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The map label for this gene is metC [H]

Identifier: 110634707

GI number: 110634707

Start: 2515541

End: 2516737

Strand: Reverse

Name: metC [H]

Synonym: Meso_2364

Alternate gene names: 110634707

Gene position: 2516737-2515541 (Counterclockwise)

Preceding gene: 110634708

Following gene: 110634706

Centisome position: 57.04

GC content: 63.99

Gene sequence:

>1197_bases
ATGCCTATGTCGCCGTTGCTTATCAACCCGCCGCAGGATGATGACACTTGCTGTGTCCACCATCCCGAGATCGACGAGAC
CGGCTTTGCGGCCGTCACTGTTCCGGTCTGGCGCGCCTCGACCATCGTCTTTCCCGATATGGCCGCCTATGCGGCGCGCA
ACAGCAAGGGCCATGACGCCTACAGCTACGGCCTGCACGGTACGCCCACGACCCGCACCCTTGAGGCGCAGATCGCGCGG
CTGGAAGGAGGGGGCCGCTCGATCGTGACGAGCTCGGGCCTGTCGGCGATCACGATGACGCTGCAGACGATGCTGTCGCC
CGGCGATACGGTCCTGCTCGTCGATACTGTCTACCCACCCGTGCGGGAATTCGCCGACCGCTTTCTCCGACGGATGGGGG
TCGATATCGTCTACTACGACCCGGCGATAGGAGCGGGAATCGCCGAGCTGATCACCGCCACGACGAGGCTGGTGTGGATG
GAGTCGCCGGGATCCACGACGATGGAGGTCCAGGACATCCCCGCGATCGTGGCGGCCGCGCGTGCGCGTGGCGTACCCAC
GGCCATCGACAACACCTGGGCCACTCCGCTTCTGCTCAAACCTCTGGAACTGGGTGTTGATATCGTCATACAGGCGGTCA
GCAAATATATGGCGGGTCATTCGGACCTGCTCATGGGGGCGGTGACCGTACGCGACCTCGCGCTCTTCGACAGGTTGAGA
ACAGCATTCAAGCTGCTGGGGCACGGCGTTTCTCCCGACGATTGCTCGCTCGTCCTGCGAGGGCTGGAGACGCTGGCCGT
CCGGCTGCGACAATCCTCGGCTTCCGCATTGGATCTGGCGAGGATGCTGGAGGAAAGCGGGCGCTTTCAGGCCGTTCTCC
ACCCGGCATTGCCCAGCTTTTCCGGCCACGCAATTTGGAAGCGCGACTTCAAGGGTGCGAGCGGAGTGTTCAGCGTGGTG
CTTAAGCCAGAAAGCCTCGATCGGCTGCCAAACGCGCTCTCCCGGCTAAGAGTTTTCGCCATAGGCGCGTCCTGGGGCGG
AACGCACAGCTTGGTCGCACCCATGGATATTACGGCCGCGCGCACGGCGACGGCATGCCCATGGAGATGTCCGATCATCC
GCCTCAGCGTCGGTATGGAAGGCCTCGCCGACCTGCGCGCGGACCTCCAGGCATTCGCCGGGGGACTGACGTCGTGA

Upstream 100 bases:

>100_bases
GTCGAAGTGACCGACACTGGATGGAACCCCATAACCGAACTGTCGCGCCACCTGCACGTCTGCACCGGCGGACGCGCTGA
AGTTCTTGCCTCCTGACGAG

Downstream 100 bases:

>100_bases
AGCACCGAGACTGCCGAATAGGAATGGACGGGAAAATCATGCCGTCGTGCCGGCCGGCCAGCATACGACATCCAGCACGG
GGCAGTCGTCGATGGCAAAC

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase; ORF5 [H]

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MPMSPLLINPPQDDDTCCVHHPEIDETGFAAVTVPVWRASTIVFPDMAAYAARNSKGHDAYSYGLHGTPTTRTLEAQIAR
LEGGGRSIVTSSGLSAITMTLQTMLSPGDTVLLVDTVYPPVREFADRFLRRMGVDIVYYDPAIGAGIAELITATTRLVWM
ESPGSTTMEVQDIPAIVAAARARGVPTAIDNTWATPLLLKPLELGVDIVIQAVSKYMAGHSDLLMGAVTVRDLALFDRLR
TAFKLLGHGVSPDDCSLVLRGLETLAVRLRQSSASALDLARMLEESGRFQAVLHPALPSFSGHAIWKRDFKGASGVFSVV
LKPESLDRLPNALSRLRVFAIGASWGGTHSLVAPMDITAARTATACPWRCPIIRLSVGMEGLADLRADLQAFAGGLTS

Sequences:

>Translated_398_residues
MPMSPLLINPPQDDDTCCVHHPEIDETGFAAVTVPVWRASTIVFPDMAAYAARNSKGHDAYSYGLHGTPTTRTLEAQIAR
LEGGGRSIVTSSGLSAITMTLQTMLSPGDTVLLVDTVYPPVREFADRFLRRMGVDIVYYDPAIGAGIAELITATTRLVWM
ESPGSTTMEVQDIPAIVAAARARGVPTAIDNTWATPLLLKPLELGVDIVIQAVSKYMAGHSDLLMGAVTVRDLALFDRLR
TAFKLLGHGVSPDDCSLVLRGLETLAVRLRQSSASALDLARMLEESGRFQAVLHPALPSFSGHAIWKRDFKGASGVFSVV
LKPESLDRLPNALSRLRVFAIGASWGGTHSLVAPMDITAARTATACPWRCPIIRLSVGMEGLADLRADLQAFAGGLTS
>Mature_397_residues
PMSPLLINPPQDDDTCCVHHPEIDETGFAAVTVPVWRASTIVFPDMAAYAARNSKGHDAYSYGLHGTPTTRTLEAQIARL
EGGGRSIVTSSGLSAITMTLQTMLSPGDTVLLVDTVYPPVREFADRFLRRMGVDIVYYDPAIGAGIAELITATTRLVWME
SPGSTTMEVQDIPAIVAAARARGVPTAIDNTWATPLLLKPLELGVDIVIQAVSKYMAGHSDLLMGAVTVRDLALFDRLRT
AFKLLGHGVSPDDCSLVLRGLETLAVRLRQSSASALDLARMLEESGRFQAVLHPALPSFSGHAIWKRDFKGASGVFSVVL
KPESLDRLPNALSRLRVFAIGASWGGTHSLVAPMDITAARTATACPWRCPIIRLSVGMEGLADLRADLQAFAGGLTS

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=295, Percent_Identity=33.8983050847458, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI299473759, Length=299, Percent_Identity=30.1003344481605, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI25453487, Length=294, Percent_Identity=29.5918367346939, Blast_Score=129, Evalue=5e-30,
Organism=Escherichia coli, GI1789383, Length=386, Percent_Identity=39.8963730569948, Blast_Score=266, Evalue=1e-72,
Organism=Escherichia coli, GI1790375, Length=371, Percent_Identity=29.3800539083558, Blast_Score=153, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17538055, Length=340, Percent_Identity=35, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17560056, Length=355, Percent_Identity=34.3661971830986, Blast_Score=181, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI71980708, Length=370, Percent_Identity=31.0810810810811, Blast_Score=175, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6321170, Length=325, Percent_Identity=39.3846153846154, Blast_Score=247, Evalue=2e-66,
Organism=Saccharomyces cerevisiae, GI6319307, Length=347, Percent_Identity=29.1066282420749, Blast_Score=137, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6321254, Length=398, Percent_Identity=27.8894472361809, Blast_Score=107, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6321904, Length=325, Percent_Identity=28.6153846153846, Blast_Score=100, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6323333, Length=436, Percent_Identity=24.7706422018349, Blast_Score=100, Evalue=6e-22,
Organism=Drosophila melanogaster, GI19922554, Length=382, Percent_Identity=33.7696335078534, Blast_Score=196, Evalue=2e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 42645; Mature: 42514

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPMSPLLINPPQDDDTCCVHHPEIDETGFAAVTVPVWRASTIVFPDMAAYAARNSKGHDA
CCCCCCEECCCCCCCCEEEECCCCCCCCCEEEEEEEECCCEEECCCHHHHHHCCCCCCCC
YSYGLHGTPTTRTLEAQIARLEGGGRSIVTSSGLSAITMTLQTMLSPGDTVLLVDTVYPP
EECCCCCCCCCHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCH
VREFADRFLRRMGVDIVYYDPAIGAGIAELITATTRLVWMESPGSTTMEVQDIPAIVAAA
HHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHEEEEEECCCCCEEEHHHHHHHHHHH
RARGVPTAIDNTWATPLLLKPLELGVDIVIQAVSKYMAGHSDLLMGAVTVRDLALFDRLR
HHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
TAFKLLGHGVSPDDCSLVLRGLETLAVRLRQSSASALDLARMLEESGRFQAVLHPALPSF
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEECCCCCCC
SGHAIWKRDFKGASGVFSVVLKPESLDRLPNALSRLRVFAIGASWGGTHSLVAPMDITAA
CCCEEEHHCCCCCCCEEEEEECCHHHHHHHHHHHHEEEEEEECCCCCCCCEECCCCCHHH
RTATACPWRCPIIRLSVGMEGLADLRADLQAFAGGLTS
CCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
PMSPLLINPPQDDDTCCVHHPEIDETGFAAVTVPVWRASTIVFPDMAAYAARNSKGHDA
CCCCCEECCCCCCCCEEEECCCCCCCCCEEEEEEEECCCEEECCCHHHHHHCCCCCCCC
YSYGLHGTPTTRTLEAQIARLEGGGRSIVTSSGLSAITMTLQTMLSPGDTVLLVDTVYPP
EECCCCCCCCCHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCH
VREFADRFLRRMGVDIVYYDPAIGAGIAELITATTRLVWMESPGSTTMEVQDIPAIVAAA
HHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHEEEEEECCCCCEEEHHHHHHHHHHH
RARGVPTAIDNTWATPLLLKPLELGVDIVIQAVSKYMAGHSDLLMGAVTVRDLALFDRLR
HHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
TAFKLLGHGVSPDDCSLVLRGLETLAVRLRQSSASALDLARMLEESGRFQAVLHPALPSF
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEECCCCCCC
SGHAIWKRDFKGASGVFSVVLKPESLDRLPNALSRLRVFAIGASWGGTHSLVAPMDITAA
CCCEEEHHCCCCCCCEEEEEECCHHHHHHHHHHHHEEEEEEECCCCCCCCEECCCCCHHH
RTATACPWRCPIIRLSVGMEGLADLRADLQAFAGGLTS
CCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]