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The map label for this gene is argH1 [H]

Identifier: 110634734

GI number: 110634734

Start: 2547932

End: 2549431

Strand: Reverse

Name: argH1 [H]

Synonym: Meso_2392

Alternate gene names: 110634734

Gene position: 2549431-2547932 (Counterclockwise)

Preceding gene: 110634735

Following gene: 110634732

Centisome position: 57.78

GC content: 61.07

Gene sequence:

>1500_bases
ATGTCCCTTGCACTAAACGAAGCACGGTTGGGCAAGGCTGCCCACCCCAGCCTCGTGGAGGCCATGTATGAGCCTCTCAT
CGCGCAGGACATCGAGATGTTCGATGCTTATCTGGCCGTCGATCTGGCCCATGTCATCATGCTTGCCGACAGAGGCATCA
TAGGGCCTGATCCGGCACGTGCCTTGGTCGGCGTCCTCTCGAAATTGCGGTCCGATGGGCCGGCATCGATCAAAATCGAC
GCATCGTTCGGGGGCTTTCTGCTGCAGGTCGAGCGGCATATCGCGTCCGTATCCGGTCCGGATGCGGCGGGAATGCTTCA
ACTGGGACGAAGCCGGATCGATCAGAACGCTGCCGTGGCCCGCGTCTACGCGCGCAATTCGCTCATCTCAGTCATGAATC
AGCTCGTCGACCTCCAGGGCGTGGTGCTTGATCGCGCGCGGGAGTGGAAGGCGGTAATCATGCCTGGTTACACGCATTTG
CAGCACGCGCAGCCCTGGGTGCTCGGACACTATCTTCTAGGCCAGCATGATGTCTTTCAACGCGATTTCCAACGGCTGGT
CGGGGTCTACGGACGAACCAATCTGGGATCGCTGGGTGGGGTCGCCCTTTCAGGCACATCCTGGCCGATCGATAGGCGCT
ACACGGCAGAGTTGCTGGGCCATGCGGGAATAGTTCGAAATTCGAAGGACGCGGGCAATTTCGTGATGGATCACCAGCCC
GAGCTCGCTGCCATGCTCTCGATCCTGATGAGCGCGCTGGGACGTTTGGCATCGGAACTCTACATATGGTCGTCTTGGGA
ATTCGGCCTCGTGGAACTGGATGAAAGCCTTTGTGGTACCTCCAGCATCATGCCGCAGAAGAAGAATCCCTATGCCCTGG
AGCGTATTCGCGCCTTGGCGGGAGAGGCGATTGGTTGGCTGCCCGGCCAACTGGGGCTGTTCAAGACACCCACGACCAGC
GATTGCGACCGCTCCTTCTCGTCCGGCATCACGCCCTGCTTCAAGGCCACGCGATGGGGCCTCCTGCTGATGAGCGAGGC
GCTGCGCACGATGCGAATCGACGAAAACCGGATGAGGGAGCGCGCAGGGGCTTTCTGGAGCACAGCGAGCAACCTTGCCG
ATCTCATCGTACGTGAAAGGGGGCTGGATTTCCGTCGCGCCCATCATGTGGTCGGCGCCCTGGTCAAGACGGCCGTTGCG
GACGGGCTTCGGCCGAGCGATGTCGGAGCGGCAGAGGTCGACGCAGCGGCCAAGGCTGTGCTTAGCCGATCCCTGGACTT
TACCGACGAGCAAATATCGACGGCTCTCAACTCCGCCGAATTCGTTGCCACGCGGGTGAGCGAAGGAAGCATCGGTCCGC
AGGAAATAGAGAAGCAACTGAACCTGGCGATGGAGGATCATGCTGCCGCCCGTTCATGGATGGAGGAAGAGCGCGCCAGG
CTGAGCGCCGCGGAAGACAGGCTGGCGGCGGCTGCGTCCCGCATCATAGCCGCTGCTTGA

Upstream 100 bases:

>100_bases
AACGCGACGATGGATATGTTGCAAAGGCGCGCCGGGATCAGGTGAACCGCCGATCATCACTTGAGGCCGTGCCGGTGATT
TGTGACGAGGAGTTGGAACC

Downstream 100 bases:

>100_bases
CGCTCACCGGGGTATGGTCTCGCTTCGCTGGCCTACATAGCTCGCGCGCGGCCGGATGACCCGGCCGTCACTGTGCTGCT
CAAGCGCGTGCGCGATCCAG

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL 1; Arginosuccinase 1 [H]

Number of amino acids: Translated: 499; Mature: 498

Protein sequence:

>499_residues
MSLALNEARLGKAAHPSLVEAMYEPLIAQDIEMFDAYLAVDLAHVIMLADRGIIGPDPARALVGVLSKLRSDGPASIKID
ASFGGFLLQVERHIASVSGPDAAGMLQLGRSRIDQNAAVARVYARNSLISVMNQLVDLQGVVLDRAREWKAVIMPGYTHL
QHAQPWVLGHYLLGQHDVFQRDFQRLVGVYGRTNLGSLGGVALSGTSWPIDRRYTAELLGHAGIVRNSKDAGNFVMDHQP
ELAAMLSILMSALGRLASELYIWSSWEFGLVELDESLCGTSSIMPQKKNPYALERIRALAGEAIGWLPGQLGLFKTPTTS
DCDRSFSSGITPCFKATRWGLLLMSEALRTMRIDENRMRERAGAFWSTASNLADLIVRERGLDFRRAHHVVGALVKTAVA
DGLRPSDVGAAEVDAAAKAVLSRSLDFTDEQISTALNSAEFVATRVSEGSIGPQEIEKQLNLAMEDHAAARSWMEEERAR
LSAAEDRLAAAASRIIAAA

Sequences:

>Translated_499_residues
MSLALNEARLGKAAHPSLVEAMYEPLIAQDIEMFDAYLAVDLAHVIMLADRGIIGPDPARALVGVLSKLRSDGPASIKID
ASFGGFLLQVERHIASVSGPDAAGMLQLGRSRIDQNAAVARVYARNSLISVMNQLVDLQGVVLDRAREWKAVIMPGYTHL
QHAQPWVLGHYLLGQHDVFQRDFQRLVGVYGRTNLGSLGGVALSGTSWPIDRRYTAELLGHAGIVRNSKDAGNFVMDHQP
ELAAMLSILMSALGRLASELYIWSSWEFGLVELDESLCGTSSIMPQKKNPYALERIRALAGEAIGWLPGQLGLFKTPTTS
DCDRSFSSGITPCFKATRWGLLLMSEALRTMRIDENRMRERAGAFWSTASNLADLIVRERGLDFRRAHHVVGALVKTAVA
DGLRPSDVGAAEVDAAAKAVLSRSLDFTDEQISTALNSAEFVATRVSEGSIGPQEIEKQLNLAMEDHAAARSWMEEERAR
LSAAEDRLAAAASRIIAAA
>Mature_498_residues
SLALNEARLGKAAHPSLVEAMYEPLIAQDIEMFDAYLAVDLAHVIMLADRGIIGPDPARALVGVLSKLRSDGPASIKIDA
SFGGFLLQVERHIASVSGPDAAGMLQLGRSRIDQNAAVARVYARNSLISVMNQLVDLQGVVLDRAREWKAVIMPGYTHLQ
HAQPWVLGHYLLGQHDVFQRDFQRLVGVYGRTNLGSLGGVALSGTSWPIDRRYTAELLGHAGIVRNSKDAGNFVMDHQPE
LAAMLSILMSALGRLASELYIWSSWEFGLVELDESLCGTSSIMPQKKNPYALERIRALAGEAIGWLPGQLGLFKTPTTSD
CDRSFSSGITPCFKATRWGLLLMSEALRTMRIDENRMRERAGAFWSTASNLADLIVRERGLDFRRAHHVVGALVKTAVAD
GLRPSDVGAAEVDAAAKAVLSRSLDFTDEQISTALNSAEFVATRVSEGSIGPQEIEKQLNLAMEDHAAARSWMEEERARL
SAAEDRLAAAASRIIAAA

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=315, Percent_Identity=33.015873015873, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI68303542, Length=315, Percent_Identity=33.015873015873, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI68303547, Length=313, Percent_Identity=31.9488817891374, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI68303549, Length=315, Percent_Identity=30.1587301587302, Blast_Score=110, Evalue=3e-24,
Organism=Escherichia coli, GI1790398, Length=360, Percent_Identity=31.6666666666667, Blast_Score=166, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6321806, Length=326, Percent_Identity=34.6625766871166, Blast_Score=163, Evalue=5e-41,
Organism=Drosophila melanogaster, GI221473854, Length=365, Percent_Identity=32.0547945205479, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI78706858, Length=365, Percent_Identity=32.0547945205479, Blast_Score=144, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 54209; Mature: 54077

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLALNEARLGKAAHPSLVEAMYEPLIAQDIEMFDAYLAVDLAHVIMLADRGIIGPDPAR
CCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
ALVGVLSKLRSDGPASIKIDASFGGFLLQVERHIASVSGPDAAGMLQLGRSRIDQNAAVA
HHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHH
RVYARNSLISVMNQLVDLQGVVLDRAREWKAVIMPGYTHLQHAQPWVLGHYLLGQHDVFQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHCCCCHHHHHHHHCCHHHHH
RDFQRLVGVYGRTNLGSLGGVALSGTSWPIDRRYTAELLGHAGIVRNSKDAGNFVMDHQP
HHHHHHHHHHCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCH
ELAAMLSILMSALGRLASELYIWSSWEFGLVELDESLCGTSSIMPQKKNPYALERIRALA
HHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHH
GEAIGWLPGQLGLFKTPTTSDCDRSFSSGITPCFKATRWGLLLMSEALRTMRIDENRMRE
HHHHHCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
RAGAFWSTASNLADLIVRERGLDFRRAHHVVGALVKTAVADGLRPSDVGAAEVDAAAKAV
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
LSRSLDFTDEQISTALNSAEFVATRVSEGSIGPQEIEKQLNLAMEDHAAARSWMEEERAR
HHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSAAEDRLAAAASRIIAAA
HHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SLALNEARLGKAAHPSLVEAMYEPLIAQDIEMFDAYLAVDLAHVIMLADRGIIGPDPAR
CCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
ALVGVLSKLRSDGPASIKIDASFGGFLLQVERHIASVSGPDAAGMLQLGRSRIDQNAAVA
HHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHH
RVYARNSLISVMNQLVDLQGVVLDRAREWKAVIMPGYTHLQHAQPWVLGHYLLGQHDVFQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHCCCCHHHHHHHHCCHHHHH
RDFQRLVGVYGRTNLGSLGGVALSGTSWPIDRRYTAELLGHAGIVRNSKDAGNFVMDHQP
HHHHHHHHHHCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCH
ELAAMLSILMSALGRLASELYIWSSWEFGLVELDESLCGTSSIMPQKKNPYALERIRALA
HHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHH
GEAIGWLPGQLGLFKTPTTSDCDRSFSSGITPCFKATRWGLLLMSEALRTMRIDENRMRE
HHHHHCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
RAGAFWSTASNLADLIVRERGLDFRRAHHVVGALVKTAVADGLRPSDVGAAEVDAAAKAV
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
LSRSLDFTDEQISTALNSAEFVATRVSEGSIGPQEIEKQLNLAMEDHAAARSWMEEERAR
HHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSAAEDRLAAAASRIIAAA
HHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA