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The map label for this gene is murB

Identifier: 110634355

GI number: 110634355

Start: 2151446

End: 2152411

Strand: Reverse

Name: murB

Synonym: Meso_2005

Alternate gene names: 110634355

Gene position: 2152411-2151446 (Counterclockwise)

Preceding gene: 110634356

Following gene: 110634354

Centisome position: 48.78

GC content: 62.01

Gene sequence:

>966_bases
GTGACCCGCGGCTCCGTACTCCTTGAAAAGCTCGGCGACCGGCTATCCGGCCTGCGCGGGCGGCTCACGCCGGATGCCGG
CATGGACAAGATCACCTGGTTCCGCGCGGGTGGAGAGGCGGACCTGCTTTTCCAGCCGCAGGATGAGGAGGATCTCGCGG
CCTTTCTTAAAGCGGTGCCTGAAGAAATCCCGGTGACGATTGTCGGCATTGGCTCCAATCTTCTGGTTCGCGACGACGGC
ATGCGCGGTTTCGTCGTGCGGCTTTCAGCCAAGGGCTTTGGTGAAGCCGAGGTGATTTCGCCCACCCGTATCCGAGCAGG
CGCGGCGATACCGGACAAGCGGCTTGCCGCCTTCGCGCTCGAAGCAGGCATCGGCGGCTTCCATTTTTTCCATGGCATTC
CCGGAGGTTTGGGCGGTGCGCTGCGCATGAATGCCGGCGCGAATGGCGTGGAGACGAGCGAACGTGTCGTGGAGGTGCGC
GCGCTCGACCGTCGGGGCGAGCTGCACGTGTTTTCCAATGCCGAGATGGGGTATTCCTACCGCGCATCGGCGGCATCGCA
GGGGCTTATCTTCACATCGGCTGTGCTTGAAGGCTACGCGGAGGATCGCGAGGCCATCCGGGCTGCCATGGATGCCGTTC
AGCATCATCGCGAAACGGTCCAGCCCATCCGGGAGAAGACAGGAGGCTCGACCTTCAAAAACCCGGAGGGCACCTCCGCC
TGGAAGGAGATCGACAGGGCCGGCTGCCGCGGCCTGATGATTGGCGGCGCCCAAATGTCGCCCATGCATTGCAATTTCAT
GATCAATACCGGCACGGCAACCGGCTACGATCTCGAATATCTGGGCGAAACGGTTCGCGCACGCGTTTTGGAGAATTCCG
GCATAAAGCTGGAGTGGGAGATCAAGCGTATCGGCGCCTTTAAGCCGGACCATTCGGTCGATCCGTTCCTCGGCCAATTG
CTTTAG

Upstream 100 bases:

>100_bases
CCATCGTGCGCGAGGCGGCCAATGAAGGCGATTTCGTCGTCTTTCTCGGCGCGGGCAATATCACTCAATGGGCCTATGCC
CTGCCCAAGGAACTCTGTTC

Downstream 100 bases:

>100_bases
TTTCTCAGGGGTGTGCTGTCGGCACTTGAATGCCGATCCGCATGTTCACCGTTCAGGAGCACCGGGGCTCTCGTTGCGCG
GAGGCTATGGCTGCGTCTGC

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase

Number of amino acids: Translated: 321; Mature: 320

Protein sequence:

>321_residues
MTRGSVLLEKLGDRLSGLRGRLTPDAGMDKITWFRAGGEADLLFQPQDEEDLAAFLKAVPEEIPVTIVGIGSNLLVRDDG
MRGFVVRLSAKGFGEAEVISPTRIRAGAAIPDKRLAAFALEAGIGGFHFFHGIPGGLGGALRMNAGANGVETSERVVEVR
ALDRRGELHVFSNAEMGYSYRASAASQGLIFTSAVLEGYAEDREAIRAAMDAVQHHRETVQPIREKTGGSTFKNPEGTSA
WKEIDRAGCRGLMIGGAQMSPMHCNFMINTGTATGYDLEYLGETVRARVLENSGIKLEWEIKRIGAFKPDHSVDPFLGQL
L

Sequences:

>Translated_321_residues
MTRGSVLLEKLGDRLSGLRGRLTPDAGMDKITWFRAGGEADLLFQPQDEEDLAAFLKAVPEEIPVTIVGIGSNLLVRDDG
MRGFVVRLSAKGFGEAEVISPTRIRAGAAIPDKRLAAFALEAGIGGFHFFHGIPGGLGGALRMNAGANGVETSERVVEVR
ALDRRGELHVFSNAEMGYSYRASAASQGLIFTSAVLEGYAEDREAIRAAMDAVQHHRETVQPIREKTGGSTFKNPEGTSA
WKEIDRAGCRGLMIGGAQMSPMHCNFMINTGTATGYDLEYLGETVRARVLENSGIKLEWEIKRIGAFKPDHSVDPFLGQL
L
>Mature_320_residues
TRGSVLLEKLGDRLSGLRGRLTPDAGMDKITWFRAGGEADLLFQPQDEEDLAAFLKAVPEEIPVTIVGIGSNLLVRDDGM
RGFVVRLSAKGFGEAEVISPTRIRAGAAIPDKRLAAFALEAGIGGFHFFHGIPGGLGGALRMNAGANGVETSERVVEVRA
LDRRGELHVFSNAEMGYSYRASAASQGLIFTSAVLEGYAEDREAIRAAMDAVQHHRETVQPIREKTGGSTFKNPEGTSAW
KEIDRAGCRGLMIGGAQMSPMHCNFMINTGTATGYDLEYLGETVRARVLENSGIKLEWEIKRIGAFKPDHSVDPFLGQLL

Specific function: Cell wall formation

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURB_MESSB (Q11GS7)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_674563.1
- ProteinModelPortal:   Q11GS7
- SMR:   Q11GS7
- STRING:   Q11GS7
- GeneID:   4182798
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_2005
- NMPDR:   fig|266779.1.peg.600
- eggNOG:   COG0812
- HOGENOM:   HBG686573
- OMA:   SKKHAGF
- PhylomeDB:   Q11GS7
- ProtClustDB:   PRK13905
- BioCyc:   MSP266779:MESO_2005-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00037
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094
- Gene3D:   G3DSA:3.30.465.10
- Gene3D:   G3DSA:3.30.43.10
- Gene3D:   G3DSA:3.90.78.10
- PANTHER:   PTHR21071
- TIGRFAMs:   TIGR00179

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C; SSF56176 FAD-binding_2; SSF56194 MurB_C

EC number: =1.1.1.158

Molecular weight: Translated: 34662; Mature: 34531

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS51387 FAD_PCMH

Important sites: ACT_SITE 181-181 ACT_SITE 230-230 ACT_SITE 300-300

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRGSVLLEKLGDRLSGLRGRLTPDAGMDKITWFRAGGEADLLFQPQDEEDLAAFLKAVP
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCEEEEECCCCHHHHHHHHHHCC
EEIPVTIVGIGSNLLVRDDGMRGFVVRLSAKGFGEAEVISPTRIRAGAAIPDKRLAAFAL
HHCCEEEEEECCCEEEEECCCCEEEEEEECCCCCCCEECCCCCEECCCCCCHHHHHHHHH
EAGIGGFHFFHGIPGGLGGALRMNAGANGVETSERVVEVRALDRRGELHVFSNAEMGYSY
HHCCCHHHHHHCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCEE
RASAASQGLIFTSAVLEGYAEDREAIRAAMDAVQHHRETVQPIREKTGGSTFKNPEGTSA
ECCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHH
WKEIDRAGCRGLMIGGAQMSPMHCNFMINTGTATGYDLEYLGETVRARVLENSGIKLEWE
HHHHHHHCCCEEEECCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCEEEEE
IKRIGAFKPDHSVDPFLGQLL
EEEECCCCCCCCCCHHHHHCC
>Mature Secondary Structure 
TRGSVLLEKLGDRLSGLRGRLTPDAGMDKITWFRAGGEADLLFQPQDEEDLAAFLKAVP
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCEEEEECCCCHHHHHHHHHHCC
EEIPVTIVGIGSNLLVRDDGMRGFVVRLSAKGFGEAEVISPTRIRAGAAIPDKRLAAFAL
HHCCEEEEEECCCEEEEECCCCEEEEEEECCCCCCCEECCCCCEECCCCCCHHHHHHHHH
EAGIGGFHFFHGIPGGLGGALRMNAGANGVETSERVVEVRALDRRGELHVFSNAEMGYSY
HHCCCHHHHHHCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCEE
RASAASQGLIFTSAVLEGYAEDREAIRAAMDAVQHHRETVQPIREKTGGSTFKNPEGTSA
ECCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHH
WKEIDRAGCRGLMIGGAQMSPMHCNFMINTGTATGYDLEYLGETVRARVLENSGIKLEWE
HHHHHHHCCCEEEECCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCEEEEE
IKRIGAFKPDHSVDPFLGQLL
EEEECCCCCCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA