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The map label for this gene is yisK [H]

Identifier: 110634846

GI number: 110634846

Start: 2683648

End: 2684517

Strand: Reverse

Name: yisK [H]

Synonym: Meso_2505

Alternate gene names: 110634846

Gene position: 2684517-2683648 (Counterclockwise)

Preceding gene: 110634847

Following gene: 110634845

Centisome position: 60.84

GC content: 59.43

Gene sequence:

>870_bases
ATGACAGCAATTCCCGCTCGCATCGCGGCGTTCCGGGCAAATGGCGCCGATCGCTTCGGTGTGGTGACCGAAGAAGGCAT
CATCGATATGACGCTCGAATATGGCAGCCGCTTCAAGGGCCTGAAGGAGGTGATCGAGGCGGGGGCGCTCGAGGAGGTGA
TCGGCTCCGCCAAGGGGCGTGCGCCGACCTACCGCGAAGAGGATGTTACTTACCTCATTCCGATCGCAACTCCCGAAAAG
CTGATCTGCATCGGCGTGAACTATCCGGACCGCAATGCCGAATACAAGGATGGCCAGTCCCAACCGACGAAGCCCTCCAT
ATTCATTCGTTTCCCGCGGACTTTCACCGGACATGGCCAGAATCTCGTTCGTCCGCCGGAAAGCGAGCAGCTCGACTATG
AGGGTGAGGTGGCGATCGTCATCGGCAAGGGCGGCCGCCGCATCGCCAGAGAGCACGCCTATGATCATATCGCGGCGCTC
ACCCTCTGCAATGAAGGCACGATCCGTGATTGGGTGCGCCATGCGAAATTCAACGTGACGCAAGGCAAGAACTGGGAAAG
ATCGGGCTCGCTTGGTCCATGGCTGGTGCCTTTTCGCGATGCATCGCAGCTTGATATCGAGCTGACCACGCGTGTGAATG
GCGAAGTCCGCCAACAGGACCGCACCAGGAACATGATCTTCGATTTCCGCTATATCATCGAATATGTATCGACCTTCTGC
GCGCTTGCACCGGGTGATGTGATCATCTGCGGGACGCCCACAGGCGCGGGCGCGAGGTTCGATCCGCCGGTTTGGCTCAA
GCCCGGCGATGTGGTGGAGGTCGAAGCCGAAGGCATAGGCATCCTGCGCAACGGCATTGAGGACGAGTGA

Upstream 100 bases:

>100_bases
CCAGCCTCGTGAAGCAAGCGGCCCTGATTGGGAACCGGTAAGTACCCGCCAGCGAGAGTGCGCTTTAGCGCCAGTAAGAA
TTCAAGGGAGGACCATGGTC

Downstream 100 bases:

>100_bases
TGCTGAGCAGGGCTGAGATCGAACTGGCTGCGGCCGATCTGTTGCGTGCCGAAGAGACGTGCGCTCAGATCGGGCTTCTG
TCCATCCGGCACCCCGAGAT

Product: fumarylacetoacetate (FAA) hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 289; Mature: 288

Protein sequence:

>289_residues
MTAIPARIAAFRANGADRFGVVTEEGIIDMTLEYGSRFKGLKEVIEAGALEEVIGSAKGRAPTYREEDVTYLIPIATPEK
LICIGVNYPDRNAEYKDGQSQPTKPSIFIRFPRTFTGHGQNLVRPPESEQLDYEGEVAIVIGKGGRRIAREHAYDHIAAL
TLCNEGTIRDWVRHAKFNVTQGKNWERSGSLGPWLVPFRDASQLDIELTTRVNGEVRQQDRTRNMIFDFRYIIEYVSTFC
ALAPGDVIICGTPTGAGARFDPPVWLKPGDVVEVEAEGIGILRNGIEDE

Sequences:

>Translated_289_residues
MTAIPARIAAFRANGADRFGVVTEEGIIDMTLEYGSRFKGLKEVIEAGALEEVIGSAKGRAPTYREEDVTYLIPIATPEK
LICIGVNYPDRNAEYKDGQSQPTKPSIFIRFPRTFTGHGQNLVRPPESEQLDYEGEVAIVIGKGGRRIAREHAYDHIAAL
TLCNEGTIRDWVRHAKFNVTQGKNWERSGSLGPWLVPFRDASQLDIELTTRVNGEVRQQDRTRNMIFDFRYIIEYVSTFC
ALAPGDVIICGTPTGAGARFDPPVWLKPGDVVEVEAEGIGILRNGIEDE
>Mature_288_residues
TAIPARIAAFRANGADRFGVVTEEGIIDMTLEYGSRFKGLKEVIEAGALEEVIGSAKGRAPTYREEDVTYLIPIATPEKL
ICIGVNYPDRNAEYKDGQSQPTKPSIFIRFPRTFTGHGQNLVRPPESEQLDYEGEVAIVIGKGGRRIAREHAYDHIAALT
LCNEGTIRDWVRHAKFNVTQGKNWERSGSLGPWLVPFRDASQLDIELTTRVNGEVRQQDRTRNMIFDFRYIIEYVSTFCA
LAPGDVIICGTPTGAGARFDPPVWLKPGDVVEVEAEGIGILRNGIEDE

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAH family [H]

Homologues:

Organism=Homo sapiens, GI40786394, Length=268, Percent_Identity=34.7014925373134, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI156231349, Length=268, Percent_Identity=34.7014925373134, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI66348062, Length=211, Percent_Identity=31.2796208530806, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI215422413, Length=182, Percent_Identity=29.6703296703297, Blast_Score=95, Evalue=7e-20,
Organism=Homo sapiens, GI13654274, Length=182, Percent_Identity=29.6703296703297, Blast_Score=95, Evalue=7e-20,
Organism=Escherichia coli, GI1787428, Length=207, Percent_Identity=30.4347826086957, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17557057, Length=198, Percent_Identity=33.8383838383838, Blast_Score=108, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6324161, Length=234, Percent_Identity=26.0683760683761, Blast_Score=73, Evalue=4e-14,
Organism=Drosophila melanogaster, GI28572127, Length=241, Percent_Identity=34.4398340248963, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24663695, Length=283, Percent_Identity=30.3886925795053, Blast_Score=127, Evalue=8e-30,
Organism=Drosophila melanogaster, GI28571789, Length=222, Percent_Identity=27.4774774774775, Blast_Score=82, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002529
- InterPro:   IPR011234 [H]

Pfam domain/function: PF01557 FAA_hydrolase [H]

EC number: NA

Molecular weight: Translated: 32098; Mature: 31966

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAIPARIAAFRANGADRFGVVTEEGIIDMTLEYGSRFKGLKEVIEAGALEEVIGSAKGR
CCCCCCCCEEEECCCCCCCCEEECCCEEEEEEHHCHHHHHHHHHHHCCCHHHHHHCCCCC
APTYREEDVTYLIPIATPEKLICIGVNYPDRNAEYKDGQSQPTKPSIFIRFPRTFTGHGQ
CCCCCCCCCEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCEECCCCC
NLVRPPESEQLDYEGEVAIVIGKGGRRIAREHAYDHIAALTLCNEGTIRDWVRHAKFNVT
CCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHEEEEEEECCCCHHHHHHHHEEECC
QGKNWERSGSLGPWLVPFRDASQLDIELTTRVNGEVRQQDRTRNMIFDFRYIIEYVSTFC
CCCCCCCCCCCCCEEEECCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ALAPGDVIICGTPTGAGARFDPPVWLKPGDVVEVEAEGIGILRNGIEDE
HCCCCCEEEEECCCCCCCCCCCCEEECCCCEEEEECCCCEEECCCCCCC
>Mature Secondary Structure 
TAIPARIAAFRANGADRFGVVTEEGIIDMTLEYGSRFKGLKEVIEAGALEEVIGSAKGR
CCCCCCCEEEECCCCCCCCEEECCCEEEEEEHHCHHHHHHHHHHHCCCHHHHHHCCCCC
APTYREEDVTYLIPIATPEKLICIGVNYPDRNAEYKDGQSQPTKPSIFIRFPRTFTGHGQ
CCCCCCCCCEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCEECCCCC
NLVRPPESEQLDYEGEVAIVIGKGGRRIAREHAYDHIAALTLCNEGTIRDWVRHAKFNVT
CCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHEEEEEEECCCCHHHHHHHHEEECC
QGKNWERSGSLGPWLVPFRDASQLDIELTTRVNGEVRQQDRTRNMIFDFRYIIEYVSTFC
CCCCCCCCCCCCCEEEECCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ALAPGDVIICGTPTGAGARFDPPVWLKPGDVVEVEAEGIGILRNGIEDE
HCCCCCEEEEECCCCCCCCCCCCEEECCCCEEEEECCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353931; 9384377 [H]