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The map label for this gene is lpxC [H]

Identifier: 110634350

GI number: 110634350

Start: 2144930

End: 2145913

Strand: Reverse

Name: lpxC [H]

Synonym: Meso_2000

Alternate gene names: 110634350

Gene position: 2145913-2144930 (Counterclockwise)

Preceding gene: 110634351

Following gene: 110634349

Centisome position: 48.63

GC content: 60.87

Gene sequence:

>984_bases
ATGAGACACGGGCAAAGGCTGTGGGCAAGCTCGCTGGGGGTAGAATTGCTGGAATATCAAACGACTCTCAAGTCGCGCTT
TACGCTGTCCGGCGTCGGTGTCCACACCGGCAAGGCCGTATCCATCCATTTCAGTCCCGCCGAAGCTGATACCGGCATTG
TCTTTCAGCGCATCGATAGTGGCGCGTCTGGAAAGGTGATCCGCGCCCTCGTATCGGATGTTGGCGCAACGGACCTTTGC
ACTGGCCTCGGCGATCCGGCGGGCGACCATGTCGCCACCGTCGAGCATCTGATGGCCGCGCTGCTCGGCATGGGCGTTGA
CAATGTCTCGATCGAGATAGACGGTCCCGAGGTGCCCATCATGGATGGCAGCGCCGCGGCTTTTGTCGACGCTTTTACGC
AGACCGGCCTCGTCCAGCTTTCGGAGAAGCGGCGCTATATTCGCATCGTGAAGCCGGTGCGGTTCGAATCAGGAAGCTCA
TGGGCCGAGTTCCAGCCCTATAACGGCACGCGCTTCGAAGTGGAGATCGATTTCGAAAGTCCAGCCATCGGGCGCCAGTC
CTTCGCCACCGATTTCACGCCCGAGATCTTTAAACGGGATATCTCTCGTGCGCGCACCTTCGGTTTCATCAAGGATGTGG
AGCGGCTTTGGGCCGCGGGATATGCGCTTGGCTCTTCGCTCGAAAATTCCGTGGTGATCGGCGAGGATCACCGCGTGATC
AATATGGAAGGGCTGCGTTACCCGAACGAGTTCGTCCGTCACAAGATGCTGGACGCCGTGGGCGATCTGGCGCTTGCAGG
GGCGCGCTTCATCGGCTGCTTCCGCTCCTATCGGGGCGGTCATCGCGTCAATGCGGCGGCGCTGCGCCATCTGCTCACAG
ACCGTTCCGCGTTCGAAATCGTGGAGGCAACTCGCGTGGGCCGTGGCCGCGGTGCCGAAATGATCGCCGTCAACGCGCCG
CTATACGCGCCCTGGATGCTTTAG

Upstream 100 bases:

>100_bases
AAAGCGTGATTTGGCGCGGGCCGGCGGCATCACTATGTTCCTGCTGTTTTCAGGCAGGGTGCCTTCAGCAGGCCTGCCAA
CGTACAGAGCCGGCCGGAAC

Downstream 100 bases:

>100_bases
GGGCGCTGCTTTCTTCTGTGGATTGCGGGGCGGCAATACCCTCTCAATCCACAGACACAGATGGTCCCTCTGGTCTTTCG
CCACAAAAATGTGCCAATAG

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MRHGQRLWASSLGVELLEYQTTLKSRFTLSGVGVHTGKAVSIHFSPAEADTGIVFQRIDSGASGKVIRALVSDVGATDLC
TGLGDPAGDHVATVEHLMAALLGMGVDNVSIEIDGPEVPIMDGSAAAFVDAFTQTGLVQLSEKRRYIRIVKPVRFESGSS
WAEFQPYNGTRFEVEIDFESPAIGRQSFATDFTPEIFKRDISRARTFGFIKDVERLWAAGYALGSSLENSVVIGEDHRVI
NMEGLRYPNEFVRHKMLDAVGDLALAGARFIGCFRSYRGGHRVNAAALRHLLTDRSAFEIVEATRVGRGRGAEMIAVNAP
LYAPWML

Sequences:

