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The map label for this gene is hbd [H]

Identifier: 110635277

GI number: 110635277

Start: 3207035

End: 3208555

Strand: Reverse

Name: hbd [H]

Synonym: Meso_2948

Alternate gene names: 110635277

Gene position: 3208555-3207035 (Counterclockwise)

Preceding gene: 110635278

Following gene: 110635276

Centisome position: 72.72

GC content: 60.36

Gene sequence:

>1521_bases
ATGACCGAGATCAAGAAGGTTGCCATCTGCGGCGCAGGCGGAACCATGGGGGCGGGTATAGCGATGGTGGCTGCCCGAGC
CGGTTTTCAGACAATCTGTTTCGACCAGAATGGCGAAGCGTTGAGACGTAGCATCGGCGCTGCTGAGGATTTTTTTCGCA
AATCGGTGGAAAAGGGCCGGATGAGCCCGGACGATTGCGACAATGCTTTATCCCGGATGACGACTTCGACCAATCTGAAG
GATTTGGCTGATTGCGACCTGATCATCGAGGCGATCTTCGAAAACCTCGAGGCTAAGCAGCAGCTGTTCCGCAGTCTGAA
CGAGATCTGTAAGCCCGAGACCATACTGGCCTCCAACACTTCGACTCTCTCAATCACACAGATCGCGTCGGGCTGCGGCC
GTGAGGACCGCGTGGTGGGAACGCATTTTTGCCTGCCCGCTCAGCTGATGAAACTGGTCGAGATGTCACGCGGCATCAAC
ACTTCCGACGGCGTCTTTTCCGCCGCCCTTGCGTGGACGAAGGCGGCGGGGCAATTGCCGGTCGAGACGCAGGATAAGCC
AGGCTTCATCCTCAACGCGCTTCTGGTTCCGTTCAATAACGACGTGTTGCGCGCCATAGAGGCTGGACTTGCCACAGCTG
AGGATATCGACCTGGCGATACGCTCGGGTCTTGGCTATAAAATGGGGCCCTGCACGCTGCTGGACCTGATCGGACTTGAT
ACACAGGTCCGGCTGGGCGAGGCGTTCTATCCGATCACGCTGGACAAACGCGCCTCTGTTCCGCCGATACTGCGCCGCAT
GGTTGCCGCTGGTGTTCTGGGAAATAAATCCGGCAAGGGCCTGCTGACGGGATATGAGCCCAAGCGCGCCAGCCGAGTAC
CCTCTTTCGAGGCCATGGCAGCAGGTGAGAGCCGGTCCTTTCCCAAGGGCGATGATGCGTTCCTCTCAAGAGCTGTAGAT
GGTGGCGAGGTGCTTGTTTGTCTTGGCGGCGCTTATCAGGAAGATTCCGGGCGGAAGGCGGTACTCGTTGAGTTGGGCAG
CGAATGCCTTGGCTTTCATACCGGTGAGAATTCGGGGCGCGAAGGATCAAATGTGCTTGGCTTCGCGCGTTATCGTAACG
GCGGGGACGCGCCGACAAATTTGGTTGAGCTGGTCCGCCAGCCCCGCACGGATGCCGAAGCGATCATGGCTGCCCGCGCG
ATCTTCGAGGATGCGGGTTTCGATGTGGTGATCTGCGCAGATCAGCCGGGCCGCATCGTCGACCGTCTCGTTCGGCCGAA
ATACAACGACGCTCTGCGCCTTCTCGACGAGGGGCTGGCAACGGCCGAGGACATGGACATGACCTGCCGCCTGGGCCTGG
GATATCCCGAGGGCCCGATCGAACGTGTGACCCGAGGAGGACTGGCCTATCACTGTGCCGTGAGCGGAGAGATCTACCGG
CTGACGGGGCTTCCGGCATATGCGCCGGCGCGGCGCGCCGTGGTCGCTGCCGATCGCGCGGCACAACGAGGCCCCGTATG
A

Upstream 100 bases:

>100_bases
ACCGCGCCGAGCGGCTGATGCGCGATGCCAAGATCACCCAGATCTGGGAAGGCACGAACCAGATTCACCGCCAACTCATC
GGACGGAGCTTCAGAACAAA

Downstream 100 bases:

>100_bases
AAGCGGTCGTCAGCCACGAATTCGCACCGTTCAGGCACGTTCTAGTCGAGCAGATGCCCGACCCTGTGCCAGGGACTGGC
GAGCTTGTGATCGACATCGA

Product: 3-hydroxyacyl-CoA dehydrogenase, NAD-binding

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 506; Mature: 505

Protein sequence:

>506_residues
MTEIKKVAICGAGGTMGAGIAMVAARAGFQTICFDQNGEALRRSIGAAEDFFRKSVEKGRMSPDDCDNALSRMTTSTNLK
DLADCDLIIEAIFENLEAKQQLFRSLNEICKPETILASNTSTLSITQIASGCGREDRVVGTHFCLPAQLMKLVEMSRGIN
TSDGVFSAALAWTKAAGQLPVETQDKPGFILNALLVPFNNDVLRAIEAGLATAEDIDLAIRSGLGYKMGPCTLLDLIGLD
TQVRLGEAFYPITLDKRASVPPILRRMVAAGVLGNKSGKGLLTGYEPKRASRVPSFEAMAAGESRSFPKGDDAFLSRAVD
GGEVLVCLGGAYQEDSGRKAVLVELGSECLGFHTGENSGREGSNVLGFARYRNGGDAPTNLVELVRQPRTDAEAIMAARA
IFEDAGFDVVICADQPGRIVDRLVRPKYNDALRLLDEGLATAEDMDMTCRLGLGYPEGPIERVTRGGLAYHCAVSGEIYR
LTGLPAYAPARRAVVAADRAAQRGPV

Sequences:

>Translated_506_residues
MTEIKKVAICGAGGTMGAGIAMVAARAGFQTICFDQNGEALRRSIGAAEDFFRKSVEKGRMSPDDCDNALSRMTTSTNLK
DLADCDLIIEAIFENLEAKQQLFRSLNEICKPETILASNTSTLSITQIASGCGREDRVVGTHFCLPAQLMKLVEMSRGIN
TSDGVFSAALAWTKAAGQLPVETQDKPGFILNALLVPFNNDVLRAIEAGLATAEDIDLAIRSGLGYKMGPCTLLDLIGLD
TQVRLGEAFYPITLDKRASVPPILRRMVAAGVLGNKSGKGLLTGYEPKRASRVPSFEAMAAGESRSFPKGDDAFLSRAVD
GGEVLVCLGGAYQEDSGRKAVLVELGSECLGFHTGENSGREGSNVLGFARYRNGGDAPTNLVELVRQPRTDAEAIMAARA
IFEDAGFDVVICADQPGRIVDRLVRPKYNDALRLLDEGLATAEDMDMTCRLGLGYPEGPIERVTRGGLAYHCAVSGEIYR
LTGLPAYAPARRAVVAADRAAQRGPV
>Mature_505_residues
TEIKKVAICGAGGTMGAGIAMVAARAGFQTICFDQNGEALRRSIGAAEDFFRKSVEKGRMSPDDCDNALSRMTTSTNLKD
LADCDLIIEAIFENLEAKQQLFRSLNEICKPETILASNTSTLSITQIASGCGREDRVVGTHFCLPAQLMKLVEMSRGINT
SDGVFSAALAWTKAAGQLPVETQDKPGFILNALLVPFNNDVLRAIEAGLATAEDIDLAIRSGLGYKMGPCTLLDLIGLDT
QVRLGEAFYPITLDKRASVPPILRRMVAAGVLGNKSGKGLLTGYEPKRASRVPSFEAMAAGESRSFPKGDDAFLSRAVDG
GEVLVCLGGAYQEDSGRKAVLVELGSECLGFHTGENSGREGSNVLGFARYRNGGDAPTNLVELVRQPRTDAEAIMAARAI
FEDAGFDVVICADQPGRIVDRLVRPKYNDALRLLDEGLATAEDMDMTCRLGLGYPEGPIERVTRGGLAYHCAVSGEIYRL
TGLPAYAPARRAVVAADRAAQRGPV

