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The map label for this gene is dhaT [H]

Identifier: 110634218

GI number: 110634218

Start: 2007780

End: 2008925

Strand: Reverse

Name: dhaT [H]

Synonym: Meso_1868

Alternate gene names: 110634218

Gene position: 2008925-2007780 (Counterclockwise)

Preceding gene: 110634219

Following gene: 110634216

Centisome position: 45.53

GC content: 63.53

Gene sequence:

>1146_bases
ATGAGCATCACAGCAAACTGGAGCTACCCGACGGCAGTCAAATTCGGCGCGGGCAGGATCAGGGAACTTGCCGAGCATTG
CAAGGCCGTTGGCATGAAGCGGCCCCTGCTTATCACCGACCGCGGTCTTGCGCCGATGGCCATCACGCAGAACGCGCTGG
ACATCCTCGATGCGGCCGGCCTCGGACACGCTTTGTTTGCCGATGTCGATCCCAACCCGAACGACAAAAATCTCGAGGCG
GGCGTAAAAGCCCTAAGGGACGGGGATCATGACGGCGTCGTGGCCTTCGGCGGCGGCTCGGGTCTCGATCTAGGCAAGGC
GGTTGCCTTCATGGCCGGGCAGACGCGGCCGGTGTGGGACTTCGAGGACATAGGCGATTGGTGGACGCGCGCCTCGGTCG
AGGGCATCGCACCCATCGTCGCGGTGCCGACCACGGCCGGTACCGGTTCGGAAGTTGGCCGGGCATCGGTCATCACCCAC
TCCGAGACACACACAAAAAAGGTGATCTTCCATCCAAAATTTCTCCCTGCAGTGACGATCTGCGACCCCGAGCTGACGGT
CGGGATGCCAAAGGCCATCACAGTGGGAACCGGAATGGACGCCTTTGCCCATTGTCTCGAAGCGTATTCCTCGCCGTCCT
ATCACCCGATGAGCCAGGGCATCGCACTGGAAGGCATGCGACTGGTGAAGGATAACCTCCCAGAGGCCGTCAAGGACGGC
TCCAACATCGAGGCCCGCTCGCACATGATGTCCGCAGCGGCGATGGGCGCGGTGGCCTTCCAGAAGGGCCTGGGTGCGAT
CCACGCGCTGTCTCATCCCGTCGGCGCGATCTACAACACGCATCACGGCATGACCAATGCCGTCGTGATGCCGACGGTCC
TTCGCTTCAACCGGCCGGCCGTGGAGGCGAGGCTCGCGACGGCGGCAGCCTATCTCGGGATAAAGGGCGGCTTCGACGGC
TTCTATGATTTCGTGCTCGCGCTGCGGGCCGAACTCGGCGTCCCGGACAAGCTGTTCCAGCTTGGCGTCGGCACGGACCG
TATCGACGAGATGGCGGCGATGGCGATCGTCGATCCGACGGCGGGCGGCAACCCGGTGGAACTTACGCTGGAGGCGGCCA
AGTCGCTCTACGCCGAGTGCATCTGA

Upstream 100 bases:

>100_bases
GGACGGGCGTCAAGAATACGGGTCGCGGCGGGTCGCTGTCGGCGATAGGTTTCCACAACCTGACCCGTCCAAAATCCTAC
CATCTCAAGAAAGTCACCGC

Downstream 100 bases:

>100_bases
CTATCGACCCCGAGCCGGGTTGAACCTGCCAGTGAGGTCTTCGCCCGCGCCGGCATCAAGGACATCCTTGTCGAACCAGG
TGTGCGGCGCAGCCAAGATC

Product: iron-containing alcohol dehydrogenase

Products: NA

Alternate protein names: 1,3-propanediol oxidoreductase; 3-hydroxypropionaldehyde reductase [H]

Number of amino acids: Translated: 381; Mature: 380

Protein sequence:

>381_residues
MSITANWSYPTAVKFGAGRIRELAEHCKAVGMKRPLLITDRGLAPMAITQNALDILDAAGLGHALFADVDPNPNDKNLEA
GVKALRDGDHDGVVAFGGGSGLDLGKAVAFMAGQTRPVWDFEDIGDWWTRASVEGIAPIVAVPTTAGTGSEVGRASVITH
SETHTKKVIFHPKFLPAVTICDPELTVGMPKAITVGTGMDAFAHCLEAYSSPSYHPMSQGIALEGMRLVKDNLPEAVKDG
SNIEARSHMMSAAAMGAVAFQKGLGAIHALSHPVGAIYNTHHGMTNAVVMPTVLRFNRPAVEARLATAAAYLGIKGGFDG
FYDFVLALRAELGVPDKLFQLGVGTDRIDEMAAMAIVDPTAGGNPVELTLEAAKSLYAECI

Sequences:

>Translated_381_residues
MSITANWSYPTAVKFGAGRIRELAEHCKAVGMKRPLLITDRGLAPMAITQNALDILDAAGLGHALFADVDPNPNDKNLEA
GVKALRDGDHDGVVAFGGGSGLDLGKAVAFMAGQTRPVWDFEDIGDWWTRASVEGIAPIVAVPTTAGTGSEVGRASVITH
SETHTKKVIFHPKFLPAVTICDPELTVGMPKAITVGTGMDAFAHCLEAYSSPSYHPMSQGIALEGMRLVKDNLPEAVKDG
SNIEARSHMMSAAAMGAVAFQKGLGAIHALSHPVGAIYNTHHGMTNAVVMPTVLRFNRPAVEARLATAAAYLGIKGGFDG
FYDFVLALRAELGVPDKLFQLGVGTDRIDEMAAMAIVDPTAGGNPVELTLEAAKSLYAECI
>Mature_380_residues
SITANWSYPTAVKFGAGRIRELAEHCKAVGMKRPLLITDRGLAPMAITQNALDILDAAGLGHALFADVDPNPNDKNLEAG
VKALRDGDHDGVVAFGGGSGLDLGKAVAFMAGQTRPVWDFEDIGDWWTRASVEGIAPIVAVPTTAGTGSEVGRASVITHS
ETHTKKVIFHPKFLPAVTICDPELTVGMPKAITVGTGMDAFAHCLEAYSSPSYHPMSQGIALEGMRLVKDNLPEAVKDGS
NIEARSHMMSAAAMGAVAFQKGLGAIHALSHPVGAIYNTHHGMTNAVVMPTVLRFNRPAVEARLATAAAYLGIKGGFDGF
YDFVLALRAELGVPDKLFQLGVGTDRIDEMAAMAIVDPTAGGNPVELTLEAAKSLYAECI

Specific function: Most active with substrates containing two primary alcohol groups separated by one or two carbon atoms. In the physiological direction, 3-hydroxypropionaldehyde is the preferred substrate [H]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=351, Percent_Identity=27.9202279202279, Blast_Score=114, Evalue=2e-25,
Organism=Escherichia coli, GI48994951, Length=381, Percent_Identity=31.2335958005249, Blast_Score=203, Evalue=2e-53,
Organism=Escherichia coli, GI1789163, Length=378, Percent_Identity=30.952380952381, Blast_Score=180, Evalue=1e-46,
Organism=Escherichia coli, GI87082107, Length=375, Percent_Identity=32, Blast_Score=180, Evalue=1e-46,
Organism=Escherichia coli, GI1787493, Length=390, Percent_Identity=28.974358974359, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI1789386, Length=390, Percent_Identity=26.9230769230769, Blast_Score=92, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17537053, Length=289, Percent_Identity=26.9896193771626, Blast_Score=117, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6321181, Length=375, Percent_Identity=33.6, Blast_Score=214, Evalue=3e-56,
Organism=Drosophila melanogaster, GI24657991, Length=337, Percent_Identity=26.4094955489614, Blast_Score=111, Evalue=7e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.202 [H]

Molecular weight: Translated: 40084; Mature: 39953

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00913 ADH_IRON_1 ; PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSITANWSYPTAVKFGAGRIRELAEHCKAVGMKRPLLITDRGLAPMAITQNALDILDAAG
CEEECCCCCCCEEECCHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHCC
LGHALFADVDPNPNDKNLEAGVKALRDGDHDGVVAFGGGSGLDLGKAVAFMAGQTRPVWD
CCCEEEECCCCCCCCCCHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHCCCCCCCCC
FEDIGDWWTRASVEGIAPIVAVPTTAGTGSEVGRASVITHSETHTKKVIFHPKFLPAVTI
HHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCEEEEECCCCCCEEEEECCCCCCEEEE
CDPELTVGMPKAITVGTGMDAFAHCLEAYSSPSYHPMSQGIALEGMRLVKDNLPEAVKDG
ECCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCCCHHCCCHHHHHHHHHHCCCHHHHCC
SNIEARSHMMSAAAMGAVAFQKGLGAIHALSHPVGAIYNTHHGMTNAVVMPTVLRFNRPA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHHCCCCH
VEARLATAAAYLGIKGGFDGFYDFVLALRAELGVPDKLFQLGVGTDRIDEMAAMAIVDPT
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHEEECCC
AGGNPVELTLEAAKSLYAECI
CCCCCEEEEHHHHHHHHHHCC
>Mature Secondary Structure 
SITANWSYPTAVKFGAGRIRELAEHCKAVGMKRPLLITDRGLAPMAITQNALDILDAAG
EEECCCCCCCEEECCHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHCC
LGHALFADVDPNPNDKNLEAGVKALRDGDHDGVVAFGGGSGLDLGKAVAFMAGQTRPVWD
CCCEEEECCCCCCCCCCHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHCCCCCCCCC
FEDIGDWWTRASVEGIAPIVAVPTTAGTGSEVGRASVITHSETHTKKVIFHPKFLPAVTI
HHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCEEEEECCCCCCEEEEECCCCCCEEEE
CDPELTVGMPKAITVGTGMDAFAHCLEAYSSPSYHPMSQGIALEGMRLVKDNLPEAVKDG
ECCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCCCHHCCCHHHHHHHHHHCCCHHHHCC
SNIEARSHMMSAAAMGAVAFQKGLGAIHALSHPVGAIYNTHHGMTNAVVMPTVLRFNRPA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHHCCCCH
VEARLATAAAYLGIKGGFDGFYDFVLALRAELGVPDKLFQLGVGTDRIDEMAAMAIVDPT
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHEEECCC
AGGNPVELTLEAAKSLYAECI
CCCCCEEEEHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7721705 [H]