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The map label for this gene is galE [C]

Identifier: 110635113

GI number: 110635113

Start: 3028140

End: 3029249

Strand: Reverse

Name: galE [C]

Synonym: Meso_2780

Alternate gene names: 110635113

Gene position: 3029249-3028140 (Counterclockwise)

Preceding gene: 110635120

Following gene: 110635112

Centisome position: 68.65

GC content: 60.45

Gene sequence:

>1110_bases
GTGAGCAAGAAAGCGCTTATTACCGGGGGCTGCGGCTTTATCGGCCGCCAAGTCACTGAAGAACTTCTGGAAAATGGATA
TTCGGTTTCGGTTCTCGACAATCTGGTTGAACAAGTTCACGGAGAAGCGGCCCCGCCTAAAGACGAACGCGTCGACTACC
ACATAGGAGACGTCCGGGACCCCGATTGCGTGAAGGCGGCGCTGAAGGGCGCCGATTTCGTGGTGCATCTGGCGGCTGAG
GTCGGCGTTGGCCAGTCCATGTACGAGATCGCCCGCTATGTTGGCGTGAACGATCTTGGGACAGCGGTGCTTCTGGAAGC
GCTGATCGAGCGGCCGGTCGAGCGCATTGTCGTCGCCTCTTCGATGAGCGTCTATGGCGAAGGCCTTTACCAGACTGCCG
AGGGCCGGCGTTTCGATCGTGCCCGCCGGCGCAAGGACAGGCTGACGGCCGGGCAATGGGATCCGGTGGATGCCAGCGCC
ATGGCTCTCAGGCCGATTGCCACGGATGAGGAGAAGCCTGTCGAACTTGCCTCGATCTATGCGCTTACAAAATACGCGCA
GGAAAGGGCGGTTCTGATCTTCGGCGAGGCCTATCCAGTCGAAGCGGTGGCACTTAGGCTTTTCAACGTTTTTGGGCCGG
GGCAGGCGCTTTCGAACCCCTATACGGGCGTGCTTGCCAATTTCGCGTCGCGCCTTGCCAACAACCAGCCGCCTTTGATT
TTCGAAGATGGGCGGCAGAAGCGCGATTTCGTGCATGTCCGCGACGTGGCGCGGGCATTCCGCCTTGCGCTGGAGAGCAA
GACTGCTGCCGGCCAGGTGATCAATGTCGGCAGCGGGAACGCTTACACAATCCAGCAGGTGGCGGAGATCCTCGCCGATG
CGATGGGACTTGCGGAAATCAAGCCGGAGATCATGAACAAGATGCGTTCGGGCGATATCCGGCACTGTTTTGCCGATATT
TCCAAGGCGCATGACCTGCTCGGGTTCGAGCCGCAGCATCGGCTCGAAGACACGGTCGCGGAGTTCGCTGAATGGGTGCG
GGAGACGGGCGCCGTCGACAACGCCGCACAGATGCGCCGGCAATTGGAAGAGCGGGGGCTGGTCTCATGA

Upstream 100 bases:

>100_bases
AGCGGTCGGTTTGCCGGCTCACCACGTCTACGGGGAACCAAAGCGCAATTTAGTTGTTTGTAGCTCGCGACCCCTCTTCT
TCATCACAGCAGGAGCAGCC

Downstream 100 bases:

>100_bases
GCGGGACGAATCCGAATGGTCCGGACCCGTCAGGGAGCGGCGCGGGGGAGCCGGTCGTCATCAGCGGTGGCAGCGGCTTT
ATCGGCTGCAATCTGGCTGA

Product: NAD-dependent epimerase/dehydratase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 369; Mature: 368

Protein sequence:

>369_residues
MSKKALITGGCGFIGRQVTEELLENGYSVSVLDNLVEQVHGEAAPPKDERVDYHIGDVRDPDCVKAALKGADFVVHLAAE
VGVGQSMYEIARYVGVNDLGTAVLLEALIERPVERIVVASSMSVYGEGLYQTAEGRRFDRARRRKDRLTAGQWDPVDASA
MALRPIATDEEKPVELASIYALTKYAQERAVLIFGEAYPVEAVALRLFNVFGPGQALSNPYTGVLANFASRLANNQPPLI
FEDGRQKRDFVHVRDVARAFRLALESKTAAGQVINVGSGNAYTIQQVAEILADAMGLAEIKPEIMNKMRSGDIRHCFADI
SKAHDLLGFEPQHRLEDTVAEFAEWVRETGAVDNAAQMRRQLEERGLVS

Sequences:

>Translated_369_residues
MSKKALITGGCGFIGRQVTEELLENGYSVSVLDNLVEQVHGEAAPPKDERVDYHIGDVRDPDCVKAALKGADFVVHLAAE
VGVGQSMYEIARYVGVNDLGTAVLLEALIERPVERIVVASSMSVYGEGLYQTAEGRRFDRARRRKDRLTAGQWDPVDASA
MALRPIATDEEKPVELASIYALTKYAQERAVLIFGEAYPVEAVALRLFNVFGPGQALSNPYTGVLANFASRLANNQPPLI
FEDGRQKRDFVHVRDVARAFRLALESKTAAGQVINVGSGNAYTIQQVAEILADAMGLAEIKPEIMNKMRSGDIRHCFADI
SKAHDLLGFEPQHRLEDTVAEFAEWVRETGAVDNAAQMRRQLEERGLVS
>Mature_368_residues
SKKALITGGCGFIGRQVTEELLENGYSVSVLDNLVEQVHGEAAPPKDERVDYHIGDVRDPDCVKAALKGADFVVHLAAEV
GVGQSMYEIARYVGVNDLGTAVLLEALIERPVERIVVASSMSVYGEGLYQTAEGRRFDRARRRKDRLTAGQWDPVDASAM
ALRPIATDEEKPVELASIYALTKYAQERAVLIFGEAYPVEAVALRLFNVFGPGQALSNPYTGVLANFASRLANNQPPLIF
EDGRQKRDFVHVRDVARAFRLALESKTAAGQVINVGSGNAYTIQQVAEILADAMGLAEIKPEIMNKMRSGDIRHCFADIS
KAHDLLGFEPQHRLEDTVAEFAEWVRETGAVDNAAQMRRQLEERGLVS

Specific function: Galactose metabolism; third step. [C]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI56237023, Length=383, Percent_Identity=25.065274151436, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI56118217, Length=383, Percent_Identity=25.065274151436, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI189083684, Length=383, Percent_Identity=25.065274151436, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI7657641, Length=375, Percent_Identity=26.4, Blast_Score=99, Evalue=8e-21,
Organism=Escherichia coli, GI1786974, Length=370, Percent_Identity=25.1351351351351, Blast_Score=80, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319493, Length=374, Percent_Identity=27.0053475935829, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI19923002, Length=369, Percent_Identity=25.2032520325203, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21356223, Length=349, Percent_Identity=24.9283667621776, Blast_Score=92, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 40514; Mature: 40383

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKALITGGCGFIGRQVTEELLENGYSVSVLDNLVEQVHGEAAPPKDERVDYHIGDVRD
CCCCCEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCC
PDCVKAALKGADFVVHLAAEVGVGQSMYEIARYVGVNDLGTAVLLEALIERPVERIVVAS
HHHHHHHHCCCHHEEHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
SMSVYGEGLYQTAEGRRFDRARRRKDRLTAGQWDPVDASAMALRPIATDEEKPVELASIY
HHHHHHCHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCHHHEECCCCCCCCCCHHHHHHH
ALTKYAQERAVLIFGEAYPVEAVALRLFNVFGPGQALSNPYTGVLANFASRLANNQPPLI
HHHHHHHCCEEEEECCCCCHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHCCCCCCEE
FEDGRQKRDFVHVRDVARAFRLALESKTAAGQVINVGSGNAYTIQQVAEILADAMGLAEI
ECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCEEEHHHHHHHHHHHHHHHHC
KPEIMNKMRSGDIRHCFADISKAHDLLGFEPQHRLEDTVAEFAEWVRETGAVDNAAQMRR
CHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
QLEERGLVS
HHHHCCCCC
>Mature Secondary Structure 
SKKALITGGCGFIGRQVTEELLENGYSVSVLDNLVEQVHGEAAPPKDERVDYHIGDVRD
CCCCEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCC
PDCVKAALKGADFVVHLAAEVGVGQSMYEIARYVGVNDLGTAVLLEALIERPVERIVVAS
HHHHHHHHCCCHHEEHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
SMSVYGEGLYQTAEGRRFDRARRRKDRLTAGQWDPVDASAMALRPIATDEEKPVELASIY
HHHHHHCHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCHHHEECCCCCCCCCCHHHHHHH
ALTKYAQERAVLIFGEAYPVEAVALRLFNVFGPGQALSNPYTGVLANFASRLANNQPPLI
HHHHHHHCCEEEEECCCCCHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHCCCCCCEE
FEDGRQKRDFVHVRDVARAFRLALESKTAAGQVINVGSGNAYTIQQVAEILADAMGLAEI
ECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCEEEHHHHHHHHHHHHHHHHC
KPEIMNKMRSGDIRHCFADISKAHDLLGFEPQHRLEDTVAEFAEWVRETGAVDNAAQMRR
CHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
QLEERGLVS
HHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]