Click here to switch to the map view.

The map label for this gene is purN [H]

Identifier: 110634317

GI number: 110634317

Start: 2108027

End: 2108737

Strand: Direct

Name: purN [H]

Synonym: Meso_1967

Alternate gene names: 110634317

Gene position: 2108027-2108737 (Clockwise)

Preceding gene: 110634316

Following gene: 110634318

Centisome position: 47.77

GC content: 62.73

Gene sequence:

>711_bases
ATGAGGGTGAGGAAGAAAACAGCGATCCTTATCTCCGGGCGAGGCTCCAACATGACGGCGCTTATCCGCGCCGCGGCCGA
AGCCGATTTTCCGGCGGAGATCGCCTGTGTTCTCAGCGACAAGTCGGATGCGCCGGGGCTCGCGGCAGCGATGGCGGCCG
GAATCCCGGCCATAGCCGTGCCGCGGAGTGATTTCCCCGACAAAGCCTCCCACGAAGCAGCCATTGAAGAAGCGCTCGGG
CAGCATGGCGTGGAGCTGATCTGCCTCGCCGGATTCATGCGCATGTTGAGCGCTGAGTTTGTCGAGCGCTGGCAAGGGCG
GATGATCAACATCCATCCTTCGCTGCTGCCGCTTTTCAAAGGCCTCGATTCACACCGGAAGGCGCTGGACGCCGGCATGC
GGATCCATGGCTGCACGGTGCATTTCGTGACGCATGAAATGGATGCAGGCCCGATTATCGCGCAGGCGGCAACACCGGTT
CTGCCCGGCGACGACGAAGCTTCTTTGGCAGAGCGGGTCCTGAAGGCCGAGCACCGTTTGTACCCGCTGGCGCTCTCTCT
TGTTGCTTCGGGCCGCGCGCGCGTGGAAGAAGGCAGGACTTTCTTTGCCCCCACCGTGGATATTGGCTGGGGCGCTCAGG
CAAGCCTCATGGTCCCTTCATCGGTGGAGGAGACGGCCGATCTCGAAGACCTCGCGCGCCTGACCCCTTAA

Upstream 100 bases:

>100_bases
TTGCGGCCGTCCTGCAAAAGGAAGGTGAGCACGTGGAGATCCTGGGCAGCATCGTGCCACGGAGGGACAAGGGCGTGATC
TATCAAGGAGCGCTGGAGCT

Downstream 100 bases:

>100_bases
GCTGTGATCATTGACTTGAAGCTCGGCTGGCTCGCAGACACACCCGTTGGATCCGCACGAATTGTGATCCGCGCGTGAGG
CGTTCTGCCATAGAACAAAC

Product: phosphoribosylglycinamide formyltransferase

Products: NA

Alternate protein names: 5'-phosphoribosylglycinamide transformylase; GAR transformylase; GART [H]

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MRVRKKTAILISGRGSNMTALIRAAAEADFPAEIACVLSDKSDAPGLAAAMAAGIPAIAVPRSDFPDKASHEAAIEEALG
QHGVELICLAGFMRMLSAEFVERWQGRMINIHPSLLPLFKGLDSHRKALDAGMRIHGCTVHFVTHEMDAGPIIAQAATPV
LPGDDEASLAERVLKAEHRLYPLALSLVASGRARVEEGRTFFAPTVDIGWGAQASLMVPSSVEETADLEDLARLTP

Sequences:

>Translated_236_residues
MRVRKKTAILISGRGSNMTALIRAAAEADFPAEIACVLSDKSDAPGLAAAMAAGIPAIAVPRSDFPDKASHEAAIEEALG
QHGVELICLAGFMRMLSAEFVERWQGRMINIHPSLLPLFKGLDSHRKALDAGMRIHGCTVHFVTHEMDAGPIIAQAATPV
LPGDDEASLAERVLKAEHRLYPLALSLVASGRARVEEGRTFFAPTVDIGWGAQASLMVPSSVEETADLEDLARLTP
>Mature_236_residues
MRVRKKTAILISGRGSNMTALIRAAAEADFPAEIACVLSDKSDAPGLAAAMAAGIPAIAVPRSDFPDKASHEAAIEEALG
QHGVELICLAGFMRMLSAEFVERWQGRMINIHPSLLPLFKGLDSHRKALDAGMRIHGCTVHFVTHEMDAGPIIAQAATPV
LPGDDEASLAERVLKAEHRLYPLALSLVASGRARVEEGRTFFAPTVDIGWGAQASLMVPSSVEETADLEDLARLTP

Specific function: De novo purine biosynthesis; third step. [C]

COG id: COG0299

COG function: function code F; Folate-dependent phosphoribosylglycinamide formyltransferase PurN

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GART family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=196, Percent_Identity=46.4285714285714, Blast_Score=190, Evalue=8e-49,
Organism=Homo sapiens, GI209869995, Length=196, Percent_Identity=46.4285714285714, Blast_Score=190, Evalue=8e-49,
Organism=Homo sapiens, GI209869993, Length=196, Percent_Identity=46.4285714285714, Blast_Score=190, Evalue=8e-49,
Organism=Escherichia coli, GI1788846, Length=190, Percent_Identity=42.6315789473684, Blast_Score=163, Evalue=9e-42,
Organism=Escherichia coli, GI1787483, Length=201, Percent_Identity=29.3532338308458, Blast_Score=84, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17567511, Length=189, Percent_Identity=40.7407407407407, Blast_Score=145, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6320616, Length=196, Percent_Identity=29.0816326530612, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24582400, Length=194, Percent_Identity=47.9381443298969, Blast_Score=186, Evalue=1e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002376
- InterPro:   IPR001555
- InterPro:   IPR004607 [H]

Pfam domain/function: PF00551 Formyl_trans_N [H]

EC number: =2.1.2.2 [H]

Molecular weight: Translated: 25152; Mature: 25152

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVRKKTAILISGRGSNMTALIRAAAEADFPAEIACVLSDKSDAPGLAAAMAAGIPAIAV
CCCCCEEEEEEECCCCCHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHCCCCEEEC
PRSDFPDKASHEAAIEEALGQHGVELICLAGFMRMLSAEFVERWQGRMINIHPSLLPLFK
CCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHH
GLDSHRKALDAGMRIHGCTVHFVTHEMDAGPIIAQAATPVLPGDDEASLAERVLKAEHRL
CCHHHHHHHHCCCEEECEEEEEEEEECCCCCEEHHHCCCCCCCCCHHHHHHHHHHHHHHH
YPLALSLVASGRARVEEGRTFFAPTVDIGWGAQASLMVPSSVEETADLEDLARLTP
HHHHHHHHHCCCHHHHCCCEEECCEEECCCCCCEEEECCCCCHHHCCHHHHHHCCC
>Mature Secondary Structure
MRVRKKTAILISGRGSNMTALIRAAAEADFPAEIACVLSDKSDAPGLAAAMAAGIPAIAV
CCCCCEEEEEEECCCCCHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHCCCCEEEC
PRSDFPDKASHEAAIEEALGQHGVELICLAGFMRMLSAEFVERWQGRMINIHPSLLPLFK
CCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHH
GLDSHRKALDAGMRIHGCTVHFVTHEMDAGPIIAQAATPVLPGDDEASLAERVLKAEHRL
CCHHHHHHHHCCCEEECEEEEEEEEECCCCCEEHHHCCCCCCCCCHHHHHHHHHHHHHHH
YPLALSLVASGRARVEEGRTFFAPTVDIGWGAQASLMVPSSVEETADLEDLARLTP
HHHHHHHHHCCCHHHHCCCEEECCEEECCCCCCEEEECCCCCHHHCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]