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The map label for this gene is ldc [H]

Identifier: 110634377

GI number: 110634377

Start: 2179164

End: 2180384

Strand: Reverse

Name: ldc [H]

Synonym: Meso_2027

Alternate gene names: 110634377

Gene position: 2180384-2179164 (Counterclockwise)

Preceding gene: 110634378

Following gene: 110634374

Centisome position: 49.41

GC content: 63.47

Gene sequence:

>1221_bases
ATGCAGCGATTCGAGACCGCCCGCGACGTTGCGCTCAACATGCGCCCCGACGAATCCGTCTATTGCTTCCGGCCGGAGGT
GCTGAAGGCGGATGCGCGCGGCTTCATGGGCCTTTTCCCCGGCAAGACCGCTTATGCCGTGAAGACCAATGGTGAGCCGC
TTGTGTTGAAGACGCTGGCTGAGGCCGGCGTTACCGCCTTCGACGTGGCGTCGCCAGCGGAGTTCGCCGCCGTGCGTGCC
GTCGCTCCATCAGCCGAGATGCTCTACATGCATCCCGTCAAGGCGCAGGCGGATATCCGCCTGGCGCTCGAAGGCTATGG
CATCCGAAAAATCGCCGTGGATCACGAGGACGAGGTGACGAAGCTTACGCGCGTCGTGCGCGCGCTCGATATCGATCCGG
GCAGGCTCACCGTCTTCGTGCGCATCCAAACCAAGGGGCAGGCGACCTATGAGCTCTCGAAGAAGTTTGGCGCGGGGCCG
GCCCAAGCGGTACAGCTTCTGCAGCGTCTTCATCGCAACGGCTATAAGGTAGGCATCTGCTTTCACGTCGGCAGCCAGAT
CGAGGAGCCCTATGTCTATGAGCGGGCGCTCGCCTCGGCAGATTGGGTGCGGGGCAGGGCGGGCGTGCCGCTTGCGGCGC
TGGATATCGGCGGCGGGTTTCCGGCTGAATACGGCCACGACCCAAATCGCCGAAAGTCCGAAATGCCTTCGCTGGAAGAG
CTCATGGCGCGGGTGAGGGCCGACATTGCCGAATGGGGCTTCGATACGCTGCCGCTGGTGGCCGAGCCCGGCCGCGTGAT
CGTCGCACGCGCCTTCTCACTGATCGTGCGGGTGCTTCTGCGCAAGGGCAGGCGGCTCTACATCAATGACGGCATCTGGG
CATCATTGTCCGATTCCTGGACGGGCAAGATAACGCTGCCCGCCCGCTTCATCCCCGACCCGGCCATTCGCTCGCGCAGC
GGCAGTGCCGAGAATATCGTGCCGTTTCGTGTCTGCGGCGCGACCTGCGATTCGGTCGACATTCTCTCACGGCCCTTTTG
GCTCCCCGAAACCGTCGACACGGGCGACTGGATCGAGATCGGCCATATCGGCGCCTATTCCATGGCGCTGCGGACCCGCT
TTAACGGATTTTATCCCGACACCTTCGTCGAGGTGGAAAGACCATTCGACGAAGGCGCTGCTCCTGAGGGGATGGCGAGC
CTGGAGACGATGGCCGACTAA

Upstream 100 bases:

>100_bases
CACTGGCAAGACGGGCCTTGCTTTTCCGGGTGAACTTGACGGCGGCGGTTTCCCTTGCAGCAACCGCGGACTAGTTTCTT
CCAGCACCGGAGAACCCGCC

Downstream 100 bases:

>100_bases
GGCCGCAAGGCAGTATGCTTATGGTGCCTGGACAACCCTAGTGAGTTGTCTTTCCCTACTGTCCTAGCCCGATCAGCAGC
GTCTGCGTTGGCCATCCATC

Product: Orn/DAP/Arg decarboxylase 2

Products: NA

Alternate protein names: LDC [H]

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MQRFETARDVALNMRPDESVYCFRPEVLKADARGFMGLFPGKTAYAVKTNGEPLVLKTLAEAGVTAFDVASPAEFAAVRA
VAPSAEMLYMHPVKAQADIRLALEGYGIRKIAVDHEDEVTKLTRVVRALDIDPGRLTVFVRIQTKGQATYELSKKFGAGP
AQAVQLLQRLHRNGYKVGICFHVGSQIEEPYVYERALASADWVRGRAGVPLAALDIGGGFPAEYGHDPNRRKSEMPSLEE
LMARVRADIAEWGFDTLPLVAEPGRVIVARAFSLIVRVLLRKGRRLYINDGIWASLSDSWTGKITLPARFIPDPAIRSRS
GSAENIVPFRVCGATCDSVDILSRPFWLPETVDTGDWIEIGHIGAYSMALRTRFNGFYPDTFVEVERPFDEGAAPEGMAS
LETMAD

Sequences:

