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The map label for this gene is fdhB1 [H]

Identifier: 110634791

GI number: 110634791

Start: 2626573

End: 2627169

Strand: Direct

Name: fdhB1 [H]

Synonym: Meso_2450

Alternate gene names: 110634791

Gene position: 2626573-2627169 (Clockwise)

Preceding gene: 110634790

Following gene: 110634792

Centisome position: 59.53

GC content: 62.98

Gene sequence:

>597_bases
ATGGCCAGGATGAAGTTCCTTTGCGATGCCGACCGCTGCATCGAGTGCAACGCATGCGTCACCGCCTGCAAGAACGAGCA
TGACGTGCCCTGGGGCATCAACCGGCGGCGCGTCGTCACGATCAACGACGGCAAGCCGGGCGAGCGCTCGGTTTCGATGG
CCTGCATGCACTGCACGGACGCTCCCTGCGCAGCGGTGTGTCCGGTCGACTGCTTCTACACGACAGCCGATGCGGTGGTG
CTGCACTCAAAGGATCTATGTATCGGCTGCGGCTATTGCTTCTACGCCTGCCCTTTCGGCGCTCCGCAATATCCGCGCGT
CGGCAATTTCGGCACGCGCGGCAAGATGGACAAATGCACCTTCTGTGCGGCCGGCCCGGAAGAGGACTCAACCGAGATCG
AATATGCGAAATACGGCGCCAACCGCCTGGCGGAAGGCAAGCTGCCGCTCTGTGCCGAAATGTGCTCGACCAAATCGCTG
CTCGCCGGCGACGGCGAAATCATCGCCGCCATCTACAAGGAGCGGGTCACACAGCGCGGCTACGGCTCGGGGGCATGGGG
ATGGCAGACCGCGTACAGGGAGACGGTGGAAGTCTAG

Upstream 100 bases:

>100_bases
ACACCATCACGACCTACGGCTACGATCCGGTGACCGGCATGCAGGAGCCCAAGGTCACGCTTTGCCAGATCGCGGCGGCG
TAACAGGGAGGAACGAAAAA

Downstream 100 bases:

>100_bases
GCATTTTGCAGGCAAGCGGAATTGCTTGCCGTCGCACAAATGCGGCCAAAAAAACAGCCAGAGCGAAGGCGCGAACATGG
AGGAGCGCATTCGCTCCAGC

Product: 4Fe-4S ferredoxin, iron-sulfur binding

Products: CO2; NADH

Alternate protein names: NA

Number of amino acids: Translated: 198; Mature: 197

Protein sequence:

>198_residues
MARMKFLCDADRCIECNACVTACKNEHDVPWGINRRRVVTINDGKPGERSVSMACMHCTDAPCAAVCPVDCFYTTADAVV
LHSKDLCIGCGYCFYACPFGAPQYPRVGNFGTRGKMDKCTFCAAGPEEDSTEIEYAKYGANRLAEGKLPLCAEMCSTKSL
LAGDGEIIAAIYKERVTQRGYGSGAWGWQTAYRETVEV

Sequences:

>Translated_198_residues
MARMKFLCDADRCIECNACVTACKNEHDVPWGINRRRVVTINDGKPGERSVSMACMHCTDAPCAAVCPVDCFYTTADAVV
LHSKDLCIGCGYCFYACPFGAPQYPRVGNFGTRGKMDKCTFCAAGPEEDSTEIEYAKYGANRLAEGKLPLCAEMCSTKSL
LAGDGEIIAAIYKERVTQRGYGSGAWGWQTAYRETVEV
>Mature_197_residues
ARMKFLCDADRCIECNACVTACKNEHDVPWGINRRRVVTINDGKPGERSVSMACMHCTDAPCAAVCPVDCFYTTADAVVL
HSKDLCIGCGYCFYACPFGAPQYPRVGNFGTRGKMDKCTFCAAGPEEDSTEIEYAKYGANRLAEGKLPLCAEMCSTKSLL
AGDGEIIAAIYKERVTQRGYGSGAWGWQTAYRETVEV

Specific function: This chain is an electron transfer unit containing 18 cysteine residues, 16 of which occur in four clusters [H]

COG id: COG0437

COG function: function code C; Fe-S-cluster-containing hydrogenase components 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 3 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Escherichia coli, GI1787122, Length=169, Percent_Identity=33.7278106508876, Blast_Score=92, Evalue=2e-20,
Organism=Escherichia coli, GI1787872, Length=172, Percent_Identity=33.1395348837209, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1789370, Length=200, Percent_Identity=29, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI2367345, Length=191, Percent_Identity=33.5078534031414, Blast_Score=81, Evalue=5e-17,
Organism=Escherichia coli, GI226510944, Length=184, Percent_Identity=32.0652173913043, Blast_Score=81, Evalue=5e-17,
Organism=Escherichia coli, GI1790326, Length=201, Percent_Identity=27.8606965174129, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1789079, Length=181, Percent_Identity=30.939226519337, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1787749, Length=204, Percent_Identity=26.4705882352941, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI87082114, Length=193, Percent_Identity=27.4611398963731, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI87082180, Length=102, Percent_Identity=37.2549019607843, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR000813 [H]

Pfam domain/function: PF00037 Fer4 [H]

EC number: 1.2.1.2

Molecular weight: Translated: 21611; Mature: 21480

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

9.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
12.1 %Cys+Met (Translated Protein)
9.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
11.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARMKFLCDADRCIECNACVTACKNEHDVPWGINRRRVVTINDGKPGERSVSMACMHCTD
CCCCCEEECCCCEEECHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCCEEEEEECCC
APCAAVCPVDCFYTTADAVVLHSKDLCIGCGYCFYACPFGAPQYPRVGNFGTRGKMDKCT
CCCCEECCCHHHHCCCCEEEEECCCCEEECCHHHHCCCCCCCCCCCCCCCCCCCCCCCEE
FCAAGPEEDSTEIEYAKYGANRLAEGKLPLCAEMCSTKSLLAGDGEIIAAIYKERVTQRG
EEECCCCCCCCEEEHHHHCCCCCCCCCCCHHHHHHCCCCEECCCCHHHHHHHHHHHHHCC
YGSGAWGWQTAYRETVEV
CCCCCCCHHHHHHHHCCC
>Mature Secondary Structure 
ARMKFLCDADRCIECNACVTACKNEHDVPWGINRRRVVTINDGKPGERSVSMACMHCTD
CCCCEEECCCCEEECHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCCEEEEEECCC
APCAAVCPVDCFYTTADAVVLHSKDLCIGCGYCFYACPFGAPQYPRVGNFGTRGKMDKCT
CCCCEECCCHHHHCCCCEEEEECCCCEEECCHHHHCCCCCCCCCCCCCCCCCCCCCCCEE
FCAAGPEEDSTEIEYAKYGANRLAEGKLPLCAEMCSTKSLLAGDGEIIAAIYKERVTQRG
EEECCCCCCCCEEEHHHHCCCCCCCCCCCHHHHHHCCCCEECCCCHHHHHHHHHHHHHCC
YGSGAWGWQTAYRETVEV
CCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: formate; NAD+

Specific reaction: formate + NAD+ = CO2 + NADH

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1781728; 14500908 [H]