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The map label for this gene is menB [H]

Identifier: 110635282

GI number: 110635282

Start: 3212822

End: 3213601

Strand: Reverse

Name: menB [H]

Synonym: Meso_2953

Alternate gene names: 110635282

Gene position: 3213601-3212822 (Counterclockwise)

Preceding gene: 110635283

Following gene: 110635281

Centisome position: 72.83

GC content: 56.67

Gene sequence:

>780_bases
ATGACCTACCAGCAGATCCTCTATGAAGAAGACGGACCAATCGGCACCATTACGCTGAATCGTCCGGACAATGGCAACAT
GTTTACGGCCACCATGTGCCACGAGATCCGCGATTGCCTCAACGAGATACGGCGGGAGACGCGCACCCGCGTCATCGTGT
TGACGGGCGCCGGCGATAAATTCTTCTGCATCGGCGGAGAAAAGACCGGCATGGAGGATTCCAAGCTCTATGCGGGAACG
CTGCCAGTTCTGGAGATATATGACGCGATCGATAAGCTGCAAAAGCCGGTCATTGCCTCGGTCAATGGCTTCGCCGTGGG
CGGGGGCAATGTGCTTCAGGTCGTCTGCGATCTCACCATTGCGAAGGAAAGCGCGATTTTTCGTCAGGTCGGGCCGTCGA
TGGGCTCTTTTGATGCCGGTTATGGCACCTGGTATCTGGAGGATCTTGTCGGGAAGAAGCGCGCCAAGGAAATTTGGTAC
TGCAACAACAAGATGACAGCCGCCGAGGCTCTGGACATCGGTCTGATCAACCGCGTGGTTCCCGACGATCAGCTGAAGGA
AAAAACGCGCGAATTCGCGCTCGAGATCGCCCGTCGGGGTGCGTTTGCGCTTGCATCGATCAAAAGCGCTTTCCTGGCGC
GGCATGGAGGCGTCGCCGGCTTGTCACGCGTGACGCACGATCTGCTGTTGTCCCAATATCTGGGCACGGAAGAACAGAAG
GAGCTTTTCGCAAGCTTCAATGAACGGCGTGAGCCCGATAGCTCCAAATTCGGCCATTGA

Upstream 100 bases:

>100_bases
GCGGTCGGGCCCGCCACTTCTGGGCCAGCACACAGAGGAGGTGCTGACCAGGTTTCGCGGCGCTTGTTAGTGAATTCCGG
AGCGAGTGAAAGGACATCAA

Downstream 100 bases:

>100_bases
CGAGAGCGGCATGCGACCATTCCTGACACTGCACGATCCCGGACAGGCCAGATCCTTCTATGGAAAGGGCCTGTGGGGCG
ACGACACGTTCTACGATTTG

Product: 1,4-dihydroxy-2-naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 259; Mature: 258

Protein sequence:

>259_residues
MTYQQILYEEDGPIGTITLNRPDNGNMFTATMCHEIRDCLNEIRRETRTRVIVLTGAGDKFFCIGGEKTGMEDSKLYAGT
LPVLEIYDAIDKLQKPVIASVNGFAVGGGNVLQVVCDLTIAKESAIFRQVGPSMGSFDAGYGTWYLEDLVGKKRAKEIWY
CNNKMTAAEALDIGLINRVVPDDQLKEKTREFALEIARRGAFALASIKSAFLARHGGVAGLSRVTHDLLLSQYLGTEEQK
ELFASFNERREPDSSKFGH

Sequences:

>Translated_259_residues
MTYQQILYEEDGPIGTITLNRPDNGNMFTATMCHEIRDCLNEIRRETRTRVIVLTGAGDKFFCIGGEKTGMEDSKLYAGT
LPVLEIYDAIDKLQKPVIASVNGFAVGGGNVLQVVCDLTIAKESAIFRQVGPSMGSFDAGYGTWYLEDLVGKKRAKEIWY
CNNKMTAAEALDIGLINRVVPDDQLKEKTREFALEIARRGAFALASIKSAFLARHGGVAGLSRVTHDLLLSQYLGTEEQK
ELFASFNERREPDSSKFGH
>Mature_258_residues
TYQQILYEEDGPIGTITLNRPDNGNMFTATMCHEIRDCLNEIRRETRTRVIVLTGAGDKFFCIGGEKTGMEDSKLYAGTL
PVLEIYDAIDKLQKPVIASVNGFAVGGGNVLQVVCDLTIAKESAIFRQVGPSMGSFDAGYGTWYLEDLVGKKRAKEIWYC
NNKMTAAEALDIGLINRVVPDDQLKEKTREFALEIARRGAFALASIKSAFLARHGGVAGLSRVTHDLLLSQYLGTEEQKE
LFASFNERREPDSSKFGH

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=261, Percent_Identity=30.2681992337165, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI70995211, Length=253, Percent_Identity=29.2490118577075, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI37594469, Length=155, Percent_Identity=32.258064516129, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI37594471, Length=155, Percent_Identity=33.5483870967742, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI260274832, Length=190, Percent_Identity=28.4210526315789, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI45643119, Length=190, Percent_Identity=28.4210526315789, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI260275230, Length=190, Percent_Identity=28.4210526315789, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI68989263, Length=187, Percent_Identity=29.9465240641711, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI4502327, Length=258, Percent_Identity=25.968992248062, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI31542718, Length=250, Percent_Identity=25.2, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1788597, Length=262, Percent_Identity=40.8396946564886, Blast_Score=185, Evalue=3e-48,
Organism=Escherichia coli, GI1787659, Length=245, Percent_Identity=29.3877551020408, Blast_Score=97, Evalue=8e-22,
Organism=Escherichia coli, GI221142681, Length=252, Percent_Identity=30.5555555555556, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1787660, Length=219, Percent_Identity=31.5068493150685, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI87082183, Length=267, Percent_Identity=23.5955056179775, Blast_Score=72, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17554946, Length=252, Percent_Identity=30.1587301587302, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI25145438, Length=242, Percent_Identity=29.3388429752066, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17540714, Length=205, Percent_Identity=29.2682926829268, Blast_Score=98, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17536985, Length=274, Percent_Identity=25.5474452554745, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17535521, Length=191, Percent_Identity=28.2722513089005, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17549921, Length=182, Percent_Identity=28.5714285714286, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17560910, Length=204, Percent_Identity=27.9411764705882, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI20129971, Length=179, Percent_Identity=35.7541899441341, Blast_Score=101, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24653477, Length=179, Percent_Identity=35.7541899441341, Blast_Score=101, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24653139, Length=250, Percent_Identity=30.4, Blast_Score=98, Evalue=7e-21,
Organism=Drosophila melanogaster, GI21357171, Length=262, Percent_Identity=25.9541984732824, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19922422, Length=252, Percent_Identity=24.6031746031746, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24650670, Length=207, Percent_Identity=28.5024154589372, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 28669; Mature: 28538

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYQQILYEEDGPIGTITLNRPDNGNMFTATMCHEIRDCLNEIRRETRTRVIVLTGAGDK
CCHHHHEEECCCCEEEEEECCCCCCCEEHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCE
FFCIGGEKTGMEDSKLYAGTLPVLEIYDAIDKLQKPVIASVNGFAVGGGNVLQVVCDLTI
EEEECCCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCEECCCCEEECCCHHHHHHHHHHH
AKESAIFRQVGPSMGSFDAGYGTWYLEDLVGKKRAKEIWYCNNKMTAAEALDIGLINRVV
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHCC
PDDQLKEKTREFALEIARRGAFALASIKSAFLARHGGVAGLSRVTHDLLLSQYLGTEEQK
CCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHH
ELFASFNERREPDSSKFGH
HHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TYQQILYEEDGPIGTITLNRPDNGNMFTATMCHEIRDCLNEIRRETRTRVIVLTGAGDK
CHHHHEEECCCCEEEEEECCCCCCCEEHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCE
FFCIGGEKTGMEDSKLYAGTLPVLEIYDAIDKLQKPVIASVNGFAVGGGNVLQVVCDLTI
EEEECCCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCEECCCCEEECCCHHHHHHHHHHH
AKESAIFRQVGPSMGSFDAGYGTWYLEDLVGKKRAKEIWYCNNKMTAAEALDIGLINRVV
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHCC
PDDQLKEKTREFALEIARRGAFALASIKSAFLARHGGVAGLSRVTHDLLLSQYLGTEEQK
CCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHH
ELFASFNERREPDSSKFGH
HHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629163; 8566759; 9387221; 9384377 [H]