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The map label for this gene is apt

Identifier: 110634512

GI number: 110634512

Start: 2313217

End: 2313762

Strand: Reverse

Name: apt

Synonym: Meso_2163

Alternate gene names: 110634512

Gene position: 2313762-2313217 (Counterclockwise)

Preceding gene: 110634513

Following gene: 110634511

Centisome position: 52.44

GC content: 62.27

Gene sequence:

>546_bases
ATGAAACAGTCGCTTGAAGATACCCTACTGGCCGCCATCCGCACCATTCCCGACTATCCGAGGCCGGGAATCCTCTTTCG
CGACATCACTACGCTGCTTGGTGACGCACGCGCCTTCCGCCGGGCCGTGGATGAACTCGTCCATCCCTATGCCGGCGCGA
AGATAGACAAGATCGCAGGTATCGAGGCGCGCGGCTTCATCCTGGGCGGTGCCATTGCCCATCAGCTCTCCTCGGGCTTT
ATCCCCATCCGCAAGAAGGGCAAGCTCCCGCACGAGACCGTGCGCGTCGCCTACAGCCTGGAATACGGGCTCGACGAGAT
GGAGATGCACATCGATGCCGTCTCGCCGGGCGAGAAAGTCATCCTTGTCGACGATCTGATTGCGACGGGCGGGACGGCGG
AGGCTGCCGTGAGGCTCTTGCGGCAGATGGGAGCGGAGATTGTGGCTGCATGCTTCGTCATCGACCTGCCGGATCTCGGC
GGCCGTGCAAAGCTGGAAGCGGAAGGCGTGGATGTGCGCACGCTGGTTTCGTTCGAGGGGCATTGA

Upstream 100 bases:

>100_bases
CTAGCAGTAGGCCTGAAATCGGAACAAAGGGCGCCGAGTGGCGCCCTTTTCTTTGCCGGCAGGAAGAGGCACAAAAGGAC
AAACGGGGGACTTGGCCTCA

Downstream 100 bases:

>100_bases
ACGGTTCCGGGTTTATTTGGTAACGAGCGACCTATCGACCCAAACGAGAACCGAACTTTTCCGTGTCGGCCGACTTTGGT
CACAACAGCATTTGTGACGC

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 181; Mature: 181

Protein sequence:

>181_residues
MKQSLEDTLLAAIRTIPDYPRPGILFRDITTLLGDARAFRRAVDELVHPYAGAKIDKIAGIEARGFILGGAIAHQLSSGF
IPIRKKGKLPHETVRVAYSLEYGLDEMEMHIDAVSPGEKVILVDDLIATGGTAEAAVRLLRQMGAEIVAACFVIDLPDLG
GRAKLEAEGVDVRTLVSFEGH

Sequences:

>Translated_181_residues
MKQSLEDTLLAAIRTIPDYPRPGILFRDITTLLGDARAFRRAVDELVHPYAGAKIDKIAGIEARGFILGGAIAHQLSSGF
IPIRKKGKLPHETVRVAYSLEYGLDEMEMHIDAVSPGEKVILVDDLIATGGTAEAAVRLLRQMGAEIVAACFVIDLPDLG
GRAKLEAEGVDVRTLVSFEGH
>Mature_181_residues
MKQSLEDTLLAAIRTIPDYPRPGILFRDITTLLGDARAFRRAVDELVHPYAGAKIDKIAGIEARGFILGGAIAHQLSSGF
IPIRKKGKLPHETVRVAYSLEYGLDEMEMHIDAVSPGEKVILVDDLIATGGTAEAAVRLLRQMGAEIVAACFVIDLPDLG
GRAKLEAEGVDVRTLVSFEGH

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=156, Percent_Identity=46.1538461538462, Blast_Score=146, Evalue=1e-35,
Organism=Homo sapiens, GI71773201, Length=121, Percent_Identity=47.9338842975207, Blast_Score=121, Evalue=3e-28,
Organism=Escherichia coli, GI1786675, Length=179, Percent_Identity=52.5139664804469, Blast_Score=199, Evalue=7e-53,
Organism=Caenorhabditis elegans, GI17509087, Length=171, Percent_Identity=40.9356725146199, Blast_Score=122, Evalue=8e-29,
Organism=Saccharomyces cerevisiae, GI6323619, Length=168, Percent_Identity=40.4761904761905, Blast_Score=114, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6320649, Length=171, Percent_Identity=38.0116959064327, Blast_Score=99, Evalue=5e-22,
Organism=Drosophila melanogaster, GI17136334, Length=174, Percent_Identity=40.2298850574713, Blast_Score=121, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_MESSB (Q11GC0)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_674720.1
- ProteinModelPortal:   Q11GC0
- SMR:   Q11GC0
- STRING:   Q11GC0
- GeneID:   4182248
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_2163
- NMPDR:   fig|266779.1.peg.1747
- eggNOG:   COG0503
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- PhylomeDB:   Q11GC0
- ProtClustDB:   PRK02304
- BioCyc:   MSP266779:MESO_2163-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 19544; Mature: 19544

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQSLEDTLLAAIRTIPDYPRPGILFRDITTLLGDARAFRRAVDELVHPYAGAKIDKIAG
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCC
IEARGFILGGAIAHQLSSGFIPIRKKGKLPHETVRVAYSLEYGLDEMEMHIDAVSPGEKV
CCCCCEEEHHHHHHHHHCCCEEECCCCCCCHHHHEEEEHHHCCCCHHHHEEECCCCCCEE
ILVDDLIATGGTAEAAVRLLRQMGAEIVAACFVIDLPDLGGRAKLEAEGVDVRTLVSFEG
EEEECHHCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCEEEECCCCEEEEEEECC
H
C
>Mature Secondary Structure
MKQSLEDTLLAAIRTIPDYPRPGILFRDITTLLGDARAFRRAVDELVHPYAGAKIDKIAG
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCC
IEARGFILGGAIAHQLSSGFIPIRKKGKLPHETVRVAYSLEYGLDEMEMHIDAVSPGEKV
CCCCCEEEHHHHHHHHHCCCEEECCCCCCCHHHHEEEEHHHCCCCHHHHEEECCCCCCEE
ILVDDLIATGGTAEAAVRLLRQMGAEIVAACFVIDLPDLGGRAKLEAEGVDVRTLVSFEG
EEEECHHCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCEEEECCCCEEEEEEECC
H
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA