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The map label for this gene is ndk

Identifier: 110634329

GI number: 110634329

Start: 2120226

End: 2120648

Strand: Reverse

Name: ndk

Synonym: Meso_1979

Alternate gene names: 110634329

Gene position: 2120648-2120226 (Counterclockwise)

Preceding gene: 110634334

Following gene: 110634323

Centisome position: 48.06

GC content: 56.03

Gene sequence:

>423_bases
ATGGCGATCGAACGCACTTTTTCCATGATCAAACCGGATGCCACCAAGCGCAATCTTACCGGCGCAATCACAAAGATGCT
GGAGGATGCAGGCCTGAAGGTCGTGGCCTCCAAGCGCGTCTGGATGAGCCGTCGCCAGGCTGAAGGTTTCTATGCAGTGC
ATAAGGATCGCCCCTTCTTCGACGAGCTTTGCGAGTTCATGTCTTCAGGTCCGACGGTGATCCAGGTTCTCGAAGGCGAG
AATGCAATTGCCAAGAACCGCGAGGTGATGGGCGCGACAAACCCGGCAAATGCCGCCGAGGGCACTATCCGTAAGGTTTT
CGCGCTTTCCATCGGCGAAAACTCGGTGCACGGATCTGATGCCCCGGAAACGGCCGAGCAGGAAATTCGTTACTGGTTCT
CGGAAACTGAAATCGTCGGCTGA

Upstream 100 bases:

>100_bases
TGCTGGCCGGATGAAGGTTATGGCCCCATCCCCTTCACAGCGGGCGTTGTCGCCGCTATAGACCCGCAATCCCTTATTTC
CCTTATGCGAAGGATGTGAA

Downstream 100 bases:

>100_bases
CTGCCGTAGGTTCAGCAGAAAGCCGGGCTCTGCCCGGCTTTCTTATTTCTTCCAGCGCTCAAGGGCGTTTTCGTCTTCCG
CCTTGGCTTCCACCCATTGG

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 140; Mature: 139

Protein sequence:

>140_residues
MAIERTFSMIKPDATKRNLTGAITKMLEDAGLKVVASKRVWMSRRQAEGFYAVHKDRPFFDELCEFMSSGPTVIQVLEGE
NAIAKNREVMGATNPANAAEGTIRKVFALSIGENSVHGSDAPETAEQEIRYWFSETEIVG

Sequences:

>Translated_140_residues
MAIERTFSMIKPDATKRNLTGAITKMLEDAGLKVVASKRVWMSRRQAEGFYAVHKDRPFFDELCEFMSSGPTVIQVLEGE
NAIAKNREVMGATNPANAAEGTIRKVFALSIGENSVHGSDAPETAEQEIRYWFSETEIVG
>Mature_139_residues
AIERTFSMIKPDATKRNLTGAITKMLEDAGLKVVASKRVWMSRRQAEGFYAVHKDRPFFDELCEFMSSGPTVIQVLEGEN
AIAKNREVMGATNPANAAEGTIRKVFALSIGENSVHGSDAPETAEQEIRYWFSETEIVG

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI66392203, Length=137, Percent_Identity=44.5255474452555, Blast_Score=126, Evalue=7e-30,
Organism=Homo sapiens, GI66392227, Length=137, Percent_Identity=44.5255474452555, Blast_Score=126, Evalue=7e-30,
Organism=Homo sapiens, GI66392205, Length=137, Percent_Identity=44.5255474452555, Blast_Score=126, Evalue=7e-30,
Organism=Homo sapiens, GI4505409, Length=137, Percent_Identity=44.5255474452555, Blast_Score=126, Evalue=7e-30,
Organism=Homo sapiens, GI66392192, Length=137, Percent_Identity=44.5255474452555, Blast_Score=126, Evalue=7e-30,
Organism=Homo sapiens, GI38045913, Length=136, Percent_Identity=44.8529411764706, Blast_Score=123, Evalue=7e-29,
Organism=Homo sapiens, GI4557797, Length=136, Percent_Identity=44.8529411764706, Blast_Score=122, Evalue=8e-29,
Organism=Homo sapiens, GI37693993, Length=138, Percent_Identity=42.7536231884058, Blast_Score=122, Evalue=1e-28,
Organism=Homo sapiens, GI4826862, Length=136, Percent_Identity=37.5, Blast_Score=102, Evalue=1e-22,
Organism=Homo sapiens, GI37574614, Length=136, Percent_Identity=30.8823529411765, Blast_Score=82, Evalue=1e-16,
Organism=Homo sapiens, GI7019465, Length=136, Percent_Identity=30.8823529411765, Blast_Score=82, Evalue=1e-16,
Organism=Homo sapiens, GI4505413, Length=139, Percent_Identity=30.2158273381295, Blast_Score=73, Evalue=7e-14,
Organism=Homo sapiens, GI148839372, Length=138, Percent_Identity=29.7101449275362, Blast_Score=72, Evalue=1e-13,
Organism=Homo sapiens, GI5031951, Length=138, Percent_Identity=31.8840579710145, Blast_Score=71, Evalue=3e-13,
Organism=Escherichia coli, GI1788866, Length=138, Percent_Identity=54.3478260869565, Blast_Score=162, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=45.9259259259259, Blast_Score=125, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6322783, Length=136, Percent_Identity=42.6470588235294, Blast_Score=122, Evalue=3e-29,
Organism=Drosophila melanogaster, GI45549037, Length=136, Percent_Identity=48.5294117647059, Blast_Score=138, Evalue=1e-33,
Organism=Drosophila melanogaster, GI18860097, Length=136, Percent_Identity=30.8823529411765, Blast_Score=77, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_MESSB (Q11GV3)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_674537.1
- ProteinModelPortal:   Q11GV3
- SMR:   Q11GV3
- STRING:   Q11GV3
- GeneID:   4182585
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_1979
- NMPDR:   fig|266779.1.peg.574
- eggNOG:   COG0105
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- PhylomeDB:   Q11GV3
- ProtClustDB:   PRK00668
- BioCyc:   MSP266779:MESO_1979-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15500; Mature: 15369

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 117-117 BINDING 11-11 BINDING 59-59 BINDING 87-87 BINDING 93-93 BINDING 104-104 BINDING 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIERTFSMIKPDATKRNLTGAITKMLEDAGLKVVASKRVWMSRRQAEGFYAVHKDRPFF
CCCHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHCCCEEEEECCCCCH
DELCEFMSSGPTVIQVLEGENAIAKNREVMGATNPANAAEGTIRKVFALSIGENSVHGSD
HHHHHHHCCCCEEEEEECCCCCHHCCCCEECCCCCCCCHHHHHHHHHEEECCCCCCCCCC
APETAEQEIRYWFSETEIVG
CCHHHHHHHHHHHCCCEECC
>Mature Secondary Structure 
AIERTFSMIKPDATKRNLTGAITKMLEDAGLKVVASKRVWMSRRQAEGFYAVHKDRPFF
CCHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHCCCEEEEECCCCCH
DELCEFMSSGPTVIQVLEGENAIAKNREVMGATNPANAAEGTIRKVFALSIGENSVHGSD
HHHHHHHCCCCEEEEEECCCCCHHCCCCEECCCCCCCCHHHHHHHHHEEECCCCCCCCCC
APETAEQEIRYWFSETEIVG
CCHHHHHHHHHHHCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA