Click here to switch to the map view.

The map label for this gene is hom [H]

Identifier: 110634272

GI number: 110634272

Start: 2056442

End: 2057752

Strand: Reverse

Name: hom [H]

Synonym: Meso_1922

Alternate gene names: 110634272

Gene position: 2057752-2056442 (Counterclockwise)

Preceding gene: 110634273

Following gene: 110634271

Centisome position: 46.64

GC content: 62.62

Gene sequence:

>1311_bases
ATGGCCGACGCCTTGCGCATAGGAATTGCGGGTCTTGGTACCGTTGGCGCGAGCGTTGTCCGCATGCTGGGCGCCAAGGG
GGCGGAGCTGACGCGGCAATGCGGCCGCGAGATAGCGCCCGTGGCCGTATCCGCGCGTGATCGCTCGCGCGATCGCGGCA
TTGATCTCGGCAATGCGCAATGGTTCGATGATCCGGTCGAGCTGGCGCGTTCCGCCGAAATCGATGTCTATGTCGAACTG
ATCGGCGGCGAGGATGGTGCCGCTTTTGATTCCGTGCGCGCCGCGCTGGAGGCGGGCCGTCATGTGGTGACCGCCAACAA
GGCCCTGCTTTCCAAGCATGGGGTCGATCTTGCGGCCATTGCGGAAGCAAACGGCGTGCTTCTCAATTACGAAGCCGCTG
TTGCGGGAGGGATTCCCGTCATCAAAACAATGCGCGAGGCGCTGGCGGGAAATCATGTGAGCCGGGTTTTCGGCATCCTC
AACGGCACCTGCAACTACATCCTTACGCGTATGGAGGCGGAGGGGCTCTCATTCGAGCAGTGTTTGAGCGAAGCCCAGCG
GCTCGGCTATGCGGAGGCCGATCCCACCTTCGATATCGAAGGGCACGACACCGCGCATAAGCTCTCAATTCTGACCAGCA
TTGCCTTTGGCTGCCGCATTTCGGCGGATGATATCTATCTGGAAGGCATCTCGAACATCACGCAGGCGGATATCCGGGCG
GCCGGCGAGCTTGGATACCGCATCAAGCTTCTCGGCGTTGCGCAGAAGACAGAAAGCGGGATCGAGCAGCGTGTGCACCC
GACCATGGTGCCCACCAGCTCCGTTATCGCCCAGGTTCACGGTGTCACGAATGCGGTCGCCATAGAGACGGACATGCTCG
GAGAACTGCTTCTCTCCGGCCCTGGCGCCGGCGGCGATGCCACGGCCTCGGCCGTTATCGGCGACCTGGCGGATATTGCA
AAAAGCCGGCCGGGGTTCCAGCACGGTCCGGTATTCGGGCGGCCAGCAAAGGAACTTGCCCCCTACAAGCGCGCCGCCAT
GCGCTCACACGCGGGCGGATACTTCATCCGCTTATCCGTGCACGACCGCATCGGCGTCTTTGCCGCGATTGCCAAGCGTA
TGGCGGACAACGAGATTTCGCTTGAGTCGATCGTCCAGCATGGCGATGTCACTCACGCCGACCAGAAGACGGTGATCCTC
GTCACCCATGAGACGACGGAGGCGGCGGTCCGCAGGGCCGTGGAGTGCGTCACCGAGGACGGGCATTTGCTCGACCTGCC
GCAGGTGATCCGGATCGAACGAGCGGCCTAG

Upstream 100 bases:

>100_bases
TTCCTTGCCACGGCGGCGGAGCACCCCAGCAACGTCGTCCCGTTTGCGGCTACCCGCTAAGCGGCTGCAAAATCATAATA
GTTGAAGGAAGGCATTAAAC

Downstream 100 bases:

>100_bases
ACTTTTTTCTTCACTGCCAGCTGCCCGGACCGCAGGCGGTTCAGAGTCGGTCAGGCATGATTCTCGGGCTTTTACCCCGA
GGGTCCATGCCTGTGCCTTG

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MADALRIGIAGLGTVGASVVRMLGAKGAELTRQCGREIAPVAVSARDRSRDRGIDLGNAQWFDDPVELARSAEIDVYVEL
IGGEDGAAFDSVRAALEAGRHVVTANKALLSKHGVDLAAIAEANGVLLNYEAAVAGGIPVIKTMREALAGNHVSRVFGIL
NGTCNYILTRMEAEGLSFEQCLSEAQRLGYAEADPTFDIEGHDTAHKLSILTSIAFGCRISADDIYLEGISNITQADIRA
AGELGYRIKLLGVAQKTESGIEQRVHPTMVPTSSVIAQVHGVTNAVAIETDMLGELLLSGPGAGGDATASAVIGDLADIA
KSRPGFQHGPVFGRPAKELAPYKRAAMRSHAGGYFIRLSVHDRIGVFAAIAKRMADNEISLESIVQHGDVTHADQKTVIL
VTHETTEAAVRRAVECVTEDGHLLDLPQVIRIERAA

Sequences:

>Translated_436_residues
MADALRIGIAGLGTVGASVVRMLGAKGAELTRQCGREIAPVAVSARDRSRDRGIDLGNAQWFDDPVELARSAEIDVYVEL
IGGEDGAAFDSVRAALEAGRHVVTANKALLSKHGVDLAAIAEANGVLLNYEAAVAGGIPVIKTMREALAGNHVSRVFGIL
NGTCNYILTRMEAEGLSFEQCLSEAQRLGYAEADPTFDIEGHDTAHKLSILTSIAFGCRISADDIYLEGISNITQADIRA
AGELGYRIKLLGVAQKTESGIEQRVHPTMVPTSSVIAQVHGVTNAVAIETDMLGELLLSGPGAGGDATASAVIGDLADIA
KSRPGFQHGPVFGRPAKELAPYKRAAMRSHAGGYFIRLSVHDRIGVFAAIAKRMADNEISLESIVQHGDVTHADQKTVIL
VTHETTEAAVRRAVECVTEDGHLLDLPQVIRIERAA
>Mature_435_residues
ADALRIGIAGLGTVGASVVRMLGAKGAELTRQCGREIAPVAVSARDRSRDRGIDLGNAQWFDDPVELARSAEIDVYVELI
GGEDGAAFDSVRAALEAGRHVVTANKALLSKHGVDLAAIAEANGVLLNYEAAVAGGIPVIKTMREALAGNHVSRVFGILN
GTCNYILTRMEAEGLSFEQCLSEAQRLGYAEADPTFDIEGHDTAHKLSILTSIAFGCRISADDIYLEGISNITQADIRAA
GELGYRIKLLGVAQKTESGIEQRVHPTMVPTSSVIAQVHGVTNAVAIETDMLGELLLSGPGAGGDATASAVIGDLADIAK
SRPGFQHGPVFGRPAKELAPYKRAAMRSHAGGYFIRLSVHDRIGVFAAIAKRMADNEISLESIVQHGDVTHADQKTVILV
THETTEAAVRRAVECVTEDGHLLDLPQVIRIERAA

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=250, Percent_Identity=30.4, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1790376, Length=357, Percent_Identity=25.2100840336134, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6322599, Length=230, Percent_Identity=28.695652173913, Blast_Score=70, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 46106; Mature: 45975

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADALRIGIAGLGTVGASVVRMLGAKGAELTRQCGREIAPVAVSARDRSRDRGIDLGNAQ
CCCCEEECCHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCEEEECCCCCHHCCCCCCCCC
WFDDPVELARSAEIDVYVELIGGEDGAAFDSVRAALEAGRHVVTANKALLSKHGVDLAAI
CCCCHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHCCCEEEEHHHHHHHHCCCCEEEE
AEANGVLLNYEAAVAGGIPVIKTMREALAGNHVSRVFGILNGTCNYILTRMEAEGLSFEQ
ECCCCEEEEECHHHHCCCHHHHHHHHHHCCCHHHHHHHHHCCCHHHHEEHHHCCCCCHHH
CLSEAQRLGYAEADPTFDIEGHDTAHKLSILTSIAFGCRISADDIYLEGISNITQADIRA
HHHHHHHCCCCCCCCCEECCCCCHHHHHHHHHHHHHCCEECCCCEEECCHHHHHHHHHHH
AGELGYRIKLLGVAQKTESGIEQRVHPTMVPTSSVIAQVHGVTNAVAIETDMLGELLLSG
HHCCCCEEEEEEEHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEEHHHHHHHHHCC
PGAGGDATASAVIGDLADIAKSRPGFQHGPVFGRPAKELAPYKRAAMRSHAGGYFIRLSV
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEE
HDRIGVFAAIAKRMADNEISLESIVQHGDVTHADQKTVILVTHETTEAAVRRAVECVTED
CCHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHCCC
GHLLDLPQVIRIERAA
CCEECCHHHHHHCCCC
>Mature Secondary Structure 
ADALRIGIAGLGTVGASVVRMLGAKGAELTRQCGREIAPVAVSARDRSRDRGIDLGNAQ
CCCEEECCHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCEEEECCCCCHHCCCCCCCCC
WFDDPVELARSAEIDVYVELIGGEDGAAFDSVRAALEAGRHVVTANKALLSKHGVDLAAI
CCCCHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHCCCEEEEHHHHHHHHCCCCEEEE
AEANGVLLNYEAAVAGGIPVIKTMREALAGNHVSRVFGILNGTCNYILTRMEAEGLSFEQ
ECCCCEEEEECHHHHCCCHHHHHHHHHHCCCHHHHHHHHHCCCHHHHEEHHHCCCCCHHH
CLSEAQRLGYAEADPTFDIEGHDTAHKLSILTSIAFGCRISADDIYLEGISNITQADIRA
HHHHHHHCCCCCCCCCEECCCCCHHHHHHHHHHHHHCCEECCCCEEECCHHHHHHHHHHH
AGELGYRIKLLGVAQKTESGIEQRVHPTMVPTSSVIAQVHGVTNAVAIETDMLGELLLSG
HHCCCCEEEEEEEHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEEHHHHHHHHHCC
PGAGGDATASAVIGDLADIAKSRPGFQHGPVFGRPAKELAPYKRAAMRSHAGGYFIRLSV
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEE
HDRIGVFAAIAKRMADNEISLESIVQHGDVTHADQKTVILVTHETTEAAVRRAVECVTED
CCHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHCCC
GHLLDLPQVIRIERAA
CCEECCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]