>Translated_406_residues
MQRFETARDVALNMRPDESVYCFRPEVLKADARGFMGLFPGKTAYAVKTNGEPLVLKTLAEAGVTAFDVASPAEFAAVRA
VAPSAEMLYMHPVKAQADIRLALEGYGIRKIAVDHEDEVTKLTRVVRALDIDPGRLTVFVRIQTKGQATYELSKKFGAGP
AQAVQLLQRLHRNGYKVGICFHVGSQIEEPYVYERALASADWVRGRAGVPLAALDIGGGFPAEYGHDPNRRKSEMPSLEE
LMARVRADIAEWGFDTLPLVAEPGRVIVARAFSLIVRVLLRKGRRLYINDGIWASLSDSWTGKITLPARFIPDPAIRSRS
GSAENIVPFRVCGATCDSVDILSRPFWLPETVDTGDWIEIGHIGAYSMALRTRFNGFYPDTFVEVERPFDEGAAPEGMAS
LETMAD
>Mature_406_residues
MQRFETARDVALNMRPDESVYCFRPEVLKADARGFMGLFPGKTAYAVKTNGEPLVLKTLAEAGVTAFDVASPAEFAAVRA
VAPSAEMLYMHPVKAQADIRLALEGYGIRKIAVDHEDEVTKLTRVVRALDIDPGRLTVFVRIQTKGQATYELSKKFGAGP
AQAVQLLQRLHRNGYKVGICFHVGSQIEEPYVYERALASADWVRGRAGVPLAALDIGGGFPAEYGHDPNRRKSEMPSLEE
LMARVRADIAEWGFDTLPLVAEPGRVIVARAFSLIVRVLLRKGRRLYINDGIWASLSDSWTGKITLPARFIPDPAIRSRS
GSAENIVPFRVCGATCDSVDILSRPFWLPETVDTGDWIEIGHIGAYSMALRTRFNGFYPDTFVEVERPFDEGAAPEGMAS
LETMAD

Specific function: Decarboxylates both L-lysine and L-ornithine with similar catalytic efficiency [H]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=378, Percent_Identity=29.3650793650794, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI16506287, Length=360, Percent_Identity=25.8333333333333, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI22538418, Length=363, Percent_Identity=27.2727272727273, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI21361583, Length=363, Percent_Identity=27.2727272727273, Blast_Score=102, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17562780, Length=357, Percent_Identity=29.1316526610644, Blast_Score=117, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6322664, Length=368, Percent_Identity=28.5326086956522, Blast_Score=109, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24586472, Length=357, Percent_Identity=29.1316526610644, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24586474, Length=353, Percent_Identity=30.028328611898, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183
- InterPro:   IPR002433 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.17; =4.1.1.18 [H]

Molecular weight: Translated: 44750; Mature: 44750

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRFETARDVALNMRPDESVYCFRPEVLKADARGFMGLFPGKTAYAVKTNGEPLVLKTLA
CCCHHCCHHEEEECCCCCCEEEECCHHHHHCCCCCEEECCCCEEEEEECCCCCEEEEEHH
EAGVTAFDVASPAEFAAVRAVAPSAEMLYMHPVKAQADIRLALEGYGIRKIAVDHEDEVT
HCCCEEEECCCCHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEECCCEEEEEECCCHHHH
KLTRVVRALDIDPGRLTVFVRIQTKGQATYELSKKFGAGPAQAVQLLQRLHRNGYKVGIC
HHHHHHHHHCCCCCEEEEEEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEE
FHVGSQIEEPYVYERALASADWVRGRAGVPLAALDIGGGFPAEYGHDPNRRKSEMPSLEE
EECCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCHHCCCCHHH
LMARVRADIAEWGFDTLPLVAEPGRVIVARAFSLIVRVLLRKGRRLYINDGIWASLSDSW
HHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCEEEEECCEEEECCCCC
TGKITLPARFIPDPAIRSRSGSAENIVPFRVCGATCDSVDILSRPFWLPETVDTGDWIEI
CEEEEECHHCCCCHHHHCCCCCCCCCCEEEEECCCCCCHHHHCCCCCCCCCCCCCCEEEE
GHIGAYSMALRTRFNGFYPDTFVEVERPFDEGAAPEGMASLETMAD
CCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHCC
>Mature Secondary Structure
MQRFETARDVALNMRPDESVYCFRPEVLKADARGFMGLFPGKTAYAVKTNGEPLVLKTLA
CCCHHCCHHEEEECCCCCCEEEECCHHHHHCCCCCEEECCCCEEEEEECCCCCEEEEEHH
EAGVTAFDVASPAEFAAVRAVAPSAEMLYMHPVKAQADIRLALEGYGIRKIAVDHEDEVT
HCCCEEEECCCCHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEECCCEEEEEECCCHHHH
KLTRVVRALDIDPGRLTVFVRIQTKGQATYELSKKFGAGPAQAVQLLQRLHRNGYKVGIC
HHHHHHHHHCCCCCEEEEEEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEE
FHVGSQIEEPYVYERALASADWVRGRAGVPLAALDIGGGFPAEYGHDPNRRKSEMPSLEE
EECCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCHHCCCCHHH
LMARVRADIAEWGFDTLPLVAEPGRVIVARAFSLIVRVLLRKGRRLYINDGIWASLSDSW
HHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCEEEEECCEEEECCCCC
TGKITLPARFIPDPAIRSRSGSAENIVPFRVCGATCDSVDILSRPFWLPETVDTGDWIEI
CEEEEECHHCCCCHHHHCCCCCCCCCCEEEEECCCCCCHHHHCCCCCCCCCCCCCCEEEE
GHIGAYSMALRTRFNGFYPDTFVEVERPFDEGAAPEGMASLETMAD
CCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11073919 [H]