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The map label for this gene is murC

Identifier: 110634356

GI number: 110634356

Start: 2152408

End: 2153805

Strand: Reverse

Name: murC

Synonym: Meso_2006

Alternate gene names: 110634356

Gene position: 2153805-2152408 (Counterclockwise)

Preceding gene: 110634357

Following gene: 110634355

Centisome position: 48.81

GC content: 62.52

Gene sequence:

>1398_bases
ATGAAAATGCCGCAGACAATCGGAGTGGTGCACTTTGTGGGCATCGGCGGCATCGGCATGAGCGGCATCGCAGAGGTTCT
GCACACGCTCGGCTACCATGTGCAGGGCTCCGACCAGGCCGAAAATGCCAATGTGGTGCGCCTGCGCGAAAAGGGCATCA
AAGCCTTCATCGGCCATGCAGCGGAGAATCTGGGCGATGCGGAGGTCGTGGTGATCTCCAGCGCCATCAAGCGCGACAAC
CCGGAATATGTCGCCGCGCGCGAAAGGCACCTTCCCATCGTGCGCCGCGCGGAAATGCTCGCCGAGCTCATGCGTTTCCG
TCAGGCGGTCGCCATCGGCGGCACGCACGGCAAGACCACGACCACCTCCATGGTGGCCGCCCTCCTGGATGCGGGCGGGC
TTGACCCGACGGTCATCAATGGCGGTATCATCAACGTCTACGGCACCAATGCCCGCATGGGAGAGGGCGACTGGATGGTG
GTGGAAGCCGATGAGAGCGATGGCACCTTTCTCAAGCTCCCCGCCGATATTGCGGTGATAACCAATATCGACCCGGAGCA
TCTCGATCATTACGGCTCCTTCGACAAGGTCCGCGAGGCCTTCCGCCAGTTCGTCGAGAACGTGCCGTTCTACGGTCTCG
GCGTCATGTGCATTGATCACCCGGAAGTGCAGGCGCTTGTCTCCCGCATCGAGGACCGGCGCGTCGTCACCTATGGCGAG
AACCTTCAGGCGGATGTCCGGTTCGAGAACCATCGGATGGAGAACGGCCACTCCGTATTCGACGTCATCATCCGCGCGCG
CAAGAGCGATGCTGTGAAAGCAATGCGCGACCTGCGCCTTCCGATGCCCGGCCGGCACAATGTATCCAACGCCACCGCCG
CCATTGCCGTCGCCAACGAACTTGGTATGGGCGAAGAGGCTATCCGCAAGGGCCTTGCCGCCTTTGGCGGAGTCAAGCGC
CGTTTCACGCTGACCGGCACCTGGAATGGCATCAGCATCTTCGACGATTACGGGCATCACCCGGTGGAGATCCGCGCCGT
GCTGAAAGCTGCGCGCGAGGCCACGTCGGGCCGCATCATCGCGATCGCCCAACCGCACCGCTATACGCGGCTGCGCGATC
TGTTCGATGAATTCTCCGCCTGCTTCAACGATGCCGATACGGTTTTGGTGGCGCCGGTCTATGCGGCGGGCGAATCGCCG
ATCGCCGGCATCTCCTCCGAAGCGCTGGTGGCTAGTCTGCGCGCTGCCGGGCACCGCGATGCACGCTTTATACCGGGCCC
GGAAGCGATTGCTCCCATCGTGCGCGAGGCGGCCAATGAAGGCGATTTCGTCGTCTTTCTCGGCGCGGGCAATATCACTC
AATGGGCCTATGCCCTGCCCAAGGAACTCTGTTCGTGA

Upstream 100 bases:

>100_bases
AAAGCGTCGGCCGGCCGGATGCTTCGAGATTGCTGGCGGACGTTACGGAAGCTATTGCATCGGGGGAGACTGTTACAGAG
TTCAAACGGAGAAGAAGCGC

Downstream 100 bases:

>100_bases
CCCGCGGCTCCGTACTCCTTGAAAAGCTCGGCGACCGGCTATCCGGCCTGCGCGGGCGGCTCACGCCGGATGCCGGCATG
GACAAGATCACCTGGTTCCG

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MKMPQTIGVVHFVGIGGIGMSGIAEVLHTLGYHVQGSDQAENANVVRLREKGIKAFIGHAAENLGDAEVVVISSAIKRDN
PEYVAARERHLPIVRRAEMLAELMRFRQAVAIGGTHGKTTTTSMVAALLDAGGLDPTVINGGIINVYGTNARMGEGDWMV
VEADESDGTFLKLPADIAVITNIDPEHLDHYGSFDKVREAFRQFVENVPFYGLGVMCIDHPEVQALVSRIEDRRVVTYGE
NLQADVRFENHRMENGHSVFDVIIRARKSDAVKAMRDLRLPMPGRHNVSNATAAIAVANELGMGEEAIRKGLAAFGGVKR
RFTLTGTWNGISIFDDYGHHPVEIRAVLKAAREATSGRIIAIAQPHRYTRLRDLFDEFSACFNDADTVLVAPVYAAGESP
IAGISSEALVASLRAAGHRDARFIPGPEAIAPIVREAANEGDFVVFLGAGNITQWAYALPKELCS

Sequences:

>Translated_465_residues
MKMPQTIGVVHFVGIGGIGMSGIAEVLHTLGYHVQGSDQAENANVVRLREKGIKAFIGHAAENLGDAEVVVISSAIKRDN
PEYVAARERHLPIVRRAEMLAELMRFRQAVAIGGTHGKTTTTSMVAALLDAGGLDPTVINGGIINVYGTNARMGEGDWMV
VEADESDGTFLKLPADIAVITNIDPEHLDHYGSFDKVREAFRQFVENVPFYGLGVMCIDHPEVQALVSRIEDRRVVTYGE
NLQADVRFENHRMENGHSVFDVIIRARKSDAVKAMRDLRLPMPGRHNVSNATAAIAVANELGMGEEAIRKGLAAFGGVKR
RFTLTGTWNGISIFDDYGHHPVEIRAVLKAAREATSGRIIAIAQPHRYTRLRDLFDEFSACFNDADTVLVAPVYAAGESP
IAGISSEALVASLRAAGHRDARFIPGPEAIAPIVREAANEGDFVVFLGAGNITQWAYALPKELCS
>Mature_465_residues
MKMPQTIGVVHFVGIGGIGMSGIAEVLHTLGYHVQGSDQAENANVVRLREKGIKAFIGHAAENLGDAEVVVISSAIKRDN
PEYVAARERHLPIVRRAEMLAELMRFRQAVAIGGTHGKTTTTSMVAALLDAGGLDPTVINGGIINVYGTNARMGEGDWMV
VEADESDGTFLKLPADIAVITNIDPEHLDHYGSFDKVREAFRQFVENVPFYGLGVMCIDHPEVQALVSRIEDRRVVTYGE
NLQADVRFENHRMENGHSVFDVIIRARKSDAVKAMRDLRLPMPGRHNVSNATAAIAVANELGMGEEAIRKGLAAFGGVKR
RFTLTGTWNGISIFDDYGHHPVEIRAVLKAAREATSGRIIAIAQPHRYTRLRDLFDEFSACFNDADTVLVAPVYAAGESP
IAGISSEALVASLRAAGHRDARFIPGPEAIAPIVREAANEGDFVVFLGAGNITQWAYALPKELCS

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=461, Percent_Identity=45.3362255965293, Blast_Score=340, Evalue=1e-94,
Organism=Escherichia coli, GI1790680, Length=455, Percent_Identity=27.6923076923077, Blast_Score=163, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_MESSB (Q11GS6)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_674564.1
- ProteinModelPortal:   Q11GS6
- SMR:   Q11GS6
- STRING:   Q11GS6
- GeneID:   4182799
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_2006
- NMPDR:   fig|266779.1.peg.601
- eggNOG:   COG0773
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- PhylomeDB:   Q11GS6
- ProtClustDB:   PRK00421
- BioCyc:   MSP266779:MESO_2006-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 50426; Mature: 50426

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMPQTIGVVHFVGIGGIGMSGIAEVLHTLGYHVQGSDQAENANVVRLREKGIKAFIGHA
CCCCCHHCCEEEEECCCCCHHHHHHHHHHHCCEECCCCCCCCCCEEEEHHHHHHHHHHHH
AENLGDAEVVVISSAIKRDNPEYVAARERHLPIVRRAEMLAELMRFRQAVAIGGTHGKTT
HHCCCCCEEEEEEHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCH
TTSMVAALLDAGGLDPTVINGGIINVYGTNARMGEGDWMVVEADESDGTFLKLPADIAVI
HHHHHHHHHHCCCCCCEEECCCEEEEEECCCEECCCCEEEEEECCCCCCEEEECCCEEEE
TNIDPEHLDHYGSFDKVREAFRQFVENVPFYGLGVMCIDHPEVQALVSRIEDRRVVTYGE
ECCCHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHCCCEEEEECC
NLQADVRFENHRMENGHSVFDVIIRARKSDAVKAMRDLRLPMPGRHNVSNATAAIAVANE
CCEEEEEECCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCHHEEEEEHHH
LGMGEEAIRKGLAAFGGVKRRFTLTGTWNGISIFDDYGHHPVEIRAVLKAAREATSGRII
CCCCHHHHHHHHHHHCCCCEEEEEEEECCCEEEECCCCCCCHHHHHHHHHHHHCCCCCEE
AIAQPHRYTRLRDLFDEFSACFNDADTVLVAPVYAAGESPIAGISSEALVASLRAAGHRD
EEECCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCC
ARFIPGPEAIAPIVREAANEGDFVVFLGAGNITQWAYALPKELCS
CCCCCCHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MKMPQTIGVVHFVGIGGIGMSGIAEVLHTLGYHVQGSDQAENANVVRLREKGIKAFIGHA
CCCCCHHCCEEEEECCCCCHHHHHHHHHHHCCEECCCCCCCCCCEEEEHHHHHHHHHHHH
AENLGDAEVVVISSAIKRDNPEYVAARERHLPIVRRAEMLAELMRFRQAVAIGGTHGKTT
HHCCCCCEEEEEEHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCH
TTSMVAALLDAGGLDPTVINGGIINVYGTNARMGEGDWMVVEADESDGTFLKLPADIAVI
HHHHHHHHHHCCCCCCEEECCCEEEEEECCCEECCCCEEEEEECCCCCCEEEECCCEEEE
TNIDPEHLDHYGSFDKVREAFRQFVENVPFYGLGVMCIDHPEVQALVSRIEDRRVVTYGE
ECCCHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHCCCEEEEECC
NLQADVRFENHRMENGHSVFDVIIRARKSDAVKAMRDLRLPMPGRHNVSNATAAIAVANE
CCEEEEEECCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCHHEEEEEHHH
LGMGEEAIRKGLAAFGGVKRRFTLTGTWNGISIFDDYGHHPVEIRAVLKAAREATSGRII
CCCCHHHHHHHHHHHCCCCEEEEEEEECCCEEEECCCCCCCHHHHHHHHHHHHCCCCCEE
AIAQPHRYTRLRDLFDEFSACFNDADTVLVAPVYAAGESPIAGISSEALVASLRAAGHRD
EEECCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCC
ARFIPGPEAIAPIVREAANEGDFVVFLGAGNITQWAYALPKELCS
CCCCCCHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA