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The map label for this gene is trpE(G) [H]

Identifier: 110634548

GI number: 110634548

Start: 2346589

End: 2348778

Strand: Reverse

Name: trpE(G) [H]

Synonym: Meso_2199

Alternate gene names: 110634548

Gene position: 2348778-2346589 (Counterclockwise)

Preceding gene: 110634549

Following gene: 110634547

Centisome position: 53.23

GC content: 63.47

Gene sequence:

>2190_bases
ATGAGCTTGGAAGTCTTGGAAGACGGCAGCGAGCGCTTCGTCACGGCGGGCGGTATCGCGATTACCCGTTCGCGCATGGA
GGTGCCTTACGGCGGCGCAATCGACGCCTATATCGACGCGCTCGACAGCCGCCGAGGGGCGGTGTTTTCCTCCAATTACG
AGTATCCAGGCCGCTATACGCGCTGGGATACGGCCATTGTCGATCCTCCACTTGTGATTTCCGCGCGTGGCCGCGCCATG
AAGATCGAGGCGCTGAACAGGCGCGGTGAAGCGATGCTGCCTGCCATCGCCGGCGTCGTCGAGGCGCTGCCGGAGGTAAC
CATGGCCCTCGCGCAGCCGCGGCTGATCACGGTCGATGTGTCCGAGCCGACGGAGGTCTTTGCGGAGGAGGAGCGCTCCC
GCGTTCCTTCCGTCTTCACCGTGCTTCGCGCCATCACCAATCTCTTCCACACGGACAACGACAGCAATCTCGGACTCTAC
GGCGCGTTCGGCTACGATCTTGCCTTCCAGTTTGACCCGGTGAAGCTGCGGCTCGACCGGCCGGAGAGCCAGCGCGATCT
GGTGCTGTTCCTGCCCGACGAGATCCTCGTGGTCGATCACTACACGGCCAAGGCATGGCATGACCGCTACGACTATGCGG
GCGAGGGCTTTTCCACCGAGGGCCTGCCGCGGGAGGGCCGTGAGGAGCCGTTCCAGAAGCCGTTGAAAGTGCCGCCGCGC
TGCGATCATGAGCCTGGCGAATATGCGAGCCTCGTCGAGAAGGCGAAAGAGAGTTTTCGGCGCGGCGACCTCTTCGAGGT
GGTGCCGGGGCAGATGTTTTTCGAGCAATGCCAGAACCCGCCCTCGGCCATCTGCCGCAGGCTGAAGCAGATCAATCCAT
CGCCCTATTCCTTCTTCATCAATCTCGGTGAGGGGGAATATCTCGTCGGCGCCTCGCCGGAGATGTTCGTGCGTGTGTCG
GGCCGGCGCGTTGAGACCTGCCCGATCTCCGGCACCATCAAGCGCGGCGACGACGCGATCTCCGATTCGGAGCAGATCCT
GAAGCTCTTGAACTCCAAGAAGGACGAGTCGGAGCTGACAATGTGCTCGGATGTCGACCGCAACGATAAGAGCCGCGTGT
GCGAGCCGGGCTCGGTGCGCGTGATCGGGCGGCGGCAGATCGAAATGTACTCGCGCCTGATCCACACGGTGGACCATATC
GAAGGCCGGCTGCGCGAGGGCATGGACGCCTATGATGCGTTCCTCAGCCATGCCTGGGCAGTCACCGTTACTGGCGCGCC
GAAGCTCTGGGCCATGCGTTTCATCGAGGAGAACGAGAAGAGCCCGCGCGCCTGGTATGGCGGGGCGGTCGGCATGGTCC
ATTTCAACGGCGACATGAACACGGGCCTGACGCTGCGCACCATACGCATCAAGGACGGCATCGCCGAAGTGCGGGCAGGG
GCGACGCTTCTCTTCGATTCCAATGGAGAGGAAGAGGAGGCCGAAACGGAACTCAAGGCTTCTGCAATGCTTTCGGCCAT
TCGCGACGCGGGGAAGACGAATATGGCCAATGAAGAACGAGAGACAGCGCGCGTGGGCGAGGGCGTGAAAATCCTCCTGG
TGGATCACGAGGACTCCTTCGTGCACACGCTCGCAAACTATTTCCGGCAGACGGGCGCGGAGGTGACGACCGTGCGCACG
CCGGTTGCCGAAAGCGTGTTCGAGCGCGTGAAACCGGATCTTGTGGTGCTTTCGCCGGGGCCGGGCACGCCGGAGGACTT
CGACTGCACGGCTACGATCAAAAAGGCGCGCGGGCGGGAACTCCCGATTTTCGGCGTCTGTCTCGGCCTGCAGGCGCTGG
TGGTTGCCTATGGCGGCGAGCTGCGCCACCTGCACGAGCCGATGCACGGCAAGCCCTCGCGCATCCGCGCCGGCCACAAC
AGCCTTATCTTCTCGGGTCTGCCGCAGGAGGTGACGGTGGGGCGCTATCACTCGATCTTCGCCGATCCGGTGCGCCTGCC
GAAGCCCTTCGTCGTCACGGCAGAGACGGAGGACGGCGTGGTGATGGCGATCGAGCATGAGAGCGAGCCGGTGGCGGCTG
TGCAGTTTCACCCCGAATCCATCATGACGCTCGGCCACAATGCCGGCATGCGCATGATCGAGAACGTTGTGGCGCATCTG
CCGCGGAAATCCAAGGTGAAGGCGGCGTGA

Upstream 100 bases:

>100_bases
CTAGCATGAGCGTTTGAACTTCGACGATGGCCGCAGGTGAAAACCGGGCGGCCATTTTAGTTTGGGGCTTCCCGGCGGCA
TCTTGAAACGGGAGCAGGAG

Downstream 100 bases:

>100_bases
CCATGCCGCCTTTTCATAACTCCGCGGCAATGGCCGCCGCGTAGCCAATGCCGAAGCGCTCCAACATCCGCCGTCTGTCC
ACGTGGACCATCGTGGTCGG

Product: anthranilate synthase

Products: NA

Alternate protein names: Glutamine amidotransferase [H]

Number of amino acids: Translated: 729; Mature: 728

Protein sequence:

>729_residues
MSLEVLEDGSERFVTAGGIAITRSRMEVPYGGAIDAYIDALDSRRGAVFSSNYEYPGRYTRWDTAIVDPPLVISARGRAM
KIEALNRRGEAMLPAIAGVVEALPEVTMALAQPRLITVDVSEPTEVFAEEERSRVPSVFTVLRAITNLFHTDNDSNLGLY
GAFGYDLAFQFDPVKLRLDRPESQRDLVLFLPDEILVVDHYTAKAWHDRYDYAGEGFSTEGLPREGREEPFQKPLKVPPR
CDHEPGEYASLVEKAKESFRRGDLFEVVPGQMFFEQCQNPPSAICRRLKQINPSPYSFFINLGEGEYLVGASPEMFVRVS
GRRVETCPISGTIKRGDDAISDSEQILKLLNSKKDESELTMCSDVDRNDKSRVCEPGSVRVIGRRQIEMYSRLIHTVDHI
EGRLREGMDAYDAFLSHAWAVTVTGAPKLWAMRFIEENEKSPRAWYGGAVGMVHFNGDMNTGLTLRTIRIKDGIAEVRAG
ATLLFDSNGEEEEAETELKASAMLSAIRDAGKTNMANEERETARVGEGVKILLVDHEDSFVHTLANYFRQTGAEVTTVRT
PVAESVFERVKPDLVVLSPGPGTPEDFDCTATIKKARGRELPIFGVCLGLQALVVAYGGELRHLHEPMHGKPSRIRAGHN
SLIFSGLPQEVTVGRYHSIFADPVRLPKPFVVTAETEDGVVMAIEHESEPVAAVQFHPESIMTLGHNAGMRMIENVVAHL
PRKSKVKAA

Sequences:

>Translated_729_residues
MSLEVLEDGSERFVTAGGIAITRSRMEVPYGGAIDAYIDALDSRRGAVFSSNYEYPGRYTRWDTAIVDPPLVISARGRAM
KIEALNRRGEAMLPAIAGVVEALPEVTMALAQPRLITVDVSEPTEVFAEEERSRVPSVFTVLRAITNLFHTDNDSNLGLY
GAFGYDLAFQFDPVKLRLDRPESQRDLVLFLPDEILVVDHYTAKAWHDRYDYAGEGFSTEGLPREGREEPFQKPLKVPPR
CDHEPGEYASLVEKAKESFRRGDLFEVVPGQMFFEQCQNPPSAICRRLKQINPSPYSFFINLGEGEYLVGASPEMFVRVS
GRRVETCPISGTIKRGDDAISDSEQILKLLNSKKDESELTMCSDVDRNDKSRVCEPGSVRVIGRRQIEMYSRLIHTVDHI
EGRLREGMDAYDAFLSHAWAVTVTGAPKLWAMRFIEENEKSPRAWYGGAVGMVHFNGDMNTGLTLRTIRIKDGIAEVRAG
ATLLFDSNGEEEEAETELKASAMLSAIRDAGKTNMANEERETARVGEGVKILLVDHEDSFVHTLANYFRQTGAEVTTVRT
PVAESVFERVKPDLVVLSPGPGTPEDFDCTATIKKARGRELPIFGVCLGLQALVVAYGGELRHLHEPMHGKPSRIRAGHN
SLIFSGLPQEVTVGRYHSIFADPVRLPKPFVVTAETEDGVVMAIEHESEPVAAVQFHPESIMTLGHNAGMRMIENVVAHL
PRKSKVKAA
>Mature_728_residues
SLEVLEDGSERFVTAGGIAITRSRMEVPYGGAIDAYIDALDSRRGAVFSSNYEYPGRYTRWDTAIVDPPLVISARGRAMK
IEALNRRGEAMLPAIAGVVEALPEVTMALAQPRLITVDVSEPTEVFAEEERSRVPSVFTVLRAITNLFHTDNDSNLGLYG
AFGYDLAFQFDPVKLRLDRPESQRDLVLFLPDEILVVDHYTAKAWHDRYDYAGEGFSTEGLPREGREEPFQKPLKVPPRC
DHEPGEYASLVEKAKESFRRGDLFEVVPGQMFFEQCQNPPSAICRRLKQINPSPYSFFINLGEGEYLVGASPEMFVRVSG
RRVETCPISGTIKRGDDAISDSEQILKLLNSKKDESELTMCSDVDRNDKSRVCEPGSVRVIGRRQIEMYSRLIHTVDHIE
GRLREGMDAYDAFLSHAWAVTVTGAPKLWAMRFIEENEKSPRAWYGGAVGMVHFNGDMNTGLTLRTIRIKDGIAEVRAGA
TLLFDSNGEEEEAETELKASAMLSAIRDAGKTNMANEERETARVGEGVKILLVDHEDSFVHTLANYFRQTGAEVTTVRTP
VAESVFERVKPDLVVLSPGPGTPEDFDCTATIKKARGRELPIFGVCLGLQALVVAYGGELRHLHEPMHGKPSRIRAGHNS
LIFSGLPQEVTVGRYHSIFADPVRLPKPFVVTAETEDGVVMAIEHESEPVAAVQFHPESIMTLGHNAGMRMIENVVAHLP
RKSKVKAA

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=466, Percent_Identity=31.3304721030043, Blast_Score=187, Evalue=2e-48,
Organism=Escherichia coli, GI1788114, Length=356, Percent_Identity=30.3370786516854, Blast_Score=139, Evalue=7e-34,
Organism=Escherichia coli, GI1789760, Length=189, Percent_Identity=39.1534391534392, Blast_Score=126, Evalue=4e-30,
Organism=Escherichia coli, GI1787517, Length=198, Percent_Identity=37.8787878787879, Blast_Score=123, Evalue=5e-29,
Organism=Escherichia coli, GI1786809, Length=227, Percent_Identity=29.9559471365639, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320935, Length=290, Percent_Identity=37.5862068965517, Blast_Score=166, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6322638, Length=193, Percent_Identity=37.3056994818653, Blast_Score=127, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6324361, Length=217, Percent_Identity=27.6497695852535, Blast_Score=71, Evalue=6e-13,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR006805
- InterPro:   IPR006220
- InterPro:   IPR010112
- InterPro:   IPR001317
- InterPro:   IPR015890
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR006221 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind; PF00117 GATase [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 80894; Mature: 80763

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLEVLEDGSERFVTAGGIAITRSRMEVPYGGAIDAYIDALDSRRGAVFSSNYEYPGRYT
CCCEEEECCCCEEEEECCEEEEECCCCCCCCCHHHHHHHHHHCCCCCEEECCCCCCCCCC
RWDTAIVDPPLVISARGRAMKIEALNRRGEAMLPAIAGVVEALPEVTMALAQPRLITVDV
CCCCEECCCCEEEECCCCEEEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEC
SEPTEVFAEEERSRVPSVFTVLRAITNLFHTDNDSNLGLYGAFGYDLAFQFDPVKLRLDR
CCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCEEEEECCEEEEECC
PESQRDLVLFLPDEILVVDHYTAKAWHDRYDYAGEGFSTEGLPREGREEPFQKPLKVPPR
CCCCCCEEEECCCCEEEEECCHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCC
CDHEPGEYASLVEKAKESFRRGDLFEVVPGQMFFEQCQNPPSAICRRLKQINPSPYSFFI
CCCCCCHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEE
NLGEGEYLVGASPEMFVRVSGRRVETCPISGTIKRGDDAISDSEQILKLLNSKKDESELT
ECCCCCEEECCCCCEEEEECCCEEEECCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHH
MCSDVDRNDKSRVCEPGSVRVIGRRQIEMYSRLIHTVDHIEGRLREGMDAYDAFLSHAWA
EHHCCCCCCHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCEE
VTVTGAPKLWAMRFIEENEKSPRAWYGGAVGMVHFNGDMNTGLTLRTIRIKDGIAEVRAG
EEECCCCHHHHHHHHHHCCCCCCEEECCEEEEEEECCCCCCCEEEEEEEECCCHHHHHCC
ATLLFDSNGEEEEAETELKASAMLSAIRDAGKTNMANEERETARVGEGVKILLVDHEDSF
EEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCEEEEEEECCCHH
VHTLANYFRQTGAEVTTVRTPVAESVFERVKPDLVVLSPGPGTPEDFDCTATIKKARGRE
HHHHHHHHHHCCCEEEEEECHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHCCCCC
LPIFGVCLGLQALVVAYGGELRHLHEPMHGKPSRIRAGHNSLIFSGLPQEVTVGRYHSIF
CCHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCHHEECCCCCEEECCCCCHHCCCHHHHHH
ADPVRLPKPFVVTAETEDGVVMAIEHESEPVAAVQFHPESIMTLGHNAGMRMIENVVAHL
CCCCCCCCCEEEEEECCCCEEEEEECCCCCEEEEEECCHHHHHCCCCCCHHHHHHHHHHC
PRKSKVKAA
CCCCCCCCC
>Mature Secondary Structure 
SLEVLEDGSERFVTAGGIAITRSRMEVPYGGAIDAYIDALDSRRGAVFSSNYEYPGRYT
CCEEEECCCCEEEEECCEEEEECCCCCCCCCHHHHHHHHHHCCCCCEEECCCCCCCCCC
RWDTAIVDPPLVISARGRAMKIEALNRRGEAMLPAIAGVVEALPEVTMALAQPRLITVDV
CCCCEECCCCEEEECCCCEEEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEC
SEPTEVFAEEERSRVPSVFTVLRAITNLFHTDNDSNLGLYGAFGYDLAFQFDPVKLRLDR
CCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCEEEEECCEEEEECC
PESQRDLVLFLPDEILVVDHYTAKAWHDRYDYAGEGFSTEGLPREGREEPFQKPLKVPPR
CCCCCCEEEECCCCEEEEECCHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCC
CDHEPGEYASLVEKAKESFRRGDLFEVVPGQMFFEQCQNPPSAICRRLKQINPSPYSFFI
CCCCCCHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEE
NLGEGEYLVGASPEMFVRVSGRRVETCPISGTIKRGDDAISDSEQILKLLNSKKDESELT
ECCCCCEEECCCCCEEEEECCCEEEECCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHH
MCSDVDRNDKSRVCEPGSVRVIGRRQIEMYSRLIHTVDHIEGRLREGMDAYDAFLSHAWA
EHHCCCCCCHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCEE
VTVTGAPKLWAMRFIEENEKSPRAWYGGAVGMVHFNGDMNTGLTLRTIRIKDGIAEVRAG
EEECCCCHHHHHHHHHHCCCCCCEEECCEEEEEEECCCCCCCEEEEEEEECCCHHHHHCC
ATLLFDSNGEEEEAETELKASAMLSAIRDAGKTNMANEERETARVGEGVKILLVDHEDSF
EEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCEEEEEEECCCHH
VHTLANYFRQTGAEVTTVRTPVAESVFERVKPDLVVLSPGPGTPEDFDCTATIKKARGRE
HHHHHHHHHHCCCEEEEEECHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHCCCCC
LPIFGVCLGLQALVVAYGGELRHLHEPMHGKPSRIRAGHNSLIFSGLPQEVTVGRYHSIF
CCHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCHHEECCCCCEEECCCCCHHCCCHHHHHH
ADPVRLPKPFVVTAETEDGVVMAIEHESEPVAAVQFHPESIMTLGHNAGMRMIENVVAHL
CCCCCCCCCEEEEEECCCCEEEEEECCCCCEEEEEECCHHHHHCCCCCCHHHHHHHHHHC
PRKSKVKAA
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2656657; 11481430 [H]