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=285, Percent_Identity=39.6491228070175, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI296179427, Length=302, Percent_Identity=37.4172185430464, Blast_Score=188, Evalue=8e-48,
Organism=Homo sapiens, GI20127408, Length=285, Percent_Identity=30.5263157894737, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI68989263, Length=294, Percent_Identity=32.312925170068, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI261878539, Length=294, Percent_Identity=32.312925170068, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI115430219, Length=243, Percent_Identity=27.1604938271605, Blast_Score=83, Evalue=6e-16,
Organism=Escherichia coli, GI1787661, Length=282, Percent_Identity=39.3617021276596, Blast_Score=201, Evalue=9e-53,
Organism=Escherichia coli, GI1788682, Length=275, Percent_Identity=31.2727272727273, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1790281, Length=218, Percent_Identity=29.3577981651376, Blast_Score=122, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17549919, Length=290, Percent_Identity=36.8965517241379, Blast_Score=177, Evalue=8e-45,
Organism=Caenorhabditis elegans, GI17553560, Length=291, Percent_Identity=36.7697594501718, Blast_Score=172, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI71985923, Length=242, Percent_Identity=33.0578512396694, Blast_Score=141, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI17563036, Length=289, Percent_Identity=34.6020761245675, Blast_Score=141, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17508953, Length=338, Percent_Identity=29.585798816568, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17508951, Length=338, Percent_Identity=29.585798816568, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI25144276, Length=299, Percent_Identity=30.1003344481605, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17558304, Length=338, Percent_Identity=28.4023668639053, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI71985930, Length=280, Percent_Identity=28.5714285714286, Blast_Score=118, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI115533614, Length=198, Percent_Identity=26.2626262626263, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI193203623, Length=198, Percent_Identity=26.2626262626263, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24583077, Length=297, Percent_Identity=29.96632996633, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24583079, Length=297, Percent_Identity=29.96632996633, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI19921000, Length=297, Percent_Identity=29.96632996633, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI45549573, Length=227, Percent_Identity=27.3127753303965, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI20129993, Length=226, Percent_Identity=24.3362831858407, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 53993; Mature: 53862

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEIKKVAICGAGGTMGAGIAMVAARAGFQTICFDQNGEALRRSIGAAEDFFRKSVEKGR
CCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCCHHHHHHHCHHHHHHHHHHHHCC
MSPDDCDNALSRMTTSTNLKDLADCDLIIEAIFENLEAKQQLFRSLNEICKPETILASNT
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
STLSITQIASGCGREDRVVGTHFCLPAQLMKLVEMSRGINTSDGVFSAALAWTKAAGQLP
CEEEHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCC
VETQDKPGFILNALLVPFNNDVLRAIEAGLATAEDIDLAIRSGLGYKMGPCTLLDLIGLD
CCCCCCCCEEEEEEEECCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHCCC
TQVRLGEAFYPITLDKRASVPPILRRMVAAGVLGNKSGKGLLTGYEPKRASRVPSFEAMA
CEEEECCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCEECCCCHHHHCCCCHHHHH
AGESRSFPKGDDAFLSRAVDGGEVLVCLGGAYQEDSGRKAVLVELGSECLGFHTGENSGR
CCCCCCCCCCCHHHHHHCCCCCCEEEEECCCEECCCCCEEEEEECCHHHHCEECCCCCCC
EGSNVLGFARYRNGGDAPTNLVELVRQPRTDAEAIMAARAIFEDAGFDVVICADQPGRIV
CCCCCEEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHH
DRLVRPKYNDALRLLDEGLATAEDMDMTCRLGLGYPEGPIERVTRGGLAYHCAVSGEIYR
HHHHCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCHHHHHHCCCEEEEEEECCCEEE
LTGLPAYAPARRAVVAADRAAQRGPV
EECCCCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TEIKKVAICGAGGTMGAGIAMVAARAGFQTICFDQNGEALRRSIGAAEDFFRKSVEKGR
CCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCCHHHHHHHCHHHHHHHHHHHHCC
MSPDDCDNALSRMTTSTNLKDLADCDLIIEAIFENLEAKQQLFRSLNEICKPETILASNT
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
STLSITQIASGCGREDRVVGTHFCLPAQLMKLVEMSRGINTSDGVFSAALAWTKAAGQLP
CEEEHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCC
VETQDKPGFILNALLVPFNNDVLRAIEAGLATAEDIDLAIRSGLGYKMGPCTLLDLIGLD
CCCCCCCCEEEEEEEECCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHCCC
TQVRLGEAFYPITLDKRASVPPILRRMVAAGVLGNKSGKGLLTGYEPKRASRVPSFEAMA
CEEEECCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCEECCCCHHHHCCCCHHHHH
AGESRSFPKGDDAFLSRAVDGGEVLVCLGGAYQEDSGRKAVLVELGSECLGFHTGENSGR
CCCCCCCCCCCHHHHHHCCCCCCEEEEECCCEECCCCCEEEEEECCHHHHCEECCCCCCC
EGSNVLGFARYRNGGDAPTNLVELVRQPRTDAEAIMAARAIFEDAGFDVVICADQPGRIV
CCCCCEEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHH
DRLVRPKYNDALRLLDEGLATAEDMDMTCRLGLGYPEGPIERVTRGGLAYHCAVSGEIYR
HHHHCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCHHHHHHCCCEEEEEEECCCEEE
LTGLPAYAPARRAVVAADRAAQRGPV
EECCCCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA