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The map label for this gene is cadA [H]

Identifier: 110634596

GI number: 110634596

Start: 2402312

End: 2404177

Strand: Direct

Name: cadA [H]

Synonym: Meso_2249

Alternate gene names: 110634596

Gene position: 2402312-2404177 (Clockwise)

Preceding gene: 110634595

Following gene: 110634597

Centisome position: 54.44

GC content: 66.72

Gene sequence:

>1866_bases
TTGACTGAGGCGTTTCTCAGGCGGGTTCTCCTCGGCATCGCCCTGCTTGGACTTGCCGCCGGCCTCGCGATGAGGGCCGG
ACTCCAACCTCAGCTTTCGATGGGCATTGGTCCCGAGGAAATCTGGGCCGCCGGAGCCATTCCCGTTGTCATCGTGCTCT
TCGTCTCGATCCTGCGGGATTTTTGGATCGGCCGGTTCGGCGTCGATGCCATCGCTCTGGTTTCGATCTCCGCGGCGCTG
CTGCTTGATCAGTCGCTTGCCGCGGTCGTGGTGGCGATCATGTATGCCGGCGGCACGGTGCTGGAGGATTTCGCGCGCGG
TCGGGCCGAGCGCAGCCTCAAGGCGTTGACCGACAGGTCGCCGCGCTTTGCACTCCGGAAATCTGCGGAAGCCGTCGAGA
CGATCCCGGTCGACGATGTTCGTGTTGGCGACGAGATCCTCGTTCGCGCCGGTGATGTGCTTCCGGTGGACGGCCATCTG
CTCGACCCGGCGGCAAAGATCGATGAGCAAGCCGTCACCGGCGAGCCACTGCCAGAAAACCGCCACGCGGGGGACTTGCT
GCGCAGCGGCACCGTCAATGCCGGTGAGGCTTTCACGATGCGTGCGTCGGCTCCTGCGGACCAAAGCACCTATGCAGGGA
TCGTGCGCATGGTCGCAATTGCCCAGACGGCCAAGGCGCCCTTCATCCGCATGGCGGACCGCTTTGCCCTTCTCCTGCTG
CCGGCTACGCTGATTGTCGCCGCGCTCGCCTGGTATGCCTCGAGCGATCCTATCCGCGCGCTCGCCGTTCTGGTCGTTGC
AACCCCCTGCCCGCTGATCCTCGCAACCCCGGTCGCGTTCATCGGTGGTGTCTCGCGGGCTGCGCGCGCCGGCATTCTGA
TGAAGGGCAGCGAAGCACTGGAGGCCCTTGCGCGAGCGCGTACCGCCGTCTTTGACAAGACCGGCACGCTCACCCGCGGC
GGCGCCCAGTTGGTGGAACAGGAGACCGCACCAGGCCGCGACCCGGAGGAGGTGCTGCGACTGCTCGCCTCCCTGGAGCA
GGCTTCCCATCACGTGCTGGCGGACGCCATCGCTGGCGAGGCGCGTGCCCGCAATCTGCCGCTGTCACATCCCGCCAAGG
TGAGGGAACACCGTGGCGCCGGGCTGGAAGGCATCGTAGACGGAACGCAGATCCGTGCCGGCTCGCGCGTCCTCGTGTTG
GGCGGCAGCGTCGCTCCGATCTGGGCAACGGACGGCGAAAGACGTTATGGCGGCCAGCCGGTGCTGAGGGTCTATGTTGC
CCTCGACGATCGCCTTGCCGGCATCTTCACCTTCGGCGATGCCTTGCGTGGCGACGCCGCCGAGACACTTCGCATGTTGA
AAGCGTTCGGCATCGGCCGAACGGTCATGCTGACCGGAGATGACCGCCAGACCGCGGCGCGTGTGGCCGCACAGCTCGAC
TTCGATACCGTGGTCGCCGATGCAAACCCCGCGGAAAAGGTCGAAGCGGTAAAAGAGGAGATGCGGCAGGCGCCGACCAT
GATGATCGGCGACGGCATCAACGATGCCCCCGCCCTGGCCGCCGCCACGGTCGGCGTTGCCATGGGCGCGCGCGGCGCCA
CCGCGTCCTCGCAAACCGCGGATGTGGTTGTCCTGACAGACCGCCTGCGCCCGGTGGGTGAGGCCCTGCAGATCGCGCAC
CGCACGCGCGCGATCGCCCTGCAAAGCATCGTCGTCGGCCTGACCCTCTCGGGAGTGGCGATGATTGCTGCCGCTTTCGG
GCTGATTACGCCGGTCGCGGGCGCCGTCCTGCAGGAGGGGATCGACATCGCGGTCATTCTCAATGCCTTGCGGGCACTTG
GCCGCGGTTCTGTGACGACCGGCTGA

Upstream 100 bases:

>100_bases
AACTGAACTGCCGCTGCCGGTTCCACCTGCGGGCCGCGTGCTGGAGCAACTGAGTGCAGCGGCAGGCCGGGAAAAAGGCC
CCGCCGCATGGAAGATCATT

Downstream 100 bases:

>100_bases
CACAGGCGAACGAAAGCAGCGGGCCAAACGCCGACATGGCGGACATTCTCTGCCGGATTTGATCCAGAGCAAAGTCGGGC
CCGGCCCGATGCCTCAAAGC

Product: heavy metal translocating P-type ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 621; Mature: 620

Protein sequence:

>621_residues
MTEAFLRRVLLGIALLGLAAGLAMRAGLQPQLSMGIGPEEIWAAGAIPVVIVLFVSILRDFWIGRFGVDAIALVSISAAL
LLDQSLAAVVVAIMYAGGTVLEDFARGRAERSLKALTDRSPRFALRKSAEAVETIPVDDVRVGDEILVRAGDVLPVDGHL
LDPAAKIDEQAVTGEPLPENRHAGDLLRSGTVNAGEAFTMRASAPADQSTYAGIVRMVAIAQTAKAPFIRMADRFALLLL
PATLIVAALAWYASSDPIRALAVLVVATPCPLILATPVAFIGGVSRAARAGILMKGSEALEALARARTAVFDKTGTLTRG
GAQLVEQETAPGRDPEEVLRLLASLEQASHHVLADAIAGEARARNLPLSHPAKVREHRGAGLEGIVDGTQIRAGSRVLVL
GGSVAPIWATDGERRYGGQPVLRVYVALDDRLAGIFTFGDALRGDAAETLRMLKAFGIGRTVMLTGDDRQTAARVAAQLD
FDTVVADANPAEKVEAVKEEMRQAPTMMIGDGINDAPALAAATVGVAMGARGATASSQTADVVVLTDRLRPVGEALQIAH
RTRAIALQSIVVGLTLSGVAMIAAAFGLITPVAGAVLQEGIDIAVILNALRALGRGSVTTG

Sequences:

>Translated_621_residues
MTEAFLRRVLLGIALLGLAAGLAMRAGLQPQLSMGIGPEEIWAAGAIPVVIVLFVSILRDFWIGRFGVDAIALVSISAAL
LLDQSLAAVVVAIMYAGGTVLEDFARGRAERSLKALTDRSPRFALRKSAEAVETIPVDDVRVGDEILVRAGDVLPVDGHL
LDPAAKIDEQAVTGEPLPENRHAGDLLRSGTVNAGEAFTMRASAPADQSTYAGIVRMVAIAQTAKAPFIRMADRFALLLL
PATLIVAALAWYASSDPIRALAVLVVATPCPLILATPVAFIGGVSRAARAGILMKGSEALEALARARTAVFDKTGTLTRG
GAQLVEQETAPGRDPEEVLRLLASLEQASHHVLADAIAGEARARNLPLSHPAKVREHRGAGLEGIVDGTQIRAGSRVLVL
GGSVAPIWATDGERRYGGQPVLRVYVALDDRLAGIFTFGDALRGDAAETLRMLKAFGIGRTVMLTGDDRQTAARVAAQLD
FDTVVADANPAEKVEAVKEEMRQAPTMMIGDGINDAPALAAATVGVAMGARGATASSQTADVVVLTDRLRPVGEALQIAH
RTRAIALQSIVVGLTLSGVAMIAAAFGLITPVAGAVLQEGIDIAVILNALRALGRGSVTTG
>Mature_620_residues
TEAFLRRVLLGIALLGLAAGLAMRAGLQPQLSMGIGPEEIWAAGAIPVVIVLFVSILRDFWIGRFGVDAIALVSISAALL
LDQSLAAVVVAIMYAGGTVLEDFARGRAERSLKALTDRSPRFALRKSAEAVETIPVDDVRVGDEILVRAGDVLPVDGHLL
DPAAKIDEQAVTGEPLPENRHAGDLLRSGTVNAGEAFTMRASAPADQSTYAGIVRMVAIAQTAKAPFIRMADRFALLLLP
ATLIVAALAWYASSDPIRALAVLVVATPCPLILATPVAFIGGVSRAARAGILMKGSEALEALARARTAVFDKTGTLTRGG
AQLVEQETAPGRDPEEVLRLLASLEQASHHVLADAIAGEARARNLPLSHPAKVREHRGAGLEGIVDGTQIRAGSRVLVLG
GSVAPIWATDGERRYGGQPVLRVYVALDDRLAGIFTFGDALRGDAAETLRMLKAFGIGRTVMLTGDDRQTAARVAAQLDF
DTVVADANPAEKVEAVKEEMRQAPTMMIGDGINDAPALAAATVGVAMGARGATASSQTADVVVLTDRLRPVGEALQIAHR
TRAIALQSIVVGLTLSGVAMIAAAFGLITPVAGAVLQEGIDIAVILNALRALGRGSVTTG

Specific function: Couples the hydrolysis of ATP with the transport of cadmium, zinc and cobalt out of the cell. Does not seem to transport copper [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=547, Percent_Identity=29.6160877513711, Blast_Score=182, Evalue=6e-46,
Organism=Homo sapiens, GI55743073, Length=517, Percent_Identity=29.9806576402321, Blast_Score=172, Evalue=1e-42,
Organism=Homo sapiens, GI115529486, Length=315, Percent_Identity=28.5714285714286, Blast_Score=114, Evalue=4e-25,
Organism=Escherichia coli, GI1789879, Length=564, Percent_Identity=34.0425531914894, Blast_Score=248, Evalue=8e-67,
Organism=Escherichia coli, GI1786691, Length=540, Percent_Identity=35, Blast_Score=223, Evalue=3e-59,
Organism=Escherichia coli, GI1786914, Length=537, Percent_Identity=29.4227188081937, Blast_Score=136, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17556548, Length=352, Percent_Identity=30.3977272727273, Blast_Score=110, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6320475, Length=542, Percent_Identity=28.5977859778598, Blast_Score=197, Evalue=6e-51,
Organism=Saccharomyces cerevisiae, GI6319772, Length=558, Percent_Identity=26.1648745519713, Blast_Score=149, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6321430, Length=523, Percent_Identity=26.7686424474187, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6325221, Length=602, Percent_Identity=25.9136212624585, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI221329854, Length=334, Percent_Identity=30.8383233532934, Blast_Score=117, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR001366
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: =3.6.3.3; =3.6.3.5 [H]

Molecular weight: Translated: 64655; Mature: 64524

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS00154 ATPASE_E1_E2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEAFLRRVLLGIALLGLAAGLAMRAGLQPQLSMGIGPEEIWAAGAIPVVIVLFVSILRD
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCHHHHHHCCHHHHHHHHHHHHHHH
FWIGRFGVDAIALVSISAALLLDQSLAAVVVAIMYAGGTVLEDFARGRAERSLKALTDRS
HHCCHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCC
PRFALRKSAEAVETIPVDDVRVGDEILVRAGDVLPVDGHLLDPAAKIDEQAVTGEPLPEN
CHHHHHHCCHHHHCCCCCCCCCCHHHHHCCCCEECCCCCEECCHHHHCCCCCCCCCCCCC
RHAGDLLRSGTVNAGEAFTMRASAPADQSTYAGIVRMVAIAQTAKAPFIRMADRFALLLL
CCHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
PATLIVAALAWYASSDPIRALAVLVVATPCPLILATPVAFIGGVSRAARAGILMKGSEAL
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHCCEEEECHHHH
EALARARTAVFDKTGTLTRGGAQLVEQETAPGRDPEEVLRLLASLEQASHHVLADAIAGE
HHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCH
ARARNLPLSHPAKVREHRGAGLEGIVDGTQIRAGSRVLVLGGSVAPIWATDGERRYGGQP
HHHCCCCCCCCHHHHHHCCCCCCCCCCCCEECCCCEEEEECCCCCEEEECCCCCCCCCCC
VLRVYVALDDRLAGIFTFGDALRGDAAETLRMLKAFGIGRTVMLTGDDRQTAARVAAQLD
EEEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHCC
FDTVVADANPAEKVEAVKEEMRQAPTMMIGDGINDAPALAAATVGVAMGARGATASSQTA
HHHEEECCCHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
DVVVLTDRLRPVGEALQIAHRTRAIALQSIVVGLTLSGVAMIAAAFGLITPVAGAVLQEG
EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
IDIAVILNALRALGRGSVTTG
CHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TEAFLRRVLLGIALLGLAAGLAMRAGLQPQLSMGIGPEEIWAAGAIPVVIVLFVSILRD
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCHHHHHHCCHHHHHHHHHHHHHHH
FWIGRFGVDAIALVSISAALLLDQSLAAVVVAIMYAGGTVLEDFARGRAERSLKALTDRS
HHCCHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCC
PRFALRKSAEAVETIPVDDVRVGDEILVRAGDVLPVDGHLLDPAAKIDEQAVTGEPLPEN
CHHHHHHCCHHHHCCCCCCCCCCHHHHHCCCCEECCCCCEECCHHHHCCCCCCCCCCCCC
RHAGDLLRSGTVNAGEAFTMRASAPADQSTYAGIVRMVAIAQTAKAPFIRMADRFALLLL
CCHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
PATLIVAALAWYASSDPIRALAVLVVATPCPLILATPVAFIGGVSRAARAGILMKGSEAL
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHCCEEEECHHHH
EALARARTAVFDKTGTLTRGGAQLVEQETAPGRDPEEVLRLLASLEQASHHVLADAIAGE
HHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCH
ARARNLPLSHPAKVREHRGAGLEGIVDGTQIRAGSRVLVLGGSVAPIWATDGERRYGGQP
HHHCCCCCCCCHHHHHHCCCCCCCCCCCCEECCCCEEEEECCCCCEEEECCCCCCCCCCC
VLRVYVALDDRLAGIFTFGDALRGDAAETLRMLKAFGIGRTVMLTGDDRQTAARVAAQLD
EEEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHCC
FDTVVADANPAEKVEAVKEEMRQAPTMMIGDGINDAPALAAATVGVAMGARGATASSQTA
HHHEEECCCHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
DVVVLTDRLRPVGEALQIAHRTRAIALQSIVVGLTLSGVAMIAAAFGLITPVAGAVLQEG
EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
IDIAVILNALRALGRGSVTTG
CHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]