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The map label for this gene is pepQ [H]

Identifier: 110634708

GI number: 110634708

Start: 2516742

End: 2517944

Strand: Reverse

Name: pepQ [H]

Synonym: Meso_2365

Alternate gene names: 110634708

Gene position: 2517944-2516742 (Counterclockwise)

Preceding gene: 110634709

Following gene: 110634707

Centisome position: 57.06

GC content: 65.17

Gene sequence:

>1203_bases
ATGAGCCGGCGCGATCTGGATCAACTGTCCCTGGCCTCTCAGCTTCGATCGCGGGTTTTTGCGCGAGGGCCGAACTTCGA
CGCGCTTATCACGTCCGACCCCGACCATGTGGGTTATCTGACCGGCTATCGAAGCATGTCCAGCGACATGAATCGCTATT
ATCCCATTGCGGCCGTCGCAACGGCGGACGATGCCATCCTAATCGTCAGCGCCGGCGACGCTCCGCCGGCCCGCGAGGTC
GTGGGCCAGGCAGTGATGACCTACGGTCGCTTCTTCGTGATGCAGGACGGCGCGTTCCAGCCTTCCGATGCGGATGAAGA
GCGCTCGTTCGGCGTCGCCATCGTCCAAGCCGTGAACAGGCTCTGCGGCCCACGCGCGACCGTAGGCCTGGACTGCACTG
GCCTCTCGGCACACGACGTCCGATCGGTTATTCAGCGCGACCTGCCGAATCTGCGGACCGTTTCTGCATCCCAATGGCTG
CGCGACTGCCGCCGCACCAAGCTGCCCGGTGAAATCGGGCAACTGCGCCGTGCCGCACGCCTGCTGGAGCGCGGCATCGA
AGCCGCTCTCGCAGCGGCGGAGCCTGGCGTGACCGAGCGATACATCGCCGCCCGGATCGCAAGCGCGGTGGTGGAGGGCG
GCGGCGTACCGCGCTCGCTGGCGGTCACCTCGGGCCCGCGATCGGCCTTGGTCGACGCCTATGCGGCCGAGCGGGAACTT
CAGCCGGGCGACCTGCTCAGGCTCGACCTCAGCTGTACGTTTCAGGGCTATTGGGCCGATATGGCCCGGACAGCCGTCAT
CGAAGGCCCATCTCCGCTGCAGCGGCAGTATTTCGATGCCATTTCTTCGGGTCTGGCTGCTCAGCGCGAGATATTGCGCG
CGGGCATTGAGGCGCGCCGGCTTTTTGACGTGGCGGTCGAAGCCACGCGCGGCAACGGTATCCCGCACTACCGCCGCCAT
CATTGCGGCCATGGCATCGGGGTTACGATCAACGAGTTTCCGGTGTTGTCGCCCGAAAACACCGCAGAGCTGGAGTCGGG
GATGGTGCTGTGCATCGAGACACCGCTCTACGCGGCGGGCTGGGGCGGCATGATGACTGAGGACATCGTCGAAGTGACCG
ACACTGGATGGAACCCCATAACCGAACTGTCGCGCCACCTGCACGTCTGCACCGGCGGACGCGCTGAAGTTCTTGCCTCC
TGA

Upstream 100 bases:

>100_bases
GCGCGCGTCTGGAAGCGCGGATCGCTGCCTTGAATAGCGCGGAGCGAAAGCGGGCGGCGGCCATAGCGGCCATTTTGAAC
GCGCCGGAGGCGGCAACCCG

Downstream 100 bases:

>100_bases
CGAGATGCCTATGTCGCCGTTGCTTATCAACCCGCCGCAGGATGATGACACTTGCTGTGTCCACCATCCCGAGATCGACG
AGACCGGCTTTGCGGCCGTC

Product: peptidase M24

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MSRRDLDQLSLASQLRSRVFARGPNFDALITSDPDHVGYLTGYRSMSSDMNRYYPIAAVATADDAILIVSAGDAPPAREV
VGQAVMTYGRFFVMQDGAFQPSDADEERSFGVAIVQAVNRLCGPRATVGLDCTGLSAHDVRSVIQRDLPNLRTVSASQWL
RDCRRTKLPGEIGQLRRAARLLERGIEAALAAAEPGVTERYIAARIASAVVEGGGVPRSLAVTSGPRSALVDAYAAEREL
QPGDLLRLDLSCTFQGYWADMARTAVIEGPSPLQRQYFDAISSGLAAQREILRAGIEARRLFDVAVEATRGNGIPHYRRH
HCGHGIGVTINEFPVLSPENTAELESGMVLCIETPLYAAGWGGMMTEDIVEVTDTGWNPITELSRHLHVCTGGRAEVLAS

Sequences:

>Translated_400_residues
MSRRDLDQLSLASQLRSRVFARGPNFDALITSDPDHVGYLTGYRSMSSDMNRYYPIAAVATADDAILIVSAGDAPPAREV
VGQAVMTYGRFFVMQDGAFQPSDADEERSFGVAIVQAVNRLCGPRATVGLDCTGLSAHDVRSVIQRDLPNLRTVSASQWL
RDCRRTKLPGEIGQLRRAARLLERGIEAALAAAEPGVTERYIAARIASAVVEGGGVPRSLAVTSGPRSALVDAYAAEREL
QPGDLLRLDLSCTFQGYWADMARTAVIEGPSPLQRQYFDAISSGLAAQREILRAGIEARRLFDVAVEATRGNGIPHYRRH
HCGHGIGVTINEFPVLSPENTAELESGMVLCIETPLYAAGWGGMMTEDIVEVTDTGWNPITELSRHLHVCTGGRAEVLAS
>Mature_399_residues
SRRDLDQLSLASQLRSRVFARGPNFDALITSDPDHVGYLTGYRSMSSDMNRYYPIAAVATADDAILIVSAGDAPPAREVV
GQAVMTYGRFFVMQDGAFQPSDADEERSFGVAIVQAVNRLCGPRATVGLDCTGLSAHDVRSVIQRDLPNLRTVSASQWLR
DCRRTKLPGEIGQLRRAARLLERGIEAALAAAEPGVTERYIAARIASAVVEGGGVPRSLAVTSGPRSALVDAYAAERELQ
PGDLLRLDLSCTFQGYWADMARTAVIEGPSPLQRQYFDAISSGLAAQREILRAGIEARRLFDVAVEATRGNGIPHYRRHH
CGHGIGVTINEFPVLSPENTAELESGMVLCIETPLYAAGWGGMMTEDIVEVTDTGWNPITELSRHLHVCTGGRAEVLAS

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788728, Length=220, Percent_Identity=32.7272727272727, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1789275, Length=256, Percent_Identity=25.390625, Blast_Score=68, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 43251; Mature: 43120

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRRDLDQLSLASQLRSRVFARGPNFDALITSDPDHVGYLTGYRSMSSDMNRYYPIAAVA
CCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCEEEEE
TADDAILIVSAGDAPPAREVVGQAVMTYGRFFVMQDGAFQPSDADEERSFGVAIVQAVNR
ECCCEEEEEECCCCCHHHHHHHHHHHHHCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHH
LCGPRATVGLDCTGLSAHDVRSVIQRDLPNLRTVSASQWLRDCRRTKLPGEIGQLRRAAR
HCCCCCEEECEECCCCHHHHHHHHHHCCCCCEECCHHHHHHHHHHCCCCHHHHHHHHHHH
LLERGIEAALAAAEPGVTERYIAARIASAVVEGGGVPRSLAVTSGPRSALVDAYAAEREL
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHCCC
QPGDLLRLDLSCTFQGYWADMARTAVIEGPSPLQRQYFDAISSGLAAQREILRAGIEARR
CCCCEEEEEEEEEECHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFDVAVEATRGNGIPHYRRHHCGHGIGVTINEFPVLSPENTAELESGMVLCIETPLYAAG
HHHHHHHHHCCCCCCCHHHHHCCCCCCEEECCCCCCCCCCHHHHHCCEEEEEECCCEECC
WGGMMTEDIVEVTDTGWNPITELSRHLHVCTGGRAEVLAS
CCCCHHHHHHHHHCCCCCHHHHHHHHEEEECCCCHHHCCC
>Mature Secondary Structure 
SRRDLDQLSLASQLRSRVFARGPNFDALITSDPDHVGYLTGYRSMSSDMNRYYPIAAVA
CCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCEEEEE
TADDAILIVSAGDAPPAREVVGQAVMTYGRFFVMQDGAFQPSDADEERSFGVAIVQAVNR
ECCCEEEEEECCCCCHHHHHHHHHHHHHCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHH
LCGPRATVGLDCTGLSAHDVRSVIQRDLPNLRTVSASQWLRDCRRTKLPGEIGQLRRAAR
HCCCCCEEECEECCCCHHHHHHHHHHCCCCCEECCHHHHHHHHHHCCCCHHHHHHHHHHH
LLERGIEAALAAAEPGVTERYIAARIASAVVEGGGVPRSLAVTSGPRSALVDAYAAEREL
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHCCC
QPGDLLRLDLSCTFQGYWADMARTAVIEGPSPLQRQYFDAISSGLAAQREILRAGIEARR
CCCCEEEEEEEEEECHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFDVAVEATRGNGIPHYRRHHCGHGIGVTINEFPVLSPENTAELESGMVLCIETPLYAAG
HHHHHHHHHCCCCCCCHHHHHCCCCCCEEECCCCCCCCCCHHHHHCCEEEEEECCCEECC
WGGMMTEDIVEVTDTGWNPITELSRHLHVCTGGRAEVLAS
CCCCHHHHHHHHHCCCCCHHHHHHHHEEEECCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9733678; 11223522; 11210522 [H]