>Translated_327_residues
MRHGQRLWASSLGVELLEYQTTLKSRFTLSGVGVHTGKAVSIHFSPAEADTGIVFQRIDSGASGKVIRALVSDVGATDLC
TGLGDPAGDHVATVEHLMAALLGMGVDNVSIEIDGPEVPIMDGSAAAFVDAFTQTGLVQLSEKRRYIRIVKPVRFESGSS
WAEFQPYNGTRFEVEIDFESPAIGRQSFATDFTPEIFKRDISRARTFGFIKDVERLWAAGYALGSSLENSVVIGEDHRVI
NMEGLRYPNEFVRHKMLDAVGDLALAGARFIGCFRSYRGGHRVNAAALRHLLTDRSAFEIVEATRVGRGRGAEMIAVNAP
LYAPWML
>Mature_327_residues
MRHGQRLWASSLGVELLEYQTTLKSRFTLSGVGVHTGKAVSIHFSPAEADTGIVFQRIDSGASGKVIRALVSDVGATDLC
TGLGDPAGDHVATVEHLMAALLGMGVDNVSIEIDGPEVPIMDGSAAAFVDAFTQTGLVQLSEKRRYIRIVKPVRFESGSS
WAEFQPYNGTRFEVEIDFESPAIGRQSFATDFTPEIFKRDISRARTFGFIKDVERLWAAGYALGSSLENSVVIGEDHRVI
NMEGLRYPNEFVRHKMLDAVGDLALAGARFIGCFRSYRGGHRVNAAALRHLLTDRSAFEIVEATRVGRGRGAEMIAVNAP
LYAPWML

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=290, Percent_Identity=44.8275862068966, Blast_Score=257, Evalue=8e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.-

Molecular weight: Translated: 35693; Mature: 35693

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRHGQRLWASSLGVELLEYQTTLKSRFTLSGVGVHTGKAVSIHFSPAEADTGIVFQRIDS
CCCCHHHHHHHHHHHHHHHHHHHHHCEEEEECCEECCCEEEEEECCCCCCCCEEEEECCC
GASGKVIRALVSDVGATDLCTGLGDPAGDHVATVEHLMAALLGMGVDNVSIEIDGPEVPI
CCCCHHHHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCE
MDGSAAAFVDAFTQTGLVQLSEKRRYIRIVKPVRFESGSSWAEFQPYNGTRFEVEIDFES
ECCCHHHHHHHHHHCCHHEECCCCCEEEEECCEEECCCCCCCEECCCCCCEEEEEEECCC
PAIGRQSFATDFTPEIFKRDISRARTFGFIKDVERLWAAGYALGSSLENSVVIGEDHRVI
CCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCEEE
NMEGLRYPNEFVRHKMLDAVGDLALAGARFIGCFRSYRGGHRVNAAALRHLLTDRSAFEI
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHH
VEATRVGRGRGAEMIAVNAPLYAPWML
HHHHHCCCCCCCEEEEECCCCCCCCCC
>Mature Secondary Structure
MRHGQRLWASSLGVELLEYQTTLKSRFTLSGVGVHTGKAVSIHFSPAEADTGIVFQRIDS
CCCCHHHHHHHHHHHHHHHHHHHHHCEEEEECCEECCCEEEEEECCCCCCCCEEEEECCC
GASGKVIRALVSDVGATDLCTGLGDPAGDHVATVEHLMAALLGMGVDNVSIEIDGPEVPI
CCCCHHHHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCE
MDGSAAAFVDAFTQTGLVQLSEKRRYIRIVKPVRFESGSSWAEFQPYNGTRFEVEIDFES
ECCCHHHHHHHHHHCCHHEECCCCCEEEEECCEEECCCCCCCEECCCCCCEEEEEEECCC
PAIGRQSFATDFTPEIFKRDISRARTFGFIKDVERLWAAGYALGSSLENSVVIGEDHRVI
CCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCEEE
NMEGLRYPNEFVRHKMLDAVGDLALAGARFIGCFRSYRGGHRVNAAALRHLLTDRSAFEI
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHH
VEATRVGRGRGAEMIAVNAPLYAPWML
HHHHHCCCCCCCEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA