRAPLATSPELTKAIAAIRNVVPSLEEDRYM
ANDLKAATVLIASGSLNESVSSGILPALEV

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family

Homologues:

Organism=Homo sapiens, GI4504333, Length=480, Percent_Identity=43.3333333333333, Blast_Score=354, Evalue=1e-97,
Organism=Caenorhabditis elegans, GI17567831, Length=515, Percent_Identity=40.3883495145631, Blast_Score=332, Evalue=4e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTH_MESSB (Q11E18)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_675522.1
- ProteinModelPortal:   Q11E18
- SMR:   Q11E18
- STRING:   Q11E18
- GeneID:   4181421
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_2985
- NMPDR:   fig|266779.1.peg.1513
- eggNOG:   COG2986
- HOGENOM:   HBG510887
- OMA:   HIEGDER
- ProtClustDB:   PRK09367
- BioCyc:   MSP266779:MESO_2985-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00229
- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313
- TIGRFAMs:   TIGR01225

Pfam domain/function: PF00221 PAL; SSF48557 L-Aspartase-like

EC number: =4.3.1.3

Molecular weight: Translated: 53243; Mature: 53112

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIILHPGSVLLRDLATIYWTGVPARLDPSFDAGIVKAADRIAEIAAGNAPVYGINTGFG
CEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCC
KLASIKIDSADVAALQRNLVLSHCCGVGEALPENVVRLMMALKLVSLGRGASGVRLELVR
CEEEEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
LIEAMLARGVIPVIPEKGSVGASGDLAPLAHMAAVMMGHGEAFFGGERLNGATALLKAGL
HHHHHHHCCCEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHCCC
QPVELAAKEGLALINGTQTSTALALAGLFRAHRAAQSALITGAMSTDAAMGSSAPFHPEI
CHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCCH
HTLRGHRGQIDTAEALRALLENSPIRQSHIEGDERVQDPYCIRCQPQVDGACLDLLRSVA
HHCCCCCCCCCHHHHHHHHHCCCCCCHHHCCCHHHCCCCEEEEECCCCCHHHHHHHHHHH
RTLEIEANAVTDNPLVLSDNSVVAGGNFHAEPVAFAADQIVLAICEIGAIAQRRIALLVD
HHEEEEEEEECCCCEEEECCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEC
PALSYGLPAFLAKKPGLNSGLMIAEVTSAALMSENKQMSHPASVDSTPTSANQEDHVSMA
CHHHHCCCHHHHCCCCCCCCEEHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHH
CHGARRLLPMTENLFAIIGIEALCAAQGVELRAPLATSPELTKAIAAIRNVVPSLEEDRY
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCCHH
MANDLKAATVLIASGSLNESVSSGILPALEV
HHHHHCEEEEEEECCCCCHHHHHCCCCCCCC
>Mature Secondary Structure 
TIILHPGSVLLRDLATIYWTGVPARLDPSFDAGIVKAADRIAEIAAGNAPVYGINTGFG
EEEECCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCC
KLASIKIDSADVAALQRNLVLSHCCGVGEALPENVVRLMMALKLVSLGRGASGVRLELVR
CEEEEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
LIEAMLARGVIPVIPEKGSVGASGDLAPLAHMAAVMMGHGEAFFGGERLNGATALLKAGL
HHHHHHHCCCEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHCCC
QPVELAAKEGLALINGTQTSTALALAGLFRAHRAAQSALITGAMSTDAAMGSSAPFHPEI
CHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCCH
HTLRGHRGQIDTAEALRALLENSPIRQSHIEGDERVQDPYCIRCQPQVDGACLDLLRSVA
HHCCCCCCCCCHHHHHHHHHCCCCCCHHHCCCHHHCCCCEEEEECCCCCHHHHHHHHHHH
RTLEIEANAVTDNPLVLSDNSVVAGGNFHAEPVAFAADQIVLAICEIGAIAQRRIALLVD
HHEEEEEEEECCCCEEEECCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEC
PALSYGLPAFLAKKPGLNSGLMIAEVTSAALMSENKQMSHPASVDSTPTSANQEDHVSMA
CHHHHCCCHHHHCCCCCCCCEEHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHH
CHGARRLLPMTENLFAIIGIEALCAAQGVELRAPLATSPELTKAIAAIRNVVPSLEEDRY
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCCHH
MANDLKAATVLIASGSLNESVSSGILPALEV
HHHHHCEEEEEEECCCCCHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA