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The map label for this gene is etrA [H]

Identifier: 110634593

GI number: 110634593

Start: 2400211

End: 2400912

Strand: Direct

Name: etrA [H]

Synonym: Meso_2246

Alternate gene names: 110634593

Gene position: 2400211-2400912 (Clockwise)

Preceding gene: 110634591

Following gene: 110634595

Centisome position: 54.4

GC content: 65.95

Gene sequence:

>702_bases
GTGCCGAAGCTCGATGCATCGCTGATTGCTGGCCTGCCACCTTTCGAAGGCCTCGAGAAGGACGACCTCGAGCAAGTGCT
CGCCCCCGCCCGGTCCTTGCGGTTCGCAAGAGAGAAGCCGATTTTCGAGCAGGAGGGGGAGGCGCGATTCTTCTTCGTTC
TGCTCGACGGGCATGTGCGTGTGGTGCGCACCACGCCGGAAGGCCAACAGGTCATCGTCCGCTACATCAGCGAGGGCGAG
GTCTTCGGCATCGCCGCCGCCCTTGGCCGCACCACCTATCCGGCGACCGCGATTGCCGCGGCGGATTGCCTGGTGCTGGC
TTGGCCGAGCGCGCTGTGGCCGGAACTGTCAACCCGCTATCCCACGCTCGGCGCCAACACCTACAGGACCGTCGGCAGCC
GTCTCCAGGAGGCGCATGCGCGCGTAGTCGAGATGTCGAAGGAGCAGGTGGAGCAGCGCGTGGCGCACGCTCTCCTGCGG
CTGGTGAGGCAGACGGGCCGAAAGACGGCAGAGGGGATCGAGATCGATTTCCCGATCACGCGCCAGGACATCGCGGAGAT
GACCGGCGCGACCTTGCACACTGTTAGCCGGCTCATGAGCGCGTGGGAGGGCGAGGGGATCGTCAAGAGCGGCCGCAAGC
GCGTGACCGTTTCCGACTCGCACCGCCTGATGCTGAAGGCGGAAAGCCGCGAGAAGCGATAA

Upstream 100 bases:

>100_bases
GGTCTCGGGTGTTGCATCCTGTCTATCGCCGAGAGCAGGCGGAGAATTTGCGCTCGCGCAAAGTGAGCCGAAAATATCCA
CCGAACCGCCGGGAGATGAT

Downstream 100 bases:

>100_bases
TCGCTCCTTCAACCGCCGCGATCGCCGCCCTCAACTCCTCCAGGAAGGCACCTTCGTCTATCATATGCTCGCGGCAGGCG
TCGTTGACGGTGTGAAAAGC

Product: Crp/FNR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 233; Mature: 232

Protein sequence:

>233_residues
MPKLDASLIAGLPPFEGLEKDDLEQVLAPARSLRFAREKPIFEQEGEARFFFVLLDGHVRVVRTTPEGQQVIVRYISEGE
VFGIAAALGRTTYPATAIAAADCLVLAWPSALWPELSTRYPTLGANTYRTVGSRLQEAHARVVEMSKEQVEQRVAHALLR
LVRQTGRKTAEGIEIDFPITRQDIAEMTGATLHTVSRLMSAWEGEGIVKSGRKRVTVSDSHRLMLKAESREKR

Sequences:

>Translated_233_residues
MPKLDASLIAGLPPFEGLEKDDLEQVLAPARSLRFAREKPIFEQEGEARFFFVLLDGHVRVVRTTPEGQQVIVRYISEGE
VFGIAAALGRTTYPATAIAAADCLVLAWPSALWPELSTRYPTLGANTYRTVGSRLQEAHARVVEMSKEQVEQRVAHALLR
LVRQTGRKTAEGIEIDFPITRQDIAEMTGATLHTVSRLMSAWEGEGIVKSGRKRVTVSDSHRLMLKAESREKR
>Mature_232_residues
PKLDASLIAGLPPFEGLEKDDLEQVLAPARSLRFAREKPIFEQEGEARFFFVLLDGHVRVVRTTPEGQQVIVRYISEGEV
FGIAAALGRTTYPATAIAAADCLVLAWPSALWPELSTRYPTLGANTYRTVGSRLQEAHARVVEMSKEQVEQRVAHALLRL
VRQTGRKTAEGIEIDFPITRQDIAEMTGATLHTVSRLMSAWEGEGIVKSGRKRVTVSDSHRLMLKAESREKR

Specific function: Regulates anaerobic growth on fumarate, nitrite, Fe(3+), TMAO, DMSO, thiosulfate and sulfite, but not on nitrate nor Mn(4+) [H]

COG id: COG0664

COG function: function code T; cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH crp-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787595, Length=205, Percent_Identity=21.9512195121951, Blast_Score=68, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018490
- InterPro:   IPR000595
- InterPro:   IPR001808
- InterPro:   IPR012318
- InterPro:   IPR014710
- InterPro:   IPR018335
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00027 cNMP_binding; PF00325 Crp [H]

EC number: NA

Molecular weight: Translated: 25936; Mature: 25805

Theoretical pI: Translated: 9.05; Mature: 9.05

Prosite motif: PS50042 CNMP_BINDING_3 ; PS51063 HTH_CRP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKLDASLIAGLPPFEGLEKDDLEQVLAPARSLRFAREKPIFEQEGEARFFFVLLDGHVR
CCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCEE
VVRTTPEGQQVIVRYISEGEVFGIAAALGRTTYPATAIAAADCLVLAWPSALWPELSTRY
EEEECCCHHHHHHHHHHCCCEEEHHHHHCCCCCCHHHHHHHHHHEEECCHHHCCHHHCCC
PTLGANTYRTVGSRLQEAHARVVEMSKEQVEQRVAHALLRLVRQTGRKTAEGIEIDFPIT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCC
RQDIAEMTGATLHTVSRLMSAWEGEGIVKSGRKRVTVSDSHRLMLKAESREKR
HHHHHHHCCHHHHHHHHHHHHHCCCCHHHCCCEEEEECCCCEEEEEECCCCCC
>Mature Secondary Structure 
PKLDASLIAGLPPFEGLEKDDLEQVLAPARSLRFAREKPIFEQEGEARFFFVLLDGHVR
CCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCEE
VVRTTPEGQQVIVRYISEGEVFGIAAALGRTTYPATAIAAADCLVLAWPSALWPELSTRY
EEEECCCHHHHHHHHHHCCCEEEHHHHHCCCCCCHHHHHHHHHHEEECCHHHCCHHHCCC
PTLGANTYRTVGSRLQEAHARVVEMSKEQVEQRVAHALLRLVRQTGRKTAEGIEIDFPIT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCC
RQDIAEMTGATLHTVSRLMSAWEGEGIVKSGRKRVTVSDSHRLMLKAESREKR
HHHHHHHCCHHHHHHHHHHHHHCCCCHHHCCCEEEEECCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8253682; 12368813 [H]