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The map label for this gene is purM

Identifier: 110634316

GI number: 110634316

Start: 2106924

End: 2108030

Strand: Direct

Name: purM

Synonym: Meso_1966

Alternate gene names: 110634316

Gene position: 2106924-2108030 (Clockwise)

Preceding gene: 110634310

Following gene: 110634317

Centisome position: 47.75

GC content: 61.88

Gene sequence:

>1107_bases
GTGCCAATAGCCCGAGAACGAAAAGCGCGACTGGAAAATGCCATGAGCAGGAAAAAAACTGGGCTCAGCTATGCCGATGC
CGGCGTGGACATCGACGCGGGCAACGCGCTCGTGGAAAAGATCAAGCCGCTGGTGCGCGCGACACGCCGCCCAGGCGCGG
ACGGTGAGATTGGCGGGTTCGGCGGTCTTTTCGATCTGAAGGCTGCCGGTTTTACCGATCCCATCCTGATTGCCGCCAAT
GACGGGGTTGGCACCAAGCTAAAGGTCGCAATCGAGGCGGGAAAGCACGATACCGTAGGCATCGATCTCGTGGCCATGTG
CGTGAACGACCTCGTGGTGCAGGGCGCAGAACCTCTCTTTTTCCTCGATTATTTCGCGACCGGAAAACTCGATCCCGACC
AGGGAGCCGCAATTGTCGCCGGCATCGCCGAGGGATGCCGGCAAGCAGGTTGCGCGCTGATAGGCGGCGAGACCGCCGAG
ATGCCGGGCATGTACCGCGACGGCGACTACGATCTGGCAGGCTTTGCCGTTGGTGCCGCCGAGCGCGGCCGGCTTCTGCC
GACCAATGATATCGTTGAAGGCGACGTGATCCTCGGCCTTGCATCCACGGGCGTTCACTCCAACGGCTTCTCCCTGGTGC
GCAGAATCGTAGAGGTGAGCGGGCTTGATTGGAACGATCCCGCCCCATTTGATTCCGACCGCTCTCTTGCAGAGGCGCTG
CTCACGCCCACCCGCATTTACGTCAAGCCCATACTTTCCGCCATTGCAAGGACACATGGCATCAAGGCATTGGCACACAT
CACCGGCGGCGGATTTCCAGAAAACATTCCCCGCGTCCTTCCCCCGGCCTATGCGGCCGAGATCGACCTGGAGGCGGTAA
ACGTCCTCCCGGTCTTCTCCTGGCTCGCCGAGCGCGGTGGCGTGGCCGCCCAGGAGATGCTGCGCACGTTCAACTGCGGA
ATCGGCATGATCGCGGTTGTCGCTGCCGGCCAGGCCGCACAAGTTGCGGCCGTCCTGCAAAAGGAAGGTGAGCACGTGGA
GATCCTGGGCAGCATCGTGCCACGGAGGGACAAGGGCGTGATCTATCAAGGAGCGCTGGAGCTATGA

Upstream 100 bases:

>100_bases
TGCCGGAATAAATGGCTGTGCTTGCGTGGCACCGCAAGAGTGAGATTTGGTCAAACTCTGTGTGCCGCCTGGACGGGCTC
CTTGCGGCGGAGTGGCCTTC

Downstream 100 bases:

>100_bases
GGGTGAGGAAGAAAACAGCGATCCTTATCTCCGGGCGAGGCTCCAACATGACGGCGCTTATCCGCGCCGCGGCCGAAGCC
GATTTTCCGGCGGAGATCGC

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase

Number of amino acids: Translated: 368; Mature: 367

Protein sequence:

>368_residues
MPIARERKARLENAMSRKKTGLSYADAGVDIDAGNALVEKIKPLVRATRRPGADGEIGGFGGLFDLKAAGFTDPILIAAN
DGVGTKLKVAIEAGKHDTVGIDLVAMCVNDLVVQGAEPLFFLDYFATGKLDPDQGAAIVAGIAEGCRQAGCALIGGETAE
MPGMYRDGDYDLAGFAVGAAERGRLLPTNDIVEGDVILGLASTGVHSNGFSLVRRIVEVSGLDWNDPAPFDSDRSLAEAL
LTPTRIYVKPILSAIARTHGIKALAHITGGGFPENIPRVLPPAYAAEIDLEAVNVLPVFSWLAERGGVAAQEMLRTFNCG
IGMIAVVAAGQAAQVAAVLQKEGEHVEILGSIVPRRDKGVIYQGALEL

Sequences:

>Translated_368_residues
MPIARERKARLENAMSRKKTGLSYADAGVDIDAGNALVEKIKPLVRATRRPGADGEIGGFGGLFDLKAAGFTDPILIAAN
DGVGTKLKVAIEAGKHDTVGIDLVAMCVNDLVVQGAEPLFFLDYFATGKLDPDQGAAIVAGIAEGCRQAGCALIGGETAE
MPGMYRDGDYDLAGFAVGAAERGRLLPTNDIVEGDVILGLASTGVHSNGFSLVRRIVEVSGLDWNDPAPFDSDRSLAEAL
LTPTRIYVKPILSAIARTHGIKALAHITGGGFPENIPRVLPPAYAAEIDLEAVNVLPVFSWLAERGGVAAQEMLRTFNCG
IGMIAVVAAGQAAQVAAVLQKEGEHVEILGSIVPRRDKGVIYQGALEL
>Mature_367_residues
PIARERKARLENAMSRKKTGLSYADAGVDIDAGNALVEKIKPLVRATRRPGADGEIGGFGGLFDLKAAGFTDPILIAAND
GVGTKLKVAIEAGKHDTVGIDLVAMCVNDLVVQGAEPLFFLDYFATGKLDPDQGAAIVAGIAEGCRQAGCALIGGETAEM
PGMYRDGDYDLAGFAVGAAERGRLLPTNDIVEGDVILGLASTGVHSNGFSLVRRIVEVSGLDWNDPAPFDSDRSLAEALL
TPTRIYVKPILSAIARTHGIKALAHITGGGFPENIPRVLPPAYAAEIDLEAVNVLPVFSWLAERGGVAAQEMLRTFNCGI
GMIAVVAAGQAAQVAAVLQKEGEHVEILGSIVPRRDKGVIYQGALEL

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family

Homologues:

Organism=Homo sapiens, GI4503915, Length=362, Percent_Identity=54.1436464088398, Blast_Score=386, Evalue=1e-107,
Organism=Homo sapiens, GI209869995, Length=362, Percent_Identity=54.1436464088398, Blast_Score=386, Evalue=1e-107,
Organism=Homo sapiens, GI209869993, Length=362, Percent_Identity=54.1436464088398, Blast_Score=386, Evalue=1e-107,
Organism=Escherichia coli, GI1788845, Length=335, Percent_Identity=55.5223880597015, Blast_Score=364, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17567511, Length=336, Percent_Identity=47.0238095238095, Blast_Score=295, Evalue=2e-80,
Organism=Saccharomyces cerevisiae, GI6321203, Length=349, Percent_Identity=55.0143266475645, Blast_Score=373, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24582400, Length=289, Percent_Identity=47.7508650519031, Blast_Score=268, Evalue=4e-72,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR5_MESSB (Q11GW6)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_674524.1
- ProteinModelPortal:   Q11GW6
- SMR:   Q11GW6
- STRING:   Q11GW6
- GeneID:   4182572
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_1966
- NMPDR:   fig|266779.1.peg.561
- eggNOG:   COG0150
- HOGENOM:   HBG531222
- OMA:   HYDLAGF
- PhylomeDB:   Q11GW6
- ProtClustDB:   PRK05385
- BioCyc:   MSP266779:MESO_1966-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00741_B
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188
- TIGRFAMs:   TIGR00878

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.3.1

Molecular weight: Translated: 38520; Mature: 38388

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIARERKARLENAMSRKKTGLSYADAGVDIDAGNALVEKIKPLVRATRRPGADGEIGGF
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCEECCCHHHHHHHHHHHHHHCCCCCCCCCCCC
GGLFDLKAAGFTDPILIAANDGVGTKLKVAIEAGKHDTVGIDLVAMCVNDLVVQGAEPLF
CCCCCCCCCCCCCCEEEEECCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEE
FLDYFATGKLDPDQGAAIVAGIAEGCRQAGCALIGGETAEMPGMYRDGDYDLAGFAVGAA
EEEEHHCCCCCCCCCCCHHHHHHHHHHHCCCEEECCCHHHCCCCCCCCCCCCHHEEECHH
ERGRLLPTNDIVEGDVILGLASTGVHSNGFSLVRRIVEVSGLDWNDPAPFDSDRSLAEAL
HCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
LTPTRIYVKPILSAIARTHGIKALAHITGGGFPENIPRVLPPAYAAEIDLEAVNVLPVFS
HCCHHHHHHHHHHHHHHHHHHHHEEHHCCCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHH
WLAERGGVAAQEMLRTFNCGIGMIAVVAAGQAAQVAAVLQKEGEHVEILGSIVPRRDKGV
HHHHHCCHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHCCCCEEEEHHHHCCCCCCCE
IYQGALEL
EEECCCCC
>Mature Secondary Structure 
PIARERKARLENAMSRKKTGLSYADAGVDIDAGNALVEKIKPLVRATRRPGADGEIGGF
CCCHHHHHHHHHHHHHHHCCCCCCCCCCEECCCHHHHHHHHHHHHHHCCCCCCCCCCCC
GGLFDLKAAGFTDPILIAANDGVGTKLKVAIEAGKHDTVGIDLVAMCVNDLVVQGAEPLF
CCCCCCCCCCCCCCEEEEECCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEE
FLDYFATGKLDPDQGAAIVAGIAEGCRQAGCALIGGETAEMPGMYRDGDYDLAGFAVGAA
EEEEHHCCCCCCCCCCCHHHHHHHHHHHCCCEEECCCHHHCCCCCCCCCCCCHHEEECHH
ERGRLLPTNDIVEGDVILGLASTGVHSNGFSLVRRIVEVSGLDWNDPAPFDSDRSLAEAL
HCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
LTPTRIYVKPILSAIARTHGIKALAHITGGGFPENIPRVLPPAYAAEIDLEAVNVLPVFS
HCCHHHHHHHHHHHHHHHHHHHHEEHHCCCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHH
WLAERGGVAAQEMLRTFNCGIGMIAVVAAGQAAQVAAVLQKEGEHVEILGSIVPRRDKGV
HHHHHCCHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHCCCCEEEEHHHHCCCCCCCE
IYQGALEL
EEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA